Advances in Brief:

Enhancement of Oxidative Cell Injury and Antitumor Effects of Localized 44°C Hyperthermia upon Combination with Respiratory Hyperoxia and Xanthine Oxidase

Juergen Frank, Debra K. Kelleher, Alfonso Pompella, Oliver Thews, Hans K. Biesalski, and Peter Vaupel
Cancer Res 1998 58: 2693-2698. [Abstract] [PDF]  

Perturbation of TSG101 Protein Affects Cell Cycle Progression

Qing Zhong, Yumay Chen, Diane Jones, and Wen-Hwa Lee
Cancer Res 1998 58: 2699-2702. [Abstract] [PDF]  

Interleukin 1ß-converting Enzyme (Caspase-1) Is Overexpressed in Adenocarcinoma of the Pancreas

Susanne Gansauge, Frank Gansauge, Yinmo Yang, Jörg Müller, Thomas Seufferlein, Marco Ramadani, and Hans G. Beger
Cancer Res 1998 58: 2703-2706. [Abstract] [PDF]  

Vaccination with Tumor Cells Engineered to Secrete Interleukin 2-Immunoglobulin G Fusion Protein Induces Tumor Rejection

Silvia Bulfone-Paus, Horst von Bernuth, René Rückert, Joachim Wachtlin, Daniela Ungureanu, Michael Notter, Hans Krause, Thomas Pohl, Ralf Paus, and Ulrich Kunzendorf
Cancer Res 1998 58: 2707-2710. [Abstract] [PDF]  

Unsymmetrically Substituted Polyamine Analogue Induces Caspase-independent Programmed Cell Death in Bcl-2-Overexpressing Cells

Hyo Chol Ha, Patrick M. Woster, and Robert A. Casero, Jr.
Cancer Res 1998 58: 2711-2714. [Abstract] [PDF]  

Genetic Changes in Inherited and Sporadic Ovarian Carcinomas by Comparative Genomic Hybridization: Extensive Similarity Except for a Difference at Chromosome 2q24–q32

Johanna Tapper, Laura Sarantaus, Pia Vahteristo, Heli Nevanlinna, Samuli Hemmer, Markku Seppälä, Sakari Knuutila, and Ralf Butzow
Cancer Res 1998 58: 2715-2719. [Abstract] [PDF]  

Frequent Inactivation of PTEN in Prostate Cancer Cell Lines and Xenografts

Remko J. Vlietstra, Dirk C. J. G. van Alewijk, Karin G. L. Hermans, Gert J. van Steenbrugge, and Jan Trapman
Cancer Res 1998 58: 2720-2723. [Abstract] [PDF]  

Absence of PTEN/MMAC1 Germ-Line Mutations in Sporadic Bannayan-Riley-Ruvalcaba Syndrome

John M. Carethers, Frank B. Furnari, Andrew F. Zigman, Joel E. Lavine, Marilyn C. Jones, Gail E. Graham, Ahmad S. Teebi, H-J. Su Huang, Hannah T. Ha, Dharam P. Chauhan, Christina L. Chang, Webster K. Cavenee, and C. Richard Boland
Cancer Res 1998 58: 2724-2726. [Abstract] [PDF]  

Type I Transforming Growth Factor ß Receptor Maps to 9q22 and Exhibits a Polymorphism and a Rare Variant within a Polyalanine Tract

Boris Pasche, Yan Luo, Pulivarthi H. Rao, Stephen D. Nimer, Ethan Dmitrovsky, Philip Caron, Lucio Luzzatto, Kenneth Offit, Carlos Cordon-Cardo, Béatrice Renault, Jaya M. Satagopan, Vundavalli V. V. S. Murty, and Joan Massagué
Cancer Res 1998 58: 2727-2732. [Abstract] [PDF]  

Procathepsin-L, a Proteinase that Cleaves Human C3 (the Third Component of Complement), Confers High Tumorigenic and Metastatic Properties to Human Melanoma Cells

Raymond Frade, Fernando Rodrigues-Lima, Suyun Huang, Keping Xie, Nathalie Guillaume, and Menashe Bar-Eli
Cancer Res 1998 58: 2733-2736. [Abstract] [PDF]  

Thymidine Phosphorylase Moderates Thymidine-dependent Rescue after Exposure to the Thymidylate Synthase Inhibitor ZD1694 (Tomudex) in Vitro

Adam V. Patterson, Denis C. Talbot, Ian J. Stratford, and Adrian L. Harris
Cancer Res 1998 58: 2737-2740. [Abstract] [PDF]  

Isolation of MOAT-B, a Widely Expressed Multidrug Resistance-associated Protein/Canalicular Multispecific Organic Anion Transporter-related Transporter

Kun Lee, Martin G. Belinsky, Daphne W. Bell, Joseph R. Testa, and Gary D. Kruh
Cancer Res 1998 58: 2741-2747. [Abstract] [PDF]  

Carcinogenesis:

Ornithine Decarboxylase Induction in Transformation by H-Ras and RhoA

Lisa M. Shantz and Anthony E. Pegg
Cancer Res 1998 58: 2748-2753. [Abstract] [PDF]  

Diosmin and Diosmetin Are Agonists of the Aryl Hydrocarbon Receptor That Differentially Affect Cytochrome P450 1A1 Activity

Henry P. Ciolino, Thomas T. Y. Wang, and Grace Chao Yeh
Cancer Res 1998 58: 2754-2760. [Abstract] [PDF]  

Clinical Investigations:

Detection and Quantitation of Circulating Cancer Cells in the Peripheral Blood of Lung Cancer Patients

Konan Peck, Yuh-Pyng Sher, Jin-Yuan Shih, Steve R. Roffler, Cheng-Wen Wu, and Pan-Chyr Yang
Cancer Res 1998 58: 2761-2765. [Abstract] [PDF]  

The Relationship between nm23, Angiogenesis, and the Metastatic Proclivity of Node-negative Breast Cancer

Ruth Heimann, Donald J. Ferguson, and Samuel Hellman
Cancer Res 1998 58: 2766-2771. [Abstract] [PDF]  

Epidemiology and Prevention:

Aspirin Toxicity for Human Colonic Tumor Cells Results from Necrosis and Is Accompanied by Cell Cycle Arrest

Roopa Subbegowda and Thomas O. Frommel
Cancer Res 1998 58: 2772-2776. [Abstract] [PDF]  

Experimental Therapeutics:

Androgen-dependent and -independent Human Prostate Xenograft Tumors as Models for Drug Activity Evaluation

Chiung-Tong Chen, Yuebo Gan, Jessie L-S. Au, and M. Guillaume Wientjes
Cancer Res 1998 58: 2777-2783. [Abstract] [PDF]  

Squalamine Inhibits Angiogenesis and Solid Tumor Growth in Vivo and Perturbs Embryonic Vasculature

Allen K. Sills, Jr., Jon I. Williams, Betty M. Tyler, Darin S. Epstein, Eric P. Sipos, John D. Davis, Michael P. McLane, Simon Pitchford, Kimberly Cheshire, Francis H. Gannon, William A. Kinney, Tessa L. Chao, Mark Donowitz, John Laterra, Michael Zasloff, and Henry Brem
Cancer Res 1998 58: 2784-2792. [Abstract] [PDF]  

Phase I Trial of Intraperitoneal Iododeoxyuridine with and without Intravenous High-Dose Folinic Acid in the Treatment of Advanced Malignancies Primarily Confined to the Peritoneal Cavity: Flow Cytometric and Pharmacokinetic Analysis

Robert J. Morgan, Jr., Edward M. Newman, James H. Doroshow, Kathryn McGonigle, Kim Margolin, James Raschko, Warren Chow, George Somlo, Lucille Leong, Merry Tetef, Stephen Shibata, Victor Hamasaki, Mary Carroll, Steven Vasilev, Steven Akman, Paul Coluzzi, Lawrence Wagman, Jeff Longmate, Benjamin Paz, Yun Yen, and Robert Klevecz
Cancer Res 1998 58: 2793-2800. [Abstract] [PDF]  

Death of Tumor Cells after Intracellular Acidification Is Dependent on Stress-activated Protein Kinases (SAPK/JNK) Pathway Activation and Cannot Be Inhibited by Bcl-2 Expression or Interleukin 1ß-converting Enzyme Inhibition

Brent W. Zanke, Carol Lee, Sara Arab, and Ian F. Tannock
Cancer Res 1998 58: 2801-2808. [Abstract] [PDF]  

Sensitivity of K562 and HL-60 Cells to Edelfosine, an Ether Lipid Drug, Correlates with Production of Reactive Oxygen Species

Brett A. Wagner, Garry R. Buettner, Larry W. Oberley, and C. Patrick Burns
Cancer Res 1998 58: 2809-2816. [Abstract] [PDF]  

Explaining Differences in Sensitivity to Killing by Ionizing Radiation between Human Lymphoid Cell Lines

David R. Aldridge and Ian R. Radford
Cancer Res 1998 58: 2817-2824. [Abstract] [PDF]  

Recombinant Humanized Anti-HER2 Antibody (Herceptin^TM) Enhances the Antitumor Activity of Paclitaxel and Doxorubicin against HER2/neu Overexpressing Human Breast Cancer Xenografts

Jose Baselga, Larry Norton, Joan Albanell, Young-Mee Kim, and John Mendelsohn
Cancer Res 1998 58: 2825-2831. [Abstract] [PDF]  

Immunology:

IFN- Induces Cell Growth Inhibition by Fas-mediated Apoptosis: Requirement of STAT1 Protein for Up-Regulation of Fas and FasL Expression

Xiulong Xu, Xin-Yuan Fu, Janet Plate, and Anita S-F. Chong
Cancer Res 1998 58: 2832-2837. [Abstract] [PDF]  

Effective Adoptive Immunotherapy by T-LAK Cells Retargeted with Bacterial Superantigen-conjugated Antibody to MUC1 in Xenografted Severe Combined Immunodeficient Mice

Masao Shinoda, Toshio Kudo, Masanori Suzuki, Yu Katayose, Naoki Sakurai, Hisaaki Saeki, Hideaki Kodama, Kenji Fukuhara, Kohzoh Imai, Yuji Hinoda, and Seiki Matsuno
Cancer Res 1998 58: 2838-2843. [Abstract] [PDF]  

Antibodies against GD2 Ganglioside Can Eradicate Syngeneic Cancer Micrometastases

Helen Zhang, Shengle Zhang, Nai-Kong V. Cheung, Govindaswami Ragupathi, and Philip O. Livingston
Cancer Res 1998 58: 2844-2849. [Abstract] [PDF]  

Molecular Biology and Genetics:

Elevated Frequencies of Benzo(a)pyrene-induced Hprt Mutations in Internal Tissue of XPA-deficient Mice

Sandra A. M. Bol, Harry van Steeg, Jacob G. Jansen, Conny Van Oostrom, Annemieke de Vries, Anton J. L. de Groot, Ad D. Tates, Harry Vrieling, Albert A. van Zeeland, and Leon H. F. Mullenders
Cancer Res 1998 58: 2850-2856. [Abstract] [PDF]  

Chemically Induced Mutations in Mitochondrial DNA of Human Cells: Mutational Spectrum of N-Methyl-N'-nitro-N-nitrosoguanidine

Luisa A. Marcelino, Paulo C. André, Konstantin Khrapko, Hilary A. Coller, Jacqueline Griffith, and William G. Thilly
Cancer Res 1998 58: 2857-2862. [Abstract] [PDF]  

Human Chromosome 21 Determines Growth Factor Dependence in Human/Mouse B-Cell Hybridomas

Saskia B. Ebeling, Hanny M. Klaasse Bos, Rosalyn Slater, Wilhelmina J. I. Overkamp, Andrew P. Cuthbert, Robert F. Newbold, Malgorzata Z. Zdzienicka, and Lucien A. Aarden
Cancer Res 1998 58: 2863-2868. [Abstract] [PDF]  

Tumor Biology:

Mitochondrial Membrane Potential (_mt) in the Coordination of p53-independent Proliferation and Apoptosis Pathways in Human Colonic Carcinoma Cells

Barbara G. Heerdt, Michele A. Houston, Gillian M. Anthony, and Leonard H. Augenlicht
Cancer Res 1998 58: 2869-2875. [Abstract] [PDF]  

Frequent Overexpression of the Cyclin D1 Oncogene in Invasive Lobular Carcinoma of the Breast

Tetsunari Oyama, Kenji Kashiwabara, Katsuhiko Yoshimoto, Andrew Arnold, and Frederick Koerner
Cancer Res 1998 58: 2876-2880. [Abstract] [PDF]  

Progression of Hepatic Neoplasms Is Severely Retarded in Mice Lacking the Bisecting N-Acetylglucosamine on N-Glycans: Evidence for a Glycoprotein Factor that Facilitates Hepatic Tumor Progression

Mantu Bhaumik, Thomas Harris, Subha Sundaram, Linda Johnson, Joseph Guttenplan, Charles Rogler, and Pamela Stanley
Cancer Res 1998 58: 2881-2887. [Abstract] [PDF]  

p53 Genes Mutated in the DNA Binding Site or at a Specific COOH-terminal Site Exert Divergent Effects on Thyroid Cell Growth and Differentiation

Amelia Casamassimi, Maria Giuseppina Miano, Antonio Porcellini, Gabriella De Vita, Filomena de Nigris, Mariastella Zannini, Roberto Di Lauro, Tommaso Russo, Vittorio Enrico Avvedimento, and Alfredo Fusco
Cancer Res 1998 58: 2888-2894. [Abstract] [PDF]  

Meeting Report:

The University of California, Los Angeles/Jennifer Jones Simon Foundation Symposium on Prostate Cancer and Epithelial Cell Biology: Bringing Together Basic Scientists and Clinicians in the Fight against Advanced Prostate Cancer

John Naitoh, Owen Witte, and Arie Belldegrun
Cancer Res 1998 58: 2895-2900. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1998 58: 2901-2903. [PDF]  

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