Advances in Brief:

Molecular Genetic Characterization of BRCA1- and BRCA2-Linked Hereditary Ovarian Cancers

Esther Rhei, Faina Bogomolniy, Mark G. Federici, Diane L. Maresco, Kenneth Offit, Mark E. Robson, Patricia E. Saigo, and Jeff Boyd
Cancer Res 1998 58: 3193-3196. [Abstract] [PDF]  

Altered Estrogen Receptor and ß Messenger RNA Expression during Human Breast Tumorigenesis

Etienne Leygue, Helmut Dotzlaw, Peter H. Watson, and Leigh C. Murphy
Cancer Res 1998 58: 3197-3201. [Abstract] [PDF]  

"Loop" Domain Is Necessary for Taxol-induced Mobility Shift and Phosphorylation of Bcl-2 as Well as for Inhibiting Taxol-induced Cytosolic Accumulation of Cytochrome c and Apoptosis

Guofu Fang, Brian S. Chang, Caryn N. Kim, Charles Perkins, Craig B. Thompson, and Kapil N. Bhalla
Cancer Res 1998 58: 3202-3208. [Abstract] [PDF]  

Inhibition of Vascular Endothelial Growth Factor-induced Receptor Activation with Anti-Kinase Insert Domain-containing Receptor Single-Chain Antibodies from a Phage Display Library

Zhenping Zhu, Patricia Rockwell, Dan Lu, Helen Kotanides, Bronislaw Pytowski, Daniel J. Hicklin, Peter Bohlen, and Larry Witte
Cancer Res 1998 58: 3209-3214. [Abstract] [PDF]  

Modulation of Apoptotic Response of a Radiation-resistant Human Carcinoma by Pseudomonas Exotoxin-Chimeric Protein

Saraswathy Seetharam, Edwardine Nodzenski, Michael A. Beckett, Ruth Heimann, Amy Cha, Inger Margulies, Ira Pastan, Donald W. Kufe, and Ralph R. Weichselbaum
Cancer Res 1998 58: 3215-3220. [Abstract] [PDF]  

Induction of Potent Antitumor Natural Killer Cell Activity by Herpes Simplex Virus-Thymidine Kinase and Ganciclovir Therapy in an Orthotopic Mouse Model of Prostate Cancer

Simon J. Hall, Michael A. Sanford, Gertrude Atkinson, and Shu-Hsia Chen
Cancer Res 1998 58: 3221-3225. [Abstract] [PDF]  

Identification of a Consistent Region of Allelic Loss on 1p32 in Meningiomas: Correlation with Increased Morbidity

Erik P. Sulman, Jan P. Dumanski, Peter S. White, Huaqing Zhao, John M. Maris, Tiit Mathiesen, Carl Bruder, Avital Cnaan, and Garrett M. Brodeur
Cancer Res 1998 58: 3226-3230. [Abstract] [PDF]  

Negative Regulation of Wee1 Expression and Cdc2 Phosphorylation during p53-mediated Growth Arrest and Apoptosis

Steven D. Leach, Caroline D. Scatena, Christopher J. Keefer, Holly A. Goodman, Si Young Song, Liying Yang, and Jennifer A. Pietenpol
Cancer Res 1998 58: 3231-3236. [Abstract] [PDF]  

Characterization of a Breast Cancer Cell Line Derived from a Germ-Line BRCA1 Mutation Carrier

Gail E. Tomlinson, Tina T-L. Chen, Victor A. Stastny, Arvind K. Virmani, Monique A. Spillman, Vijay Tonk, Joanne L. Blum, Nancy R. Schneider, Ignacio I. Wistuba, Jerry W. Shay, John D. Minna, and Adi F. Gazdar
Cancer Res 1998 58: 3237-3242. [Abstract] [PDF]  

Regulation of the M_r 72,000 Type IV Collagenase by the Type I Insulin-like Growth Factor Receptor

Li Long, Roya Navab, and Pnina Brodt
Cancer Res 1998 58: 3243-3247. [Abstract] [PDF]  

Unpredicted Clinical Pharmacology of UCN-01 Caused by Specific Binding to Human ₁-Acid Glycoprotein

Eiichi Fuse, Hiromi Tanii, Noriaki Kurata, Hiroyuki Kobayashi, Yasuhiro Shimada, Tomohide Tamura, Yasutsuna Sasaki, Yusuke Tanigawara, Richard D. Lush, Donna Headlee, William D. Figg, Susan G. Arbuck, Adrian M. Senderowicz, Edward A. Sausville, Shiro Akinaga, Takashi Kuwabara, and Satoshi Kobayashi
Cancer Res 1998 58: 3248-3253. [Abstract] [PDF]  

PTEN Mutations and Microsatellite Instability in Complex Atypical Hyperplasia, a Precursor Lesion to Uterine Endometrioid Carcinoma

Ross L. Levine, Colyn B. Cargile, Marian S. Blazes, Bastiaan van Rees, Robert J. Kurman, and Lora Hedrick Ellenson
Cancer Res 1998 58: 3254-3258. [Abstract] [PDF]  

Human Breast Cancer Cells Contain an Error-prone DNA Replication Apparatus

Jennifer W. Sekowski, Linda H. Malkas, Lauren Schnaper, Pamela E. Bechtel, Brian J. Long, and Robert J. Hickey
Cancer Res 1998 58: 3259-3263. [Abstract] [PDF]  

A Unique Form of Proliferating Cell Nuclear Antigen Is Present in Malignant Breast Cells

Pamela E. Bechtel, Robert J. Hickey, Lauren Schnaper, Jennifer W. Sekowski, Brian J. Long, Robert Freund, Ni Liu, Carla Rodriguez-Valenzuela, and Linda H. Malkas
Cancer Res 1998 58: 3264-3269. [Abstract] [PDF]  

Interleukin 15 Offers Selective Protection from Irinotecan-induced Intestinal Toxicity in a Preclinical Animal Model

Shousong Cao, Jennifer D. Black, Anthony B. Troutt, and Youcef M. Rustum
Cancer Res 1998 58: 3270-3274. [Abstract] [PDF]  

Biochemistry and Biophysics:

Radiation-induced Apoptosis Mediated by Retinoblastoma Protein

Cai Bowen, Sarah Spiegel, and Edward P. Gelmann
Cancer Res 1998 58: 3275-3281. [Abstract] [PDF]  

Carcinogenesis:

Influence of N-Methyl-N-Nitrosourea, Testosterone, and N-(4-Hydroxyphenyl)-all-trans-retinamide on Prostate Cancer Induction in Wistar-Unilever Rats

David L. McCormick, K. V. N. Rao, Lawrence Dooley, Vernon E. Steele, Ronald A. Lubet, Gary J. Kelloff, and Maarten C. Bosland
Cancer Res 1998 58: 3282-3288. [Abstract] [PDF]  

K-ras Codon 12 Mutation Determines the Polypoid Growth of Colorectal Cancer

Jy-Ming Chiang, Yah-Huei Wu Chou, and Tze-Bin Chou
Cancer Res 1998 58: 3289-3293. [Abstract] [PDF]  

Clinical Investigations:

Soluble Receptor for Urokinase Plasminogen Activator in Both Full-Length and a Cleaved Form Is Present in High Concentration in Cystic Fluid from Ovarian Cancer

Karin Wahlberg, Gunilla Høyer-Hansen, and Bertil Casslén
Cancer Res 1998 58: 3294-3298. [Abstract] [PDF]  

Endocrinology:

Development of an Androgen Receptor-null Model for Identifying the Initiation Site for Androgen Stimulation of Proliferation and Suppression of Programmed (Apoptotic) Death of PC-82 Human Prostate Cancer Cells

Jin Gao and John T. Isaacs
Cancer Res 1998 58: 3299-3306. [Abstract] [PDF]  

Epidemiology and Prevention:

A Prospective Study of N-Acetyltransferase Genotype, Red Meat Intake, and Risk of Colorectal Cancer

Jia Chen, Meir J. Stampfer, Heather L. Hough, Montserrat Garcia-Closas, Walter C. Willett, Charles H. Hennekens, Karl T. Kelsey, and David J. Hunter
Cancer Res 1998 58: 3307-3311. [Abstract] [PDF]  

Experimental Therapeutics:

Dietary -3 Polyunsaturated Fatty Acids Promote Colon Carcinoma Metastasis in Rat Liver

Patrizia Griffini, Olav Fehres, Lars Klieverik, Ilse M. C. Vogels, Wikky Tigchelaar, Susanne M. Smorenburg, and Cornelis J. F. Van Noorden
Cancer Res 1998 58: 3312-3319. [Abstract] [PDF]  

In Vitro and in Vivo Targeting of Immunoliposomal Doxorubicin to Human B-Cell Lymphoma

Daniel E. Lopes de Menezes, Linda M. Pilarski, and Theresa M. Allen
Cancer Res 1998 58: 3320-3330. [Abstract] [PDF]  

Bcl-x_L Is Phosphorylated in Malignant Cells following Microtubule Disruption

Marianne S. Poruchynsky, Emily E. Wang, Charles M. Rudin, Mikhail V. Blagosklonny, and Tito Fojo
Cancer Res 1998 58: 3331-3338. [Abstract] [PDF]  

Regional Pharmacokinetics of Doxorubicin following Hepatic Arterial and Portal Venous Administration: Evaluation with Hepatic Venous Isolation and Charcoal Hemoperfusion

Takeshi Iwasaki, Yonson Ku, Nobuya Kusunoki, Masahiro Tominaga, Takumi Fukumoto, Sanshiro Muramatsu, and Yoshikazu Kuroda
Cancer Res 1998 58: 3339-3343. [Abstract] [PDF]  

Ligand for Peroxisome Proliferator-activated Receptor (Troglitazone) Has Potent Antitumor Effect against Human Prostate Cancer Both in Vitro and in Vivo

Tetsuya Kubota, Kozo Koshizuka, Elizabeth A. Williamson, Hiroya Asou, Jonathan W. Said, Stuart Holden, Isao Miyoshi, and H. Phillip Koeffler
Cancer Res 1998 58: 3344-3352. [Abstract] [PDF]  

A Dominant Negative Mutant of the Insulin-like Growth Factor-I Receptor Inhibits the Adhesion, Invasion, and Metastasis of Breast Cancer

Sandra E. Dunn, Michael Ehrlich, Nicholas J. H. Sharp, Kris Reiss, Gregory Solomon, Rebecca Hawkins, Renato Baserga, and J. Carl Barrett
Cancer Res 1998 58: 3353-3361. [Abstract] [PDF]  

Viral Vector-targeted Antiangiogenic Gene Therapy Utilizing an Angiostatin Complementary DNA

Toshihide Tanaka, Yihai Cao, Judah Folkman, and Howard A. Fine
Cancer Res 1998 58: 3362-3369. [Abstract] [PDF]  

19-nor-26,27-bishomo-Vitamin D₃ Analogs: A Unique Class of Potent Inhibitors of Proliferation of Prostate, Breast, and Hematopoietic Cancer Cells

Tetsuya Kubota, Kozo Koshizuka, Michiaki Koike, Milan Uskokovic, Isao Miyoshi, and H. Phillip Koeffler
Cancer Res 1998 58: 3370-3375. [Abstract] [PDF]  

Immunology:

Maturation of Cytotoxic T Lymphocytes against a B7-transfected Nonmetastatic Tumor: A Critical Role for Costimulation by B7 on Both Tumor and Host Antigen-presenting Cells

Maja Maric, Pan Zheng, Supria Sarma, Yong Guo, and Yang Liu
Cancer Res 1998 58: 3376-3384. [Abstract] [PDF]  

A Novel Hydrophobized Polysaccharide/Oncoprotein Complex Vaccine Induces in Vitro and in Vivo Cellular and Humoral Immune Responses against HER2-expressing Murine Sarcomas

Xiao-Gang Gu, Michael Schmitt, Atsunori Hiasa, Yasuhiro Nagata, Hiroaki Ikeda, Yoshihiro Sasaki, Kazunari Akiyoshi, Junzo Sunamoto, Hideo Nakamura, Kagemasa Kuribayashi, and Hiroshi Shiku
Cancer Res 1998 58: 3385-3390. [Abstract] [PDF]  

Molecular Biology and Genetics:

Inhibition of Fas (CD95) Expression and Fas-mediated Apoptosis by Oncogenic Ras

Robert G. Fenton, Julie A. Hixon, Paul W. Wright, Alan D. Brooks, and Thomas J. Sayers
Cancer Res 1998 58: 3391-3400. [Abstract] [PDF]  

The Murine Fhit Locus: Isolation, Characterization, and Expression in Normal and Tumor Cells

Yuri Pekarsky, Teresa Druck, Maria Grazia Cotticelli, Masataka Ohta, Jiang Shou, Jeannine Mendrola, Jeffry C. Montgomery, Arthur M. Buchberg, Linda D. Siracusa, Giacomo Manenti, Louise Y. Y. Fong, Tommaso A. Dragani, Carlo M. Croce, and Kay Huebner
Cancer Res 1998 58: 3401-3408. [Abstract] [PDF]  

The Murine Fhit Gene Is Highly Similar to Its Human Orthologue and Maps to a Common Fragile Site Region

Thomas W. Glover, Ann W. Hoge, Diane E. Miller, June E. Ascara-Wilke, Ayla N. Adam, Susan L. Dagenais, Charles M. Wilke, Herman A. Dierick, and David G. Beer
Cancer Res 1998 58: 3409-3414. [Abstract] [PDF]  

ErbB-4 Ribozymes Abolish Neuregulin-induced Mitogenesis

Careen K. Tang, David J. Goldstein, Jennifer Payne, Frank Czubayko, Maurizio Alimandi, Ling-Mei Wang, Jacalyn H. Pierce, and Marc E. Lippman
Cancer Res 1998 58: 3415-3422. [Abstract] [PDF]  

Altered Expression of Ubiquitous Kinesin Heavy Chain Results in Resistance to Etoposide and Hypersensitivity to Colchicine: Mapping of the Domain Associated with Drug Response

Sergey A. Axenovich, Alexander R. Kazarov, Alexander D. Boiko, Gabriella Armin, Igor B. Roninson, and Andrei V. Gudkov
Cancer Res 1998 58: 3423-3428. [Abstract] [PDF]  

Methylation of the 5' CpG Island of the FHIT Gene Is Closely Associated with Transcriptional Inactivation in Esophageal Squamous Cell Carcinomas

Hisashi Tanaka, Yutaka Shimada, Hideki Harada, Masayuki Shinoda, Syunzo Hatooka, Masayuki Imamura, and Kanji Ishizaki
Cancer Res 1998 58: 3429-3434. [Abstract] [PDF]  

Complex Genetic Response of Human Cells to Sublethal Levels of Pure Nitric Oxide

John C. Marquis and Bruce Demple
Cancer Res 1998 58: 3435-3440. [Abstract] [PDF]  

Cells Deleted for Brca2 COOH Terminus Exhibit Hypersensitivity to -Radiation and Premature Senescence

Masami Morimatsu, Greg Donoho, and Paul Hasty
Cancer Res 1998 58: 3441-3447. [Abstract] [PDF]  

Overexpression of p27^Kip1 Inhibits the Growth of Both Normal and Transformed Human Mammary Epithelial Cells

Alessandro Sgambato, Yu-Jing Zhang, Marco Ciaparrone, Jae-Won Soh, Achille Cittadini, Regina M. Santella, and I. Bernard Bernard Weinstein
Cancer Res 1998 58: 3448-3454. [Abstract] [PDF]  

Hypermethylation of the hMLH1 Promoter in Colon Cancer with Microsatellite Instability

Julie M. Cunningham, Eric R. Christensen, David J. Tester, Cheong-Yong Kim, Patrick C. Roche, Lawrence J. Burgart, and Stephen N. Thibodeau
Cancer Res 1998 58: 3455-3460. [Abstract] [PDF]  

Tumor Biology:

Effect of Nucleoside Analogue BCH-4556 on Prostate Cancer Growth and Metastases in Vitro and in Vivo

Shafaat A. Rabbani, Penelope Harakidas, Terry Bowlin, and Giorgio Attardo
Cancer Res 1998 58: 3461-3465. [Abstract] [PDF]  

Extended Survivability of Prostate Cancer Cells in the Absence of Trophic Factors: Increased Proliferation, Evasion of Apoptosis, and the Role of Apoptosis Proteins

Dean G. Tang, Li Li, Dharam P. Chopra, and Arthur T. Porter
Cancer Res 1998 58: 3466-3479. [Abstract] [PDF]  

Meeting Report:

Seventh International Workshop on Ataxia-Telangiectasia

Nancy Uhrhammer, Jacques-Olivier Bay, and Yves-Jean Bignon
Cancer Res 1998 58: 3480-3485. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1998 58: 3486-3488. [PDF]  

Errata

Cancer Res 1998 58: 3488 [PDF]  

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