Advances in Brief:

CD8⁺ T Cells Infiltrated within Cancer Cell Nests as a Prognostic Factor in Human Colorectal Cancer

Yoshitaka Naito, Kazuya Saito, Kenichi Shiiba, Akio Ohuchi, Katsunori Saigenji, Hiroshi Nagura, and Haruo Ohtani
Cancer Res 1998 58: 3491-3494. [Abstract] [PDF]  

Irreversible Binding of Poly(ADP)Ribose Polymerase Cleavage Product to DNA Ends Revealed by Atomic Force Microscopy: Possible Role in Apoptosis

Mark E. Smulson, Dalong Pang, Mira Jung, Alexander Dimtchev, Sergey Chasovskikh, Alexander Spoonde, Cynthia Simbulan-Rosenthal, Dean Rosenthal, Alexander Yakovlev, and Anatoly Dritschilo
Cancer Res 1998 58: 3495-3498. [Abstract] [PDF]  

Isolation and Characterization of a Novel Human Lung-specific Gene Homologous to Lysosomal Membrane Glycoproteins 1 and 2: Significantly Increased Expression in Cancers of Various Tissues

Kouichi Ozaki, Masami Nagata, Mikio Suzuki, Tsutomu Fujiwara, Kazuki Ueda, Yasuo Miyoshi, Ei-ichi Takahashi, and Yusuke Nakamura
Cancer Res 1998 58: 3499-3503. [Abstract] [PDF]  

A Glial-specific, Repressible, Adenovirus Vector for Brain Tumor Gene Therapy

Jun Chen, Trevor Bezdek, Jen Chang, Abdullah W. Kherzai, Timothy Willingham, Matthew Azzara, and Perry D. Nisen
Cancer Res 1998 58: 3504-3507. [Abstract] [PDF]  

Loss of p16^INK4 Expression by Methylation Is Associated with Lifespan Extension of Human Mammary Epithelial Cells

Lily I. Huschtscha, Jane R. Noble, Axel A. Neumann, Elsa L. Moy, Peter Barry, John R. Melki, Susan J. Clark, and Roger R. Reddel
Cancer Res 1998 58: 3508-3512. [Abstract] [PDF]  

Rare Loss-of-Function Mutation of a Death Receptor Gene in Head and Neck Cancer

Sara I. Pai, Gen Sheng Wu, Nesrin Özören, Li Wu, Jin Jen, David Sidransky, and Wafik S. El-Deiry
Cancer Res 1998 58: 3513-3518. [Abstract] [PDF]  

Development of a Retrovirus-based Complementary DNA Expression System for the Cloning of Tumor Antigens

Rong-Fu Wang, Xiang Wang, Samuel L. Johnston, Gang Zeng, Paul F. Robbins, and Steven A. Rosenberg
Cancer Res 1998 58: 3519-3525. [Abstract] [PDF]  

ß-Catenin Mutation in Carcinoma of the Uterine Endometrium

Takeshi Fukuchi, Michiie Sakamoto, Hitoshi Tsuda, Keiji Maruyama, Shiro Nozawa, and Setsuo Hirohashi
Cancer Res 1998 58: 3526-3528. [Abstract] [PDF]  

Suicide Gene Therapy of Chemically Induced Mammary Tumor in Rat: Efficacy and Distant Bystander Effect

Ming X. Wei, Philippe Bougnoux, Béatrice Sacré-Salem, Marie-Bénédicte Peyrat, Claude Lhuillery, Jean-Loup Salzmann, and David Klatzmann
Cancer Res 1998 58: 3529-3532. [Abstract] [PDF]  

Physical and Functional Mapping of a Tumor Suppressor Locus for Renal Cell Carcinoma within Chromosome 3p12

Steven Trent Lott, Mercedes Lovell, Susan L. Naylor, and Ann McNeill Killary
Cancer Res 1998 58: 3533-3537. [Abstract] [PDF]  

Overexpression of the Fanconi Anemia Group C Gene (FAC) Protects Hematopoietic Progenitors from Death Induced by Fas-mediated Apoptosis

Jianxiang Wang, Tetsuya Otsuki, Hagop Youssoufian, Jerome Lo Ten Foe, Sonnie Kim, Marcel Devetten, Jianmei Yu, Youlin Li, Daniel Dunn, and Johnson M. Liu
Cancer Res 1998 58: 3538-3541. [Abstract] [PDF]  

Up-Regulation of MET but not Neural Cell Adhesion Molecule Expression by the PAX3-FKHR Fusion Protein in Alveolar Rhabdomyosarcoma

Jill P. Ginsberg, Richard J. Davis, Jeannette L. Bennicelli, Lauren E. Nauta, and Frederic G. Barr
Cancer Res 1998 58: 3542-3546. [Abstract] [PDF]  

Identification of Nonproliferating but Viable Hypoxic Tumor Cells in Vivo

Ralph E. Durand and James A. Raleigh
Cancer Res 1998 58: 3547-3550. [Abstract] [PDF]  

Src Stimulates Insulin-like Growth Factor I (IGF-I)-dependent Cell Proliferation by Increasing IGF-I Receptor Number in Human Pancreatic Carcinoma Cells

Berenike B. M. Flossmann-Kast, Peter M. Jehle, Andreas Hoeflich, Guido Adler, and Manfred P. Lutz
Cancer Res 1998 58: 3551-3554. [Abstract] [PDF]  

Genetic Alterations in Primary Bladder Cancers and Their Metastases

Regina M. Hovey, Lisa Chu, Margit Balazs, Sandy DeVries, Dan Moore, Guido Sauter, Peter R. Carroll, and Frederic M. Waldman
Cancer Res 1998 58: 3555-3560. [Abstract] [PDF]  

Identification of a Novel Metastasis-suppressor Region on Human Chromosome 12

Hue H. Luu, Gregory P. Zagaja, Zita Dubauskas, Stephen L. Chen, Robert C. Smith, Kounosuke Watabe, Yayoi Ichikawa, Tomohiko Ichikawa, Elizabeth M. Davis, Michelle M. Le Beau, and Carrie W. Rinker-Schaeffer
Cancer Res 1998 58: 3561-3565. [Abstract] [PDF]  

Hepatitis B Virus X Protein Transcription Activation Domains Are Neither Required nor Sufficient for Cell Transformation

Katrin Gottlob, Sabrina Pagano, Massimo Levrero, and Adolf Graessmann
Cancer Res 1998 58: 3566-3570. [Abstract] [PDF]  

Biochemistry and Biophysics:

Tolyporphin: A Natural Product from Cyanobacteria with Potent Photosensitizing Activity against Tumor Cells in Vitro and in Vivo

Patrice Morlière, Jean-Claude Mazière, René Santus, Charles D. Smith, Michèle R. Prinsep, Corinne C. Stobbe, Matthew C. Fenning, Joanna L. Golberg, and J. Donald Chapman
Cancer Res 1998 58: 3571-3578. [Abstract] [PDF]  

The Role of hMLH1, hMSH3, and hMSH6 Defects in Cisplatin and Oxaliplatin Resistance: Correlation with Replicative Bypass of Platinum-DNA Adducts

Alexandra Vaisman, Maria Varchenko, Asad Umar, Thomas A. Kunkel, John I. Risinger, J. Carl Barrett, Thomas C. Hamilton, and Stephen G. Chaney
Cancer Res 1998 58: 3579-3585. [Abstract] [PDF]  

Dexamethasone Up-Regulates Cadherin Expression and Cohesion of HT-1080 Human Fibrosarcoma Cells

Ramsey A. Foty, Siobhan A. Corbett, Jean E. Schwarzbauer, and Malcolm S. Steinberg
Cancer Res 1998 58: 3586-3589. [Abstract] [PDF]  

Carcinogenesis:

Epidermal Growth Factor and Transforming Growth Factor--associated Overexpression of Cyclin D1, Cdk4, and c-Myc during Hepatocarcinogenesis in Helicobacter hepaticus-infected A/JCr Mice

Danica Ramljak, Ann B. Jones, Bhalchandra A. Diwan, Alan O. Perantoni, James F. Hochadel, and Lucy M. Anderson
Cancer Res 1998 58: 3590-3597. [Abstract] [PDF]  

Clinical Investigations:

Uterine Cervical Carcinoma: Comparison of Standard and Pharmacokinetic Analysis of Time-Intensity Curves for Assessment of Tumor Angiogenesis and Patient Survival

Hans Hawighorst, Paul G. Knapstein, Michael V. Knopp, Wolfgang Weikel, Gunnar Brix, Ivan Zuna, Stefan O. Schönberg, Marco Essig, Peter Vaupel, and Gerhard van Kaick
Cancer Res 1998 58: 3598-3602. [Abstract] [PDF]  

Epidemiology and Prevention:

The Role of N-Acetylation Polymorphisms in Smoking-associated Bladder Cancer: Evidence of a Gene-Gene-Exposure Three-Way Interaction

Jack A. Taylor, David M. Umbach, Elizabeth Stephens, Trisha Castranio, David Paulson, Cary Robertson, James L. Mohler, and Douglas A. Bell
Cancer Res 1998 58: 3603-3610. [Abstract] [PDF]  

Experimental Therapeutics:

Fostriecin-mediated G₂-M-phase Growth Arrest Correlates with Abnormal Centrosome Replication, the Formation of Aberrant Mitotic Spindles, and the Inhibition of Serine/Threonine Protein Phosphatase Activity

Aiyang Cheng, Ron Balczon, Zhuang Zuo, Jamie S. Koons, Aimée H. Walsh, and Richard E. Honkanen
Cancer Res 1998 58: 3611-3619. [Abstract] [PDF]  

Mechanisms of Taxol-induced Cell Death Are Concentration Dependent

Keila Torres and Susan Band Horwitz
Cancer Res 1998 58: 3620-3626. [Abstract] [PDF]  

Cellular Localization Domains of a Rabbit and a Human Carboxylesterase: Influence on Irinotecan (CPT-11) Metabolism by the Rabbit Enzyme

Philip M. Potter, Judith S. Wolverton, Christopher L. Morton, Monika Wierdl, and Mary K. Danks
Cancer Res 1998 58: 3627-3632. [Abstract] [PDF]  

Paclitaxel-induced Apoptosis Is Associated with Expression and Activation of c-Mos Gene Product in Human Ovarian Carcinoma SKOV3 Cells

Yi-He Ling, Yandan Yang, Carmen Tornos, Balraj Singh, and Roman Perez-Soler
Cancer Res 1998 58: 3633-3640. [Abstract] [PDF]  

Effect of Multidrug Resistance Modulators on the Hepatobiliary Disposition of Doxorubicin in the Isolated Perfused Rat Liver

Catherine L. Booth, Kenneth R. Brouwer, and Kim L. R. Brouwer
Cancer Res 1998 58: 3641-3648. [Abstract] [PDF]  

Complete Regression of Established Human Glioblastoma Tumor Xenograft by Interleukin-4 Toxin Therapy

Syed R. Husain, Niti Behari, Robert J. Kreitman, Ira Pastan, and Raj K. Puri
Cancer Res 1998 58: 3649-3653. [Abstract] [PDF]  

Inhibition of Cancer Cell Growth and c-Myc Transcriptional Activity by a c-Myc Helix 1-Type Peptide Fused to an Internalization Sequence

Laura Giorello, Luana Clerico, Maria Pia Pescarolo, Faina Vikhanskaya, Mario Salmona, Gennaro Colella, Silvia Bruno, Tommaso Mancuso, Luca Bagnasco, Patrizia Russo, and Silvio Parodi
Cancer Res 1998 58: 3654-3659. [Abstract] [PDF]  

Immunology:

Down-Regulation of the Transporter for Antigen Presentation, Proteasome Subunits, and Class I Major Histocompatibility Complex in Tumor Cell Lines

Alyssa Johnsen, John France, Man-Sun Sy, and Clifford V. Harding
Cancer Res 1998 58: 3660-3667. [Abstract] [PDF]  

Effects of Interleukin-1, Interleukin-1 Receptor Antagonist, and Neutralizing Antibody on Proinflammatory Cytokine Expression by Human Squamous Cell Carcinoma Lines

Zhong Chen, Iris Colon, Nerian Ortiz, Matthew Callister, Gang Dong, Michelle Y. Pegram, Oneida Arosarena, Scott Strome, John C. Nicholson, and Carter Van Waes
Cancer Res 1998 58: 3668-3676. [Abstract] [PDF]  

Molecular Biology and Genetics:

The Human Homologue for the Caenorhabditis elegans cul-4 Gene Is Amplified and Overexpressed in Primary Breast Cancers

Ling-Chun Chen, Sharmila Manjeshwar, You Lu, Dan Moore, Britt-Marie Ljung, Wen-Lin Kuo, Shanaz H. Dairkee, Meredith Wernick, Colin Collins, and Helene S. Smith
Cancer Res 1998 58: 3677-3683. [Abstract] [PDF]  

Resistance of Human Leukemic CEM-C1 Cells Is Overcome by Synergism between Glucocorticoid and Protein Kinase A Pathways: Correlation with c-Myc Suppression

Rheem D. Medh, Mohammad F. Saeed, Betty H. Johnson, and E. Brad Thompson
Cancer Res 1998 58: 3684-3693. [Abstract] [PDF]  

Multigenic and Imprinting Control of Ovarian Granulosa Cell Tumorigenesis in Mice

Wesley G. Beamer, Kathryn L. Shultz, Barbara J. Tennent, Joseph H. Nadeau, Gary A. Churchill, and Eva M. Eicher
Cancer Res 1998 58: 3694-3699. [Abstract] [PDF]  

A Novel Tumor Suppressor Locus on Chromosome 18q Involved in the Development of Human Lung Cancer

Kimiko Takei, Takashi Kohno, Kunihiro Hamada, Junko Takita, Masayuki Noguchi, Yoshihiro Matsuno, Setsuo Hirohashi, Hiroshi Uezato, and Jun Yokota
Cancer Res 1998 58: 3700-3705. [Abstract] [PDF]  

Localization of Putative Tumor Suppressor Loci by Genome-wide Allelotyping in Human Pancreatic Endocrine Tumors

Daniel C. Chung, Suzanne B. Brown, Fiona Graeme-Cook, Loyal G. Tillotson, Andrew L. Warshaw, Robert T. Jensen, and Andrew Arnold
Cancer Res 1998 58: 3706-3711. [Abstract] [PDF]  

Apoptosis, Reproductive Failure, and Oxidative Stress in Chinese Hamster Ovary Cells with Compromised Genomic Integrity

Charles L. Limoli, Andreas Hartmann, Lee Shephard, Chin-rang Yang, David A. Boothman, Jim Bartholomew, and William F. Morgan
Cancer Res 1998 58: 3712-3718. [Abstract] [PDF]  

Tumor Biology:

Expression of Antisense CD44 Variant 6 Inhibits Colorectal Tumor Metastasis and Tumor Growth in a Wound Environment

Jennifer A. Reeder, David C. Gotley, Michael D. Walsh, Jonathan Fawcett, and Toni M. Antalis
Cancer Res 1998 58: 3719-3726. [Abstract] [PDF]  

In Vitro Determination of Basement Membrane Invasion Predicts Liver Metastases in Human Gastrointestinal Carcinoma

Katsuo Uemura, Sonshin Takao, and Takashi Aikou
Cancer Res 1998 58: 3727-3731. [Abstract] [PDF]  

Identification of Genes Expressed Differentially by LNCaP or PC-3 Prostate Cancer Cell Lines

Meiheng Yang, Massimo Loda, and Arthur J. Sytkowski
Cancer Res 1998 58: 3732-3735. [Abstract] [PDF]  

Site-specific De-N-glycosylation of CD44 Can Activate Hyaluronan Binding, and CD44 Activation States Show Distinct Threshold Densities for Hyaluronan Binding

Nicole M. English, Jayne F. Lesley, and Robert Hyman
Cancer Res 1998 58: 3736-3742. [Abstract] [PDF]  

Remodeling of Collagen Matrix by Human Tumor Cells Requires Activation and Cell Surface Association of Matrix Metalloproteinase-2

Elena I. Deryugina, Mario A. Bourdon, Ralph A. Reisfeld, and Alex Strongin
Cancer Res 1998 58: 3743-3750. [Abstract] [PDF]  

Suppression of Hepatoma Growth and Angiogenesis by a Fumagillin Derivative TNP470: Possible Involvement of Nitric Oxide Synthase

Taku Yoshida, Yoshiyasu Kaneko, Ayumi Tsukamoto, Katsuken Han, Masao Ichinose, and Satoshi Kimura
Cancer Res 1998 58: 3751-3756. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1998 58: 3757-3759. [PDF]  

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