Advances in Brief:

Increased Expression of Cyclooxygenase 2 Occurs Frequently in Human Lung Cancers, Specifically in Adenocarcinomas

Toyoaki Hida, Yasushi Yatabe, Hiroyuki Achiwa, Hideki Muramatsu, Ken-ichi Kozaki, Shigeo Nakamura, Makoto Ogawa, Tetsuya Mitsudomi, Takahiko Sugiura, and Takashi Takahashi
Cancer Res 1998 58: 3761-3764. [Abstract] [PDF]  

Hypoxia and Vascular Endothelial Growth Factor Expression in Human Squamous Cell Carcinomas Using Pimonidazole as a Hypoxia Marker

James A. Raleigh, Dennise P. Calkins-Adams, Lillian H. Rinker, Cynthia A. Ballenger, Mark C. Weissler, Wesley C. Fowler, Jr., Debra B. Novotny, and Mahesh A. Varia
Cancer Res 1998 58: 3765-3768. [Abstract] [PDF]  

The Helix-Loop-Helix Protein Id2 Is Overexpressed in Human Pancreatic Cancer

Jörg Kleeff, Toshiyuki Ishiwata, Helmut Friess, Markus W. Büchler, Mark A. Israel, and Murray Korc
Cancer Res 1998 58: 3769-3772. [Abstract] [PDF]  

Antisense Oligodeoxyribonucleotide against the MLL-LTG19 Chimeric Transcript Inhibits Cell Growth and Induces Apoptosis in Cells of an Infantile Leukemia Cell Line Carrying the t(11;19) Chromosomal Translocation

Yukihiro Akao, Hiromi Mizoguchi, Konrad Misiura, Wojciech J. Stec, Masao Seto, Nobuko Ohishi, and Kunio Yagi
Cancer Res 1998 58: 3773-3776. [Abstract] [PDF]  

The Coding Region of the Bloom Syndrome BLM Gene and of the CBL Proto-Oncogene Is Mutated in Genetically Unstable Sporadic Gastrointestinal Tumors

George Calin, Vlad Herlea, Giuseppe Barbanti-Brodano, and Massimo Negrini
Cancer Res 1998 58: 3777-3781. [Abstract] [PDF]  

Topotecan Lactone Selectively Binds to Double- and Single-Stranded DNA in the Absence of Topoisomerase I

Shijie Yao, Dhanabala Murali, Peddaiahgari Seetharamulu, Kochat Haridas, Pavankumar N. V. Petluru, Dasharatha G. Reddy, and Frederick H. Hausheer
Cancer Res 1998 58: 3782-3786. [Abstract] [PDF]  

Frequent Somatic Mutations in Serine/Threonine Kinase 11/Peutz-Jeghers Syndrome Gene in Left-sided Colon Cancer

Seung Myung Dong, Kyoung Mee Kim, Su Young Kim, Min Sun Shin, Eun Young Na, Sug Hyung Lee, Wong Sang Park, Nam Jin Yoo, Ja June Jang, Chang Young Yoon, Jong Won Kim, Se Young Kim, Young Mok Yang, Sang Ho Kim, Choo Soung Kim, and Jung Young Lee
Cancer Res 1998 58: 3787-3790. [Abstract] [PDF]  

Biochemistry and Biophysics:

Quantitative ¹H Nuclear Magnetic Resonance Diffusion Spectroscopy of BT4C Rat Glioma during Thymidine Kinase-mediated Gene Therapy in Vivo: Identification of Apoptotic Response

Juhana M. Hakumäki, Harish Poptani, Anu-Maaria Puumalainen, Sami Loimas, Leo A. Paljärvi, Seppo Ylä-Herttuala, and Risto A. Kauppinen
Cancer Res 1998 58: 3791-3799. [Abstract] [PDF]  

Cancer-associated Expression of Glycolipid Sulfotransferase Gene in Human Renal Cell Carcinoma Cells

Koichi Honke, Masayuki Tsuda, Yukie Hirahara, Noriomi Miyao, Taiji Tsukamoto, Makoto Satoh, and Yoshinao Wada
Cancer Res 1998 58: 3800-3805. [Abstract] [PDF]  

Carcinogenesis:

High Susceptibility of p53(+/-) Knockout Mice in N-Butyl-N-(4-hydroxybutyl)nitrosamine Urinary Bladder Carcinogenesis and Lack of Frequent Mutation in Residual Allele

Keisuke Ozaki, Tokuo Sukata, Shinji Yamamoto, Satoshi Uwagawa, Takaki Seki, Hajime Kawasaki, Akira Yoshitake, Hideki Wanibuchi, Akihiro Koide, Yukio Mori, and Shoji Fukushima
Cancer Res 1998 58: 3806-3811. [Abstract] [PDF]  

Telomerase Activity Exclusively in Cervical Carcinomas and a Subset of Cervical Intraepithelial Neoplasia Grade III Lesions: Strong Association with Elevated Messenger RNA Levels of Its Catalytic Subunit and High-Risk Human Papillomavirus DNA

Peter J. F. Snijders, Mark van Duin, Jan M. M. Walboomers, Renske D. M. Steenbergen, Elle K. J. Risse, Theo J. M. Helmerhorst, René H. M. Verheijen, and Chris J. L. M. Meijer
Cancer Res 1998 58: 3812-3818. [Abstract] [PDF]  

Clinical Investigations:

Ionizing Radiation Inhibits Chemotherapy-induced Apoptosis in Cultured Glioma Cells: Implications for Combined Modality Therapy

Garret L. Yount, Daphne A. Haas-Kogan, Kiera S. Levine, Ken D. Aldape, and Mark A. Israel
Cancer Res 1998 58: 3819-3825. [Abstract] [PDF]  

Endocrinology:

Effects of Some Novel Inhibitors of C_17,20-Lyase and 5-Reductase in Vitro and in Vivo and Their Potential Role in the Treatment of Prostate Cancer

Ivo P. Nnane, Katsuya Kato, Yang Liu, Qing Lu, Xin Wang, Yang-zhi Ling, and Angela Brodie
Cancer Res 1998 58: 3826-3832. [Abstract] [PDF]  

Estrogenic Effects of Genistein on the Growth of Estrogen Receptor-positive Human Breast Cancer (MCF-7) Cells in Vitro and in Vivo

Ching-Yi Hsieh, Ross C. Santell, Sandra Z. Haslam, and William G. Helferich
Cancer Res 1998 58: 3833-3838. [Abstract] [PDF]  

Epidemiology and Prevention:

Risk of Anal Carcinoma in Situ in Relation to Human Papillomavirus Type 16 Variants

Long Fu Xi, Cathy W. Critchlow, Cosette M. Wheeler, Laura A. Koutsky, Denise A. Galloway, Jane Kuypers, James P. Hughes, Stephen E. Hawes, Christina Surawicz, Gary Goldbaum, King K. Holmes, and Nancy B. Kiviat
Cancer Res 1998 58: 3839-3844. [Abstract] [PDF]  

Experimental Therapeutics:

Fractionated Ionizing Radiation Accelerates Loss of Amplified MDR1 Genes Harbored by Extrachromosomal DNA in Tumor Cells

Ana M. Sanchez, John T. Barrett, and Patricia V. Schoenlein
Cancer Res 1998 58: 3845-3854. [Abstract] [PDF]  

Irreversible G₂-M Arrest and Cytoskeletal Reorganization Induced by Cytotoxic Nucleoside Analogues

Patrick J. Halloran and Robert G. Fenton
Cancer Res 1998 58: 3855-3865. [Abstract] [PDF]  

Tumor Targeting with Biotinylated Tumor Necrosis Factor : Structure-Activity Relationships and Mechanism of Action on Avidin Pretargeted Tumor Cells

Angelo Corti, Anna Gasparri, Angelina Sacchi, Flavio Curnis, Romina Sangregorio, Barbara Colombo, Antonio G. Siccardi, and Fulvio Magni
Cancer Res 1998 58: 3866-3872. [Abstract] [PDF]  

Superior Cytotoxicity with Ganciclovir Compared with Acyclovir and 1-ß-D-Arabinofuranosylthymine in Herpes Simplex Virus-Thymidine Kinase-expressing Cells: A Novel Paradigm for Cell Killing

Laura Z. Rubsam, Beverly L. Davidson, and Donna S. Shewach
Cancer Res 1998 58: 3873-3882. [Abstract] [PDF]  

Lysosomal Sequestration of Polyamine Analogues in Chinese Hamster Ovary Cells Resistant to the S-Adenosylmethionine Decarboxylase Inhibitor, CGP-48664

Debora L. Kramer, Jennifer D. Black, Helmut Mett, Raymond J. Bergeron, and Carl W. Porter
Cancer Res 1998 58: 3883-3890. [Abstract] [PDF]  

Allogeneic Cell Therapy for a Murine Mammary Carcinoma

Shoshana Morecki, Ellena Yacovlev, Adi Diab, and Shimon Slavin
Cancer Res 1998 58: 3891-3895. [Abstract] [PDF]  

Docetaxel Chronopharmacology in Mice

Marco Tampellini, Elisabeth Filipski, Xu Hui Liu, Guy Lemaigre, Xiao Mei Li, Patricia Vrignaud, Emmanuel François, Marie Christine Bissery, and Francis Lévi
Cancer Res 1998 58: 3896-3904. [Abstract] [PDF]  

Immunology:

Chimeric Human-Mouse IgG Antibodies with Shuffled Constant Region Exons Demonstrate that Multiple Domains Contribute to in Vivo Half-Life

Lionel S. Zuckier, Chee J. Chang, Matthew D. Scharff, and Sherie L. Morrison
Cancer Res 1998 58: 3905-3908. [Abstract] [PDF]  

Antigen Expressed on Tumor Cells Fails to Elicit an Immune Response, Even in the Presence of Increased Numbers of Tumor-specific Cytotoxic T Lymphocyte Precursors

Ian F. Hermans, Angela Daish, Jianping Yang, David S. Ritchie, and Franca Ronchese
Cancer Res 1998 58: 3909-3917. [Abstract] [PDF]  

Induction of Persistent Tumor-protective Immunity in Mice Cured of Established Colon Carcinoma Metastases

Rong Xiang, Holger N. Lode, Torsten Dreier, Stephen D. Gillies, and Ralph A. Reisfeld
Cancer Res 1998 58: 3918-3925. [Abstract] [PDF]  

Molecuiar Biology and Genetics:

The Human p19^ARF Protein Encoded by the ß Transcript of the p16^INK4a Gene Is Frequently Lost in Small Cell Lung Cancer

Sylvie Gazzeri, Veronique Della Valle, Laure Chaussade, Christian Brambilla, Christian-Jacques Larsen, and Elisabeth Brambilla
Cancer Res 1998 58: 3926-3931. [Abstract] [PDF]  

Expression of the ErbB-Neuregulin Signaling Network during Human Cerebellar Development: Implications for the Biology of Medulloblastoma

Richard J. Gilbertson, Steven C. Clifford, William MacMeekin, Chris Wright, Robert H. Perry, Peter Kelly, Andrew D. J. Pearson, and John Lunec
Cancer Res 1998 58: 3932-3941. [Abstract] [PDF]  

Hypermethylation of the p16^INK4a Promoter in Colectomy Specimens of Patients with Long-standing and Extensive Ulcerative Colitis

Chih-Jen Hsieh, Bodo Klump, Karlheinz Holzmann, Franz Borchard, Michael Gregor, and Rainer Porschen
Cancer Res 1998 58: 3942-3945. [Abstract] [PDF]  

Mutation Rate of a Microsatellite Sequence in Normal Human Fibroblasts

Jayne C. Boyer and Rosann A. Farber
Cancer Res 1998 58: 3946-3949. [Abstract] [PDF]  

Regulation of Expression of the DNA Repair Gene O⁶-Methylguanine-DNA Methyltransferase via Protein Kinase C-mediated Signaling

Istvan Boldogh, Chilakamarti V. Ramana, Zhenping Chen, Tapan Biswas, Tapas K. Hazra, Sabine Grösch, Thomas Grombacher, Sankar Mitra, and Bernd Kaina
Cancer Res 1998 58: 3950-3956. [Abstract] [PDF]  

Improved Quantitation of Minimal Residual Disease in Multiple Myeloma Using Real-Time Polymerase Chain Reaction and Plasmid-DNA Complementarity Determining Region III Standards

Christopher J. Gerard, Katherine Olsson, Rajeev Ramanathan, Chris Reading, and Elie G. Hanania
Cancer Res 1998 58: 3957-3964. [Abstract] [PDF]  

Mammalian 3-Methyladenine DNA Glycosylase Protects against the Toxicity and Clastogenicity of Certain Chemotherapeutic DNA Cross-Linking Agents

James M. Allan, Bevin P. Engelward, Andrew J. Dreslin, Michael D. Wyatt, Maria Tomasz, and Leona D. Samson
Cancer Res 1998 58: 3965-3973. [Abstract] [PDF]  

Tumor Biology:

Centrosome Defects and Genetic Instability in Malignant Tumors

German A. Pihan, Aruna Purohit, Janice Wallace, Hans Knecht, Bruce Woda, Peter Quesenberry, and Stephen J. Doxsey
Cancer Res 1998 58: 3974-3985. [Abstract] [PDF]  

Genomic Instability and Catalase Gene Amplification Induced by Chronic Exposure to Oxidative Stress

Clayton R. Hunt, Julia E. Sim, Shannon J. Sullivan, Terence Featherstone, Wendy Golden, Chris Von Kapp-Herr, Randy A. Hock, R. Ariel Gomez, Azemat J. Parsian, and Douglas R. Spitz
Cancer Res 1998 58: 3986-3992. [Abstract] [PDF]  

Human T-Cell Leukemia Virus Type I Tax Transactivates Human Interleukin 8 Gene through Acting Concurrently on AP-1 and Nuclear Factor-B-like Sites

Naoki Mori, Naofumi Mukaida, Dean W. Ballard, Kouji Matsushima, and Naoki Yamamoto
Cancer Res 1998 58: 3993-4000. [Abstract] [PDF]  

Synthetic Matrix Metalloproteinase Inhibitors and Tissue Inhibitor of Metalloproteinase (TIMP)-2, but not TIMP-1, Inhibit Shedding of Tumor Necrosis Factor- Receptors in a Human Colon Adenocarcinoma (Colo 205) Cell Line

Mark A. Lombard, Tanya L. Wallace, Marc F. Kubicek, Gary L. Petzold, Mark A. Mitchell, Susan K. Hendges, and John W. Wilks
Cancer Res 1998 58: 4001-4007. [Abstract] [PDF]  

Regulation of Vascular Endothelial Growth Factor Expression in Human Colon Cancer by Insulin-like Growth Factor-I

Yoshito Akagi, Wenbiao Liu, Brian Zebrowski, Keping Xie, and Lee M. Ellis
Cancer Res 1998 58: 4008-4014. [Abstract] [PDF]  

Letters to the Editor:

Correspondence re: Y. E. Shi et al., Antitumor Activity of the Novel Human Breast Cancer Growth Inhibitor, Mammary-derived Growth Inhibitor-related Gene, MRG. Cancer Res., 57: 3084–3091, 1997: Letter

Carsten Hohoff and Friedrich Spener
Cancer Res 1998 58: 4015-4016. [PDF]  

Correspondence re: Y. E. Shi et al., Antitumor Activity of the Novel Human Breast Cancer Growth Inhibitor, Mammary-derived Growth Inhibitor-related Gene, MRG. Cancer Res., 57: 3084–3091, 1997—Reply

Y. Eric Shi
Cancer Res 1998 58: 4016-4017. [PDF]  

Articles:

Announcements

Cancer Res 1998 58: 4018-4020. [PDF]  

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