Special Lecture:

Translational Research: Walking the Bridge between Idea and Cure—Seventeenth Bruce F. Cain Memorial Award Lecture

Bruce A. Chabner, Anthony L. Boral, and Pratik Multani
Cancer Res 1998 58: 4211-4216. [Abstract] [PDF]  

Advances in Brief:

Widespread Skeletal Metastatic Potential of Human Lung Cancer Revealed by Green Fluorescent Protein Expression

Meng Yang, Satoshi Hasegawa, Ping Jiang, Xiaoen Wang, Yuying Tan, Takashi Chishima, Hiroshi Shimada, A. R. Moossa, and Robert M. Hoffman
Cancer Res 1998 58: 4217-4221. [Abstract] [PDF]  

Loss of Chromosome 18q Is an Early Event in Pancreatic Ductal Tumorigenesis

Shinichi Fukushige, Toru Furukawa, Kennichi Satoh, Makoto Sunamura, Masao Kobari, Masaru Koizumi, and Akira Horii
Cancer Res 1998 58: 4222-4226. [Abstract] [PDF]  

Mutational Analysis of the Transforming Growth Factor ß Receptor Type II Gene in Human Ovarian Carcinoma

Melanie A. Lynch, Ryuichi Nakashima, Huijuan Song, Valerie L. DeGroff, Dian Wang, Takayuki Enomoto, and Christopher M. Weghorst
Cancer Res 1998 58: 4227-4232. [Abstract] [PDF]  

A Novel Candidate Oncogene, MCT-1, Is Involved in Cell Cycle Progression

Misha Prosniak, Jamil Dierov, Kenji Okami, Brian Tilton, Brad Jameson, Bassel E. Sawaya, and Ronald B. Gartenhaus
Cancer Res 1998 58: 4233-4237. [Abstract] [PDF]  

RIZ1, but not the Alternative RIZ2 Product of the Same Gene, Is Underexpressed in Breast Cancer, and Forced RIZ1 Expression Causes G₂-M Cell Cycle Arrest and/or Apoptosis

Liusheng He, Jack X. Yu, Limin Liu, Inge M. Buyse, Ming-sheng Wang, Qi-cheng Yang, Akira Nakagawara, Garrett M. Brodeur, Y. Eric Shi, and Shi Huang
Cancer Res 1998 58: 4238-4244. [Abstract] [PDF]  

NS398, a Selective Cyclooxygenase-2 Inhibitor, Induces Apoptosis and Down-Regulates bcl-2 Expression in LNCaP Cells

Xin-Hua Liu, Shen Yao, Alexander Kirschenbaum, and Alice C. Levine
Cancer Res 1998 58: 4245-4249. [Abstract] [PDF]  

Enhanced Expression of the Insulin Receptor Substrate-2 Docking Protein in Human Pancreatic Cancer

Marko Kornmann, Haruhisa Maruyama, Uwe Bergmann, Pam Tangvoranuntakul, Hans G. Beger, Morris F. White, and Murray Korc
Cancer Res 1998 58: 4250-4254. [Abstract] [PDF]  

Development of Helicobacter pylori-induced Gastric Carcinoma in Mongolian Gerbils

Shoji Honda, Toshio Fujioka, Masashi Tokieda, Ryugo Satoh, Akira Nishizono, and Masaru Nasu
Cancer Res 1998 58: 4255-4259. [Abstract] [PDF]  

Chromosomal Amplification Is Associated with Cisplatin Resistance of Human Male Germ Cell Tumors

Pulivarthi H. Rao, Jane Houldsworth, Nallasivam Palanisamy, V. V. V. S. Murty, Victor E. Reuter, Robert J. Motzer, George J. Bosl, and R. S. K. Chaganti
Cancer Res 1998 58: 4260-4263. [Abstract] [PDF]  

The Estrogen Receptor Variant Lacking Exon 5 Has Dominant Negative Activity in the Human Breast Epithelial Cell Line HMT-3522S1

Helle Ohlsson, Anne E. Lykkesfeldt, Mogens W. Madsen, and Per Briand
Cancer Res 1998 58: 4264-4268. [Abstract] [PDF]  

NUP98-HOXD13 Gene Fusion in Therapy-related Acute Myelogenous Leukemia

Samina Z. Raza-Egilmez, Sheila N. Jani-Sait, Mauro Grossi, Michael J. Higgins, Thomas B. Shows, and Peter D. Aplan
Cancer Res 1998 58: 4269-4273. [Abstract] [PDF]  

Genomic Alterations in Fallopian Tube Carcinoma: Comparison to Serous Uterine and Ovarian Carcinomas Reveals Similarity Suggesting Likeness in Molecular Pathogenesis

Heini Pere, Johanna Tapper, Markku Seppälä, Sakari Knuutila, and Ralf Butzow
Cancer Res 1998 58: 4274-4276. [Abstract] [PDF]  

p53 Is Involved in But Not Required for Ionizing Radiation-induced Caspase-3 Activation and Apoptosis in Human Lymphoblast Cell Lines

Yongjia Yu and John B. Little
Cancer Res 1998 58: 4277-4281. [Abstract] [PDF]  

Tumor Suppressor Proteins as Regulators of Cell Differentiation

Zhan-Rong Li, Rosemary Hromchak, Anuradha Mudipalli, and Alexander Bloch
Cancer Res 1998 58: 4282-4287. [Abstract] [PDF]  

Neuropeptides Induce M_r 92,000 Type IV Collagenase (Matrix Metalloprotease-9) Activity in Human Prostate Cancer Cell Lines

Inder Sehgal and Timothy C. Thompson
Cancer Res 1998 58: 4288-4291. [Abstract] [PDF]  

Role of E2F-1 in Chemosensitivity

Debabrata Banerjee, Barbara Schnieders, Jenny Z. Fu, Debasis Adhikari, Shi-Cheng Zhao, and Joseph R. Bertino
Cancer Res 1998 58: 4292-4296. [Abstract] [PDF]  

Biochemistry and Biophysics:

Activation of JNK and p38 but not ERK MAP Kinases in Human Skin Cells by 5-Aminolevulinate-Photodynamic Therapy

Lars-Oliver Klotz, Clemens Fritsch, Karlis Briviba, Nicolaos Tsacmacidis, Freimut Schliess, and Helmut Sies
Cancer Res 1998 58: 4297-4300. [Abstract] [PDF]  

Elevation of 26 Sialyltransferase and 12 Fucosyltransferase Activities in Human Choriocarcinoma

Keiko Fukushima, Sayuri Hara-Kuge, Akira Seko, Yukio Ikehara, and Katsuko Yamashita
Cancer Res 1998 58: 4301-4306. [Abstract] [PDF]  

Carcinogenesis:

Immunohistochemical Demonstration of Carcinogen-DNA Adducts in Tissues of Rats Given 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): Detection in Paraffin-embedded Sections and Tissue Distribution

Satoru Takahashi, Seiko Tamano, Masao Hirose, Naoya Kimoto, Yoshihisa Ikeda, Michihisa Sakakibara, Mariko Tada, Fred F. Kadlubar, Nobuyuki Ito, and Tomoyuki Shirai
Cancer Res 1998 58: 4307-4313. [Abstract] [PDF]  

Squamous Cell Hyperplastic Foci: Precursors of Cutaneous Papillomas Induced in SENCAR Mice by a Two-Stage Carcinogenesis Regimen

Robert L. Binder, Gary R. Johnson, Patricia M. Gallagher, Sharon L. Stockman, John P. Sundberg, and Claudio J. Conti
Cancer Res 1998 58: 4314-4323. [Abstract] [PDF]  

Experimental Therapeutics:

Human Single-Chain Fv Antibodies to MUC1 Core Peptide Selected from Phage Display Libraries Recognize Unique Epitopes and Predominantly Bind Adenocarcinoma

Paula Henderikx, Maria Kandilogiannaki, Claudia Petrarca, Silvia von Mensdorff-Pouilly, Joseph H. M. Hilgers, Elias Krambovitis, Jan Willem Arends, and Hennie R. Hoogenboom
Cancer Res 1998 58: 4324-4332. [Abstract] [PDF]  

Imaging Herpes Virus Thymidine Kinase Gene Transfer and Expression by Positron Emission Tomography

Juri G. Tjuvajev, Norbert Avril, Takamitsu Oku, Toshio Sasajima, Tadashi Miyagawa, Revathi Joshi, Michelle Safer, Bradley Beattie, Gene DiResta, Farhad Daghighian, Finn Augensen, Jason Koutcher, Jamal Zweit, John Humm, Steven M. Larson, Ronald Finn, and Ronald Blasberg
Cancer Res 1998 58: 4333-4341. [Abstract] [PDF]  

Tumor Growth Inhibition Induced in a Murine Model of Human Burkitt's Lymphoma by a Proteasome Inhibitor

Robert Z. Orlowski, Jairam R. Eswara, Anne Lafond-Walker, Michael R. Grever, Marian Orlowski, and Chi V. Dang
Cancer Res 1998 58: 4342-4348. [Abstract] [PDF]  

Functional Nucleoside Transporters Are Required for Gemcitabine Influx and Manifestation of Toxicity in Cancer Cell Lines

John R. Mackey, Rajam S. Mani, Milada Selner, Delores Mowles, James D. Young, Judith A. Belt, Charles R. Crawford, and Carol E. Cass
Cancer Res 1998 58: 4349-4357. [Abstract] [PDF]  

Reduction of Dimesna to Mesna by the Isolated Perfused Rat Liver

Marshall P. Goren, Li C. Hsu, and Jackie T. Li
Cancer Res 1998 58: 4358-4362. [Abstract] [PDF]  

Phase I Trial of Temozolomide Using an Extended Continuous Oral Schedule

Cathryn S. Brock, Edward S. Newlands, Steven R. Wedge, Mark Bower, Helen Evans, Iain Colquhoun, Mary Roddie, Mark Glaser, Maureen H. Brampton, and Gordon J. S. Rustin
Cancer Res 1998 58: 4363-4367. [Abstract] [PDF]  

Reversal of CPT-11 Resistance of Lung Cancer Cells by Adenovirus-mediated Gene Transfer of the Human Carboxylesterase cDNA

Akira Kojima, Neil R. Hackett, and Ronald G. Crystal
Cancer Res 1998 58: 4368-4374. [Abstract] [PDF]  

Inhibition of Phosphoinositide 3-Kinase Related Kinases by the Radiosensitizing Agent Wortmannin

Jann N. Sarkaria, Randal S. Tibbetts, Ericka C. Busby, Amy P. Kennedy, David E. Hill, and Robert T. Abraham
Cancer Res 1998 58: 4375-4382. [Abstract] [PDF]  

Influence of Melatonin on Invasive and Metastatic Properties of MCF-7 Human Breast Cancer Cells

Samuel Cos, Rosario Fernández, Andrés Güézmes, and Emilio J. Sánchez-Barceló
Cancer Res 1998 58: 4383-4390. [Abstract] [PDF]  

Retroviral Transfer of Human Cytochrome P450 Genes for Oxazaphosphorine-based Cancer Gene Therapy

Youssef Jounaidi, Jodi E. D. Hecht, and David J. Waxman
Cancer Res 1998 58: 4391-4401. [Abstract] [PDF]  

Molecular Biology and Genetics:

p53 Mutations in Skin and Internal Tumors of Xeroderma Pigmentosum Patients Belonging to the Complementation Group C

Giuseppina Giglia, Nicolas Dumaz, Christiane Drougard, Marie-Françoise Avril, Leela Daya-Grosjean, and Alain Sarasin
Cancer Res 1998 58: 4402-4409. [Abstract] [PDF]  

Apurinic Endonuclease (Ref-1) Is Induced in Mammalian Cells by Oxidative Stress and Involved in Clastogenic Adaptation

Sabine Grösch, Gerhard Fritz, and Bernd Kaina
Cancer Res 1998 58: 4410-4416. [Abstract] [PDF]  

Mutation of the MENIN Gene in Sporadic Pancreatic Endocrine Tumors

Eric H. Wang, Sam A. Ebrahimi, Allan Y. Wu, Carol Kashefi, Edward Passaro, Jr., and Mark P. Sawicki
Cancer Res 1998 58: 4417-4420. [Abstract] [PDF]  

High Incidence of Loss of Heterozygosity in Breast Tumors from Carriers of the BRCA2 999del5 Mutation

Sigurdur Ingvarsson, Ella Kristin Geirsdottir, Gudrun Johannesdottir, Bjarnveig Ingibjörg Sigbjörnsdóttir, Gudny Eiriksdottir, Gisli Ragnarsson, Bjarni Agnar Agnarsson, Julius Gudmundsson, Jon Gunnlaugur Jonasson, Asgeir Sigurdsson, Valgardur Egilsson, and Rosa Björk Barkardottir
Cancer Res 1998 58: 4421-4425. [Abstract] [PDF]  

Tumor Biology:

Insulin-like Growth Factor II and PAX3-FKHR Cooperate in the Oncogenesis of Rhabdomyosarcoma

Weiguang Wang, Pat Kumar, Weizhi Wang, John Epstein, Lee Helman, Jim V. Moore, and Shant Kumar
Cancer Res 1998 58: 4426-4433. [Abstract] [PDF]  

Aberrant Expression of Double-stranded RNA-dependent Protein Kinase in Hepatocytes of Chronic Hepatitis and Differentiated Hepatocellular Carcinoma

Akira Shimada, Goshi Shiota, Hironori Miyata, Toshio Kamahora, Hironaka Kawasaki, Kazuo Shiraki, Shigeo Hino, and Tadashi Terada
Cancer Res 1998 58: 4434-4438. [Abstract] [PDF]  

Inhibition of Tumor Cell Growth by RTP/rit42 and Its Responsiveness to p53 and DNA Damage

Siavash K. Kurdistani, Paz Arizti, Corinne L. Reimer, Mary M. Sugrue, Stuart A. Aaronson, and Sam W. Lee
Cancer Res 1998 58: 4439-4444. [Abstract] [PDF]  

Multiple Changes in Gene Expression Are Associated with Normal Cell-induced Modulation of the Neoplastic Phenotype

Gin-Wen Chang and Margaret Terzaghi-Howe
Cancer Res 1998 58: 4445-4452. [Abstract] [PDF]  

Molecular Ordering of Apoptosis Induced by Anticancer Drugs in Neuroblastoma Cells

Simone Fulda, Santos A. Susin, Guido Kroemer, and Klaus-Michael Debatin
Cancer Res 1998 58: 4453-4460. [Abstract] [PDF]  

Enhanced Expression of Urokinase Receptor Induced through the Tissue Factor-Factor VIIa Pathway in Human Pancreatic Cancer

Tadaaki Taniguchi, Ajay K. Kakkar, Edward G. D. Tuddenham, Robin C. N. Williamson, and Nicholas R. Lemoine
Cancer Res 1998 58: 4461-4467. [Abstract] [PDF]  

Selective Localization of Matrix Metalloproteinase 9, ß₁ Integrins, and Human Lymphocyte Antigen Class I Molecules on Membrane Vesicles Shed by 8701-BC Breast Carcinoma Cells

Vincenza Dolo, Angela Ginestra, Donata Cassarà, Stefania Violini, Giuseppe Lucania, Maria Rosaria Torrisi, Hideaki Nagase, Silvana Canevari, Antonio Pavan, and Maria Letizia Vittorelli
Cancer Res 1998 58: 4468-4474. [Abstract] [PDF]  

Novel Human Malignancy-associated Gene (MAG) Expressed in Various Tumors and in Some Tumor Preexisting Conditions

Julia Y. Ljubimova, Steven E. Wilson, Lidija M. Petrovic, Karen Ehrenman, Alexander V. Ljubimov, Achilles A. Demetriou, Stephen A. Geller, and Keith L. Black
Cancer Res 1998 58: 4475-4479. [Abstract] [PDF]  

Letter to the Editor:

Correspondence re: J. Benítez et al., A Region of Allelic Imbalance in 1q31–32 in Primary Breast Cancer Coincides with a Recombination Hot Spot. Cancer Res., 57: 4217–4220, 1997

Jürgen A. Kraus, Anke Koch, and Torsten Pietsch
Cancer Res 1998 58: 4480 [PDF]  

Articles:

Announcements

Cancer Res 1998 58: 4481-4482. [PDF]  

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