Perspectives in Cancer Research:

Androgen Metabolism and Prostate Cancer: Establishing a Model of Genetic Susceptibility

Ronald K. Ross, Malcolm C. Pike, Gerhard A. Coetzee, Juergen K. V. Reichardt, Mimi C. Yu, Heather Feigelson, Frank Z. Stanczyk, Laurence N. Kolonel, and Brian E. Henderson
Cancer Res 1998 58: 4497-4504. [Abstract] [PDF]  

Advances in Brief:

A Multi-Institutional Study Confirms the Presence and Expression of Simian Virus 40 in Human Malignant Mesotheliomas

Joseph R. Testa, Michele Carbone, Ari Hirvonen, Kamel Khalili, Barbara Krynska, Kaija Linnainmaa, Frederick D. Pooley, Paola Rizzo, Valerie Rusch, and Guang-Hui Xiao
Cancer Res 1998 58: 4505-4509. [Abstract] [PDF]  

Induction of Apoptosis in Proliferating Human Endothelial Cells by the Tumor-specific Antiangiogenesis Agent Combretastatin A-4

Sudha Iyer, Dai J. Chaplin, Dean S. Rosenthal, A. Hamid Boulares, Lu-Yuan Li, and Mark E. Smulson
Cancer Res 1998 58: 4510-4514. [Abstract] [PDF]  

Inactivation of Glutathione S-Transferase P1 Gene by Promoter Hypermethylation in Human Neoplasia

Manel Esteller, Paul G. Corn, Jesus M. Urena, Edward Gabrielson, Stephen B. Baylin, and James G. Herman
Cancer Res 1998 58: 4515-4518. [Abstract] [PDF]  

Induction of Apoptosis by Deregulated Expression of DNA Topoisomerase II

J. Peter McPherson and Gerald J. Goldenberg
Cancer Res 1998 58: 4519-4524. [Abstract] [PDF]  

A Novel Coculture Technique Demonstrates That Normal Human Prostatic Fibroblasts Contribute to Tumor Formation of LNCaP Cells by Retarding Cell Death

Aria F. Olumi, Paul Dazin, and Thea D. Tlsty
Cancer Res 1998 58: 4525-4530. [Abstract] [PDF]  

p53-mediated Repression of Nuclear Factor-B RelA via the Transcriptional Integrator p300

Rajani Ravi, Bijoyesh Mookerjee, Yvette van Hensbergen, Gauri C. Bedi, Antonio Giordano, Wafik S. El-Deiry, Ephraim J. Fuchs, and Atul Bedi
Cancer Res 1998 58: 4531-4536. [Abstract] [PDF]  

Human Exonuclease I Interacts with the Mismatch Repair Protein hMSH2

Christoph Schmutte, Rodica Catrinel Marinescu, Margaret M. Sadoff, Shawn Guerrette, Joan Overhauser, and Richard Fishel
Cancer Res 1998 58: 4537-4542. [Abstract] [PDF]  

Ambient Particulate Matter Causes Activation of the c-jun Kinase/Stress-activated Protein Kinase Cascade and DNA Synthesis in Lung Epithelial Cells

Cynthia Timblin, Kelly BeruBe, Andrew Churg, Kevin Driscoll, Terry Gordon, David Hemenway, Eric Walsh, Andrew B. Cummins, Pamela Vacek, and Brooke Mossman
Cancer Res 1998 58: 4543-4547. [Abstract] [PDF]  

Inhibition by Phenyl N-tert-Butyl Nitrone of Early Phase Carcinogenesis in the Livers of Rats Fed a Choline-deficient, L-Amino Acid-defined Diet

Dai Nakae, Yashige Kotake, Hideki Kishida, Kenneth L. Hensley, Ayumi Denda, Yozo Kobayashi, Wakashi Kitayama, Toshifumi Tsujiuchi, Hong Sang, Charles A. Stewart, Tahereh Tabatabaie, Robert A. Floyd, and Yoichi Konishi
Cancer Res 1998 58: 4548-4551. [Abstract] [PDF]  

Deficiency of the ATM Protein Expression Defines an Aggressive Subgroup of B-Cell Chronic Lymphocytic Leukemia

Petr Starostik, Taghi Manshouri, Susan O'Brien, Emil Freireich, Hagop Kantarjian, Mohammad Haidar, Susan Lerner, Michael Keating, and Maher Albitar
Cancer Res 1998 58: 4552-4557. [Abstract] [PDF]  

Inhibition of Growth and Proliferation of EcRG293 Cell Line Expressing High-Affinity Gonadotropin-releasing Hormone (GnRH) Receptor Under the Control of an Inducible Promoter by GnRH Agonist (D-Lys⁶)GnRH and Antagonist (Antide)

Sham S. Kakar
Cancer Res 1998 58: 4558-4560. [Abstract] [PDF]  

Overexpression of Apaf-1 Promotes Apoptosis of Untreated and Paclitaxel- or Etoposide-treated HL-60 Cells

Charles Perkins, Caryn N. Kim, Guofu Fang, and Kapil N. Bhalla
Cancer Res 1998 58: 4561-4566. [Abstract] [PDF]  

Enhanced Generation of Cytotoxic T Lymphocytes Using Recombinant Vaccinia Virus Expressing Human Tumor-associated Antigens and B7 Costimulatory Molecules

Paul Zajac, Alexander Schütz, Daniel Oertli, Christoph Noppen, Christoph Schaefer, Michael Heberer, Giulio C. Spagnoli, and Walter R. Marti
Cancer Res 1998 58: 4567-4571. [Abstract] [PDF]  

Human Chromosome 16 Suppresses Metastasis But Not Tumorigenesis in Rat Prostatic Tumor Cells

Tomoyuki Mashimo, Misako Watabe, Andrew P. Cuthbert, Robert F. Newbold, Carrie W. Rinker-Schaeffer, Eric Helfer, and Kounosuke Watabe
Cancer Res 1998 58: 4572-4576. [Abstract] [PDF]  

Selective Killing of Glioma Cell Lines Using an Astrocyte-specific Expression of the Herpes Simplex Virus-Thymidine Kinase Gene

Didier Vandier, Olivier Rixe, Michael Brenner, Alain Gouyette, and François Besnard
Cancer Res 1998 58: 4577-4580. [Abstract] [PDF]  

Identification of Superior Markers for Polymerase Chain Reaction Detection of Breast Cancer Metastases in Sentinel Lymph Nodes

C. Justus Min, Lorraine Tafra, and Kathryn M. Verbanac
Cancer Res 1998 58: 4581-4584. [Abstract] [PDF]  

No Evidence of Correlation between Polymorphism at Codon 72 of p53 and Risk of Cervical Cancer in Japanese Patients with Human Papillomavirus 16/18 Infection

Takeo Minaguchi, Yasunobu Kanamori, Mieko Matsushima, Hiroyuki Yoshikawa, Yuji Taketani, and Yusuke Nakamura
Cancer Res 1998 58: 4585-4586. [Abstract] [PDF]  

E-Cadherin and Metastasin (mts-1/S100A4) Expression Levels Are Inversely Regulated in Two Tumor Cell Families

Annick Keirsebilck, Stefan Bonné, Erik Bruyneel, Petra Vermassen, Eugene Lukanidin, Marc Mareel, and Frans van Roy
Cancer Res 1998 58: 4587-4591. [Abstract] [PDF]  

Dpc4 Transcriptional Activation and Dysfunction in Cancer Cells

Jia Le Dai, Kenan K. Turnacioglu, Mieke Schutte, Avrahom Y. Sugar, and Scott E. Kern
Cancer Res 1998 58: 4592-4597. [Abstract] [PDF]  

Differential Expression of the Zinc Finger Gene TCF17 in Testicular Tumors

Stefan A. Przyborski, Ivan Damjanov, Barbara B. Knowles, and Susan L. Ackerman
Cancer Res 1998 58: 4598-4601. [Abstract] [PDF]  

Schwann Cell-conditioned Medium Promotes Neuroblastoma Survival and Differentiation

Janet L. Kwiatkowski, J. Lynn Rutkowski, Darrell J. Yamashiro, Gihan I. Tennekoon, and Garrett M. Brodeur
Cancer Res 1998 58: 4602-4606. [Abstract] [PDF]  

Apoptosis Induction and Potent Antiestrogen Receptor-negative Breast Cancer Activity in Vivo by a Retinoid Antagonist

Andrea N. Fanjul, F. Javier Piedrafita, H. Al-Shamma, and Magnus Pfahl
Cancer Res 1998 58: 4607-4610. [Abstract] [PDF]  

Pharmacological Inhibitors of Mammalian Fatty Acid Synthase Suppress DNA Replication and Induce Apoptosis in Tumor Cell Lines

Ellen S. Pizer, Francis J. Chrest, Joseph A. DiGiuseppe, and Wan Fang Han
Cancer Res 1998 58: 4611-4615. [Abstract] [PDF]  

Biochemistry and Biophysics:

Glutathione-dependent Biotransformation of the Alkylating Drug Thiotepa and Transport of Its Metabolite Monoglutathionylthiotepa in Human MCF-7 Breast Cancer Cells

Nicole H. P. Cnubben, Angela J. M. Rommens, Martin J. Oudshoorn, and Peter J. Van Bladeren
Cancer Res 1998 58: 4616-4623. [Abstract] [PDF]  

Suppression or Elevation of Cytosolic Phospholipase A₂ Alters Keratinocyte Prostaglandin Synthesis, Growth, and Apoptosis

Herng-Hsiang Lo, Peter Teichmann, Gerhard Fürstenberger, Irma Gimenez-Conti, and Susan M. Fischer
Cancer Res 1998 58: 4624-4631. [Abstract] [PDF]  

Carcinogenesis:

Mechanism of Differential Potencies of Isothiocyanates as Inducers of Anticarcinogenic Phase 2 Enzymes

Yuesheng Zhang and Paul Talalay
Cancer Res 1998 58: 4632-4639. [Abstract] [PDF]  

Endocrinology:

Interleukin-6 Regulates Prostate-specific Protein Expression in Prostate Carcinoma Cells by Activation of the Androgen Receptor

Alfred Hobisch, Iris E. Eder, Thomas Putz, Wolfgang Horninger, Georg Bartsch, Helmut Klocker, and Zoran Culig
Cancer Res 1998 58: 4640-4645. [Abstract] [PDF]  

Experimental Therapeutics:

Infarction of Solid Hodgkin's Tumors in Mice by Antibody-directed Targeting of Tissue Factor to Tumor Vasculature

Sophia Ran, Boning Gao, Steve Duffy, Linda Watkins, Neal Rote, and Philip E. Thorpe
Cancer Res 1998 58: 4646-4653. [Abstract] [PDF]  

Angiostatin Suppresses Malignant Glioma Growth in Vivo

Matthias Kirsch, Jon Strasser, Rafael Allende, Lorenzo Bello, Jianping Zhang, and Peter McL. Black
Cancer Res 1998 58: 4654-4659. [Abstract] [PDF]  

Lck Associates with and Is Activated by Kit in a Small Cell Lung Cancer Cell Line: Inhibition of SCF-mediated Growth by the Src Family Kinase Inhibitor PP1

Geoffrey W. Krystal, Candy S. DeBerry, Diana Linnekin, and Julie Litz
Cancer Res 1998 58: 4660-4666. [Abstract] [PDF]  

Paclitaxel-associated Multimininucleation Is Permitted by the Inhibition of Caspase Activation: A Potential Early Step in Drug Resistance

Ravat Panvichian, Kim Orth, Mark L. Day, Kathleen C. Day, Mary Josephine Pilat, and Kenneth J. Pienta
Cancer Res 1998 58: 4667-4672. [Abstract] [PDF]  

Immunology:

Tumor Microenvironment Can Restrict the Effectiveness of Activated Antitumor Lymphocytes

Ruth Ganss and Douglas Hanahan
Cancer Res 1998 58: 4673-4681. [Abstract] [PDF]  

Tumor Defense by Murine Cytotoxic T Cells Specific for Peptide Bound to Nonclassical MHC Class I

Emily Griffiths, Helena Ong, Mark J. Soloski, Martin F. Bachmann, Pamela S. Ohashi, and Daniel E. Speiser
Cancer Res 1998 58: 4682-4687. [Abstract] [PDF]  

P-Glycoprotein Plays an Insignificant Role in the Presentation of Antigenic Peptides to CD8⁺ T Cells

Gustav Russ, Murali Ramachandra, Christina A. Hrycyna, Michael M. Gottesman, Ira Pastan, Jack R. Bennink, and Jonathan W. Yewdell
Cancer Res 1998 58: 4688-4693. [Abstract] [PDF]  

Molecular Biology and Genetics:

Intratumoral Cytogenetic Heterogeneity Detected by Comparative Genomic Hybridization and Laser Scanning Cytometry in Human Gliomas

Katsumi Harada, Takafumi Nishizaki, Satoshi Ozaki, Hisashi Kubota, Haruhide Ito, and Kohsuke Sasaki
Cancer Res 1998 58: 4694-4700. [Abstract] [PDF]  

Chromosomal Duplication Accompanies Allelic Loss in Non-Small Cell Lung Carcinoma

Marileila Varella-Garcia, Robert M. Gemmill, Silvia H. Rabenhorst, Alice Lotto, Harry A. Drabkin, Philip A. Archer, and Wilbur A. Franklin
Cancer Res 1998 58: 4701-4707. [Abstract] [PDF]  

Loss of FHIT Expression in Gastric Carcinoma

Raffaele Baffa, Maria Luisa Veronese, Roberto Santoro, Bernadette Mandes, Juan P. Palazzo, Massimo Rugge, Eugenio Santoro, Carlo M. Croce, and Kay Huebner
Cancer Res 1998 58: 4708-4714. [Abstract] [PDF]  

Pluripotent Tumor Cells in Benign Pituitary Adenomas Associated with Multiple Endocrine Neoplasia Type 1

Robert J. Weil, Steve Huang, Svetlana Pack, Alexander O. Vortmeyer, Maria Tsokos, Irina A. Lubensky, Edward H. Oldfield, and Zhengping Zhuang
Cancer Res 1998 58: 4715-4720. [Abstract] [PDF]  

Comparative Genomic Hybridization Analysis of Lobular Carcinoma in Situ and Atypical Lobular Hyperplasia and Potential Roles for Gains and Losses of Genetic Material in Breast Neoplasia

Yong-Jie Lu, Pinchas Osin, Sunil R. Lakhani, Silvana Di Palma, Barry A. Gusterson, and Janet M. Shipley
Cancer Res 1998 58: 4721-4727. [Abstract] [PDF]  

Microsatellite Analysis of Plasma DNA from Patients with Clear Cell Renal Carcinoma

Carsten Goessl, Rüdiger Heicappell, Ralf Münker, Philippe Anker, Maurice Stroun, Hans Krause, Markus Müller, and Kurt Miller
Cancer Res 1998 58: 4728-4732. [Abstract] [PDF]  

The Human REC2/RAD51B Gene Acts as a DNA Damage Sensor by Inducing G₁ Delay and Hypersensitivity to Ultraviolet Irradiation

Pamela A. Havre, Michael C. Rice, Mariadele Noe, and Eric B. Kmiec
Cancer Res 1998 58: 4733-4739. [Abstract] [PDF]  

Tumor Biology:

Inactivation of the p16 (INK4A) Tumor-suppressor Gene in Pancreatic Duct Lesions: Loss of Intranuclear Expression

Robb E. Wilentz, Joseph Geradts, Robert Maynard, G. Johan A. Offerhaus, Myungsa Kang, Michael Goggins, Charles J. Yeo, Scott E. Kern, and Ralph H. Hruban
Cancer Res 1998 58: 4740-4744. [Abstract] [PDF]  

Overexpression of the HIP Gene Coding for a Heparin/Heparan Sulfate-binding Protein in Human Thyroid Carcinomas

Filomena de Nigris, Roberta Visconti, Janete Cerutti, Daniela Califano, Alba Mineo, Massimo Santoro, Giovanni Santelli, and Alfredo Fusco
Cancer Res 1998 58: 4745-4751. [Abstract] [PDF]  

Transforming Growth Factor ß Signaling through Smad1 in Human Breast Cancer Cells

Xiaojie Liu, Jianbo Yue, Randall S. Frey, Qichao Zhu, and Kathleen M. Mulder
Cancer Res 1998 58: 4752-4757. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1998 58: 4758-4759. [PDF]  

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