Advances in Brief:

BRCA2 and p53 Mutations in Primary Breast Cancer in Relation to Genetic Instability

Solveig Gretarsdottir, Steinunn Thorlacius, Rut Valgardsdottir, Sigfridur Gudlaugsdottir, Stefan Sigurdsson, Margret Steinarsdottir, Jon Gunnlaugur Jonasson, Kesara Anamthawat-Jonsson, and Jorunn E. Eyfjörd
Cancer Res 1998 58: 859-862. [Abstract] [PDF]  

An Interstitial Tandem Duplication of 9p23–24 Coexists with a Mutation in the BRCA2 Gene in the Germ Line of Three Brothers with Breast Cancer

Larissa Savelyeva, Andreas Claas, Simone Gier, Peter Schlag, Lothar Finke, Jonathan Mangion, Michael R. Stratton, and Manfred Schwab
Cancer Res 1998 58: 863-866. [Abstract] [PDF]  

Suppression of Cellular Transformation by Glucocorticoid Receptor Mutants

Takashi Kameda and Hideo Iba
Cancer Res 1998 58: 867-870. [Abstract] [PDF]  

Constitutive Overexpression of Cyclin D1 Does Not Prevent Inhibition of Hormone-responsive Human Breast Cancer Cell Growth by Antiestrogens

Carmen Pacilio, Domenico Germano, Raffaele Addeo, Lucia Altucci, Valeria Belsito Petrizzi, Massimo Cancemi, Luigi Cicatiello, Salvatore Salzano, François Lallemand, Rob J. A. M. Michalides, Francesco Bresciani, and Alessandro Weisz
Cancer Res 1998 58: 871-876. [Abstract] [PDF]  

Ligand-independent Activation of the Estrogen Receptors and ß by Mutations of a Conserved Tyrosine Can Be Abolished by Antiestrogens

Gilles B. Tremblay, André Tremblay, Fernand Labrie, and Vincent Giguère
Cancer Res 1998 58: 877-881. [Abstract] [PDF]  

CD95 (Fas)-induced Caspase-mediated Proteolysis of NF-B

Rajani Ravi, Asheesh Bedi, Ephraim J. Fuchs, and Atul Bedi
Cancer Res 1998 58: 882-886. [Abstract] [PDF]  

Mutagenic Replication in a Human Cell Extract of DNAs Containing Site-specific and Stereospecific Benzo(a)pyrene-7,8-diol-9,10-epoxide DNA Adducts Placed on the Leading and Lagging Strands

Oleg V. Lavrukhin and R. Stephen Lloyd
Cancer Res 1998 58: 887-891. [Abstract] [PDF]  

Distinct Chromosomal Imbalances in Uterine Serous and Endometrioid Carcinomas

Heini Pere, Johanna Tapper, Torsten Wahlström, Sakari Knuutila, and Ralf Butzow
Cancer Res 1998 58: 892-895. [Abstract] [PDF]  

Sporadic Medulloblastomas Contain Oncogenic ß-Catenin Mutations

Russell H. Zurawel, Sharon A. Chiappa, Cory Allen, and Corey Raffel
Cancer Res 1998 58: 896-899. [Abstract] [PDF]  

Both Focal Adhesion Kinase and c-Ras Are Required for the Enhanced Matrix Metalloproteinase 9 Secretion by Fibronectin in Ovarian Cancer Cells

Kiyosumi Shibata, Fumitaka Kikkawa, Akihiro Nawa, Aye Aye Thant, Keiji Naruse, Shigehiko Mizutani, and Michinari Hamaguchi
Cancer Res 1998 58: 900-903. [Abstract] [PDF]  

Regular Articles Biochemistry and Biophysics:

Control of Breast Tumor Cell Growth Using a Targeted Cysteine Protease Inhibitor

Ruye Xing, Fei Wu, and Robert W. Mason
Cancer Res 1998 58: 904-909. [Abstract] [PDF]  

Expression of Catalytically Inactive Phospholipase Cß Disrupts Phospholipase Cß and Mitogen-activated Protein Kinase Signaling and Inhibits Small Cell Lung Cancer Growth

Andrew Beekman, Barbara Helfrich, Paul A. Bunn, Jr., and Lynn E. Heasley
Cancer Res 1998 58: 910-913. [Abstract] [PDF]  

Cyclic GMP-specific Phosphodiesterase Inhibition and Intracarotid Bradykinin Infusion Enhances Permeability into Brain Tumors

Masao Sugita and Keith L. Black
Cancer Res 1998 58: 914-920. [Abstract] [PDF]  

Regular Articles Carcinogenesis:

Modulation of Methylnitrosourea-induced Breast Cancer in Sprague Dawley Rats by Dehydroepiandrosterone: Dose-dependent Inhibition, Effects of Limited Exposure, Effects on Peroxisomal Enzymes, and Lack of Effects on Levels of Ha-Ras Mutations

Ronald A. Lubet, Gary B. Gordon, Russell A. Prough, Xiang-Dong Lei, Ming You, Yian Wang, Clinton J. Grubbs, Vernon E. Steele, Gary J. Kelloff, Cathy F. Thomas, and Richard D. Moon
Cancer Res 1998 58: 921-926. [Abstract] [PDF]  

Regular Articles Endocrinology:

In Situ Aromatization Enhances Breast Tumor Estradiol Levels and Cellular Proliferation

Wei Yue, Ji-Ping Wang, Christopher J. Hamilton, Laurence M. Demers, and Richard J. Santen
Cancer Res 1998 58: 927-932. [Abstract] [PDF]  

Regular Articles Experimental Therapeutics:

Keratinocyte Growth Factor Protects Mice from Chemotherapy and Radiation-induced Gastrointestinal Injury and Mortality

Catherine L. Farrell, James V. Bready, Karen L. Rex, Jennifer N. Chen, Christopher R. DiPalma, K. Lane Whitcomb, Songmei Yin, David C. Hill, Bernadette Wiemann, Charlie O. Starnes, Andrew M. Havill, Zhao-N. Lu, Sharon L. Aukerman, Glenn F. Pierce, Arlen Thomason, Christopher S. Potten, Thomas R. Ulich, and David L. Lacey
Cancer Res 1998 58: 933-939. [Abstract] [PDF]  

Protease Activation and Cleavage of Poly(ADP-ribose) Polymerase: An Integral Part of Apoptosis in Response to Photodynamic Treatment

Jin He, Cecilia M. Whitacre, Liang-yan Xue, Nathan A. Berger, and Nancy L. Oleinick
Cancer Res 1998 58: 940-946. [Abstract] [PDF]  

Role of Glutathione S-Transferases in the Resistance of Human Colon Cancer Cell Lines to Doxorubicin

Peter O. Beaumont, Malcolm J. Moore, Kamran Ahmad, Michelle M. Payne, Chunja Lee, and David S. Riddick
Cancer Res 1998 58: 947-955. [Abstract] [PDF]  

Highly Efficient and Consistent Gene Transfer into Dendritic Cells Utilizing a Combination of Ultraviolet-irradiated Adenovirus and Poly(L-Lysine) Conjugates

Peter Mulders, Shen Pang, Jens Dannull, Randhir Kaboo, Andreas Hinkel, Kiarash Michel, Cho-Lea Tso, Michael Roth, and Arie Belldegrun
Cancer Res 1998 58: 956-961. [Abstract] [PDF]  

Retroviral Transfer of CPP32ß Gene into Malignant Gliomas in Vitro and in Vivo

Seiji Kondo, Yoshikazu Tanaka, Yasuko Kondo, Yukihito Ishizaka, Masahiro Hitomi, Talat Haqqi, Jinbo Liu, Gene H. Barnett, Emad S. Alnemri, and Barbara P. Barna
Cancer Res 1998 58: 962-967. [Abstract] [PDF]  

Accumulation of a Recombinant Immunotoxin in a Tumor in Vivo: Fewer Than 1000 Molecules per Cell Are Sufficient for Complete Responses

Robert J. Kreitman and Ira Pastan
Cancer Res 1998 58: 968-975. [Abstract] [PDF]  

Regular Articles Molecular Biology and Genetics:

Ultraviolet-induced DNA Damage Stimulates Topoisomerase I-DNA Complex Formation in Vivo: Possible Relationship with DNA Repair

Deepa Subramanian, Barry S. Rosenstein, and Mark T. Muller
Cancer Res 1998 58: 976-984. [Abstract] [PDF]  

Overexpression of Cyclin A but not Skp 2 Correlates with the Tumor Relapse of Human Hepatocellular Carcinoma

Yee Chao, Yung-Luen Shih, Jen-Hwey Chiu, Gar-Yang Chau, Wing-Yu Lui, Wen K. Yang, Shou-Dong Lee, and Tze-Sing Huang
Cancer Res 1998 58: 985-990. [Abstract] [PDF]  

Panning Phage Antibody Libraries on Cells: Isolation of Human Fab Fragments against Ovarian Carcinoma Using Guided Selection

Mariangela Figini, Laura Obici, Delia Mezzanzanica, Andrew Griffiths, Maria I. Colnaghi, Greg Winter, and Silvana Canevari
Cancer Res 1998 58: 991-996. [Abstract] [PDF]  

Somatic Frameshift Mutations in DNA Mismatch Repair and Proapoptosis Genes in Hereditary Nonpolyposis Colorectal Cancer

Hiroyuki Yamamoto, Hisako Sawai, Thomas K. Weber, Miguel A. Rodriguez-Bigas, and Manuel Perucho
Cancer Res 1998 58: 997-1003. [Abstract] [PDF]  

Consortium Study on 1280 Breast Carcinomas: Allelic Loss on Chromosome 17 Targets Subregions Associated with Family History and Clinical Parameters

Catherine M. Phelan, Åke Borg, Marguerite Cuny, David N. Crichton, Trausti Baldersson, Tone Ikdahl Andersen, Maria Adelaide Caligo, Rosette Lidereau, Annika Lindblom, Susanne Seitz, David Kelsell, Ute Hamann, Pascale Rio, Steinunn Thorlacius, Janos Papp, Edith Olah, Bruce Ponder, Yves-Jean Bignon, Siegfried Scherneck, Rosa Barkardottir, Anne-Lise Borresen-Dale, Jorunn Eyfjörd, Charles Theillet, Alastair M. Thompson, Peter Devilee, and Catharina Larsson
Cancer Res 1998 58: 1004-1012. [Abstract] [PDF]  

Engineering Human DNA Alkyltransferases for Gene Therapy Using Random Sequence Mutagenesis

Lance P. Encell, Melissa M. Coates, and Lawrence A. Loeb
Cancer Res 1998 58: 1013-1020. [Abstract] [PDF]  

Activation of the ß-Catenin Gene by Interstitial Deletions Involving Exon 3 in Primary Colorectal Carcinomas without Adenomatous Polyposis Coli Mutations

Kyoko Iwao, Syoji Nakamori, Masao Kameyama, Shingi Imaoka, Moritoshi Kinoshita, Takafumi Fukui, Shingo Ishiguro, Yusuke Nakamura, and Yasuo Miyoshi
Cancer Res 1998 58: 1021-1026. [Abstract] [PDF]  

Ets-2 Transdominant Mutant Abolishes Anchorage-independent Growth and Macrophage Colony-stimulating Factor-stimulated Invasion by BT20 Breast Carcinoma Cells

Eva Sapi, Maryann B. Flick, Sofya Rodov, and Barry M. Kacinski
Cancer Res 1998 58: 1027-1033. [Abstract] [PDF]  

Human Lung Cancer Antigens Recognized by Autologous Antibodies: Definition of a Novel cDNA Derived from the Tumor Suppressor Gene Locus on Chromosome 3p21.3

Ali O. Güre, Nasser K. Altorki, Elisabeth Stockert, Matthew J. Scanlan, Lloyd J. Old, and Yao-Tseng Chen
Cancer Res 1998 58: 1034-1041. [Abstract] [PDF]  

p27^KIP1 in Human Lung Cancers: Differential Changes in Small Cell and Non-Small Cell Carcinomas

Yasushi Yatabe, Akira Masuda, Takashi Koshikawa, Shigeo Nakamura, Tetsuo Kuroishi, Hirotaka Osada, Toshitada Takahashi, Tetsuya Mitsudomi, and Takashi Takahashi
Cancer Res 1998 58: 1042-1047. [Abstract] [PDF]  

Reduced Angiogenesis and Tumor Progression in Gelatinase A-deficient Mice

Takeshi Itoh, Masatoshi Tanioka, Hiroshi Yoshida, Takayuki Yoshioka, Hirofumi Nishimoto, and Shigeyoshi Itohara
Cancer Res 1998 58: 1048-1051. [Abstract] [PDF]  

Genomic Imprinting of a Human Apoptosis Gene Homologue, TSSC3

Maxwell P. Lee and Andrew P. Feinberg
Cancer Res 1998 58: 1052-1056. [Abstract] [PDF]  

Regular Articles Tumor Biology:

Nucleolar Localization of the Nucleophosmin-Anaplastic Lymphoma Kinase Is Not Required for Malignant Transformation

David Y. Mason, Karen A. F. Pulford, Daniela Bischof, Martin U. Kuefer, Lisa H. Butler, Laurence Lamant, Georges Delsol, and Stephan W. Morris
Cancer Res 1998 58: 1057-1062. [Abstract] [PDF]  

Detection of Tumor Response to Chemotherapy by ¹H Nuclear Magnetic Resonance Spectroscopy: Effect of 5-Fluorouracil on Lactate Levels in Radiation-induced Fibrosarcoma 1 Tumors

Eric O. Aboagye, Zaver M. Bhujwalla, Dikoma C. Shungu, and Jerry D. Glickson
Cancer Res 1998 58: 1063-1067. [Abstract] [PDF]  

O⁶-Methylguanine-DNA Methyltransferase Activity in Adult Gliomas: Relation to Patient and Tumor Characteristics

John R. Silber, Michael S. Bobola, Saadi Ghatan, A. Blank, Douglas D. Kolstoe, and Mitchel S. Berger
Cancer Res 1998 58: 1068-1073. [Abstract] [PDF]  

Decreased PKC- Expression Increases Cellular Proliferation, Decreases Differentiation, and Enhances the Transformed Phenotype of CaCo-2 Cells

Beth Scaglione-Sewell, Clara Abraham, Marc Bissonnette, Susan F. Skarosi, John Hart, Nicholas O. Davidson, Ramesh K. Wali, Bernard H. Davis, Michael Sitrin, and Thomas A. Brasitus
Cancer Res 1998 58: 1074-1081. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1998 58: 1082-1084. [PDF]  

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