Advances in Brief:

Regulation of E2F4 Mitogenic Activity during Terminal Differentiation by Its Heterodimerization Partners for Nuclear Translocation

Pier Lorenzo Puri, Letizia Cimino, Marcella Fulco, Christian Zimmerman, Nicholas B. La Thangue, Antonio Giordano, Adolf Graessmann, and Massimo Levrero
Cancer Res 1998 58: 1325-1331. [Abstract] [PDF]  

Amplification of the ATP-Binding Cassette 2 Transporter Gene Is Functionally Linked with Enhanced Efflux of Estramustine in Ovarian Carcinoma Cells

Naomi M. Laing, Martin G. Belinsky, Gary D. Kruh, Daphne W. Bell, Jonathan T. Boyd, Linda Barone, Joseph R. Testa, and Kenneth D. Tew
Cancer Res 1998 58: 1332-1337. [Abstract] [PDF]  

Thymic Lymphomas in Mice with a Truncating Mutation in Brca2

Lori S. Friedman, Fiona C. Thistlethwaite, Ketan J. Petel, Veronica P. C. C. Yu, Hyunsook Lee, Ashok R. Venkitaraman, Kenneth J. Abel, Mark B. L. Carlton, Susan M. Hunter, William H. Colledge, Martin J. Evans, and Bruce A. J. Ponder
Cancer Res 1998 58: 1338-1343. [Abstract] [PDF]  

Mutations in the ß-Catenin Gene (CTNNB1) in Endometrioid Ovarian Carcinomas

José Palacios and Carlos Gamallo
Cancer Res 1998 58: 1344-1347. [Abstract] [PDF]  

Expression of Lumican in Human Breast Carcinoma

Etienne Leygue, Linda Snell, Helmut Dotzlaw, Kate Hole, Tamara Hiller-Hitchcock, Peter J. Roughley, Peter H. Watson, and Leigh C. Murphy
Cancer Res 1998 58: 1348-1352. [Abstract] [PDF]  

Amplification, Expression, and Steroid Regulation of the Preprogalanin Gene in Human Breast Cancer

Christopher J. Ormandy, Christine S. L. Lee, Helen F. Ormandy, Vera Fantl, John Shine, Gordon Peters, and Robert L. Sutherland
Cancer Res 1998 58: 1353-1357. [Abstract] [PDF]  

Adenoviral-mediated Transfer of a Heat-inducible Double Suicide Gene into Prostate Carcinoma Cells

Robert V. Blackburn, Sandra S. Galoforo, Peter M. Corry, and Yong J. Lee
Cancer Res 1998 58: 1358-1362. [Abstract] [PDF]  

Human Melanoma-specific, Noncytolytic CD8+ T Cells That Can Synthesize Type I Cytokine

Nitya G. Chakraborty and Bijay Mukherji
Cancer Res 1998 58: 1363-1366. [Abstract] [PDF]  

BRCA2 Germ-Line Mutations Are Frequent in Male Breast Cancer Patients without a Family History of the Disease

Karin Haraldsson, Niklas Loman, Qiu-Xia Zhang, Oskar Johannsson, Håkan Olsson, and Åke Borg
Cancer Res 1998 58: 1367-1371. [Abstract] [PDF]  

A Large Deletion Disrupts the Exon 3 Transcription Activation Domain of the BRCA2 Gene in a Breast/Ovarian Cancer Family

Margareta Nordling, Per Karlsson, Jan Wahlström, Yvonne Engwall, Arne Wallgren, and Tommy Martinsson
Cancer Res 1998 58: 1372-1375. [Abstract] [PDF]  

The Role of Ataxia-Telangiectasia Heterozygotes in Familial Breast Cancer

Jindong Chen, Gabriella Giesler Birkholtz, Per Lindblom, Carlos Rubio, and Annika Lindblom
Cancer Res 1998 58: 1376-1379. [Abstract] [PDF]  

Search for Mutations and Examination of Allelic Expression Imbalance of the p73 Gene at 1p36.33 in Human Lung Cancers

Shuji Nomoto, Nobuhiro Haruki, Masashi Kondo, Hiroyuki Konishi, Takao Takahashi, Toshitada Takahashi, and Takashi Takahashi
Cancer Res 1998 58: 1380-1383. [Abstract] [PDF]  

Low Frequency of Somatic Mutations in the LKB1/Peutz-Jeghers Syndrome Gene in Sporadic Breast Cancer

Graham R. Bignell, Rita Barfoot, Sheila Seal, Nadine Collins, William Warren, and Michael R. Stratton
Cancer Res 1998 58: 1384-1386. [Abstract] [PDF]  

Linkage of Familial Wilms' Tumor Predisposition to Chromosome 19 and a Two-Locus Model for the Etiology of Familial Tumors

J. Matthew McDonald, Edwin C. Douglass, Ross Fisher, Clementina F. Geiser, Carl E. Krill, Louise C. Strong, David Virshup, and Vicki Huff
Cancer Res 1998 58: 1387-1390. [Abstract] [PDF]  

Down-Regulation of Homeobox Gene GBX2 Expression Inhibits Human Prostate Cancer Clonogenic Ability and Tumorigenicity

Allen C. Gao, Wei Lou, and John T. Isaacs
Cancer Res 1998 58: 1391-1394. [Abstract] [PDF]  

Increased Incidence of Matrix Metalloproteinases in Urine of Cancer Patients

Marsha A. Moses, Dmitri Wiederschain, Kevin R. Loughlin, David Zurakowski, Carolyn C. Lamb, and Michael R. Freeman
Cancer Res 1998 58: 1395-1399. [Abstract] [PDF]  

DNA Interstrand Cross-Links Induced by Psoralen Are Not Repaired in Mammalian Mitochondria

Carleen Cullinane and Vilhelm A. Bohr
Cancer Res 1998 58: 1400-1404. [Abstract] [PDF]  

Molecular Detection of Genetic Alterations in the Serum of Colorectal Cancer Patients

Kenji Hibi, C. Rahj Robinson, Susan Booker, Li Wu, Stanley R. Hamilton, David Sidransky, and Jin Jen
Cancer Res 1998 58: 1405-1407. [Abstract] [PDF]  

REVIEWS:

The Unique Physiology of Solid Tumors: Opportunities (and Problems) for Cancer Therapy

J. Martin Brown and Amato J. Giaccia
Cancer Res 1998 58: 1408-1416. [Abstract] [PDF]  

Biochemistry and Biophysics:

A Relevant Dose of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Is Extensively Metabolized and Rapidly Absorbed in the Canine Tracheal Mucosa

Per Gerde, Bruce A. Muggenburg, Tony Stephens, Johnnye L. Lewis, Kee H. Pyon, and Alan R. Dahl
Cancer Res 1998 58: 1417-1422. [Abstract] [PDF]  

Differential Selectivity of Ligands for the C1a and C1b Phorbol Ester Binding Domains of Protein Kinase C: Possible Correlation with Tumor-promoting Activity

Krisztina Bögi, Patricia S. Lorenzo, Zoltán Szállási, Péter Ács, Gerhardt S. Wagner, and Peter M. Blumberg
Cancer Res 1998 58: 1423-1428. [Abstract] [PDF]  

Carcinogenesis:

Overexpression of the Myristoylated Alanine-rich C Kinase Substrate in Human Choroidal Melanoma Cells Affects Cell Proliferation

Stéphane Manenti, François Malecaze, Hugues Chap, and Jean-Marie Darbon
Cancer Res 1998 58: 1429-1434. [Abstract] [PDF]  

Topical Retinoic Acid Reduces Skin Papilloma Formation but Resistant Papillomas Are at High Risk for Malignant Conversion

Tamar Tennenbaum, David Lowry, Nadine Darwiche, David L. Morgan, Marina Gartsbein, Laura Hansen, Luigi M. De Luca, Henry Hennings, and Stuart H. Yuspa
Cancer Res 1998 58: 1435-1443. [Abstract] [PDF]  

Differential Expression of Methionine Adenosyltransferase Genes Influences the Rate of Growth of Human Hepatocellular Carcinoma Cells

Jiaxin Cai, Zebin Mao, Jung-Joo Hwang, and Shelly C. Lu
Cancer Res 1998 58: 1444-1450. [Abstract] [PDF]  

Clinical Investigations:

Prognostic Value of P53 Gene Mutations in a Large Series of Node-negative Breast Cancer Patients

Nicole Falette, Marie-Pierre Paperin, Isabelle Treilleux, Anne-Christelle Gratadour, Nadine Peloux, Hervé Mignotte, Nigel Tooke, Esfir Löfman, Mats Inganäs, Alain Bremond, Mehmet Ozturk, and Alain Puisieux
Cancer Res 1998 58: 1451-1455. [Abstract] [PDF]  

Combined Nested RT-PCR Assay for Prostate-specific Antigen and Prostate-specific Membrane Antigen in Prostate Cancer Patients: Correlation with Pathological Stage

Ying Z. Grasso, Manjula K. Gupta, Howard S. Levin, Craig D. Zippe, and Eric A. Klein
Cancer Res 1998 58: 1456-1459. [Abstract] [PDF]  

Experimental Therapeutics:

Chinese Hamster Ovary Cells Resistant to the Topoisomerase II Catalytic Inhibitor ICRF-159: A Tyr49Phe Mutation Confers High-Level Resistance to Bisdioxopiperazines

Maxwell Sehested, Irene Wessel, Lars H. Jensen, Bente Holm, Roberto S. Oliveri, Sue Kenwrick, Andrew M. Creighton, John L. Nitiss, and Peter B. Jensen
Cancer Res 1998 58: 1460-1468. [Abstract] [PDF]  

Immunology:

Mice Transgenic for Human Carcinoembryonic Antigen as a Model for Immunotherapy

Patrick Clarke, Jeffrey Mann, Jean F. Simpson, Karen Rickard-Dickson, and F. James Primus
Cancer Res 1998 58: 1469-1477. [Abstract] [PDF]  

Interleukin 2 Expression by Tumor Cells Alters Both the Immune Response and the Tumor Microenvironment

Jungeun Lee, Bruce M. Fenton, Cameron J. Koch, John G. Frelinger, and Edith M. Lord
Cancer Res 1998 58: 1478-1485. [Abstract] [PDF]  

Reduction of Established Spontaneous Mammary Carcinoma Metastases following Immunotherapy with Major Histocompatibility Complex Class II and B7.1 Cell-based Tumor Vaccines

Beth A. Pulaski and Suzanne Ostrand-Rosenberg
Cancer Res 1998 58: 1486-1493. [Abstract] [PDF]  

Molecular Biology and Genetics:

Clinicopathological Significance of Altered Loci of Replication Error and Microsatellite Instability-associated Mutations in Gastric Cancer

Ming-Shiang Wu, Chung-Wei Lee, Chia-Tung Shun, Hsiu-Po Wang, Wei-Jei Lee, Jin-Chuan Sheu, and Jaw-Town Lin
Cancer Res 1998 58: 1494-1497. [Abstract] [PDF]  

Direct Modulation of Tumor Suppressor Connexin 26 Gene by Human Chorionic Gonadotropin in Rat Mammary Glands

Shaojin You, Zheng-Jin Tu, and David T. Kiang
Cancer Res 1998 58: 1498-1502. [Abstract] [PDF]  

Characteristic Pattern of Chromosomal Gains and Losses in Merkel Cell Carcinoma Detected by Comparative Genomic Hybridization

Mireille Van Gele, Frank Speleman, Jo Vandesompele, Nadine Van Roy, and J. Helen Leonard
Cancer Res 1998 58: 1503-1508. [Abstract] [PDF]  

Inhibition of Growth of Malignant Rat Prostate Tumor Cells by Restoration of Fibroblast Growth Factor Receptor 2

Akio Matsubara, Mikio Kan, Shuju Feng, and Wallace L. McKeehan
Cancer Res 1998 58: 1509-1514. [Abstract] [PDF]  

Down-Regulation of the Novel Gene Melastatin Correlates with Potential for Melanoma Metastasis

Lyn M. Duncan, Jim Deeds, John Hunter, Jing Shao, Lisa M. Holmgren, Elizabeth A. Woolf, Robert I. Tepper, and Andrew W. Shyjan
Cancer Res 1998 58: 1515-1520. [Abstract] [PDF]  

Comparative Decreases in Tyrosinase, TRP-1, TRP-2, and Pmel 17/Silver Antigenic Proteins from Melanotic to Amelanotic Stages of Syngeneic Mouse Cutaneous Melanomas and Metastases

Seth J. Orlow, Willys K. Silvers, Bao-Kang Zhou, and Beatrice Mintz
Cancer Res 1998 58: 1521-1523. [Abstract] [PDF]  

Tumor Biology:

Role of Nitric Oxide and Superoxide Anion in Elimination of Low Metastatic Human Colorectal Carcinomas by Unstimulated Hepatic Sinusoidal Endothelial Cells

Kirsten H. Edmiston, Yutaka Shoji, Takayuki Mizoi, Rosilyn Ford, Alexander Nachman, and J. Milburn Jessup
Cancer Res 1998 58: 1524-1531. [Abstract] [PDF]  

Regulation of Interleukin 8 Expression in Human Malignant Melanoma Cells

Rakesh K. Singh and Michelle L. Varney
Cancer Res 1998 58: 1532-1537. [Abstract] [PDF]  

Overexpressed WAF1/Cip1 Renders Glioblastoma Cells Resistant to Chemotherapy Agents 1,3-Bis(2-chloroethyl)-1-nitrosourea and Cisplatin

Sanbao Ruan, M. Fatih Okcu, Jiang Ping Ren, Paul Chiao, Michael Andreeff, Victor Levin, and Wei Zhang
Cancer Res 1998 58: 1538-1543. [Abstract] [PDF]  

Enhanced Expression of (1,3)-Fucosyltransferase Genes Correlates with E-selectin-mediated Adhesion and Metastatic Potential of Human Lung Adenocarcinoma Cells

Mireia Martín-Satué, Rosabel Marrugat, José A. Cancelas, and Jerónimo Blanco
Cancer Res 1998 58: 1544-1550. [Abstract] [PDF]  

Regulation of Expression of Thymidine Phosphorylase/Platelet-derived Endothelial Cell Growth Factor in Human Colon Carcinoma Cells

Edward L. Schwartz, Emily Wan, Fu-Shen Wang, and Nicole Baptiste
Cancer Res 1998 58: 1551-1557. [Abstract] [PDF]  

Expression of Human Telomerase Subunits and Correlation with Telomerase Activity in Cervical Cancer

Masahiro Takakura, Satoru Kyo, Taro Kanaya, Masaaki Tanaka, and Masaki Inoue
Cancer Res 1998 58: 1558-1561. [Abstract] [PDF]  

In Vivo Electron Paramagnetic Resonance Imaging of Tumor Heterogeneity and Oxygenation in a Murine Model

Periannan Kuppusamy, Mobae Afeworki, Ravi A. Shankar, Deborah Coffin, Murali C. Krishna, Stephen M. Hahn, James B. Mitchell, and Jay L. Zweier
Cancer Res 1998 58: 1562-1568. [Abstract] [PDF]  

Targeted Disruption of the ß1 Integrin Gene in a Lymphoma Cell Line Greatly Reduces Metastatic Capacity

Peter J. M. Stroeken, Ellen A. M. van Rijthoven, Martin A. van der Valk, and Ed Roos
Cancer Res 1998 58: 1569-1577. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1998 58: 1578-1580. [PDF]  

Erratum

Cancer Res 1998 58: 1580 [PDF]  

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