Advances in Brief:

Granulosa Cell Tumors Express erbB4 and Are Sensitive to the Cytotoxic Action of Heregulin-ß2/PE40

Christophe Furger, Rodney J. Fiddes, David I. Quinn, Ron J. Bova, Roger J. Daly, and Robert L. Sutherland
Cancer Res 1998 58: 1773-1778. [Abstract] [PDF]  

Direct Evidence That Apoptosis Enhances Tumor Responses to Fractionated Radiotherapy

Brent A. Rupnow, Albert D. Murtha, Rodolfo M. Alarcon, Amato J. Giaccia, and Susan J. Knox
Cancer Res 1998 58: 1779-1784. [Abstract] [PDF]  

Involvement of Nitric Oxide during Phthalocyanine (Pc4) Photodynamic Therapy-mediated Apotosis

Sanjay Gupta, Nihal Ahmad, and Hasan Mukhtar
Cancer Res 1998 58: 1785-1788. [Abstract] [PDF]  

Potentiation of Chlorambucil Cytotoxicity in B-Cell Chronic Lymphocytic Leukemia by Inhibition of DNA-dependent Protein Kinase Activity Using Wortmannin

Garyfallia Christodoulopoulos, Catherine Muller, Bernard Salles, Rehan Kazmi, and Lawrence Panasci
Cancer Res 1998 58: 1789-1792. [Abstract] [PDF]  

Selective Sensitivity to Radiation of Cerebral Glioblastomas Harboring p53 Mutations

Mitsuhiro Tada, Ryoji Matsumoto, Richard D. Iggo, Rikiya Onimaru, Hiroki Shirato, Yutaka Sawamura, and Yumiko Shinohe
Cancer Res 1998 58: 1793-1797. [Abstract] [PDF]  

Missense Mutations in SMOH in Sporadic Basal Cell Carcinomas of the Skin and Primitive Neuroectodermal Tumors of the Central Nervous System

Julia Reifenberger, Marietta Wolter, Ruthild G. Weber, Mosaad Megahed, Thomas Ruzicka, Peter Lichter, and Guido Reifenberger
Cancer Res 1998 58: 1798-1803. [Abstract] [PDF]  

Chromosome 3p14 Alterations in Lung Cancer: Evidence that FHIT Exon Deletion Is a Target of Tobacco Carcinogens and Asbestos

Heather H. Nelson, John K. Wiencke, Laura Gunn, John C. Wain, David C. Christiani, and Karl T. Kelsey
Cancer Res 1998 58: 1804-1807. [Abstract] [PDF]  

Expression of A Novel Antiapoptosis Gene, Survivin, Correlated with Tumor Cell Apoptosis and p53 Accumulation in Gastric Carcinomas

Cai-De Lu, Dario C. Altieri, and Nobuhiko Tanigawa
Cancer Res 1998 58: 1808-1812. [Abstract] [PDF]  

Transactivation of Transforming Growth Factor Gene by Hepatitis B Virus preS1

Masafumi Ono, Keiko Morisawa, Jing Nie, Katsuya Ota, Taketoshi Taniguchi, Toshiji Saibara, and Saburo Onishi
Cancer Res 1998 58: 1813-1816. [Abstract] [PDF]  

Biochemistry and Biophysics:

1,25-Dihydroxyvitamin D₃ Inhibits Programmed Cell Death in HL-60 Cells by Activation of Sphingosine Kinase

Burkhard Kleuser, Olivier Cuvillier, and Sarah Spiegel
Cancer Res 1998 58: 1817-1824. [Abstract] [PDF]  

Correlation of High-Resolution Magic Angle Spinning Proton Magnetic Resonance Spectroscopy with Histopathology of Intact Human Brain Tumor Specimens

Leo Ling Cheng, I-Wen Chang, David N. Louis, and R. Gilberto Gonzalez
Cancer Res 1998 58: 1825-1832. [Abstract] [PDF]  

Carcinogenesis:

Establishment of a Salmonella Tester Strain Highly Sensitive to Mutagenic Heterocyclic Amines

Akihiro Suzuki, Hirotaka Kushida, Hiroshi Iwata, Masahiko Watanabe, Takehiko Nohmi, Ken-ichi Fujita, Frank J. Gonzalez, and Tetsuya Kamataki
Cancer Res 1998 58: 1833-1838. [Abstract] [PDF]  

Clinical Investigations:

BRCA-associated Breast Cancer: Absence of a Characteristic Immunophenotype

Marc Robson, Prabha Rajan, Paul Peter Rosen, Theresa Gilewski, Yashar Hirschaut, Peter Pressman, Bruce Haas, Larry Norton, and Kenneth Offit
Cancer Res 1998 58: 1839-1842. [Abstract] [PDF]  

The Level of Urokinase-type Plasminogen Activator Receptor Is Increased in Serum of Ovarian Cancer Patients

Cornelis F. M. Sier, Ross Stephens, Jozef Bizik, Andrea Mariani, Marianna Bassan, Nina Pedersen, Luigi Frigerio, Augusto Ferrari, Keld Danø, Nils Brünner, and Francesco Blasi
Cancer Res 1998 58: 1843-1849. [Abstract] [PDF]  

Endocrinology:

Somatostatin Receptor Subtype Specificity and in Vivo Binding of a Novel Tumor Tracer, ^99mTc-P829

Irene Virgolini, Maria Leimer, Hirsch Handmaker, Secondo Lastoria, Claudia Bischof, Pietro Muto, Thomas Pangerl, Doris Gludovacz, Markus Peck-Radosavljevic, John Lister-James, Gerhard Hamilton, Klaus Kaserer, Peter Valent, and Richard Dean
Cancer Res 1998 58: 1850-1859. [Abstract] [PDF]  

Selective Down-Regulation of Progesterone Receptor Isoform B in Poorly Differentiated Human Endometrial Cancer Cells: Implications for Unopposed Estrogen Action

Nirmala S. Kumar, Jennifer Richer, Gareth Owen, Elizabeth Litman, Kathryn B. Horwitz, and Kimberly K. Leslie
Cancer Res 1998 58: 1860-1865. [Abstract] [PDF]  

Expression of All Known Vasopressin Receptor Subtypes by Small Cell Tumors Implies a Multifaceted Role for this Neuropeptide

William G. North, Michael J. Fay, Kenneth A. Longo, and Jinlin Du
Cancer Res 1998 58: 1866-1871. [Abstract] [PDF]  

The Key to the Antiestrogenic Mechanism of Raloxifene Is Amino Acid 351 (Aspartate) in the Estrogen Receptor

Anait S. Levenson and V. Craig Jordan
Cancer Res 1998 58: 1872-1875. [Abstract] [PDF]  

Experimental Therapeutics:

Induction of Apoptosis in MCF-7:WS8 Breast Cancer Cells by ß-Lapachone

Shelly M. Wuerzberger, John J. Pink, Sarah M. Planchon, Krista L. Byers, William G. Bornmann, and David A. Boothman
Cancer Res 1998 58: 1876-1885. [Abstract] [PDF]  

Human DNA Topoisomerase II-dependent DNA Cleavage and Yeast Cell Killing by Anthracycline Analogues

Monica Binaschi, Rosalba Farinosi, Caroline A. Austin, L. Mark Fisher, Franco Zunino, and Giovanni Capranico
Cancer Res 1998 58: 1886-1892. [Abstract] [PDF]  

Intracellular Expression of a Single-Chain Antibody Directed against Human Papillomavirus Type 16 E7 Oncoprotein Achieves Targeted Antineoplastic Effects

Feng Wang-Johanning, G. Yancey Gillespie, Jon Grim, Claudine Rancourt, Ronald D. Alvarez, Gene P. Siegal, and David T. Curiel
Cancer Res 1998 58: 1893-1900. [Abstract] [PDF]  

Heterogeneity of Intracellular pH and of Mechanisms That Regulate Intracellular pH in Populations of Cultured Cells

Anne H. Lee and Ian F. Tannock
Cancer Res 1998 58: 1901-1908. [Abstract] [PDF]  

Telomerase from Human Leukemia Cells: Properties and Its Interaction with Deoxynucleoside Analogues

Rekha B. Pai, S. Balakrishna Pai, Marina Kukhanova, Ginger E. Dutschman, Xin Guo, and Yung-Chi Cheng
Cancer Res 1998 58: 1909-1913. [Abstract] [PDF]  

Prolactin Activates Stat1 But Does Not Antagonize Stat1 Activation and Growth Inhibition by Type I Interferons in Human Breast Cancer Cells

John D. Schaber, Hui Fang, Jun Xu, Philip M. Grimley, and Hallgeir Rui
Cancer Res 1998 58: 1914-1919. [Abstract] [PDF]  

A Flavonoid Antioxidant, Silymarin, Inhibits Activation of erbB1 Signaling and Induces Cyclin-dependent Kinase Inhibitors, G₁ Arrest, and Anticarcinogenic Effects in Human Prostate Carcinoma DU145 Cells

Xiaolin Zi, Adam W. Grasso, Hsing-Jien Kung, and Rajesh Agarwal
Cancer Res 1998 58: 1920-1929. [Abstract] [PDF]  

A Peptidomimetic Antagonist of the Integrin _vß₃ Inhibits Leydig Cell Tumor Growth and the Development of Hypercalcemia of Malignancy

Christopher P. Carron, Debra M. Meyer, Jodi A. Pegg, V. Wayne Engleman, Maureen A. Nickols, Steven L. Settle, William F. Westlin, Peter G. Ruminski, and G. Allen Nickols
Cancer Res 1998 58: 1930-1935. [Abstract] [PDF]  

Isolation of Human O⁶-Alkylguanine-DNA Alkyltransferase Mutants Highly Resistant to Inactivation by O⁶-Benzylguanine

Meng Xu-Welliver, Sreenivas Kanugula, and Anthony E. Pegg
Cancer Res 1998 58: 1936-1945. [Abstract] [PDF]  

Adenovirus-mediated Transduction of Escherichia coli Uracil Phosphoribosyltransferase Gene Sensitizes Cancer Cells to Low Concentrations of 5-Fluorouracil

Fumihiko Kanai, Takayuki Kawakami, Hirofumi Hamada, Akiko Sadata, Yoko Yoshida, Torao Tanaka, Makoto Ohashi, Keisuke Tateishi, Yasushi Shiratori, and Masao Omata
Cancer Res 1998 58: 1946-1951. [Abstract] [PDF]  

Vascular Endothelial Growth Factor as a Marker of Tumor Endothelium

Rolf A. Brekken, Xianming Huang, Steven W. King, and Philip E. Thorpe
Cancer Res 1998 58: 1952-1959. [Abstract] [PDF]  

Immunology:

Vaccination with Multiple Antigen Peptide as Rejection Antigen Peptide in Murine Leukemia

Akira Manki, Toshiro Ono, Akiko Uenaka, Yoshiki Seino, and Eiichi Nakayama
Cancer Res 1998 58: 1960-1964. [Abstract] [PDF]  

DNA Vaccines Encoding Full-Length or Truncated Neu Induce Protective Immunity against Neu-expressing Mammary Tumors

Ying Chen, Dan Hu, David J. Eling, Joan Robbins, and Thomas J. Kipps
Cancer Res 1998 58: 1965-1971. [Abstract] [PDF]  

Molecular Biology and Genetics:

Mechanisms of Inactivation of E-Cadherin in Breast Cancer Cell Lines

Shunsuke Hiraguri, Tony Godfrey, Haruhiko Nakamura, Jeremy Graff, Collin Collins, Laleh Shayesteh, Norman Doggett, Keith Johnson, Margaret Wheelock, James Herman, Stephen Baylin, Daniel Pinkel, and Joe Gray
Cancer Res 1998 58: 1972-1977. [Abstract] [PDF]  

Impairment of Nucleotide Excision Repair by Apoptosis in UV-irradiated Mouse Cells

Maaike P. G. Vreeswijk, Birgit E. Westland, Martin T. Hess, Hanspeter Naegeli, Harry Vrieling, Albert A. van Zeeland, and Leon H. F. Mullenders
Cancer Res 1998 58: 1978-1985. [Abstract] [PDF]  

Functional Characterization of Transforming Growth Factor ß Type II Receptor Mutants in Human Cancer

Malabika De, Wu Yan, Rosalein R. de Jonge, Laure Garrigue-Antar, Vincent F. Vellucci, and Michael Reiss
Cancer Res 1998 58: 1986-1992. [Abstract] [PDF]  

p53-dependent Signaling Sustains DNA Replication and Enhances Clonogenic Survival in 254 nm Ultraviolet-irradiated Human Fibroblasts

Cheryl A. Cistulli and William K. Kaufmann
Cancer Res 1998 58: 1993-2002. [Abstract] [PDF]  

Synchronous Oral Carcinomas: Independent or Common Clonal Origin?

Andrea G. M. Scholes, Julia A. Woolgar, Mark A. Boyle, James S. Brown, E. David Vaughan, C. Anthony Hart, Andrew S. Jones, and John K. Field
Cancer Res 1998 58: 2003-2006. [Abstract] [PDF]  

4-Oxoretinol, a Metabolite of Retinol in the Human Promyelocytic Leukemia Cell Line NB4, Induces Cell Growth Arrest and Granulocytic Differentiation

Teresa N. Faria, Roberta Rivi, Fadila Derguini, Pier Paolo Pandolfi, and Lorraine J. Gudas
Cancer Res 1998 58: 2007-2013. [Abstract] [PDF]  

Tumor Biology:

Decreased MUC1 Expression Induces E-Cadherin-mediated Cell Adhesion of Breast Cancer Cell Lines

Keiichi Kondo, Nobuoki Kohno, Akihito Yokoyama, and Kunio Hiwada
Cancer Res 1998 58: 2014-2019. [Abstract] [PDF]  

Overexpression of a Transmembrane Isoform of Neural Cell Adhesion Molecule Alters the Invasiveness of Rat CNS-1 Glioma

Geoffrey C. Owens, Elizabeth A. Orr, Bette K. Kleinschmidt DeMasters, Ruth J. Muschel, Michael E. Berens, and Carol A. Kruse
Cancer Res 1998 58: 2020-2028. [Abstract] [PDF]  

Mutant RAS Selectively Promotes Sensitivity of Myeloid Leukemia Cells to Apoptosis by a Protein Kinase C-dependent Process

Angela P. Gallagher, Alan K. Burnett, David T. Bowen, and Richard L. Darley
Cancer Res 1998 58: 2029-2035. [Abstract] [PDF]  

Absence of a Radiation-induced First-Cycle G₁-S Arrest in p53⁺ Human Tumor Cells Synchronized by Mitotic Selection

Hatsumi Nagasawa, Peter Keng, Carl Maki, Yongjia Yu, and John B. Little
Cancer Res 1998 58: 2036-2041. [Abstract] [PDF]  

Elevated Cyclins and Cyclin-dependent Kinase Activity in the Rhabdomyosarcoma Cell Line RD

Erik S. Knudsen, Claudia Pazzagli, Teresa L. Born, Bonnie L. Bertolaet, Karen E. Knudsen, Karen C. Arden, Robert R. Henry, and James R. Feramisco
Cancer Res 1998 58: 2042-2049. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1998 58: 2050-2051. [PDF]  

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