Special Lecture:

Regulation of the p53 Protein by the MDM2 Oncoprotein—Thirty-eighth G. H. A. Clowes Memorial Award Lecture

Deborah A. Freedman
Cancer Res 1999 59: 1-7. [Full Text] [PDF]  

Advances in Brief:

Molecular Cloning of cDNAs Which Are Highly Overexpressed in Mitoxantrone-resistant Cells: Demonstration of Homology to ABC Transport Genes

Keisuke Miyake, Lyn Mickley, Thomas Litman, Zhirong Zhan, Robert Robey, Barbara Cristensen, Mariafiorella Brangi, Lee Greenberger, Michael Dean, Tito Fojo, and Susan E. Bates
Cancer Res 1999 59: 8-13. [Abstract] [Full Text] [PDF]  

Retinoid Receptor-dependent and -independent Effects of N-(4-Hydroxyphenyl)retinamide in F9 Embryonal Carcinoma Cells

John L. Clifford, David G. Menter, Michael Wang, Reuben Lotan, and Scott M. Lippman
Cancer Res 1999 59: 14-18. [Abstract] [Full Text] [PDF]  

Allelic Knockout of Novel Splice Variants of Human Recombination Repair Gene RAD51B in t(12;14) Uterine Leiomyomas

Eric F. P. M. Schoenmakers, Christel Huysmans, and Wim J. M. Van de Ven
Cancer Res 1999 59: 19-23. [Abstract] [Full Text] [PDF]  

ATM Mutations in B-Cell Chronic Lymphocytic Leukemia

Florencia Bullrich, Debora Rasio, Shinichi Kitada, Petr Starostik, Thomas Kipps, Michael Keating, Maher Albitar, John C. Reed, and Carlo M. Croce
Cancer Res 1999 59: 24-27. [Abstract] [Full Text] [PDF]  

Reduced Stability of Regularly Spliced but not Alternatively Spliced p53 Protein in PARP-deficient Mouse Fibroblasts

Józefa Wesierska-Gadek, Zhao-Qi Wang, and Gerald Schmid
Cancer Res 1999 59: 28-34. [Abstract] [Full Text] [PDF]  

A Novel Member of the NF2/ERM/4.1 Superfamily with Growth Suppressing Properties in Lung Cancer

Yen K. Tran, Oliver Bögler, Karen M. Gorse, Ilse Wieland, Mark R. Green, and Irene F. Newsham
Cancer Res 1999 59: 35-43. [Abstract] [Full Text] [PDF]  

Synergistic Effects of (-)-Epigallocatechin Gallate with (-)-Epicatechin, Sulindac, or Tamoxifen on Cancer-preventive Activity in the Human Lung CancerCell Line PC-9

Masami Suganuma, Sachiko Okabe, Yasuko Kai, Naoko Sueoka, Eisaburo Sueoka, and Hirota Fujiki
Cancer Res 1999 59: 44-47. [Abstract] [Full Text] [PDF]  

Epitope Specificity of the Monoclonal Anticytokeratin Antibody TS1

Amanda Johansson, Per Sandström, Anders Ullén, Gity Behravan, Ann Erlandsson, Michael Levi, Birgitta Sundström, and Torgny Stigbrand
Cancer Res 1999 59: 48-51. [Abstract] [Full Text] [PDF]  

Poisoning of Topoisomerase I by an Antitumor Indolocarbazole Drug: Stabilization of Topoisomerase I-DNA Covalent Complexes and Specific Inhibition of the Protein Kinase Activity

Emmanuel Labourier, Jean-François Riou, Michelle Prudhomme, Carolina Carrasco, Christian Bailly, and Jamal Tazi
Cancer Res 1999 59: 52-55. [Abstract] [Full Text] [PDF]  

Migration of Human Dendritic Cells after Injection in Patients with Metastatic Malignancies

Michael A. Morse, R. Edward Coleman, Gamal Akabani, Nelson Niehaus, Doris Coleman, and H. Kim Lyerly
Cancer Res 1999 59: 56-58. [Abstract] [Full Text] [PDF]  

Human Melanoma Cells Do Not Express Fas (Apo-1/CD95) Ligand

Dale B. Chappell, Tal Z. Zaks, Steven A. Rosenberg, and Nicholas P. Restifo
Cancer Res 1999 59: 59-62. [Abstract] [Full Text] [PDF]  

The Identification of Monoclonality in Human Aberrant Crypt Foci

I-Mei Siu, Dan R. Robinson, Stuart Schwartz, Hsing-Jien Kung, Thomas G. Pretlow, Robert B. Petersen, and Theresa P. Pretlow
Cancer Res 1999 59: 63-66. [Abstract] [Full Text] [PDF]  

Detection of Aberrant Promoter Hypermethylation of Tumor Suppressor Genes in Serum DNA from Non-Small Cell Lung Cancer Patients

Manel Esteller, Montserrat Sanchez-Cespedes, Rafael Rosell, David Sidransky, Stephen B. Baylin, and James G. Herman
Cancer Res 1999 59: 67-70. [Abstract] [Full Text] [PDF]  

Detection of Aberrant p16 Methylation in the Plasma and Serum of Liver Cancer Patients

Ivy H. N. Wong, Y. M. Dennis Lo, Jun Zhang, Choong-Tsek Liew, Margaret H. L. Ng, Nathalie Wong, Paul B. S. Lai, Wan Y. Lau, N. Magnus Hjelm, and Philip J. Johnson
Cancer Res 1999 59: 71-73. [Abstract] [Full Text] [PDF]  

Germ-Line and Acquired Mutations of INI1 in Atypical Teratoid and Rhabdoid Tumors

Jaclyn A. Biegel, Jun-Ying Zhou, Lucy B. Rorke, Cindy Stenstrom, Luanne M. Wainwright, and Benjamin Fogelgren
Cancer Res 1999 59: 74-79. [Abstract] [Full Text] [PDF]  

Biochemistry:

Malignant Transformation Alters Membrane Choline Phospholipid Metabolism of Human Mammary Epithelial Cells

Eric O. Aboagye and Zaver M. Bhujwalla
Cancer Res 1999 59: 80-84. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Retinoic Acid Increases Tyrosine Phosphorylation of Focal Adhesion Kinase and Paxillin in MCF-7 Human Breast Cancer Cells

Wei-Yong Zhu, Carol S. Jones, Sonal Amin, Karen Matsukuma, Moneera Haque, Vidyasagar Vuligonda, Roshantha A. S. Chandraratna, and Luigi M. De Luca
Cancer Res 1999 59: 85-90. [Abstract] [Full Text] [PDF]  

Depentylation of [³H-pentyl]Methyl-n-amylnitrosamine by Rat Esophageal and Liver Microsomes and by Rat and Human Cytochrome P450 Isoforms

Sheng C. Chen, Xiaojie Wang, Guoping Xu, Lin Zhou, Jonathan L. Vennerstrom, Frank Gonzalez, Harry V. Gelboin, and Sidney S. Mirvish
Cancer Res 1999 59: 91-98. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

SU5416 Is a Potent and Selective Inhibitor of the Vascular Endothelial Growth Factor Receptor (Flk-1/KDR) That Inhibits Tyrosine Kinase Catalysis, Tumor Vascularization, and Growth of Multiple Tumor Types

T. Annie T. Fong, Laura K. Shawver, Li Sun, Cho Tang, Harald App, T. Jeff Powell, Young H. Kim, Randall Schreck, Xueyan Wang, Werner Risau, Axel Ullrich, K. Peter Hirth, and Gerald McMahon
Cancer Res 1999 59: 99-106. [Abstract] [Full Text] [PDF]  

Enhancement of Tumor Radioresponse in Vivo by Gemcitabine

Luka Milas, Takashi Fujii, Nancy Hunter, Mohamed Elshaikh, Kathy Mason, William Plunkett, K. Kian Ang, and Walter Hittelman
Cancer Res 1999 59: 107-114. [Abstract] [Full Text] [PDF]  

Antineoplastic Efficacy of Doxorubicin Enzymatically Assembled on Galactose Residues of a Monoclonal Antibody Specific for the Carcinoembryonic Antigen

Alexandru C. Stan, Dorel L. Radu, Sofia Casares, Constantin A. Bona, and Teodor-D. Brumeanu
Cancer Res 1999 59: 115-121. [Abstract] [Full Text] [PDF]  

In Vivo Effect of 5-Ethynyluracil on 5-Fluorouracil Metabolism Determined by ¹⁹F Nuclear Magnetic Resonance Spectroscopy

Earle R. Adams, Janine J. Leffert, Daniel J. Craig, Thomas Spector, and Giuseppe Pizzorno
Cancer Res 1999 59: 122-127. [Abstract] [Full Text] [PDF]  

Immunology:

Chemical Design of Radiolabeled Antibody Fragments for Low Renal Radioactivity Levels

Yasushi Arano, Yasushi Fujioka, Hiromichi Akizawa, Masahiro Ono, Tomoya Uehara, Kouji Wakisaka, Morio Nakayama, Harumi Sakahara, Junji Konishi, and Hideo Saji
Cancer Res 1999 59: 128-134. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Cytogenetic Changes in Radiation-induced Tumors of the Thyroid

Horst Zitzelsberger, Lars Lehmann, Ludwig Hieber, Heinz-Ulrich G. Weier, Catherine Janish, Jingly Fung, Thomas Negele, Fritz Spelsberg, Edmund Lengfelder, Eugene P. Demidchik, Konstatinos Salassidis, Albrecht M. Kellerer, Martin Werner, and Manfred Bauchinger
Cancer Res 1999 59: 135-140. [Abstract] [Full Text] [PDF]  

Comprehensive and Definitive Molecular Cytogenetic Characterization of HeLa Cells by Spectral Karyotyping

Merryn Macville, Evelin Schröck, Hesed Padilla-Nash, Catherine Keck, B. Michael Ghadimi, Drazen Zimonjic, Nicholas Popescu, and Thomas Ried
Cancer Res 1999 59: 141-150. [Abstract] [Full Text] [PDF]  

CMAP: A Novel Cystatin-like Gene Involved in Liver Metastasis

Masashi Morita, Nobuko Yoshiuchi, Hiroharu Arakawa, and Susumu Nishimura
Cancer Res 1999 59: 151-158. [Abstract] [Full Text] [PDF]  

hMLH1 Promoter Methylation and Lack of hMLH1 Expression in Sporadic Gastric Carcinomas with High-Frequency Microsatellite Instability

Suet Yi Leung, Siu Tsan Yuen, Lap Ping Chung, Kent Man Chu, Annie S. Y. Chan, and Joana C. I. Ho
Cancer Res 1999 59: 159-164. [Abstract] [Full Text] [PDF]  

Cell Transformation Results in the Loss of the Density-dependent Translational Regulation of the Expression of Fibroblast Growth Factor 2 Isoforms

Bruno Galy, Arlette Maret, Anne-Catherine Prats, and Hervé Prats
Cancer Res 1999 59: 165-171. [Abstract] [Full Text] [PDF]  

Mutational and Expression Analysis of the p73 Gene in Melanoma Cell Lines

Hensin Tsao, Xue Zhang, Paul Majewski, and Frank G. Haluska
Cancer Res 1999 59: 172-174. [Abstract] [Full Text] [PDF]  

Expression of Human MRP6, a Homologue of the Multidrug Resistance Protein Gene MRP1, in Tissues and Cancer Cells

Marcel Kool, Marcel van der Linden, Marcel de Haas, Frank Baas, and Piet Borst
Cancer Res 1999 59: 175-182. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Vascular Endothelial Growth Factor Chimeric Toxin Is Highly Active against Endothelial Cells

Naveen Arora, Rizwan Masood, Tong Zheng, Jie Cai, D. Lynne Smith, and Parkash S. Gill
Cancer Res 1999 59: 183-188. [Abstract] [Full Text] [PDF]  

Endostatin: Yeast Production, Mutants, and Antitumor Effect in Renal Cell Carcinoma

Mohanraj Dhanabal, Ramani Ramchandran, Ruediger Volk, Isaac E. Stillman, Michelle Lombardo, M. L. Iruela-Arispe, Michael Simons, and Vikas P. Sukhatme
Cancer Res 1999 59: 189-197. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Expression in Human Esophageal Carcinoma

Katja C. Zimmermann, Mario Sarbia, Artur-Aron Weber, Franz Borchard, Helmut E. Gabbert, and Karsten Schrör
Cancer Res 1999 59: 198-204. [Abstract] [Full Text] [PDF]  

In Vivo Sensitivity of Human Melanoma to Tumor Necrosis Factor (TNF)- Is Determined by Tumor Production of the Novel Cytokine Endothelial-Monocyte Activating Polypeptide II (EMAPII)

Peter C. Wu, H. Richard Alexander, James Huang, Patrick Hwu, Michael Gnant, Adam C. Berger, Ewa Turner, Olga Wilson, and Steven K. Libutti
Cancer Res 1999 59: 205-212. [Abstract] [Full Text] [PDF]  

Elevation of Cyclic Adenosine 3',5'-Monophosphate Potentiates Activation of Mitogen-activated Protein Kinase by Growth Factors in LNCaP Prostate Cancer Cells

Taosheng Chen, Richard W. Cho, Philip J. S. Stork, and Michael J. Weber
Cancer Res 1999 59: 213-218. [Abstract] [Full Text] [PDF]  

CD44 Variants but not CD44s Cooperate with ß1-containing Integrins to Permit Cells to Bind to Osteopontin Independently of Arginine-glycine-aspartic Acid, thereby Stimulating Cell Motility and Chemotaxis

Yohko U. Katagiri, Jonathan Sleeman, Hideki Fujii, Peter Herrlich, Hiroshi Hotta, Kumiko Tanaka, Shunsuke Chikuma, Hideo Yagita, Ko Okumura, Masaaki Murakami, Ikuo Saiki, Ann F. Chambers, and Toshimitsu Uede
Cancer Res 1999 59: 219-226. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor (EGF) Receptor Blockade Inhibits the Action of EGF, Insulin-like Growth Factor I, and a Protein Kinase A Activator on the Mitogen-activated Protein Kinase Pathway in Prostate Cancer Cell Lines

Thomas Putz, Zoran Culig, Iris E. Eder, Claudia Nessler-Menardi, Georg Bartsch, Hans Grunicke, Florian Überall, and Helmut Klocker
Cancer Res 1999 59: 227-233. [Abstract] [Full Text] [PDF]  

Sialidase Gene Transfection Enhances Epidermal Growth Factor Receptor Activity in an Epidermoid Carcinoma Cell Line, A431

Emmanuelle J. Meuillet, Roger Kroes, Hirotaka Yamamoto, Thomas G. Warner, Jeffry Ferrari, Barbara Mania-Farnell, David George, Abdelhadi Rebbaa, Joseph R. Moskal, and Eric G. Bremer
Cancer Res 1999 59: 234-240. [Abstract] [Full Text] [PDF]  

Phenotypic Characteristics of Cell Lines Derived from Disseminated Cancer Cells in Bone Marrow of Patients with Solid Epithelial Tumors: Establishment of Working Models for Human Micrometastases

Elmar Putz, Klaus Witter, Sonja Offner, Peter Stosiek, Alfred Zippelius, Judith Johnson, Robert Zahn, Gert Riethmüller, and Klaus Pantel
Cancer Res 1999 59: 241-248. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: C. R. Boland et al. A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: Development of International Criteria for the Determination of Microsatellite Instability in Colorectal Cancer. Cancer Res., 58: 5248–5257, 1998

Manuel Perucho, C. Richard Boland, Stephen N. Thibodeau, Stanley R. Hamilton, David Sidransky, James R. Eshleman, Randall W. Burt, Stephen J. Meltzer, Miguel A. Rodriguez-Bigas, Riccardo Fodde, G. Nadia Ranzani, Sudhir Srivastava, and Sir John Maddox
Cancer Res 1999 59: 249-256. [Full Text] [PDF]  

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