Advances in Brief:

Selection for Androgen Receptor Mutations in Prostate Cancers Treated with Androgen Antagonist

Mary-Ellen Taplin, Glenn J. Bubley, Yoo-Joung Ko, Eric J. Small, Melissa Upton, Barur Rajeshkumar, and Steven P. Balk
Cancer Res 1999 59: 2511-2515. [Abstract] [Full Text] [PDF]  

Role of the Alternative INK4A Proteins in Human Keratinocyte Senescence: Evidence for the Specific Inactivation of p16^INK4A upon Immortalization

June Munro, Francesca J. Stott, Karen H. Vousden, Gordon Peters, and E. Kenneth Parkinson
Cancer Res 1999 59: 2516-2521. [Abstract] [Full Text] [PDF]  

Endogenous Apurinic/Apyrimidinic Sites in Genomic DNA of Mammalian Tissues

Jun Nakamura and James A. Swenberg
Cancer Res 1999 59: 2522-2526. [Abstract] [Full Text] [PDF]  

A New cis Element Is Involved in the HER2 Gene Overexpression in Human Breast Cancer Cells

Madeleine Grooteclaes, Douglas Vernimmen, Serge Plaza, Françoise Pasleau, Didier Hodzic, and Rosita Winkler-Gol
Cancer Res 1999 59: 2527-2531. [Abstract] [Full Text] [PDF]  

Antifolate Resistance Mediated by the Multidrug Resistance Proteins MRP1 and MRP2

Jan Hendrik Hooijberg, Henk J. Broxterman, Marcel Kool, Yehuda G. Assaraf, Godefridus J. Peters, Paul Noordhuis, Rik J. Scheper, Piet Borst, Herbert M. Pinedo, and Gerrit Jansen
Cancer Res 1999 59: 2532-2535. [Abstract] [Full Text] [PDF]  

Recombinant Virus Vaccination against "Self" Antigens UsingAnchor-fixed Immunogens

Kari R. Irvine, Maria R. Parkhurst, Eliza P. Shulman, Janis P. Tupesis, Mary Custer, Christopher E. Touloukian, Paul F. Robbins, Alicia Gómez Yafal, Patricia Greenhalgh, Roger P. M. Sutmuller, Rienk Offringa, Steven A. Rosenberg, and Nicholas P. Restifo
Cancer Res 1999 59: 2536-2540. [Abstract] [Full Text] [PDF]  

Gain of Bcl-2 Is More Potent Than Bax Loss in Regulating Mammary Epithelial Cell Survival in Vivo

Kristel Schorr, Minglin Li, Ud Bar-Peled, Albert Lewis, Alonso Heredia, Bernadette Lewis, C. Michael Knudson, Stanley J. Korsmeyer, Richard Jäger, Hans Weiher, and Priscilla A. Furth
Cancer Res 1999 59: 2541-2545. [Abstract] [Full Text] [PDF]  

Increased Level of Exon 12 Alternatively Spliced BRCA2 Transcripts in Tumor Breast Tissue Compared with Normal Tissue

Ivan Bièche and Rosette Lidereau
Cancer Res 1999 59: 2546-2550. [Abstract] [Full Text] [PDF]  

Regulation of Akt/PKB Activity, Cellular Growth, and Apoptosis in Prostate Carcinoma Cells by MMAC/PTEN

Michael A. Davies, Dimpy Koul, Haninder Dhesi, Russell Berman, Timothy J. McDonnell, David McConkey, W. K. Alfred Yung, and Peter A. Steck
Cancer Res 1999 59: 2551-2556. [Abstract] [Full Text] [PDF]  

XRCC1 Polymorphisms: Effects on Aflatoxin B₁-DNA Adducts and Glycophorin A Variant Frequency

Ruth M. Lunn, Ronald G. Langlois, Ling Ling Hsieh, Claudia L. Thompson, and Douglas A. Bell
Cancer Res 1999 59: 2557-2561. [Abstract] [Full Text] [PDF]  

p53 Directly Enhances Rejoining of DNA Double-Strand Breaks with Cohesive Ends in -Irradiated Mouse Fibroblasts

Wei Tang, Henning Willers, and Simon N. Powell
Cancer Res 1999 59: 2562-2565. [Abstract] [Full Text] [PDF]  

Discovery and Initial Characterization of the Paullones, a Novel Class of Small-Molecule Inhibitors of Cyclin-dependent Kinases

Daniel W. Zaharevitz, Rick Gussio, Maryse Leost, Adrian M. Senderowicz, Tyler Lahusen, Conrad Kunick, Laurent Meijer, and Edward A. Sausville
Cancer Res 1999 59: 2566-2569. [Abstract] [Full Text] [PDF]  

Identification and Characterization of Human MT5-MMP, a New Membrane-bound Activator of Progelatinase A Overexpressed in Brain Tumors

Elena Llano, Alberto M. Pendás, José P. Freije, Atsuhisa Nakano, Vera Knäuper, Gillian Murphy, and Carlos López-Otin
Cancer Res 1999 59: 2570-2576. [Abstract] [Full Text] [PDF]  

Transduced p16^INK4a Peptides Inhibit Hypophosphorylation of the Retinoblastoma Protein and Cell Cycle Progression Prior to Activation of Cdk2 Complexes in Late G₁

David R. Gius, Sergei A. Ezhevsky, Michelle Becker-Hapak, Hikaru Nagahara, Michael C. Wei, and Steven F. Dowdy
Cancer Res 1999 59: 2577-2580. [Abstract] [Full Text] [PDF]  

Biochemistry:

Competitive and Noncompetitive Inhibition of the DNA-dependent Protein Kinase

Rebecca A. Izzard, Stephen P. Jackson, and Graeme C. M. Smith
Cancer Res 1999 59: 2581-2586. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

In Vivo Mutagenicity and Hepatocarcinogenicity of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in Bitransgenic c-myc/lacZ Mice

Doug-Young Ryu, Valerie S. W. Pratt, Cindy D. Davis, Herman A. J. Schut, and Elizabeth G. Snyderwine
Cancer Res 1999 59: 2587-2592. [Abstract] [Full Text] [PDF]  

Bone Marrow Pre-B-1 (Bomb1): A Quantitative Trait Locus Inducing Bone Marrow Pre-B-Cell Expansion in Lymphoma-prone SL/Kh Mice

Ling-Min Lu, Reiji Shimada, Shin Higashi, Zhaozhu Zeng, and Hiroshi Hiai
Cancer Res 1999 59: 2593-2595. [Abstract] [Full Text] [PDF]  

Resveratrol Increases Nitric Oxide Synthase, Induces Accumulation of p53 and p21^WAF1/CIP1, and Suppresses Cultured Bovine Pulmonary Artery EndothelialCell Proliferation by Perturbing Progression through S and G₂

Tze-chen Hsieh, Gloria Juan, Zbigniew Darzynkiewicz, and Joseph M. Wu
Cancer Res 1999 59: 2596-2601. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Defective Control of Apoptosis and Mitotic Spindle Checkpoint in Heterozygous Carriers of ATM Mutations

Teruko Shigeta, Masatoshi Takagi, Domenico Delia, Luciana Chessa, Satoshi Iwata, Yusuke Kanke, Minoru Asada, Mariko Eguchi, and Shuki Mizutani
Cancer Res 1999 59: 2602-2607. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Fibroblast Growth Factor 2 Retargeted Adenovirus Has Redirected Cellular Tropism: Evidence for Reduced Toxicity and Enhanced AntitumorActivity in Mice

Dan-ling Gu, Ana Maria Gonzalez, Marie A. Printz, John Doukas, Wenbin Ying, Mark D’Andrea, Diana K. Hoganson, David T. Curiel, Joanne T. Douglas, Barbara A. Sosnowski, Andrew Baird, Sharon Lea Aukerman, and Glenn F. Pierce
Cancer Res 1999 59: 2608-2614. [Abstract] [Full Text] [PDF]  

Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents

Julian Adams, Vito J. Palombella, Edward A. Sausville, Jill Johnson, Antonia Destree, Douglas D. Lazarus, Jochen Maas, Christine S. Pien, Samuel Prakash, and Peter J. Elliott
Cancer Res 1999 59: 2615-2622. [Abstract] [Full Text] [PDF]  

Intravenous Administration of ONYX-015, a Selectively Replicating Adenovirus, Induces Antitumoral Efficacy

Carla C. Heise, Angelica M. Williams, Shirley Xue, Meisa Propst, and David H. Kirn
Cancer Res 1999 59: 2623-2628. [Abstract] [Full Text] [PDF]  

Evaluation of Cell-killing Effects of 1-ß-D-Arabinofuranosylcytosine and Daunorubicin by a New Computer-controlled in Vitro Pharmacokinetic Simulation System

Shinji Kishi, Nobuyuki Goto, Toru Nakamura, and Takanori Ueda
Cancer Res 1999 59: 2629-2634. [Abstract] [Full Text] [PDF]  

High-Linear Energy Transfer (LET) versus Low-LET ß Emitters in Radioimmunotherapy of Solid Tumors: Therapeutic Efficacy and Dose-limiting Toxicity of ²¹³Bi- versus ⁹⁰Y-labeled CO17-1A Fab' Fragments in a Human Colonic Cancer Model

Thomas M. Behr, Martin Béhé, Michael G. Stabin, Eike Wehrmann, Christos Apostolidis, Roger Molinet, Frank Strutz, Afshin Fayyazi, Eberhard Wieland, Stefan Gratz, Lothar Koch, David M. Goldenberg, and Wolfgang Becker
Cancer Res 1999 59: 2635-2643. [Abstract] [Full Text] [PDF]  

1,25-Dihydroxycholecalciferol (1,25-D₃) Inhibits the Growth of Squamous Cell Carcinoma and Down-Modulates p21^Waf1/Cip1 in Vitro and in Vivo

Pamela A. Hershberger, Ruth A. Modzelewski, Zoya R. Shurin, Robert M. Rueger, Donald L. Trump, and Candace S. Johnson
Cancer Res 1999 59: 2644-2649. [Abstract] [Full Text] [PDF]  

Immunology:

Induction of Therapeutic T-Cell Immunity by Tumor Targeting with Soluble Recombinant B7-Immunoglobulin Costimulatory Molecules

Monica Moro, Anna Maria Gasparri, Stefano Pagano, Matteo Bellone, Paola Tornaghi, Fabrizio Veglia, Angelo Corti, Giulia Casorati, and Paolo Dellabona
Cancer Res 1999 59: 2650-2656. [Abstract] [Full Text] [PDF]  

Low Prevalence of Selective Human Leukocyte Antigen (HLA)-A and HLA-B Epitope Losses in Early-Passage Tumor Cell Lines

Patrizio Giacomini, Ezio Giorda, Rocco Fraioli, Maria Rita Nicotra, Nello Vitale, Andrea Setini, Laura Delfino, Anna Morabito, Maria Benevolo, Irene Venturo, Marcella Mottolese, Giovan Battista Ferrara, and Pier Giorgio Natali
Cancer Res 1999 59: 2657-2667. [Abstract] [Full Text] [PDF]  

Identification of a Promiscuous T-Cell Epitope Encoded by Multiple Members of the MAGE Family

Silvia Tanzarella, Vincenzo Russo, Ilaria Lionello, Piero Dalerba, Donata Rigatti, Claudio Bordignon, and Catia Traversari
Cancer Res 1999 59: 2668-2674. [Abstract] [Full Text] [PDF]  

A PR1-Human Leukocyte Antigen-A2 Tetramer Can Be Used to Isolate Low-Frequency Cytotoxic T Lymphocytes from Healthy Donors That Selectively Lyse Chronic Myelogenous Leukemia

Jeffrey J. Molldrem, Peter P. Lee, Changqing Wang, Richard E. Champlin, and Mark M. Davis
Cancer Res 1999 59: 2675-2681. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Reduced Fhit Expression in Sporadic and BRCA2-linked Breast Carcinomas

Sigurdur Ingvarsson, Bjarni A. Agnarsson, Bjarnveig I. Sigbjornsdottir, Juha Kononen, Olli-P. Kallioniemi, Rosa B. Barkardottir, Albert J. Kovatich, Roland Schwarting, Walter W. Hauck, Kay Huebner, and Peter A. McCue
Cancer Res 1999 59: 2682-2689. [Abstract] [Full Text] [PDF]  

Genetic Alterations in Bronchial Lavage as a Potential Marker for Individuals with a High Risk of Developing Lung Cancer

John K. Field, Triantafillos Liloglou, George Xinarianos, Wendy Prime, Patricia Fielding, Martin J. Walshaw, and Lesley Turnbull
Cancer Res 1999 59: 2690-2695. [Abstract] [Full Text] [PDF]  

A Mitotic Spindle Requirement for DNA Damage-induced Apoptosis in Chinese Hamster Ovary Cells

Penny A. Johnson, Paula Clements, Kevin Hudson, and Keith W. Caldecott
Cancer Res 1999 59: 2696-2700. [Abstract] [Full Text] [PDF]  

A New Mechanism of Acquisition of Drug Resistance by Partial Duplication of Topoisomerase I

Hideya Komatani, Masashi Morita, Nami Sakaizumi, Kazuhiro Fukasawa, Eisaku Yoshida, Akira Okura, Tomoko Yoshinari, and Susumu Nishimura
Cancer Res 1999 59: 2701-2708. [Abstract] [Full Text] [PDF]  

Characterization of a Novel Receptor That Maps Near the Natural Killer Gene Complex: Demonstration of Carbohydrate Binding and Expression in Hematopoietic Cells

Maria J. Fernandes, Alysia A. Finnegan, Linda D. Siracusa, Charles Brenner, Norman N. Iscove, and Bruno Calabretta
Cancer Res 1999 59: 2709-2717. [Abstract] [Full Text] [PDF]  

Identification of a Human Anti-CD55 Single-Chain Fv by Subtractive Panning of a Phage Library Using Tumor and Nontumor Cell Lines

John B. B. Ridgway, Eric Ng, Jeffrey A. Kern, James Lee, Jennifer Brush, Audrey Goddard, and Paul Carter
Cancer Res 1999 59: 2718-2723. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Integrin _Vß₃ Promotes M21 Melanoma Growth in Human Skin by Regulating Tumor Cell Survival

Eric Petitclerc, Staffan Strömblad, Tami L. von Schalscha, Francesc Mitjans, Jaime Piulats, Anthony M. P. Montgomery, David A. Cheresh, and Peter C. Brooks
Cancer Res 1999 59: 2724-2730. [Abstract] [Full Text] [PDF]  

Increased Smad Expression and Activation Are Associated with Apoptosis in Normal and Malignant Prostate after Castration

Greger Brodin, Peter ten Dijke, Keiko Funa, Carl-Henrik Heldin, and Maréne Landström
Cancer Res 1999 59: 2731-2738. [Abstract] [Full Text] [PDF]  

Prostaglandin J₂ and 15-Deoxy-^12,14-prostaglandin J₂ Induce Proliferation of Cyclooxygenase-depleted Colorectal Cancer Cells

Rebecca Chinery, Robert J. Coffey, Ramona Graves-Deal, Susan C. Kirkland, Stephanie C. Sanchez, William E. Zackert, John A. Oates, and Jason D. Morrow
Cancer Res 1999 59: 2739-2746. [Abstract] [Full Text] [PDF]  

Relation of TNF-related Apoptosis-inducing Ligand (TRAIL) Receptor and FLICE-inhibitory Protein Expression to TRAIL-induced Apoptosis of Melanoma

Xu Dong Zhang, Agustin Franco, Kieda Myers, Christian Gray, Tam Nguyen, and Peter Hersey
Cancer Res 1999 59: 2747-2753. [Abstract] [Full Text] [PDF]  

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