Advances in Brief:

Squamous Cell Carcinomas and Increased Apoptosis in Skin with Inhibited Rel/Nuclear Factor-B Signaling

Max van Hogerlinden, Barbro Lundh Rozell, Lars Ährlund-Richter, and Rune ToftgÅrd
Cancer Res 1999 59: 3299-3303. [Abstract] [Full Text] [PDF]  

Induction of Intratumoral Tumor Necrosis Factor (TNF) Synthesis and Hemorrhagic Necrosis by 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA) in TNF Knockout Mice

Lai-Ming Ching, David Goldsmith, Wayne R. Joseph, Heinrich Körner, Jonathon D. Sedgwick, and Bruce C. Baguley
Cancer Res 1999 59: 3304-3307. [Abstract] [Full Text] [PDF]  

Liposomes Complexed to Plasmids Encoding Angiostatin and Endostatin Inhibit Breast Cancer in Nude Mice

Qing-Rong Chen, Dhruv Kumar, Sanford A. Stass, and A. James Mixson
Cancer Res 1999 59: 3308-3312. [Abstract] [Full Text] [PDF]  

Association of Matrilysin Expression with Recurrence and Poor Prognosis in Human Esophageal Squamous Cell Carcinoma

Hiroyuki Yamamoto, Yasushi Adachi, Fumio Itoh, Shouhei Iku, Keiki Matsuno, Masanobu Kusano, Yoshiaki Arimura, Takao Endo, Yuji Hinoda, Masao Hosokawa, and Kohzoh Imai
Cancer Res 1999 59: 3313-3316. [Abstract] [Full Text] [PDF]  

Sex Differences in Lung CYP1A1 Expression and DNA Adduct Levels among Lung Cancer Patients

Steen Mollerup, David Ryberg, Allan Hewer, David H. Phillips, and Aage Haugen
Cancer Res 1999 59: 3317-3320. [Abstract] [Full Text] [PDF]  

Efficacy of the Mobilization of Peripheral Blood Stem Cells by Granulocyte Colony-Stimulating Factor in Pediatric Donors

Yoshifumi Kawano, Yoichi Takaue, Tsutomu Watanabe, Takanori Abe, Yasuhiro Okamoto, Asayuki Iwai, Tsuyako Iwai, Arata Watanabe, Etsuro Ito, Atsushi Makimoto, Ryuji Nakagawa, Hiroyoshi Watanabe, Junko Sato, Kentaro Suenaga, Hiroko Suzuya, Toshihiro Ohnishi, Sachiyo Kanamaru, Michiya Kaneko, and Yasuhiro Kuroda
Cancer Res 1999 59: 3321-3324. [Abstract] [Full Text] [PDF]  

Reversal of Hypercalcemia with the Vitamin D Analogue EB1089 in a Human Model of Squamous Cancer

Khadija El Abdaimi, Vasiliou Papavasiliou, Shafaat A. Rabbani, Johng S. Rhim, David Goltzman, and Richard Kremer
Cancer Res 1999 59: 3325-3328. [Abstract] [Full Text] [PDF]  

Antigen-presenting Cells That Phagocytose Apoptotic Tumor-derived Cells Are Potent Tumor Vaccines

Frédéric Henry, Olivier Boisteau, Laurent Bretaudeau, Blandine Lieubeau, Khaled Meflah, and Marc Grégoire
Cancer Res 1999 59: 3329-3332. [Abstract] [Full Text] [PDF]  

Induction of Apoptosis and Inhibition of Tumorigenicity and Tumor Growth by Adenovirus Vector-mediated Fragile Histidine Triad (FHIT) Gene Overexpression

Lin Ji, Bingliang Fang, Nancy Yen, Kwun Fong, John D. Minna, and Jack A. Roth
Cancer Res 1999 59: 3333-3339. [Abstract] [Full Text] [PDF]  

Biodistribution and Vaccine Efficiency of Murine Dendritic Cells Are Dependent on the Route of Administration

Andreas A. O. Eggert, Marco W. J. Schreurs, Otto C. Boerman, Wim J. C. Oyen, Annemiek J. de Boer, Cornelis J. A. Punt, Carl G. Figdor, and Gosse J. Adema
Cancer Res 1999 59: 3340-3345. [Abstract] [Full Text] [PDF]  

ß-Catenin Mutations Are Specific for Colorectal Carcinomas with Microsatellite Instability but Occur in Endometrial Carcinomas Irrespective of Mutator Pathway

Laura Mirabelli-Primdahl, Robert Gryfe, Hyeja Kim, Anna Millar, Cristina Luceri, Darlene Dale, Eric Holowaty, Bharati Bapat, Steven Gallinger, and Mark Redston
Cancer Res 1999 59: 3346-3351. [Abstract] [Full Text] [PDF]  

Transcriptional Silencing of the p73 Gene in Acute Lymphoblastic Leukemia and Burkitt’s Lymphoma Is Associated with 5' CpG Island Methylation

Paul G. Corn, Steven J. Kuerbitz, Max M. van Noesel, Manel Esteller, Nicole Compitello, Stephen B. Baylin, and James G. Herman
Cancer Res 1999 59: 3352-3356. [Abstract] [Full Text] [PDF]  

Rapid Isolation of Chromosomal Breakpoints from Patients with t(4;11) Acute Lymphoblastic Leukemia: Implications for Basic and Clinical Research

Martin Reichel, Esther Gillert, Ina Breitenlohner, Reinald Repp, Johann Greil, Jörn D. Beck, Georg H. Fey, and Rolf Marschalek
Cancer Res 1999 59: 3357-3362. [Abstract] [Full Text] [PDF]  

The S387Y Mutation of the Transforming Growth Factor-ß Receptor Type I Gene Is Uncommon in Metastases of Breast Cancer and Other Common Types of Adenocarcinoma

Ramaswamy Anbazhagan, Daniel M. Bornman, James C. Johnston, William H. Westra, and Edward Gabrielson
Cancer Res 1999 59: 3363-3364. [Abstract] [Full Text] [PDF]  

Expression of B-myb in Neuroblastoma Tumors Is a Poor Prognostic Factor Independent from MYCN Amplification

Giuseppe Raschellà, Vincenzo Cesi, Roberto Amendola, Anna Negroni, Barbara Tanno, Pierluigi Altavista, Gian Paolo Tonini, Bruno De Bernardi, and Bruno Calabretta
Cancer Res 1999 59: 3365-3368. [Abstract] [Full Text] [PDF]  

Adenovirus-mediated Delivery of Antisense Gene to Urokinase-type Plasminogen Activator Receptor Suppresses Glioma Invasion and Tumor Growth

Pamarthi M. Mohan, Shravan K. Chintala, Sanjeeva Mohanam, Candece L. Gladson, Eui So Kim, Ziya L. Gokaslan, Sajani S. Lakka, Jack A. Roth, Bingliang Fang, Raymond Sawaya, Athanassios P. Kyritsis, and Jasti S. Rao
Cancer Res 1999 59: 3369-3373. [Abstract] [Full Text] [PDF]  

Blockade of the Vascular Endothelial Growth Factor Stress Response Increases the Antitumor Effects of Ionizing Radiation

David H. Gorski, Michael A. Beckett, Nora T. Jaskowiak, Douglas P. Calvin, Helena J. Mauceri, Rabih M. Salloum, Saraswathy Seetharam, Ann Koons, Danielle M. Hari, Donald W. Kufe, and Ralph R. Weichselbaum
Cancer Res 1999 59: 3374-3378. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Transforming Growth Factor ß1 Suppresses Nonmetastatic Colon Cancer at an Early Stage of Tumorigenesis

Sandra J. Engle, James B. Hoying, Gregory P. Boivin, Ilona Ormsby, Peter S. Gartside, and Thomas Doetschman
Cancer Res 1999 59: 3379-3386. [Abstract] [Full Text] [PDF]  

Chemopreventive Efficacy of Sulindac Sulfone against Colon Cancer Depends on Time of Administration during Carcinogenic Process

Bandaru S. Reddy, Toshihiko Kawamori, Ronald A. Lubet, Vernon E. Steele, Gary J. Kelloff, and Chinthalapally V. Rao
Cancer Res 1999 59: 3387-3391. [Abstract] [Full Text] [PDF]  

Endocrinology:

Castration-induced Apoptosis of Androgen-dependent Shionogi Carcinoma Is Associated with Increased Expression of Genes Encoding Insulin-like Growth Factor-binding Proteins

Tara Nickerson, Hideaki Miyake, Martin E. Gleave, and Michael Pollak
Cancer Res 1999 59: 3392-3395. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Systemic Administration of a Recombinant Vaccinia Virus Expressing the Cytosine Deaminase Gene and Subsequent Treatment with 5-Fluorocytosine Leads to Tumor-specific Gene Expression and Prolongation of Survival in Mice

Michael F. X. Gnant, Markus Puhlmann, H. Richard Alexander, Jr., and David L. Bartlett
Cancer Res 1999 59: 3396-3403. [Abstract] [Full Text] [PDF]  

Role of Tumor Necrosis Factor in Hyperthermia-induced Apoptosis of Human Leukemia Cells

Dörthe M. Katschinski, H. Ian Robins, Martina Schad, Stilla Frede, and Joachim Fandrey
Cancer Res 1999 59: 3404-3410. [Abstract] [Full Text] [PDF]  

Highly Augmented Cytopathic Effect of a Fiber-mutant E1B-defective Adenovirus for Gene Therapy of Gliomas

Nobusada Shinoura, Yoko Yoshida, Rikiya Tsunoda, Makoto Ohashi, Weiping Zhang, Akio Asai, Takaaki Kirino, and Hirofumi Hamada
Cancer Res 1999 59: 3411-3416. [Abstract] [Full Text] [PDF]  

Increased Immunogenicity of Tumor Vaccines Complexed with Anti-Gal: Studies in Knockout Mice for 1,3Galactosyltransferase

Denise C. LaTemple, J. Todd Abrams, Shu Yun Zhang, and Uri Galili
Cancer Res 1999 59: 3417-3423. [Abstract] [Full Text] [PDF]  

Water Soluble 20(S)-Glycinate Esters of 10,11-Methylenedioxycamptothecins Are Highly Active against Human Breast Cancer Xenografts

Randy M. Wadkins, Philip M. Potter, Bogdan Vladu, Jennifer Marty, Gina Mangold, Steve Weitman, Govindarajan Manikumar, Mansukh C. Wani, Monroe E. Wall, and Daniel D. Von Hoff
Cancer Res 1999 59: 3424-3428. [Abstract] [Full Text] [PDF]  

Enhanced Apoptotic Response to Photodynamic Therapy after bcl-2 Transfection

Hyeong-Reh Choi Kim, Yu Luo, Gangyong Li, and David Kessel
Cancer Res 1999 59: 3429-3432. [Abstract] [Full Text] [PDF]  

Identification of Sulfated Oligosaccharide-based Inhibitors of Tumor Growth and Metastasis Using Novel in Vitro Assays for Angiogenesis and Heparanase Activity

Christopher R. Parish, Craig Freeman, Kathryn J. Brown, Douglas J. Francis, and William B. Cowden
Cancer Res 1999 59: 3433-3441. [Abstract] [Full Text] [PDF]  

Human Small Cell Lung Cancer NYH Cells Selected for Resistance to the Bisdioxopiperazine Topoisomerase II Catalytic Inhibitor ICRF-187 Demonstrate a Functional R162Q Mutation in the Walker A Consensus ATP Binding Domain of the Isoform

Irene Wessel, Lars H. Jensen, Peter B. Jensen, Jacob Falck, Angela Rose, Mikael Roerth, John L. Nitiss, and Maxwell Sehested
Cancer Res 1999 59: 3442-3450. [Abstract] [Full Text] [PDF]  

Direct Amifostine Effect on Renal Tubule Cells in Rats

Klaus J. Weichert-Jacobsen, Andreas Bannowski, Frank Küppers, Tillmann Loch, and Michael Stöckle
Cancer Res 1999 59: 3451-3453. [Abstract] [Full Text] [PDF]  

Immunology:

Combined Immunodeficiency Associated with Increased Apoptosis of Lymphocytes and Radiosensitivity of Fibroblasts

Jane Peake, Alastair Waugh, Francoise Le Deist, Anne Priestley, Frederic Rieux-Laucat, Nicholas Foray, Emily Capulas, Belinda K. Singleton, Jean-Pierre de Villartay, Andrew Cant, Edmond P. Malaise, Alain Fischer, Claire Hivroz, and Penny A. Jeggo
Cancer Res 1999 59: 3454-3460. [Abstract] [Full Text] [PDF]  

Two Mechanisms for Tumor Evasion of Preexisting Cytotoxic T-Cell Responses: Lessons from Recurrent Tumors

Pan Zheng, Supria Sarma, Yong Guo, and Yang Liu
Cancer Res 1999 59: 3461-3467. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Expression of a Dominant-Negative Mutant Inhibitor-B of Nuclear Factor-B in Human Head and Neck Squamous Cell Carcinoma Inhibits Survival, Proinflammatory Cytokine Expression, and Tumor Growth in Vivo

Dianne C. Duffey, Zhong Chen, Gang Dong, Frank G. Ondrey, Jeffery S. Wolf, Keith Brown, Ulrich Siebenlist, and Carter Van Waes
Cancer Res 1999 59: 3468-3474. [Abstract] [Full Text] [PDF]  

Prognostic Value of Genomic Alterations in Invasive Cervical Squamous Cell Carcinoma of Clinical Stage IB Detected by Comparative Genomic Hybridization

Athanassios Dellas, Joachim Torhorst, Feng Jiang, John Proffitt, Elisabeth Schultheiss, Wolfgang Holzgreve, Guido Sauter, Michael J. Mihatsch, and Holger Moch
Cancer Res 1999 59: 3475-3479. [Abstract] [Full Text] [PDF]  

A p21^Waf1/Cip1 Carboxyl-terminal Peptide Exhibited Cyclin-dependent Kinase-inhibitory Activity and Cytotoxicity When Introduced into Human Cells

Masato Mutoh, Feng-Di T. Lung, Ya-Qiu Long, Peter P. Roller, Robert S. Sikorski, and Patrick M. O’Connor
Cancer Res 1999 59: 3480-3488. [Abstract] [Full Text] [PDF]  

Mouse Model for the DNA Repair/Basal Transcription Disorder Trichothiodystrophy Reveals Cancer Predisposition

Jan de Boer, Harry van Steeg, Rob J. W. Berg, Johan Garssen, Jan de Wit, Conny T. M. van Oostrum, Rudolph B. Beems, GijsbertusT. J. van der Horst, Coen F. van Kreijl, Frank R. de Gruijl, Dirk Bootsma, Jan H. J. Hoeijmakers, and Geert Weeda
Cancer Res 1999 59: 3489-3494. [Abstract] [Full Text] [PDF]  

Tumor Biology:

The Host Environment Promotes the Constitutive Activation of Nuclear Factor-B and Proinflammatory Cytokine Expression during Metastatic Tumor Progression of Murine Squamous Cell Carcinoma

Gang Dong, Zhong Chen, Taiji Kato, and Carter Van Waes
Cancer Res 1999 59: 3495-3504. [Abstract] [Full Text] [PDF]  

Inhibition of Cyclin D1 Expression in Human Pancreatic Cancer Cells Is Associated with Increased Chemosensitivity and Decreased Expression of Multiple Chemoresistance Genes

Marko Kornmann, Kathleen D. Danenberg, Nadir Arber, Hans G. Beger, Peter V. Danenberg, and Murray Korc
Cancer Res 1999 59: 3505-3511. [Abstract] [Full Text] [PDF]  

Urothelium-specific Expression of an Oncogene in Transgenic Mice Induced the Formation of Carcinoma in Situ and Invasive Transitional Cell Carcinoma

Zhong-Ting Zhang, Joanne Pak, Ellen Shapiro, Tung-Tien Sun, and Xue-Ru Wu
Cancer Res 1999 59: 3512-3517. [Abstract] [Full Text] [PDF]  

Overexpression of Retinoic Acid Receptor ß in Head and Neck Squamous Cell Carcinoma Cells Increases Their Sensitivity to Retinoid-induced Suppression of Squamous Differentiation by Retinoids

Haisu Wan, Nobuhiko Oridate, Dafna Lotan, Waun K. Hong, and Reuben Lotan
Cancer Res 1999 59: 3518-3526. [Abstract] [Full Text] [PDF]  

Differential Reconstitution of Mitochondrial Respiratory Chain Activity and Plasma Redox State by Cysteine and Ornithine in a Model of Cancer Cachexia

Alexej Ushmorov, Volker Hack, and Wulf Dröge
Cancer Res 1999 59: 3527-3534. [Abstract] [Full Text] [PDF]  

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