Advances in Brief:

Transformation and Morphological Changes of Murine L Cells by Transfection with a Mutated Form of ß-Catenin

Yutaka Nagasawa, Yasuo Miyoshi, Kyoko Iwao, Yasuhisa Shinomura, Yuji Matsuzawa, and Yusuke Nakamura
Cancer Res 1999 59: 3539-3542. [Abstract] [Full Text] [PDF]  

Enhanced Phosphorylation of p53 Serine 18 following DNA Damage in DNA-dependent Protein Kinase Catalytic Subunit-deficient Cells

Ryoko Araki, Ryutaro Fukumura, Akira Fujimori, Yoichi Taya, Yosef Shiloh, Akihiro Kurimasa, Sandeep Burma, Gloria C. Li, David J. Chen, Koki Sato, Yuko Hoki, Kouichi Tatsumi, and Masumi Abe
Cancer Res 1999 59: 3543-3546. [Abstract] [Full Text] [PDF]  

BRCA2 Is Required for Ionizing Radiation-induced Assembly of Rad51 Complex in Vivo

Shyng-Shiou F. Yuan, Sou-Ying Lee, Gang Chen, Meihua Song, Gail E. Tomlinson, and Eva Y-H. P. Lee
Cancer Res 1999 59: 3547-3551. [Abstract] [Full Text] [PDF]  

Suppression of Prostate Cancer Invasive Potential and Matrix Metalloproteinase Activity by E-Cadherin Transfection

Jun Luo, David M. Lubaroff, and Mary J. C. Hendrix
Cancer Res 1999 59: 3552-3556. [Abstract] [Full Text] [PDF]  

Hormonal Treatment after Cytotoxic Therapy Stimulates Recovery of Spermatogenesis

Marvin L. Meistrich, Gene Wilson, and Ilpo Huhtaniemi
Cancer Res 1999 59: 3557-3560. [Abstract] [Full Text] [PDF]  

Reduced Risk of AIDS Lymphoma in Individuals Heterozygous for the CCR5-32 Mutation

Michael Dean, Lisa P. Jacobson, Glen McFarlane, Joseph B. Margolick, Frank J. Jenkins, O. M. Zack Howard, Hui-Fang Dong, James J. Goedert, Susan Buchbinder, Edward Gomperts, David Vlahov, Joost J. Oppenheim, Stephen J. O’Brien, and Mary Carrington
Cancer Res 1999 59: 3561-3564. [Abstract] [Full Text] [PDF]  

Caspase Inhibition in Camptothecin-treated U-937 Cells Is Coupled with a Shift from Apoptosis to Transient G₁ Arrest Followed by Necrotic Cell Death

Alain-Théophile Sané and Richard Bertrand
Cancer Res 1999 59: 3565-3569. [Abstract] [Full Text] [PDF]  

Unbalanced Germ-Line Expression of hMLH1 and hMSH2 Alleles in Hereditary Nonpolyposis Colorectal Cancer

Maria Cristina Curia, Raffaele Palmirotta, Gitana Aceto, Luca Messerini, Maria Concetta Verì, Stefania Crognale, Rosa Valanzano, Ferdinando Ficari, Pierluigi Fracasso, Vittoria Stigliano, Francesco Tonelli, Vincenzo Casale, Fiorella Guadagni, Pasquale Battista, Renato Mariani-Costantini, and Alessandro Cama
Cancer Res 1999 59: 3570-3575. [Abstract] [Full Text] [PDF]  

Multiple Regions of Chromosome 4 Demonstrating Allelic Losses in Breast Carcinomas

Narayan Shivapurkar, Sanjay Sood, Ignacio I. Wistuba, Arvind K. Virmani, Anirban Maitra, Sara Milchgrub, John D. Minna, and Adi F. Gazdar
Cancer Res 1999 59: 3576-3580. [Abstract] [Full Text] [PDF]  

Regulation of Cell Growth and Cyclin D1 Expression by the Constitutively Active FRAP-p70^s6K Pathway in Human Pancreatic Cancer Cells

Martin Grewe, Frank Gansauge, Roland M. Schmid, Guido Adler, and Thomas Seufferlein
Cancer Res 1999 59: 3581-3587. [Abstract] [Full Text] [PDF]  

Expression of Insulin-like Growth Factor-1 Receptor in Synovial Sarcoma: Association with an Aggressive Phenotype

Yuntao Xie, Björn Skytting, Gunnar Nilsson, Bertha Brodin, and Olle Larsson
Cancer Res 1999 59: 3588-3591. [Abstract] [Full Text] [PDF]  

Interaction of Adeno-associated Virus Rep78 with p53: Implications in Growth Inhibition

Ramesh B. Batchu, Masood A. Shammas, Jing Yi Wang, and Nikhil C. Munshi
Cancer Res 1999 59: 3592-3595. [Abstract] [Full Text] [PDF]  

The Chromosome 10 Monosomy Common in Human Melanomas Results from the Loss of Two Separate Tumor Suppressor Loci

Gavin P. Robertson, Rudolf A. Herbst, Motoo Nagane, H-J. Su Huang, and Webster K. Cavenee
Cancer Res 1999 59: 3596-3601. [Abstract] [Full Text] [PDF]  

Stereochemistry of Metabolites of a Tobacco-specific Lung Carcinogen in Smokers’ Urine

Steven G. Carmella, Ming Ye, Pramod Upadhyaya, and Stephen S. Hecht
Cancer Res 1999 59: 3602-3605. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Specific p53 Gene Mutations in Urinary Bladder Epithelium after the Chernobyl Accident

Shinji Yamamoto, Alina Romanenko, Min Wei, Chikayoshi Masuda, Wadim Zaparin, Wladimir Vinnichenko, Alexander Vozianov, Chyi Chia R. Lee, Keiichirou Morimura, Hideki Wanibuchi, Mitsuhiro Tada, and Shoji Fukushima
Cancer Res 1999 59: 3606-3609. [Abstract] [Full Text] [PDF]  

Difluoromethylornithine Chemoprevention of Epidermal Carcinogenesis in K14-HPV16 Transgenic Mice

Jeffrey M. Arbeit, Rebeccah R. Riley, Bing Huey, Carl Porter, Gary Kelloff, Ronald Lubet, Jerrold M. Ward, and Dan Pinkel
Cancer Res 1999 59: 3610-3620. [Abstract] [Full Text] [PDF]  

Elevated Mutant Frequencies in Lymphoid Tissues Persist throughout Plasmacytoma Development in BALB/c.LIZ Mice

Klaus Felix, Kevin A. Kelliher, Georg-Wilhelm Bornkamm, and Siegfried Janz
Cancer Res 1999 59: 3621-3626. [Abstract] [Full Text] [PDF]  

Exposure of Sprague-Dawley Rats to a 50-Hertz, 100-µTesla Magnetic Field for 27 Weeks Facilitates Mammary Tumorigenesis in the 7,12-Dimethylbenz[a]-anthracene Model of Breast Cancer

Susanne Thun-Battersby, Meike Mevissen, and Wolfgang Löscher
Cancer Res 1999 59: 3627-3633. [Abstract] [Full Text] [PDF]  

High Frequency and Heterogeneous Distribution of p53 Mutations in Aflatoxin B₁-induced Mouse Lung Tumors

Andrew S. Tam, Julie F. Foley, Theodora R. Devereux, Robert R. Maronpot, and Thomas E. Massey
Cancer Res 1999 59: 3634-3640. [Abstract] [Full Text] [PDF]  

Quinol-Glutathione Conjugate-induced Mutation Spectra in the supF Gene Replicated in Human AD293 Cells and Bacterial MBL50 Cells

Jeongmi K. Jeong, Gerald N. Wogan, Serrine S. Lau, and Terrence J. Monks
Cancer Res 1999 59: 3641-3645. [Abstract] [Full Text] [PDF]  

Endocrinology:

Idoxifene Antagonizes Estradiol-dependent MCF-7 Breast Cancer Xenograft Growth through Sustained Induction of Apoptosis

Stephen R. D. Johnston, Irene M. Boeddinghaus, Sharon Riddler, Ben P. Haynes, Ian R. Hardcastle, Martin Rowlands, Rachel Grimshaw, Michael Jarman, and Mitch Dowsett
Cancer Res 1999 59: 3646-3651. [Abstract] [Full Text] [PDF]  

Differential Regulation of Somatostatin Receptor Type 2 (sst 2) Expression in AR4-2J Tumor Cells Implanted into Mice during Octreotide Treatment

Sylvie Froidevaux, Edith Hintermann, Michael Török, Helmut R. Mäcke, Christoph Beglinger, and Alex N. Eberle
Cancer Res 1999 59: 3652-3657. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Reproductive Factors of Ovarian and Endometrial Cancer Risk in a High Fertility Population in Mexico

Eduardo Salazar-Martinez, Eduardo Cesar Lazcano-Ponce, Guillermo Gonzalez Lira-Lira, Pedro Escudero-De los Rios, Jorge Salmeron-Castro, and Mauricio Hernandez-Avila
Cancer Res 1999 59: 3658-3662. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

DNA Damage Increases Sensitivity to Vinca Alkaloids and Decreases Sensitivity to Taxanes through p53-dependent Repression of Microtubule-associated Protein 4

Christine C. Zhang, Jin-Ming Yang, Judy Bash-Babula, Eileen White, Maureen Murphy, Arnold J. Levine, and William N. Hait
Cancer Res 1999 59: 3663-3670. [Abstract] [Full Text] [PDF]  

Cell Cycle Modulation by a Multitargeted Antifolate, LY231514, Increases the Cytotoxicity and Antitumor Activity of Gemcitabine in HT29 Colon Carcinoma

John L. Tonkinson, John F. Worzalla, Chi-Hse Teng, and Laurane G. Mendelsohn
Cancer Res 1999 59: 3671-3676. [Abstract] [Full Text] [PDF]  

Tumor Radiosensitization by Sustained Intratumoral Release of Bromodeoxyuridine

Annie Doiron, Donald T. T. Yapp, Marina Olivares, Julian X. X. Zhu, and Shirley Lehnert
Cancer Res 1999 59: 3677-3681. [Abstract] [Full Text] [PDF]  

Enhanced Amsacrine-induced Mutagenesis in Plateau-Phase Chinese Hamster Ovary Cells, with Targeting of +1 Frameshifts to Free 3' Ends of Topoisomerase II Cleavable Complexes

Kathleen Patteson, Peng Wang, and Lawrence F. Povirk
Cancer Res 1999 59: 3682-3688. [Abstract] [Full Text] [PDF]  

Tethering a Type IB Topoisomerase to a DNA Site by Enzyme Fusion to a Heterologous Site-selective DNA-binding Protein Domain

Giovanni Luca Beretta, Monica Binaschi, Emanuela Zagni, Luisa Capuani, and Giovanni Capranico
Cancer Res 1999 59: 3689-3697. [Abstract] [Full Text] [PDF]  

Immunology:

Interleukin 17, a T-cell-derived Cytokine, Promotes Tumorigenicity of Human Cervical Tumors in Nude Mice

Eric Tartour, François Fossiez, Isabelle Joyeux, Annie Galinha, Alain Gey, Emmanuel Claret, Xavier Sastre-Garau, Jérôme Couturier, Veronique Mosseri, Virginie Vives, Jacques Banchereau, Wolf H. Fridman, John Wijdenes, Serge Lebecque, and Catherine Sautèes-Fridman
Cancer Res 1999 59: 3698-3704. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

The Cell Cycle Regulator p27^kip1 Contributes to Growth and Differentiation of Osteoblasts

Hicham Drissi, Dennet Hushka, Fauzia Aslam, Que Nguyen, Elizabeth Buffone, Andrew Koff, André J. van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein
Cancer Res 1999 59: 3705-3711. [Abstract] [Full Text] [PDF]  

Nonrandom Degradation of DNA in Human Leukemic Cells during Radiation-induced Apoptosis

Robert G. Dullea, Jeanne F. Robinson, and Joel S. Bedford
Cancer Res 1999 59: 3712-3718. [Abstract] [Full Text] [PDF]  

The Dermatofibrosarcoma Protuberans-associated Collagen Type I1/Platelet-derived Growth Factor (PDGF) B-Chain Fusion Gene Generates a Transforming Protein That Is Processed to Functional PDGF-BB

Akira Shimizu, Kevin P. O’Brien, Tobias Sjöblom, Kristian Pietras, Elisabeth Buchdunger, V. Peter Collins, Carl-Henrik Heldin, Jan P. Dumanski, and Arne Östman
Cancer Res 1999 59: 3719-3723. [Abstract] [Full Text] [PDF]  

Lymph Node Metastasis Is Associated with Allelic Loss on Chromosome 13q12–13 in Esophageal Squamous Cell Carcinoma¹

Hideki Harada, Hisashi Tanaka, Yutaka Shimada, Masayuki Shinoda, Masayuki Imamura, and Kanji Ishizaki
Cancer Res 1999 59: 3724-3729. [Abstract] [Full Text] [PDF]  

Concurrent DNA Hypermethylation of Multiple Genes in Acute Myeloid Leukemia

John R. Melki, Paul C. Vincent, and Susan J. Clark
Cancer Res 1999 59: 3730-3740. [Abstract] [Full Text] [PDF]  

Bdp, a New Member of a Family of DNA-binding Proteins, Associates with the Retinoblastoma Gene Product

Shin-ichiro Numata, Pier Paolo Claudio, Charity Dean, Antonio Giordano, and Carlo M. Croce
Cancer Res 1999 59: 3741-3747. [Abstract] [Full Text] [PDF]  

Identification of a Gene Encoding a Human Oxysterol-binding Protein-Homologue: A Potential General Molecular Marker for Blood Dissemination of Solid Tumors

Marcia V. Fournier, Fernanda C. Guimaraes, Marcos E. M. Paschoal, Lucienne V. Ronco, Maria da Gloria Costa Carvalho, and Arthur B. Pardee
Cancer Res 1999 59: 3748-3753. [Abstract] [Full Text] [PDF]  

Tumor Biology:

A Novel Disintegrin Salmosin Inhibits Tumor Angiogenesis

In-Cheol Kang, Young-Don Lee, and Doo-Sik Kim
Cancer Res 1999 59: 3754-3760. [Abstract] [Full Text] [PDF]  

A Senescence-like Phenotype Distinguishes Tumor Cells That Undergo Terminal Proliferation Arrest after Exposure to Anticancer Agents

Bey-Dih Chang, Eugenia V. Broude, Milos Dokmanovic, Hongming Zhu, Adam Ruth, Yongzhi Xuan, Eugene S. Kandel, Ekkehart Lausch, Konstantin Christov, and Igor B. Roninson
Cancer Res 1999 59: 3761-3767. [Abstract] [Full Text] [PDF]  

Human Natural Immunoglobulin M Antibodies Induce Apoptosis of Human Neuroblastoma Cells by Binding to a M_r 260,000 Antigen

Kerstin David, Markus W. Ollert, Caren Vollmert, Sven Heiligtag, Britta Eickhoff, Rudolf Erttmann, Reinhard Bredehorst, and Carl-Wilhelm Vogel
Cancer Res 1999 59: 3768-3775. [Abstract] [Full Text] [PDF]  

Taxane-induced Apoptosis Decompresses Blood Vessels and Lowers Interstitial Fluid Pressure in Solid Tumors: Clinical Implications

Genevièeve Griffon-Etienne, Yves Boucher, Christian Brekken, Herman D. Suit, and Rakesh K. Jain
Cancer Res 1999 59: 3776-3782. [Abstract] [Full Text] [PDF]  

Restoration of Wild-Type p16 Down-Regulates Vascular Endothelial Growth Factor Expression and Inhibits Angiogenesis in Human Gliomas

Hironobu Harada, Kou Nakagawa, Shinji Iwata, Masahiro Saito, Yoshiaki Kumon, Saburo Sakaki, Kohji Sato, and Katsuyuki Hamada
Cancer Res 1999 59: 3783-3789. [Abstract] [Full Text] [PDF]  

Frequent Loss of Expression of the Cyclin-dependent Kinase Inhibitor p27 in Epithelial Ovarian Cancer

Valeria Masciullo, Alessandro Sgambato, Carmen Pacilio, Bruna Pucci, Gabriella Ferrandina, Juan Palazzo, Arnaldo Carbone, Achille Cittadini, Salvatore Mancuso, Giovanni Scambia, and Antonio Giordano
Cancer Res 1999 59: 3790-3794. [Abstract] [Full Text] [PDF]  

Transformation Blocks Differentiation-induced Inhibition of Serum Response Factor Interactions with Serum Response Elements

Wei Ding, Michael M. Witte, and Robert E. Scott
Cancer Res 1999 59: 3795-3802. [Abstract] [Full Text] [PDF]  

Induction of a Functional Vitamin D Receptor in all-trans-Retinoic Acid-induced Monocytic Differentiation of M2-type Leukemic Blast Cells

Rossella Manfredini, Francesca Trevisan, Alexis Grande, Enrico Tagliafico, Monica Montanari, Roberto Lemoli, Giuseppe Visani, Sante Tura, Stefano Ferrari, and Sergio Ferrari
Cancer Res 1999 59: 3803-3811. [Abstract] [Full Text] [PDF]  

Eukaryotic Expression Cloning with an Antimetastatic Monoclonal Antibody Identifies a Tetraspanin (PETA-3/CD151) as an Effector of Human TumorCell Migration and Metastasis

Jacqueline E. Testa, Peter C. Brooks, Jian-Min Lin, and James P. Quigley
Cancer Res 1999 59: 3812-3820. [Abstract] [Full Text] [PDF]  

Acquisition of Neuroendocrine Characteristics by Prostate Tumor Cells Is Reversible: Implications for Prostate Cancer Progression

Michael E. Cox, Paul D. Deeble, Saquib Lakhani, and Sarah J. Parsons
Cancer Res 1999 59: 3821-3830. [Abstract] [Full Text] [PDF]  

Defective G₁-S Cell Cycle Checkpoint Function Sensitizes Cells to Microtubule Inhibitor-induced Apoptosis

Zoe A. Stewart, Deborah Mays, and Jennifer A. Pietenpol
Cancer Res 1999 59: 3831-3837. [Abstract] [Full Text] [PDF]  

Posttranslational Mechanisms Contribute to the Suppression of Specific Cyclin: CDK Complexes by All-Trans Retinoic Acid in Human Bronchial Epithelial Cells

Naoko Sueoka, Ho-Young Lee, Garrett L. Walsh, Waun Ki Hong, and Jonathan M. Kurie
Cancer Res 1999 59: 3838-3844. [Abstract] [Full Text] [PDF]  

Meeting Report:

Eighth International Workshop on Ataxia-Telangiectasia (ATW8)

Martin F. Lavin, Patrick Concannon, and Richard A. Gatti
Cancer Res 1999 59: 3845 [PDF]  

Errata:

Errata

Cancer Res 1999 59: 3853 [Full Text]  

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