Advances in Brief:

Abnormal Regulation of DNA Methyltransferase Expression during Colorectal Carcinogenesis

Angelo M. De Marzo, Valerie L. Marchi, Eddy S. Yang, Ravi Veeraswamy, Xiaohui Lin, and William G. Nelson
Cancer Res 1999 59: 3855-3860. [Abstract] [Full Text] [PDF]  

Multimodal Cancer Treatment Mediated by a Replicating Oncolytic Virus That Delivers the Oxazaphosphorine/Rat Cytochrome P450 2B1 and Ganciclovir/Herpes Simplex Virus Thymidine Kinase Gene Therapies

Manish Aghi, Ting Chao Chou, Kristen Suling, Xandra O. Breakefield, and E. Antonio Chiocca
Cancer Res 1999 59: 3861-3865. [Abstract] [Full Text] [PDF]  

FHIT Loss of Function in Human Primary Breast Cancer Correlates with Advanced Stage of the Disease

Manuela Campiglio, Yuri Pekarsky, Sylvie Menard, Elda Tagliabue, Silvana Pilotti, and Carlo M. Croce
Cancer Res 1999 59: 3866-3869. [Abstract] [Full Text] [PDF]  

Frequent Deletion of hSNF5/INI1, a Component of the SWI/SNF Complex, in Chronic Myeloid Leukemia

Francis Grand, Shashikant Kulkarni, Andrew Chase, John M. Goldman, Myrtle Gordon, and Nicholas C. P. Cross
Cancer Res 1999 59: 3870-3874. [Abstract] [Full Text] [PDF]  

Intestinal Dysplasia and Adenoma in Transgenic Mice after Overexpression of an Activated ß-Catenin

Béeatrice Romagnolo, Dominique Berrebi, Sihem Saadi-Keddoucci, Arlette Porteu, Anne-lise Pichard, Michel Peuchmaur, Alain Vandewalle, Axel Kahn, and Christine Perret
Cancer Res 1999 59: 3875-3879. [Abstract] [Full Text] [PDF]  

Mutational Activation of the ß-Catenin Proto-Oncogene Is a Common Event in the Development of Wilms’ Tumors

Robert Koesters, Ruediger Ridder, Annette Kopp-Schneider, David Betts, Volker Adams, Felix Niggli, Jakob Briner, and Magnus von Knebel Doeberitz
Cancer Res 1999 59: 3880-3882. [Abstract] [Full Text] [PDF]  

Common Nonsense Mutations in RAD52

Daphne W. Bell, Doke C. R. Wahrer, Deborah H. Kang, Melissa S. MacMahon, Michael G. FitzGerald, Chikashi Ishioka, Kurt J. Isselbacher, Michael Krainer, and Daniel A. Haber
Cancer Res 1999 59: 3883-3888. [Abstract] [Full Text] [PDF]  

Mosaic Allelic Insulin-like Growth Factor 2 Expression Patterns Reveal a Link between Wilms’ Tumorigenesis and Epigenetic Heterogeneity

Rolf Ohlsson, Hengmi Cui, Liangmei He, Susan Pfeifer, Helena Malmikumpu, Shan Jiang, Andrew P. Feinberg, and Fredrik Hedborg
Cancer Res 1999 59: 3889-3892. [Abstract] [Full Text] [PDF]  

Mutagenic Activation of Environmental Carcinogens by Microsomes of Gastric Mucosa with Intestinal Metaplasia

Masayuki Tatemichi, Sachiyo Nomura, Tsutomu Ogura, Hideko Sone, Hiroshi Nagata, and Hiroyasu Esumi
Cancer Res 1999 59: 3893-3898. [Abstract] [Full Text] [PDF]  

Quantitative Analysis of Aberrant p16 Methylation Using Real-Time Quantitative Methylation-specific Polymerase Chain Reaction

Y. M. Dennis Lo, Ivy H. N. Wong, Jun Zhang, Mark S. C. Tein, Margaret H. L. Ng, and N. Magnus Hjelm
Cancer Res 1999 59: 3899-3903. [Abstract] [Full Text] [PDF]  

Different Frequencies and Patterns of ß-Catenin Mutations in Hepatocellular Carcinomas Induced by N-Nitrosodiethylamine and a Choline-deficient L-Amino Acid-defined Diet in Rats

Toshifumi Tsujiuchi, Masahiro Tsutsumi, Yasutaka Sasaki, Makoto Takahama, and Yoichi Konishi
Cancer Res 1999 59: 3904-3907. [Abstract] [Full Text] [PDF]  

Cytochrome P450c17 Gene (CYP17) Polymorphism Predicts Use of Hormone Replacement Therapy

Heather Spencer Feigelson, Roberta McKean-Cowdin, Malcolm C. Pike, Gerhard A. Coetzee, Laurence N. Kolonel, Abraham M. Y. Nomura, Loic Le Marchand, and Brian E. Henderson
Cancer Res 1999 59: 3908-3910. [Abstract] [Full Text] [PDF]  

Hammerhead Ribozyme-mediated Inactivation of Mutant RET in Medullary Thyroid Carcinoma

Ranjani Parthasarathy, Gilbert J. Cote, and Robert F. Gagel
Cancer Res 1999 59: 3911-3914. [Abstract] [Full Text] [PDF]  

Reciprocal Positive Regulation of Hypoxia-inducible Factor 1 and Insulin-like Growth Factor 2

David Feldser, Faton Agani, Narayan V. Iyer, Brian Pak, Gloria Ferreira, and Gregg L. Semenza
Cancer Res 1999 59: 3915-3918. [Abstract] [Full Text] [PDF]  

Antitumor Activity of 13,14-Dihydro-15-deoxy-⁷-prostaglandin-A₁-methyl Ester Integrated into Lipid Microspheres against Human Ovarian Carcinoma Cells Resistant to Cisplatin in Vivo

Hiroshi Sasaki, Shigeki Niimi, Minoru Akiyama, Tadao Tanaka, Atsuo Hazato, Seiji Kurozumi, Shoji Fukushima, and Masanori Fukushima
Cancer Res 1999 59: 3919-3922. [Abstract] [Full Text] [PDF]  

An Insulin-like Growth Factor-mediated, Phosphatidylinositol 3' Kinase-independent Survival Signaling Pathway in ß Tumor Cells

Ingo Burtscher, Amelia Compagni, Gábor M. Lamm, and Gerhard Christofori
Cancer Res 1999 59: 3923-3926. [Abstract] [Full Text] [PDF]  

Identification of a Novel Complex between Human Kallikrein 2 and Protease Inhibitor-6 in Prostate Cancer Tissue

Stephen D. Mikolajczyk, Lisa S. Millar, Kathy M. Marker, Harry G. Rittenhouse, Robert L. Wolfert, Leonard S. Marks, M. Cristine Charlesworth, and Donald J. Tindall
Cancer Res 1999 59: 3927-3930. [Abstract] [Full Text] [PDF]  

Decreases in Ikaros Activity Correlate with Blast Crisis in Patients with Chronic Myelogenous Leukemia

Hiroyuki Nakayama, Fumihiko Ishimaru, Nicole Avitahl, Nobuo Sezaki, Nobuharu Fujii, Koichi Nakase, Yoshifumi Ninomiya, Akira Harashima, Jun Minowada, Junjiro Tsuchiyama, Kenji Imajoh, Teruhiko Tsubota, Shunnichi Fukuda, Tatsuo Sezaki, Kensuke Kojima, Masamichi Hara, Hidetaka Takimoto, Seiichi Yorimitsu, Isao Takahashi, Akira Miyata, Shuichi Taniguchi, Yasunobu Tokunaga, Hisashi Gondo, Yoshiyuki Niho, Shinji Nakao, Taiichi Kyo, Hiroo Dohy, Nanao Kamada, and Mine Harada
Cancer Res 1999 59: 3931-3934. [Abstract] [Full Text] [PDF]  

Effects of Geldanamycin on Signaling through Activator-Protein 1 in Hypoxic HT29 Human Colon Adenocarcinoma Cells

Irina A. Vasilevskaya and Peter J. O’Dwyer
Cancer Res 1999 59: 3935-3940. [Abstract] [Full Text] [PDF]  

Two Regions of Deletion in 9p23–24 in Sporadic Breast Cancer

Han-Xiang An, Andreas Claas, Larissa Savelyeva, Susanne Seitz, Peter Schlag, Siegfried Scherneck, and Manfred Schwab
Cancer Res 1999 59: 3941-3943. [Abstract] [Full Text] [PDF]  

Biochemistry:

P-Glycoprotein and Cytochrome P-450 3A Inhibition: Dissociation of Inhibitory Potencies

Christoph Wandel, Richard B. Kim, Shama Kajiji, F. Peter Guengerich, Grant R. Wilkinson, and Alastair J. J. Wood
Cancer Res 1999 59: 3944-3948. [Abstract] [Full Text] [PDF]  

Unusually High Expression of N-Acetylglucosaminyltransferase-IVa in Human Choriocarcinoma Cell Lines: A Possible Enzymatic Basis of the Formation of Abnormal Biantennary Sugar Chain

Shinji Takamatsu, Suguru Oguri, Mari Toba Minowa, Aruto Yoshida, Katsumi Nakamura, Makoto Takeuchi, and Akira Kobata
Cancer Res 1999 59: 3949-3953. [Abstract] [Full Text] [PDF]  

Growth Factor Signal Transduction Immediately after Two-Thirds Partial Hepatectomy in the Rat

Donna Beer Stolz, Wendy M. Mars, Bryon E. Petersen, Tae-Hyoung Kim, and George K. Michalopoulos
Cancer Res 1999 59: 3954-3960. [Abstract] [Full Text] [PDF]  

The Pro-Apoptotic Drug Camptothecin Stimulates Phospholipase D Activity and Diacylglycerol Production in the Nucleus of HL-60 Human Promyelocytic Leukemia Cells

Alberto M. Martelli, Roberta Bortul, Renato Bareggi, Giovanna Tabellini, Vittorio Grill, Giovanna Baldini, and Paola Narducci
Cancer Res 1999 59: 3961-3967. [Abstract] [Full Text] [PDF]  

Efficient Nucleotide Excision Repair of Cisplatin, Oxaliplatin, and Bis-aceto-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) PlatinumIntrastrand DNA Diadducts

Joyce T. Reardon, Alexandra Vaisman, Stephen G. Chaney, and Aziz Sancar
Cancer Res 1999 59: 3968-3971. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Delayed Apoptotic Responses Associated with Radiation-induced Neoplastic Transformation of Human Hybrid Cells

Marc S. Mendonca, Kelly L. Howard, Daphne L. Farrington, Lael A. Desmond, Toni M. Temples, Brendan M. Mayhugh, John J. Pink, and David A. Boothman
Cancer Res 1999 59: 3972-3979. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

The Protein Kinase C Inhibitor CGP41251 Suppresses Cytokine Release and Extracellular Signal-regulated Kinase 2 Expression in Cancer Patients

Parames Thavasu, David Propper, Alexander McDonald, Nicola Dobbs, Trivadi Ganesan, Dennis Talbot, Jeremy Braybrook, Francesco Caponigro, Cathy Hutchison, Christopher Twelves, Anthony Man, Doriano Fabbro, Adrian Harris, and Frances Balkwill
Cancer Res 1999 59: 3980-3984. [Abstract] [Full Text] [PDF]  

Endocrinology:

Anhydroretinol Induces Oxidative Stress and Cell Death

Yanqiu Chen, Jochen Buck, and Fadila Derguini
Cancer Res 1999 59: 3985-3990. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Indole-3-Carbinol Prevents Cervical Cancer in Human Papilloma Virus Type 16 (HPV16) Transgenic Mice

Liang Jin, Mei Qi, Da-Zhi Chen, Ann Anderson, Gaung-Yu Yang, Jeffrey M. Arbeit, and Karen J. Auborn
Cancer Res 1999 59: 3991-3997. [Abstract] [Full Text] [PDF]  

Enhancement of Antibody-directed Enzyme Prodrug Therapy in Colorectal Xenografts by an Antivascular Agent

R. Barbara Pedley, Surinder K. Sharma, Geoffrey M. Boxer, Robert Boden, Stephen M. Stribbling, Lawrence Davies, Caroline J. Springer, and Richard H. J. Begent
Cancer Res 1999 59: 3998-4003. [Abstract] [Full Text] [PDF]  

FJ5002: A Potent Telomerase Inhibitor Identified by Exploiting the Disease-oriented Screening Program with COMPARE Analysis

Imad Naasani, Hiroyuki Seimiya, Takao Yamori, and Takashi Tsuruo
Cancer Res 1999 59: 4004-4011. [Abstract] [Full Text] [PDF]  

Ku Autoantigen Affects the Susceptibility to Anticancer Drugs

Sun Hee Kim, Dooha Kim, Jeong Sil Han, Choon Sik Jeong, Byung Seon Chung, Chi Dug Kang, and Gloria C. Li
Cancer Res 1999 59: 4012-4017. [Abstract] [Full Text] [PDF]  

Pharmacokinetics and Antitumor Activity of a Bivalent Disulfide-stabilized Fv Immunotoxin with Improved Antigen Binding to erbB2

Tapan K. Bera, Jaye Viner, Elisabeth Brinkmann, and Ira Pastan
Cancer Res 1999 59: 4018-4022. [Abstract] [Full Text] [PDF]  

5,6-trans-16-ene-Vitamin D₃: A New Class of Potent Inhibitors of Proliferation of Prostate, Breast, and Myeloid Leukemic Cells

Jun-ichi Hisatake, Tetsuya Kubota, Yasuko Hisatake, Milan Uskokovic, Shigeru Tomoyasu, and H. Phillip Koeffler
Cancer Res 1999 59: 4023-4029. [Abstract] [Full Text] [PDF]  

Antisense Bcl-2 Oligodeoxynucleotides Inhibit Progression to Androgen-Independence after Castration in the Shionogi Tumor Model

Hideaki Miyake, Anthony Tolcher, and Martin E. Gleave
Cancer Res 1999 59: 4030-4034. [Abstract] [Full Text] [PDF]  

Induction of Systemic and Therapeutic Antitumor Immunity Using Intratumoral Injection of Dendritic Cells Genetically Modified to Express Interleukin 12

Yasuhiko Nishioka, Motohiro Hirao, Paul D. Robbins, Michael T. Lotze, and Hideaki Tahara
Cancer Res 1999 59: 4035-4041. [Abstract] [Full Text] [PDF]  

Potent Antitumor Activity of MS-247, a Novel DNA Minor Groove Binder, Evaluated by an in Vitro and in Vivo Human Cancer Cell Line Panel

Takao Yamori, Akio Matsunaga, Shigeo Sato, Kanami Yamazaki, Akiko Komi, Kazuhiro Ishizu, Izumi Mita, Hajime Edatsugi, Yasuhiro Matsuba, Kimiko Takezawa, Osamu Nakanishi, Hiroshi Kohno, Yuki Nakajima, Hironori Komatsu, Toshio Andoh, and Takashi Tsuruo
Cancer Res 1999 59: 4042-4049. [Abstract] [Full Text] [PDF]  

Immunology:

Analysis of the Cytolytic T Lymphocyte Response of Melanoma Patients to the Naturally HLA-A*0201-associated Tyrosinase Peptide 368–376

Danila Valmori, Mikaël J. Pittet, Cedric Vonarbourg, Donata Rimoldi, Danielle Liénard, Daniel Speiser, Rod Dunbar, Vincenzo Cerundolo, Jean-Charles Cerottini, and Pedro Romero
Cancer Res 1999 59: 4050-4055. [Abstract] [Full Text] [PDF]  

Identification of a Gene Coding for a Protein Possessing Shared Tumor Epitopes Capable of Inducing HLA-A24-restricted Cytotoxic T Lymphocytes inCancer Patients

Damu Yang, Masanobu Nakao, Shigeki Shichijo, Teruo Sasatomi, Hideo Takasu, Hajime Matsumoto, Kazunori Mori, Akihiro Hayashi, Hideaki Yamana, Kazuo Shirouzu, and Kyogo Itoh
Cancer Res 1999 59: 4056-4063. [Abstract] [Full Text] [PDF]  

Antitumor Effects of Interferon-: In Vivo Therapy of Human Tumor Xenografts in Nude Mice

Holly M. Horton, Pepe Hernandez, Suezanne E. Parker, and Kerry M. Barnhart
Cancer Res 1999 59: 4064-4068. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Identification of NKIAMRE, the Human Homologue to the Mitogen-activated Protein Kinase-/Cyclin-dependent Kinase-related Protein Kinase NKIATRE, and Its Loss in Leukemic Blasts with Chromosome Arm 5q Deletion

Michael Midmer, Rizwan Haq, Jeremy A. Squire, and Brent W. Zanke
Cancer Res 1999 59: 4069-4074. [Abstract] [Full Text] [PDF]  

Structure and Possible Mechanisms of TEL-AML1 Gene Fusions in Childhood Acute Lymphoblastic Leukemia

Joseph L. Wiemels and Mel Greaves
Cancer Res 1999 59: 4075-4082. [Abstract] [Full Text] [PDF]  

Two Novel Mucin Genes Down-Regulated in Colorectal Cancer Identified by Differential Display

Stephanie J. Williams, Michael A. McGuckin, David C. Gotley, Helen J. Eyre, Grant R. Sutherland, and Toni M. Antalis
Cancer Res 1999 59: 4083-4089. [Abstract] [Full Text] [PDF]  

Nuclear Factor B Transactivation Is Increased But Is Not Involved in the Proliferative Effects of Thioredoxin Overexpression in MCF-7 Breast Cancer Cells

Alex J. Freemerman, Alfred Gallegos, and Garth Powis
Cancer Res 1999 59: 4090-4094. [Abstract] [Full Text] [PDF]  

A Lack of a Functional NAD(P)H:Quinone Oxidoreductase Allele Is Selectively Associated with Pediatric Leukemias That Have MLL Fusions

Joseph L. Wiemels, Alistair Pagnamenta, G. Malcolm Taylor, Osborn B. Eden, Freda E. Alexander, and Mel F. Greaves
Cancer Res 1999 59: 4095-4099. [Abstract] [Full Text] [PDF]  

A New MAGE Gene with Ubiquitous Expression Does Not Code for Known MAGE Antigens Recognized by T Cells

Sophie Lucas, Francis Brasseur, and Thierry Boon
Cancer Res 1999 59: 4100-4103. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Deficiency of Connexin43 Gap Junctions Is an Independent Marker for Breast Tumors

Dale W. Laird, Paulina Fistouris, Gerald Batist, Lesley Alpert, Hung T. Huynh, George D. Carystinos, and Moulay A. Alaoui-Jamali
Cancer Res 1999 59: 4104-4110. [Abstract] [Full Text] [PDF]  

Inhibition of Bladder Carcinoma Angiogenesis, Stromal Support, and Tumor Growth by Halofuginone

Michael Elkin, Ilana Ariel, Hua-Quan Miao, Arnon Nagler, Mark Pines, Nathan de-Groot, Avraham Hochberg, and Israel Vlodavsky
Cancer Res 1999 59: 4111-4118. [Abstract] [Full Text] [PDF]  

Expression Level of Bcl-2 Determines Anti- or Proapoptotic Function

Nobusada Shinoura, Yoko Yoshida, Miyako Nishimura, Yukiko Muramatsu, Akio Asai, Takaaki Kirino, and Hirofumi Hamada
Cancer Res 1999 59: 4119-4128. [Abstract] [Full Text] [PDF]  

Augmentation of Transvascular Transport of Macromolecules and Nanoparticles in Tumors Using Vascular Endothelial Growth Factor

Wayne L. Monsky, Dai Fukumura, Takeshi Gohongi, Marek Ancukiewcz, Herbert A. Weich, Vladimir P. Torchilin, Fan Yuan, and Rakesh K. Jain
Cancer Res 1999 59: 4129-4135. [Abstract] [Full Text] [PDF]  

Available Volume Fraction of Macromolecules in the Extravascular Space of a Fibrosarcoma: Implications for Drug Delivery

Ava Krol, Julie Maresca, Mark W. Dewhirst, and Fan Yuan
Cancer Res 1999 59: 4136-4141. [Abstract] [Full Text] [PDF]  

Intragenic Mutation Analysis of the Human Epidermal Growth Factor Receptor (EGFR) Gene in Malignant Human Oral Keratinocytes

Satoru Shintani, Kou Matsuo, Constant C. Crohin, Jim McBride, Takanori Tsuji, R. Bruce Donoff, Marshall Posner, Randy Todd, and David T.W. Wong
Cancer Res 1999 59: 4142-4147. [Abstract] [Full Text] [PDF]  

Cell Cycle Arrest and Inhibition of Anoikis by Galectin-3 in Human Breast Epithelial Cells

Hyeong-Reh Choi Kim, Huei-Min Lin, Hector Biliran, and Avraham Raz
Cancer Res 1999 59: 4148-4154. [Abstract] [Full Text] [PDF]  

Errata:

H. Matsumoto et al., Cancer Res., 59: 3239–3244, 1999.

Cancer Res 1999 59: 4155-4158. [Full Text] [PDF]  

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