Perspectives in Cancer Research:

On the Prevention and Therapy of Prostate Cancer by Androgen Administration

Richmond T. Prehn
Cancer Res 1999 59: 4161-4164. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Mutational Analysis of the p63/p73L/p51/p40/CUSP/KET Gene in Human Cancer Cell Lines Using Intronic Primers

Koichi Hagiwara, Mary G. McMenamin, Ko Miura, and Curtis C. Harris
Cancer Res 1999 59: 4165-4169. [Abstract] [Full Text] [PDF]  

Alterations of the PPP1R3 Gene in Human Cancer

Takashi Kohno, Satoshi Takakura, Tatsuya Yamada, Aikou Okamoto, Tadao Tanaka, and Jun Yokota
Cancer Res 1999 59: 4170-4174. [Abstract] [Full Text] [PDF]  

Telomerase-negative Immortalized Human Cells Contain a Novel Type of Promyelocytic Leukemia (PML) Body

Thomas R. Yeager, Axel A. Neumann, Anna Englezou, Lily I. Huschtscha, Jane R. Noble, and Roger R. Reddel
Cancer Res 1999 59: 4175-4179. [Abstract] [Full Text] [PDF]  

Prostate-localized and Androgen-regulated Expression of the Membrane-bound Serine Protease TMPRSS2

Biaoyang Lin, Camari Ferguson, James T. White, Shunyou Wang, Robert Vessella, Lawrence D. True, Leroy Hood, and Peter S. Nelson
Cancer Res 1999 59: 4180-4184. [Abstract] [Full Text] [PDF]  

Ultraviolet Radiation Induces p16^CDKN2A Expression in Human Skin

Sandra Pavey, Sinead Conroy, Terry Russell, and Brian Gabrielli
Cancer Res 1999 59: 4185-4189. [Abstract] [Full Text] [PDF]  

Expression of the Steroid Receptor RNA Activator in Human Breast Tumors

Etienne Leygue, Helmut Dotzlaw, Peter H. Watson, and Leigh C. Murphy
Cancer Res 1999 59: 4190-4193. [Abstract] [Full Text] [PDF]  

Metallothionein Is Overexpressed by Hamster Fibroblasts Selected for Growth in 15 pM Folinic Acid and Provides a Growth Advantage in Low Folate

Wei-Yong Zhu and Peter W. Melera
Cancer Res 1999 59: 4194-4199. [Abstract] [Full Text] [PDF]  

The Addition of Adenovirus Type 5 Region E3 Enables Calydon Virus 787 to Eliminate Distant Prostate Tumor Xenografts

De-Chao Yu, Yu Chen, Monica Seng, Jeanette Dilley, and Daniel R. Henderson
Cancer Res 1999 59: 4200-4203. [Abstract] [Full Text] [PDF]  

Overexpression of Ribonucleotide Reductase as a Mechanism of Resistance to 2,2-Difluorodeoxycytidine in the Human KB Cancer Cell Line

Yih-Gang Goan, Bingsen Zhou, Edward Hu, Shu Mi, and Yun Yen
Cancer Res 1999 59: 4204-4207. [Abstract] [Full Text] [PDF]  

Activation of the PI3'K-AKT Pathway Masks the Proapoptotic Effects of Farnesyltransferase Inhibitors

Wei Du, Aixue Liu, and George C. Prendergast
Cancer Res 1999 59: 4208-4212. [Abstract] [Full Text] [PDF]  

Frequent Frameshift Mutations of the TCF-4 Gene in Colorectal Cancers with Microsatellite Instability

Alex Duval, Jacqueline Gayet, Xiao-Ping Zhou, Barry Iacopetta, Gilles Thomas, and Richard Hamelin
Cancer Res 1999 59: 4213-4215. [Abstract] [Full Text] [PDF]  

Four New Colon Cancer Susceptibility Loci, Scc6 to Scc9 in the Mouse

Tom van Wezel, Claudia A. L. Ruivenkamp, Alphons P. M. Stassen, Corina J. A. Moen, and Peter Demant
Cancer Res 1999 59: 4216-4218. [Abstract] [Full Text] [PDF]  

Heat Shock Cognate 70 Mutations in Sporadic Breast Carcinoma

Christopher J. Bakkenist, John Koreth, Cory S. M. Williams, Nicholas C. A. Hunt, and James O. McGee
Cancer Res 1999 59: 4219-4221. [Abstract] [Full Text] [PDF]  

Absence of Genetic Alteration at Codon 531 of the Human c-src Gene in 479 Advanced Colorectal Cancers from Japanese and Caucasian Patients

Yataro Daigo, Yoichi Furukawa, Teru Kawasoe, Hideyuki Ishiguro, Manabu Fujita, Sachiko Sugai, Shoji Nakamori, Gerrit-Jan Liefers, Rob A. E. M. Tollenaar, Cornelis J. H. van de Velde, and Yusuke Nakamura
Cancer Res 1999 59: 4222-4224. [Abstract] [Full Text] [PDF]  

Correlation between Expression of the Matrix Metalloproteinase-1 Gene in Ovarian Cancers and an Insertion/Deletion Polymorphism in Its Promoter Region

Yasunobu Kanamori, Mieko Matsushima, Takeo Minaguchi, Kanji Kobayashi, Satoru Sagae, Ryuichi Kudo, Naoki Terakawa, and Yusuke Nakamura
Cancer Res 1999 59: 4225-4227. [Abstract] [Full Text] [PDF]  

Reactivation of Insulin-like Growth Factor Binding Protein 2 Expression in Glioblastoma Multiforme: A Revelation by Parallel Gene Expression Profiling

Gregory N. Fuller, Chang Hun Rhee, Kenneth R. Hess, Laura S. Caskey, Ruoping Wang, Janet M. Bruner, W. K. Alfred Yung, and Wei Zhang
Cancer Res 1999 59: 4228-4232. [Abstract] [Full Text] [PDF]  

Distinct Expression Patterns of the p53-Homologue p73 in Malignant and Normal Hematopoiesis Assessed by a Novel Real-Time Reverse Transcription-Polymerase Chain Reaction Assay and Protein Analysis

Uwe R. Peters, Mario P. Tschan, Karl A. Kreuzer, Gökben Baskaynak, Ulrich Lass, Andreas Tobler, Martin F. Fey, and Christian A. Schmidt
Cancer Res 1999 59: 4233-4236. [Abstract] [Full Text] [PDF]  

The Mouse Bcrp1/Mxr/Abcp Gene: Amplification and Overexpression in Cell Lines Selected for Resistance to Topotecan, Mitoxantrone, or Doxorubicin

John D. Allen, Remco F. Brinkhuis, Jan Wijnholds, and Alfred H. Schinkel
Cancer Res 1999 59: 4237-4241. [Abstract] [Full Text] [PDF]  

A Single Targeted Ets2 Allele Restricts Development of Mammary Tumors in Transgenic Mice

Nickolay Neznanov, Albert K. Man, Hideyuki Yamamoto, Craig A. Hauser, Robert D. Cardiff, and Robert G. Oshima
Cancer Res 1999 59: 4242-4246. [Abstract] [Full Text] [PDF]  

Wild-Type p53 Induction Mediated by Replication-deficient Adenoviral Vectors

Christina R. McPake, Sheetal Shetty, Geoffrey R. Kitchingman, and Linda C. Harris
Cancer Res 1999 59: 4247-4251. [Abstract] [Full Text] [PDF]  

Prostase/KLK-L1 Is a New Member of the Human Kallikrein Gene Family, Is Expressed in Prostate and Breast Tissues, and Is Hormonally Regulated

George M. Yousef, Christina V. Obiezu, Liu-Ying Luo, Margot H. Black, and Eleftherios P. Diamandis
Cancer Res 1999 59: 4252-4256. [Abstract] [Full Text] [PDF]  

Frequent Somatic Mutations of the ß-Catenin Gene in Intestinal-Type Gastric Cancer

Won Sang Park, Ro Ra Oh, Jik Young Park, Sug Hyung Lee, Min Sun Shin, Young Sil Kim, Su Young Kim, Hyun Kyung Lee, Pum Joon Kim, Seong Taek Oh, Nam Jin Yoo, and Jung Young Lee
Cancer Res 1999 59: 4257-4260. [Abstract] [Full Text] [PDF]  

AF17q25, a Putative Septin Family Gene, Fuses the MLL Gene in Acute Myeloid Leukemia with t(11;17)(q23;q25)

Tomohiko Taki, Hiroaki Ohnishi, Kenji Shinohara, Masahiro Sako, Fumio Bessho, Masayoshi Yanagisawa, and Yasuhide Hayashi
Cancer Res 1999 59: 4261-4265. [Abstract] [Full Text] [PDF]  

Sp3, but not Sp1, Mediates the Transcriptional Activation of the p21/WAF1/Cip1 Gene Promoter by Histone Deacetylase Inhibitor

Yoshihiro Sowa, Tetsuro Orita, Sachie Minamikawa-Hiranabe, Takakazu Mizuno, Hitoshi Nomura, and Toshiyuki Sakai
Cancer Res 1999 59: 4266-4270. [Abstract] [Full Text] [PDF]  

Biochemistry:

Mode of Action of a New Indolocarbazole Anticancer Agent, J-107088, Targeting Topoisomerase I

Tomoko Yoshinari, Mitsuru Ohkubo, Kazuhiro Fukasawa, Shin-ichirou Egashira, Yoshikazu Hara, Mami Matsumoto, Kiyoshi Nakai, Hiroharu Arakawa, Hajime Morishima, and Susumu Nishimura
Cancer Res 1999 59: 4271-4275. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Murine Mammary Gland Carcinogenesis Is Critically Dependent on Progesterone Receptor Function

John P. Lydon, Gouqing Ge, Francis S. Kittrell, Daniel Medina, and Bert W. O’Malley
Cancer Res 1999 59: 4276-4284. [Abstract] [Full Text] [PDF]  

Patterns of DNA Adduct Formation in Liver and Mammary Epithelial Cells of Rats Treated with 7,12-Dimethylbenz(a)anthracene, and Selective Effects of Chemopreventive Agents

Alberto Izzotti, Anna Camoirano, Cristina Cartiglia, Clinton J. Grubbs, Ronald A. Lubet, Gary J. Kelloff, and Silvio De Flora
Cancer Res 1999 59: 4285-4290. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Loss of PTEN Expression in Paraffin-embedded Primary Prostate Cancer Correlates with High Gleason Score and Advanced Stage

Máirín E. McMenamin, Peggy Soung, Sauni Perera, Irving Kaplan, Massimo Loda, and William R. Sellers
Cancer Res 1999 59: 4291-4296. [Abstract] [Full Text] [PDF]  

Effect of c-kit Mutation on Prognosis of Gastrointestinal Stromal Tumors

Masahiko Taniguchi, Toshirou Nishida, Seiichi Hirota, Koji Isozaki, Toshinori Ito, Taisei Nomura, Hikaru Matsuda, and Yukihiko Kitamura
Cancer Res 1999 59: 4297-4300. [Abstract] [Full Text] [PDF]  

High Telomerase Reverse Transcriptase (hTERT) Messenger RNA Level Correlates with Tumor Recurrence in Patients with Favorable Histology Wilms’ Tumor

Jeffrey S. Dome, Seung Chung, Tracy Bergemann, Christopher B. Umbricht, Motoyasu Saji, Lisa A. Carey, Paul E. Grundy, Elizabeth J. Perlman, Norman E. Breslow, and Saraswati Sukumar
Cancer Res 1999 59: 4301-4307. [Abstract] [Full Text] [PDF]  

Endocrinology:

The Interaction of Raloxifene and the Active Metabolite of the Antiestrogen EM-800 (SC 5705) with the Human Estrogen Receptor

Jennifer I. MacGregor Schafer, Hong Liu, Debra A. Tonetti, and V. Craig Jordan
Cancer Res 1999 59: 4308-4313. [Abstract] [Full Text] [PDF]  

Altered Ligand Binding by Insulin-like Growth Factor II/Mannose 6-Phosphate Receptors Bearing Missense Mutations in Human Cancers

Gayathri R. Devi, Angus T. De Souza, James C. Byrd, Randy L. Jirtle, and Richard G. MacDonald
Cancer Res 1999 59: 4314-4319. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Well-done, Grilled Red Meat Increases the Risk of Colorectal Adenomas

Rashmi Sinha, Wong Ho Chow, Martin Kulldorff, John Denobile, James Butler, Montserrat Garcia-Closas, Rusty Weil, Robert N. Hoover, and Nathaniel Rothman
Cancer Res 1999 59: 4320-4324. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Inhibition of Cancer Cell Growth by Polyinosinic-Polycytidylic Acid/Cationic Liposome Complex: A New Biological Activity

Kazuko Hirabayashi, Junichi Yano, Toshihiko Inoue, Tohru Yamaguchi, Kazuaki Tanigawara, Gerald E. Smyth, Kouichi Ishiyama, Tadaaki Ohgi, Kiyoshi Kimura, and Tatsuro Irimura
Cancer Res 1999 59: 4325-4333. [Abstract] [Full Text] [PDF]  

Photofrin-mediated Photodynamic Therapy Induces Vascular Occlusion and Apoptosis in a Human Sarcoma Xenograft Model

Brett W. Engbrecht, Chandrakala Menon, Alexander V. Kachur, Stephen M. Hahn, and Douglas L. Fraker
Cancer Res 1999 59: 4334-4342. [Abstract] [Full Text] [PDF]  

Apoptosis Induction by a Novel Anti-Prostate Cancer Compound, BMD188 (a Fatty Acid-containing Hydroxamic Acid), Requires the Mitochondrial Respiratory Chain

Bindu Joshi, Li Li, Bonita G. Taffe, Zhenyu Zhu, Sharon Wahl, Hongsheng Tian, Edgar Ben-Josef, John D. Taylor, Arthur T. Porter, and Dean G. Tang
Cancer Res 1999 59: 4343-4355. [Abstract] [Full Text] [PDF]  

Increased Cyclooxygenase-2 Expression in Human Pancreatic Carcinomas and Cell Lines: Growth Inhibition by Nonsteroidal Anti-Inflammatory Drugs

Miguel A. Molina, Marta Sitja-Arnau, Michael G. Lemoine, Marsha L. Frazier, and Frank A. Sinicrope
Cancer Res 1999 59: 4356-4362. [Abstract] [Full Text] [PDF]  

Direct Demonstration in Synthetic Oligonucleotides that N,N'-Bis(2-chloroethyl)-nitrosourea Cross-Links N¹ of Deoxyguanosine to N³ of Deoxycytidine on Opposite Strands of Duplex DNA

Paula L. Fischhaber, Anna S. Gall, James A. Duncan, and Paul B. Hopkins
Cancer Res 1999 59: 4363-4368. [Abstract] [Full Text] [PDF]  

p53 Selective and Nonselective Replication of an E1B-deleted Adenovirus in Hepatocellular Carcinoma

Charles M. Vollmer, Antoni Ribas, Lisa H. Butterfield, Vivian B. Dissette, Kahlil J. Andrews, Fritz C. Eilber, Lara D. Montejo, Angela Y. Chen, Billy Hu, John A. Glaspy, William H. McBride, and James S. Economou
Cancer Res 1999 59: 4369-4374. [Abstract] [Full Text] [PDF]  

Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine

Jann N. Sarkaria, Ericka C. Busby, Randal S. Tibbetts, Pia Roos, Yoichi Taya, Larry M. Karnitz, and Robert T. Abraham
Cancer Res 1999 59: 4375-4382. [Abstract] [Full Text] [PDF]  

Glioma Cells Release Excitotoxic Concentrations of Glutamate

Zu-Cheng Ye and Harald Sontheimer
Cancer Res 1999 59: 4383-4391. [Abstract] [Full Text] [PDF]  

Hybrid Polar Histone Deacetylase Inhibitor Induces Apoptosis and CD95/CD95 Ligand Expression in Human Neuroblastoma

Richard D. Glick, Steven L. Swendeman, Dennis C. Coffey, Richard A. Rifkind, Paul A. Marks, Victoria M. Richon, and Michael P. La Quaglia
Cancer Res 1999 59: 4392-4399. [Abstract] [Full Text] [PDF]  

Pretargeting of Renal Cell Carcinoma: Improved Tumor Targeting with a Bivalent Chelate

Otto C. Boerman, Marion H. G. C. Kranenborg, Egbert Oosterwijk, Gary L. Griffiths, William J. McBride, Wim J. G. Oyen, Mirjam de Weijert, Jeannette Oosterwijk-Wakka, Hans J. Hansen, and Frans H. M. Corstens
Cancer Res 1999 59: 4400-4405. [Abstract] [Full Text] [PDF]  

Decrease in Susceptibility Toward Induction of Apoptosis and Alteration in G₁ Checkpoint Function as Determinants of Resistance of Human Lung Cancer Cells against the Antisignaling Drug UCN-01 (7-Hydroxystaurosporine)

Kazuyo Sugiyama, Tadakazu Akiyama, Makiko Shimizu, Tatsuya Tamaoki, Carol Courage, Andreas Gescher, and Shiro Akinaga
Cancer Res 1999 59: 4406-4412. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Protein Kinase C Lies on the Signaling Pathway for Vascular Endothelial Growth Factor-mediated Tumor Development and Angiogenesis

Hitoshi Yoshiji, Shigeki Kuriyama, D. Kirk Ways, Junichi Yoshii, Yoji Miyamoto, Mitsuhiro Kawata, Yasuhide Ikenaka, Hirohisa Tsujinoue, Toshiya Nakatani, Masabumi Shibuya, and Hiroshi Fukui
Cancer Res 1999 59: 4413-4418. [Abstract] [Full Text] [PDF]  

The Role of Hyaluronan and Interleukin 8 in the Migration of Chronic Lymphocytic Leukemia Cells within Lymphoreticular Tissues

Kathleen J. Till, Mirko Zuzel, and John C. Cawley
Cancer Res 1999 59: 4419-4426. [Abstract] [Full Text] [PDF]  

CD44 Stimulation Induces Integrin-mediated Adhesion of Colon Cancer Cell Lines to Endothelial Cells by Up-Regulation of Integrins and c-Met and Activation of Integrins

Takeshi Fujisaki, Yoshiya Tanaka, Koichi Fujii, Shinichiro Mine, Kazuyoshi Saito, Shinwa Yamada, Uki Yamashita, Tatsuro Irimura, and Sumiya Eto
Cancer Res 1999 59: 4427-4434. [Abstract] [Full Text] [PDF]  

Cloning of Tumor-associated Differentially Expressed Gene-14, a Novel Serine Protease Overexpressed by Ovarian Carcinoma

Lowell J. Underwood, Hirotoshi Tanimoto, Yinxiang Wang, Kazushi Shigemasa, Tim H. Parmley, and Timothy J. O’Brien
Cancer Res 1999 59: 4435-4439. [Abstract] [Full Text] [PDF]  

Regulation of the Urokinase-type Plasminogen Activator System by the von Hippel-Lindau Tumor Suppressor Gene

Maartje Los, Saida Zeamari, John A. Foekens, Martijn F. B. G. Gebbink, and Emile E. Voest
Cancer Res 1999 59: 4440-4445. [Abstract] [Full Text] [PDF]  

Inhibition of Nuclear Factor-B Activation Confers Sensitivity to Tumor Necrosis Factor- by Impairment of Cell Cycle Progression in Human Glioma Cells

Goro Otsuka, Takashi Nagaya, Kiyoshi Saito, Masaaki Mizuno, Jun Yoshida, and Hisao Seo
Cancer Res 1999 59: 4446-4452. [Abstract] [Full Text] [PDF]  

Osteonectin Promotes Prostate Cancer Cell Migration and Invasion: A Possible Mechanism for Metastasis to Bone

Karin Jacob, Mukta Webber, Dafna Benayahu, and Hynda K. Kleinman
Cancer Res 1999 59: 4453-4457. [Abstract] [Full Text] [PDF]  

Cellular Membrane Permeability of Anthracyclines Does Not Correlate with Their Delivery in a Tissue-isolated Tumor

Marc Heijn, Sylvie Roberge, and Rakesh K. Jain
Cancer Res 1999 59: 4458-4463. [Abstract] [Full Text] [PDF]  

Identification of Bladder Tumor-derived Hyaluronidase: Its Similarity to HYAL1

Vinata B. Lokeshwar, Marvin J. Young, Gulten Goudarzi, Naoko Iida, Ashley I. Yudin, Gary N. Cherr, and Marie G. Selzer
Cancer Res 1999 59: 4464-4470. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: Y. Chen et al., DNA Vaccines Encoding Full-Length or Truncated Neu Induce Protective Immunity against Neu-expressing Mammary Tumors. Cancer Res., 58: 1965–1971, 1998.

Roberta De Vecchi, Serenella M. Pupa, Sylvie Ménard, Pier-Luigi Lollini, and Thomas J. Kipps
Cancer Res 1999 59: 4471-4472. [Full Text] [PDF]  

Errata:

July 1, 1999 Cancer Research cover legend

Cancer Res 1999 59: 4473-4476. [Full Text] [PDF]  

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