Perspectives in Cancer Research:

Cancer Anorexia-Cachexia Syndrome: Are Neuropeptides the Key?

Akio Inui
Cancer Res 1999 59: 4493-4501. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Cripto-1 Induces Phosphatidylinositol 3'-Kinase-dependent Phosphorylation of AKT and Glycogen Synthase Kinase 3ß in Human Cervical Carcinoma Cells

Andreas D. Ebert, Christian Wechselberger, Stephan Frank, Brenda Wallace-Jones, Masaharu Seno, Isabel Martinez-Lacaci, Caterina Bianco, Marta De Santis, Hans K. Weitzel, and David S. Salomon
Cancer Res 1999 59: 4502-4505. [Abstract] [Full Text] [PDF]  

Frequent Mutation of ß-Catenin and APC Genes in Primary Colorectal Tumors from Patients with Hereditary Nonpolyposis Colorectal Cancer

Michiko Miyaki, Takeru Iijima, Junko Kimura, Masamichi Yasuno, Takeo Mori, Yukiko Hayashi, Morio Koike, Nobuyuki Shitara, Takeo Iwama, and Toshio Kuroki
Cancer Res 1999 59: 4506-4509. [Abstract] [Full Text] [PDF]  

The Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Is a ß-Adrenergic Agonist and Stimulates DNA Synthesis in Lung Adenocarcinoma via ß-Adrenergic Receptor-mediated Release of Arachidonic Acid

Hildegard M. Schuller, Patricia K. Tithof, Michelle Williams, and Howard Plummer, III
Cancer Res 1999 59: 4510-4515. [Abstract] [Full Text] [PDF]  

Essential Role of Tumor Necrosis Factor (TNF-) in Tumor Promotion as Revealed by TNF--deficient Mice

Masami Suganuma, Sachiko Okabe, Michael W. Marino, Ayako Sakai, Eisaburo Sueoka, and Hirota Fujiki
Cancer Res 1999 59: 4516-4518. [Abstract] [Full Text] [PDF]  

Two Organochlorine Pesticides, Toxaphene and Chlordane, Are Antagonists for Estrogen-related Receptor -1 Orphan Receptor

Chun Yang and Shiuan Chen
Cancer Res 1999 59: 4519-4524. [Abstract] [Full Text] [PDF]  

Hypoxic Cervical Cancers with Low Apoptotic Index Are Highly Aggressive

Michael Höckel, Karlheinz Schlenger, Susanne Höckel, and Peter Vaupel
Cancer Res 1999 59: 4525-4528. [Abstract] [Full Text] [PDF]  

Cell Cycle Checkpoint Abrogator UCN-01 Inhibits DNA Repair: Association with Attenuation of the Interaction of XPA and ERCC1 Nucleotide Excision Repair Proteins

Hong Jiang and Li-Ying Yang
Cancer Res 1999 59: 4529-4534. [Abstract] [Full Text] [PDF]  

Inactivation of CACNA1G, a T-Type Calcium Channel Gene, by Aberrant Methylation of Its 5' CpG Island in Human Tumors

Minoru Toyota, Coty Ho, Mutsumi Ohe-Toyota, Stephen B. Baylin, and Jean-Pierre J. Issa
Cancer Res 1999 59: 4535-4541. [Abstract] [Full Text] [PDF]  

Preoperative Diagnosis of Thyroid Papillary and Anaplastic Carcinomas by Real-Time Quantitative Reverse Transcription-Polymerase Chain Reaction of Oncofetal Fibronectin Messenger RNA

Toru Takano, Akira Miyauchi, Tamotsu Yokozawa, Fumio Matsuzuka, Ikuhiro Maeda, Kanji Kuma, and Nobuyuki Amino
Cancer Res 1999 59: 4542-4545. [Abstract] [Full Text] [PDF]  

14q32 Translocations and Monosomy 13 Observed in Monoclonal Gammopathy of Undetermined Significance Delineate a Multistep Process for the Oncogenesis of Multiple Myeloma

Hervé Avet-Loiseau, Thierry Facon, Axelle Daviet, Catherine Godon, Marie-José Rapp, Jean-Luc Harousseau, Bernard Grosbois, and Régis Bataille
Cancer Res 1999 59: 4546-4550. [Abstract] [Full Text] [PDF]  

Inhibition of Epidermal Growth Factor-induced Interleukin-1ß-converting Enzyme Expression Reduces Proliferation in the Pancreatic Carcinoma Cell Line AsPC-1

Sophia Schlosser, Frank Gansauge, Thomas Schnelldorfer, Marco Ramadani, Andreas Schwarz, Hans-Günther Beger, and Susanne Gansauge
Cancer Res 1999 59: 4551-4554. [Abstract] [Full Text] [PDF]  

Stromal Cell Oxidation: A Mechanism by Which Tumors Obtain Vitamin C

David B. Agus, Juan C. Vera, and David W. Golde
Cancer Res 1999 59: 4555-4558. [Abstract] [Full Text] [PDF]  

Overexpression of the BCRP/MXR/ABCP Gene in a Topotecan-selected Ovarian Tumor Cell Line

Marc Maliepaard, Margôt A. van Gastelen, Laurina A. de Jong, Dick Pluim, Robert C. A. M. van Waardenburg, Marjan C. Ruevekamp-Helmers, Ben G. J. Floot, and Jan H. M. Schellens
Cancer Res 1999 59: 4559-4563. [Abstract] [Full Text] [PDF]  

Characterization of the Human Rad51 Genomic Locus and Examination of Tumors with 15q14–15 Loss of Heterozygosity (LOH)

Christoph Schmutte, Gregory Tombline, Kerstin Rhiem, Margaret M. Sadoff, Rita Schmutzler, Andreas von Deimling, and Richard Fishel
Cancer Res 1999 59: 4564-4569. [Abstract] [Full Text] [PDF]  

k-ras Mutation and Occupational Asbestos Exposure in Lung Adenocarcinoma: Asbestos-related Cancer without Asbestosis

Heather H. Nelson, David C. Christiani, John K. Wiencke, Eugene J. Mark, John C. Wain, and Karl T. Kelsey
Cancer Res 1999 59: 4570-4573. [Abstract] [Full Text] [PDF]  

Thromboxane A₂ Is a Mediator of Cyclooxygenase-2-dependent Endothelial Migration and Angiogenesis

Thomas O. Daniel, Hua Liu, Jason D. Morrow, Brenda C. Crews, and Lawrence J. Marnett
Cancer Res 1999 59: 4574-4577. [Abstract] [Full Text] [PDF]  

Biochemistry:

Targeting Sigma Receptor-binding Benzamides as in Vivo Diagnostic and Therapeutic Agents for Human Prostate Tumors

Christy S. John, Bertold J. Vilner, Brian C. Geyer, Terry Moody, and Wayne D. Bowen
Cancer Res 1999 59: 4578-4583. [Abstract] [Full Text] [PDF]  

Identification of CD47/Integrin-associated Protein and vß3 as Two Receptors for the 3(IV) Chain of Type IV Collagen on Tumor Cells

Tracy A. Shahan, Zahra Ziaie, Sylvie Pasco, Abdelilah Fawzi, Georges Bellon, Jean-Claude Monboisse, and Nicholas A. Kefalides
Cancer Res 1999 59: 4584-4590. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Time Course for Early Adaptive Responses to Ultraviolet B Light in the Epidermis of SKH-1 Mice

Yao-Ping Lu, You-Rong Lou, Patricia Yen, David Mitchell, Mou-Tuan Huang, and Allan H. Conney
Cancer Res 1999 59: 4591-4602. [Abstract] [Full Text] [PDF]  

The K-Region trans-8,9-Diol Does Not Significantly Contribute as an Intermediate in the Metabolic Activation of Dibenzo[a,l]pyrene to DNA-binding Metabolites by Human Cytochrome P450 1A1 or 1B1

Andreas Luch, Shirley Kishiyama, Albrecht Seidel, Johannes Doehmer, Helmut Greim, and William M. Baird
Cancer Res 1999 59: 4603-4609. [Abstract] [Full Text] [PDF]  

Inhibition of Activator Protein 1 Activity and Cell Growth by Purified Green Tea and Black Tea Polyphenols in H-ras-transformed Cells: Structure-Activity Relationship and Mechanisms Involved

Jee Y. Chung, Chuanshu Huang, Xiaofeng Meng, Zigang Dong, and Chung S. Yang
Cancer Res 1999 59: 4610-4617. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Adenovirus-mediated Human Topoisomerase II Gene Transfer Increases the Sensitivity of Etoposide-resistant Human Breast Cancer Cells

Zhichao Zhou, Leonard A. Zwelling, Yasuhiko Kawakami, Taeha An, Kunihisa Kobayashi, Cynthia Herzog, and Eugenie S. Kleinerman
Cancer Res 1999 59: 4618-4624. [Abstract] [Full Text] [PDF]  

Taxol Affects Nuclear Lamina and Pore Complex Organization and Inhibits Import of Karyophilic Proteins into the Cell Nucleus

Panayiotis A. Theodoropoulos, Hara Polioudaki, Olga Kostaki, Stavros P. Derdas, Vassilis Georgoulias, Catherine Dargemont, and Spyros D. Georgatos
Cancer Res 1999 59: 4625-4633. [Abstract] [Full Text] [PDF]  

Down-Regulation of Cyclin D1 by Transcriptional Repression in MCF-7 Human Breast Carcinoma Cells Induced by Flavopiridol

Brad Carlson, Tyler Lahusen, Sheo Singh, Andrea Loaiza-Perez, Peter J. Worland, Richard Pestell, Chris Albanese, Edward A. Sausville, and Adrian M. Senderowicz
Cancer Res 1999 59: 4634-4641. [Abstract] [Full Text] [PDF]  

Immunology:

Small Cell Lung Carcinomas Express Shared and Private Tumor Antigens Presented by HLA-A1 or HLA-A2

Koichi Yamazaki, Gina Spruill, Joseph Rhoderick, Julie Spielman, Niramol Savaraj, and Eckhard R. Podack
Cancer Res 1999 59: 4642-4650. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Identification of Genetic Loci Controlling Hepatocarcinogenesis on Rat Chromosomes 7 and 10

Maria R. De Miglio, Federico Canzian, Rosa M. Pascale, Maria M. Simile, Maria R. Muroni, Diego Calvisi, Giovanni Romeo, and Francesco Feo
Cancer Res 1999 59: 4651-4657. [Abstract] [Full Text] [PDF]  

Chromosomal Imbalances in Noninvasive Papillary Bladder Neoplasms (pTa)

Jianming Zhao, Jan Richter, Urs Wagner, Beat Roth, Peter Schraml, Tobias Zellweger, Daniel Ackermann, Ulrico Schmid, Holger Moch, Michael J. Mihatsch, Thomas C. Gasser, and Guido Sauter
Cancer Res 1999 59: 4658-4661. [Abstract] [Full Text] [PDF]  

Detailed Genetic and Physical Mapping of Tumor Suppressor Loci on Chromosome 3p in Ovarian Cancer

Paul Fullwood, Sergio Marchini, Janet S. Rader, Alonso Martinez, Donia Macartney, Massimo Broggini, Cristina Morelli, Giuseppe Barbanti-Brodano, Eamonn R. Maher, and Farida Latif
Cancer Res 1999 59: 4662-4667. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Sensitization of Tumor Necrosis Factor -resistant Human Melanoma by Tumor-specific in Vivo Transfer of the Gene Encoding Endothelial Monocyte-activating Polypeptide II Using Recombinant Vaccinia Virus

Michael F. X. Gnant, Adam C. Berger, James Huang, Markus Puhlmann, Peter C. Wu, Maria J. Merino, David L. Bartlett, H. Richard Alexander, and Steven K. Libutti
Cancer Res 1999 59: 4668-4674. [Abstract] [Full Text] [PDF]  

Expression of a Novel Factor in Human Breast Cancer Cells with Metastatic Potential

Anne Hansen Ree, Marianne Tvermyr, Olav Engebraaten, Marianne Rooman, Øystein Røsok, Eivind Hovig, Leonardo A. Meza-Zepeda, Øyvind S. Bruland, and Øystein Fodstad
Cancer Res 1999 59: 4675-4680. [Abstract] [Full Text] [PDF]  

Elevated Expression of the CC Chemokine Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES) in Advanced Breast Carcinoma

Galia Luboshits, Sima Shina, Ofer Kaplan, Santiago Engelberg, Devora Nass, Beatriz Lifshitz-Mercer, Samario Chaitchik, Iafa Keydar, and Adit Ben-Baruch
Cancer Res 1999 59: 4681-4687. [Abstract] [Full Text] [PDF]  

13-Hydroxyoctadecadienoic Acid Is the Mitogenic Signal for Linoleic Acid-dependent Growth in Rat Hepatoma 7288CTC in Vivo

Leonard A. Sauer, Robert T. Dauchy, David E. Blask, Brenda J. Armstrong, and Simone Scalici
Cancer Res 1999 59: 4688-4692. [Abstract] [Full Text] [PDF]  

Melatonin Inhibition of Cancer Growth in Vivo Involves Suppression of Tumor Fatty Acid Metabolism via Melatonin Receptor-mediated Signal Transduction Events

David E. Blask, Leonard A. Sauer, Robert T. Dauchy, Eugene W. Holowachuk, Mary S. Ruhoff, and Heather S. Kopff
Cancer Res 1999 59: 4693-4701. [Abstract] [Full Text] [PDF]  

S100A4 Involvement in Metastasis: Deregulation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases in Osteosarcoma Cells Transfected with an Anti-S100A4 Ribozyme

Kristin Bjørnland, Jan Olof Winberg, Olav Tobias Ødegaard, Eivind Hovig, Thrina Loennechen, Ansgar O. Aasen, Øystein Fodstad, and Gunhild Mari Mælandsmo
Cancer Res 1999 59: 4702-4708. [Abstract] [Full Text] [PDF]  

Glut-1 and Hexokinase Expression: Relationship with 2-Fluoro-2-deoxy-D-glucose Uptake in A431 and T47D Cells in Culture

Luigi Aloj, Corradina Caracó, Elaine Jagoda, William C. Eckelman, and Ronald D. Neumann
Cancer Res 1999 59: 4709-4714. [Abstract] [Full Text] [PDF]  

The Human Embryonal Carcinoma Marker Antigen TRA-1-60 Is a Sialylated Keratan Sulfate Proteoglycan

Graeme Badcock, Christine Pigott, John Goepel, and Peter W. Andrews
Cancer Res 1999 59: 4715-4719. [Abstract] [Full Text] [PDF]  

A Search for New Metabolites of N,N',N''-Triethylenethiophosphoramide

Maria J. van Maanen, Inge M. Tijhof, J. Mirjam A. Damen, Cees Versluis, Jantien J. Ketteness van den Bosch, Albert J. R. Heck, Sjoerd Rodenhuis, and Jos H. Beijnen
Cancer Res 1999 59: 4720-4724. [Abstract] [Full Text] [PDF]  

Contextual Effects of Transforming Growth Factor ß on the Tumorigenicity of Human Colon Carcinoma Cells

Sheng-Chun Ye, Jason M. Foster, WenHui Li, JiuRong Liang, Elizabeth Zborowska, Srinivas Venkateswarlu, JianGen Gong, Michael G. Brattain, and James K. V. Willson
Cancer Res 1999 59: 4725-4731. [Abstract] [Full Text] [PDF]  

Dual Mechanisms for Lysophospholipid Induction of Proliferation of Human Breast Carcinoma Cells

Edward J. Goetzl, Hana Dolezalova, Yvonne Kong, and Li Zeng
Cancer Res 1999 59: 4732-4737. [Abstract] [Full Text] [PDF]  

Errata:

R. Sinha et al., Cancer Research 59: 4320–4324, 1999

Cancer Res 1999 59: 4738-4741. [Full Text] [PDF]  

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