Public Issues:

Prevention of Cancer in the Next Millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research

Cancer Res 1999 59: 4743-4758. [Full Text] [PDF]  

Perspectives in Cancer Research:

Application of Complementary DNA Microarray Technology to Carcinogen Identification, Toxicology, and Drug Safety Evaluation

Cynthia A. Afshari, Emile F. Nuwaysir, and J. Carl Barrett
Cancer Res 1999 59: 4759-4760. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Response of Prostate Cancer to Anti-Her-2/neu Antibody in Androgen-dependent and -independent Human Xenograft Models

David B. Agus, Howard I. Scher, Brian Higgins, William D. Fox, Glenn Heller, Melissa Fazzari, Carlos Cordon-Cardo, and David W. Golde
Cancer Res 1999 59: 4761-4764. [Abstract] [Full Text] [PDF]  

Dominant-Negative Mutations of the Tumor Suppressor p53 Relating to Early Onset of Glioblastoma Multiforme

Masumi Marutani, Hidefumi Tonoki, Mitsuhiro Tada, Masato Takahashi, Haruhiko Kashiwazaki, Yasuhiro Hida, Jun-ich Hamada, Masahiro Asaka, and Tetsuya Moriuchi
Cancer Res 1999 59: 4765-4769. [Abstract] [Full Text] [PDF]  

Tumor Development under Angiogenic Signaling: A Dynamical Theory of Tumor Growth, Treatment Response, and Postvascular Dormancy

Philip Hahnfeldt, Dipak Panigrahy, Judah Folkman, and Lynn Hlatky
Cancer Res 1999 59: 4770-4775. [Abstract] [Full Text] [PDF]  

Addition of Peroxisome Proliferator-activated Receptor to Guinea Pig Hepatocytes Confers Increased Responsiveness to Peroxisome Proliferators

Neil Macdonald, Peter R. Holden, and Ruth A. Roberts
Cancer Res 1999 59: 4776-4780. [Abstract] [Full Text] [PDF]  

Solid Tissues Removed from Atm Homozygous Deficient Mice Do Not Exhibit a Mutator Phenotype for Second-Step Autosomal Mutations

Mitchell S. Turker, Blythe M. Gage, Jennifer A. Rose, Olga N. Ponomareva, Jay A. Tischfield, Peter J. Stambrook, Carrolee Barlow, and Anthony Wynshaw-Boris
Cancer Res 1999 59: 4781-4783. [Abstract] [Full Text] [PDF]  

p53-Mutant Clones and Field Effects in Barrett’s Esophagus

Laura J. Prevo, Carissa A. Sanchez, Patricia C. Galipeau, and Brian J. Reid
Cancer Res 1999 59: 4784-4787. [Abstract] [Full Text] [PDF]  

Functional Activity of Ectopically Expressed Estrogen Receptor Is Not Sufficient for Estrogen-mediated Cyclin D1 Expression

Maricarmen D. Planas-Silva, Joana Liu Donaher, and Robert A. Weinberg
Cancer Res 1999 59: 4788-4792. [Abstract] [Full Text] [PDF]  

The Expression of a Truncated HMGI-C Gene Induces Gigantism Associated with Lipomatosis

Sabrina Battista, Vincenzo Fidanza, Monica Fedele, Andres J. P. Klein-Szanto, Eric Outwater, Han Brunner, Massimo Santoro, Carlo M. Croce, and Alfredo Fusco
Cancer Res 1999 59: 4793-4797. [Abstract] [Full Text] [PDF]  

Loss of Fhit Is Frequent in Stage I Non-Small Cell Lung Cancer and in the Lungs of Chronic Smokers

Jennifer E. Tseng, Bonnie L. Kemp, Fadlo R. Khuri, Jonathan M. Kurie, Jin Soo Lee, Xiao Zhou, Diane Liu, Waun Ki Hong, and Li Mao
Cancer Res 1999 59: 4798-4803. [Abstract] [Full Text] [PDF]  

Extracellular Signal-regulated Kinase Activation Is Required for Up-Regulation of Vascular Endothelial Growth Factor by Serum Starvation in Human Colon Carcinoma Cells

Young D. Jung, Kayo Nakano, Wenbiao Liu, Gary E. Gallick, and Lee M. Ellis
Cancer Res 1999 59: 4804-4807. [Abstract] [Full Text] [PDF]  

Biochemistry:

Decreased Sensitivity to 1-O-Octadecyl-2-O-methyl-glycerophosphocholine in MCF-7 Cells Adapted for Serum-free Growth Correlates with Constitutive Association of Raf-1 with Cellular Membranes

Pranati Samadder and Gilbert Arthur
Cancer Res 1999 59: 4808-4815. [Abstract] [Full Text] [PDF]  

Additivity of Dilantin and Vinblastine Inhibitory Effects on Microtubule Assembly

Sharon Lobert, Jeffrey W. Ingram, and John J. Correia
Cancer Res 1999 59: 4816-4822. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

High-Salt Diet Induces Gastric Epithelial Hyperplasia and Parietal Cell Loss, and Enhances Helicobacter pylori Colonization in C57BL/6 Mice

James G. Fox, Charles A. Dangler, Nancy S. Taylor, Amy King, Theodore J. Koh, and Timothy C. Wang
Cancer Res 1999 59: 4823-4828. [Abstract] [Full Text] [PDF]  

Tamoxifen-DNA Adduct Formation in Rat Liver Determined by Immunoassay and ³²P-Postlabeling

Rao L. Divi, Martin R. Osborne, Alan Hewer, David H. Phillips, and Miriam C. Poirier
Cancer Res 1999 59: 4829-4833. [Abstract] [Full Text] [PDF]  

Loss of Responsiveness to Transforming Growth Factor ß Induces Malignant Transformation of Nontumorigenic Rat Prostate Epithelial Cells

Binwu Tang, Katherine de Castro, Helen E. Barnes, W. Tony Parks, LaMonica Stewart, Erwin P. Böttinger, David Danielpour, and Lalage M. Wakefield
Cancer Res 1999 59: 4834-4842. [Abstract] [Full Text] [PDF]  

Extracellular Matrix and Radiation G₁ Cell Cycle Arrest in Human Fibroblasts

Mira Dimitrijevic-Bussod, Viviana S. Balzaretti-Maggi, and Donna M. Gadbois
Cancer Res 1999 59: 4843-4847. [Abstract] [Full Text] [PDF]  

Endocrinology:

Apoptosis Induced by Vitamin D Compounds in Breast Cancer Cells Is Inhibited by Bcl-2 but Does Not Involve Known Caspases or p53

Ida Stenfeldt Mathiasen, Ulrikm Lademann, and Marja Jäättelä
Cancer Res 1999 59: 4848-4856. [Abstract] [Full Text] [PDF]  

Effect of Combined Treatment with the Pure Antiestrogen EM-800 and Radiotherapy on the Growth of Human ZR-75-1 Breast Cancer Xenografts in Nude Mice

Steeve Couillard, Matthieu Gutman, Fernand Labrie, Bernard Candas, and Claude Labrie
Cancer Res 1999 59: 4857-4863. [Abstract] [Full Text] [PDF]  

Adrenal Androgens Stimulate the Proliferation of Breast Cancer Cells as Direct Activators of Estrogen Receptor

Marcello Maggiolini, Olivier Donzé, Elisabeth Jeannin, Sebastiano Andò, and Didier Picard
Cancer Res 1999 59: 4864-4869. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Breast Cancer Risk Associated with Genotype Polymorphism of the Estrogen-metabolizing Genes CYP17, CYP1A1, and COMT: A Multigenic Study on Cancer Susceptibility

Chiun-Sheng Huang, Herng-Der Chern, King-Jen Chang, Chun-Wen Cheng, Su-Ming Hsu, and Chen-Yang Shen
Cancer Res 1999 59: 4870-4875. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Antisense Cyclin D1 Induces Apoptosis and Tumor Shrinkage in Human Squamous Carcinomas

Edward R. Sauter, Mark Nesbit, Samuel Litwin, Andres J. P. Klein-Szanto, Susan Cheffetz, and Meenhard Herlyn
Cancer Res 1999 59: 4876-4881. [Abstract] [Full Text] [PDF]  

Hypoxia-mediated Apoptosis from Angiogenesis Inhibition Underlies Tumor Control by Recombinant Interleukin 12

Michael S. Gee, Cameron J. Koch, Sydney M. Evans, W. Timothy Jenkins, Charles H. Pletcher, Jr., Jonni S. Moore, Holly K. Koblish, Jungeun Lee, Edith M. Lord, Giorgio Trinchieri, and William M. F. Lee
Cancer Res 1999 59: 4882-4889. [Abstract] [Full Text] [PDF]  

Mouse Transporter Protein, a Membrane Protein That Regulates Cellular Multidrug Resistance, Is Localized to Lysosomes

Miguel A. Cabrita, Tom C. Hobman, Douglas L. Hogue, Karen M. King, and Carol E. Cass
Cancer Res 1999 59: 4890-4897. [Abstract] [Full Text] [PDF]  

Potent Topoisomerase I Inhibition by Novel Silatecans Eliminates Glioma Proliferation in Vitro and in Vivo

Ian F. Pollack, Melanie Erff, David Bom, Thomas G. Burke, J. Thompson Strode, and Dennis P. Curran
Cancer Res 1999 59: 4898-4905. [Abstract] [Full Text] [PDF]  

Application of the Cre Recombinase/loxP System Further Enhances Antitumor Effects in Cell Type-specific Gene Therapy against Carcinoembryonic Antigen-producing Cancer

Takashi Kijima, Tadashi Osaki, Kazumi Nishino, Toru Kumagai, Toshiki Funakoshi, Hiroyuki Goto, Isao Tachibana, Yoshiro Tanio, and Tadamitsu Kishimoto
Cancer Res 1999 59: 4906-4911. [Abstract] [Full Text] [PDF]  

Electromotive versus Passive Diffusion of Mitomycin C into Human Bladder Wall: Concentration-Depth Profiles Studies

Savino M. Di Stasi, Antonella Giannantoni, Renato Massoud, Susanna Dolci, Pierluigi Navarra, Giuseppe Vespasiani, and Robert L. Stephen
Cancer Res 1999 59: 4912-4918. [Abstract] [Full Text] [PDF]  

Antitumor Efficacy of a Novel Class of Non-thiol-containing Peptidomimetic Inhibitors of Farnesyltransferase and Geranylgeranyltransferase I: Combination Therapy with the Cytotoxic Agents Cisplatin, Taxol, and Gemcitabine

Jiazhi Sun, Michelle A. Blaskovich, David Knowles, Yimin Qian, Junko Ohkanda, Ratna D. Bailey, Andrew D. Hamilton, and Saïd M. Sebti
Cancer Res 1999 59: 4919-4926. [Abstract] [Full Text] [PDF]  

Transfection of 9-Hydroxyellipticine-resistant Chinese Hamster Fibroblasts with Human Topoisomerase II cDNA: Selective Restoration of the Sensitivity to DNA Religation Inhibitors

Tayeb Khélifa, Brigitte René, Sandrine Le Mée, Bernard Lambert, Jean-Marie Saucier, Judith Markovits, Hélène Jacquemin-Sablon, and Alain Jacquemin-Sablon
Cancer Res 1999 59: 4927-4936. [Abstract] [Full Text] [PDF]  

Arabinosylguanine-induced Apoptosis of T-Lymphoblastic Cells: Incorporation into DNA Is a Necessary Step

Carlos O. Rodriguez, Jr. and Varsha Gandhi
Cancer Res 1999 59: 4937-4943. [Abstract] [Full Text] [PDF]  

The Polyamine Oxidase Inhibitor MDL-72,527 Selectively Induces Apoptosis of Transformed Hematopoietic Cells through Lysosomotropic Effects

Haiqing Dai, Debora L. Kramer, Chunying Yang, K. Gopal Murti, Carl W. Porter, and John L. Cleveland
Cancer Res 1999 59: 4944-4954. [Abstract] [Full Text] [PDF]  

Immunology:

Modified Vaccinia Virus Ankara for Delivery of Human Tyrosinase as Melanoma-associated Antigen: Induction of Tyrosinase- and Melanoma-specific Human Leukocyte Antigen A*0201-restricted Cytotoxic T Cells in Vitro and in Vivo

Ingo Drexler, Edite Antunes, Marc Schmitz, Thomas Wölfel, Christoph Huber, Volker Erfle, Peter Rieber, Matthias Theobald, and Gerd Sutter
Cancer Res 1999 59: 4955-4963. [Abstract] [Full Text] [PDF]  

Potent Activity of Soluble B7-IgG Fusion Proteins in Therapy of Established Tumors and as Vaccine Adjuvant

Knut Sturmhoefel, Kwang Lee, Gary S. Gray, Jenifer Thomas, Richard Zollner, Margot O’Toole, Holly Swiniarski, Andrew Dorner, and Stanley F. Wolf
Cancer Res 1999 59: 4964-4972. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Expression of OVCA1, a Candidate Tumor Suppressor, Is Reduced in Tumors and Inhibits Growth of Ovarian Cancer Cells

Wendy Bruening, Amanda H. Prowse, David C. Schultz, Marina Holgado-Madruga, Albert Wong, and Andrew K. Godwin
Cancer Res 1999 59: 4973-4983. [Abstract] [Full Text] [PDF]  

Kaposi’s Sarcoma-associated Herpesvirus-encoded v-Cyclin Triggers Apoptosis in Cells with High Levels of Cyclin-dependent Kinase 6

Päivi M. Ojala, Marianne Tiainen, Petri Salven, Tanja Veikkola, Esmeralda Castaños-Vélez, Ronit Sarid, Peter Biberfeld, and Tomi P. Mäkelä
Cancer Res 1999 59: 4984-4989. [Abstract] [Full Text] [PDF]  

Identification and Characterization of Genes Associated with Human Hepatocellular Carcinogenesis

Nobuo Kondoh, Toru Wakatsuki, Akihide Ryo, Akiyuki Hada, Tsukasa Aihara, Sankichi Horiuchi, Narihide Goseki, Osamu Matsubara, Kenji Takenaka, Mizue Shichita, Kenji Tanaka, Masahiro Shuda, and Mikio Yamamoto
Cancer Res 1999 59: 4990-4996. [Abstract] [Full Text] [PDF]  

Genomic Structure, Chromosomal Mapping, and Promoter Region Analysis of Murine Uridine Phosphorylase Gene

Deliang Cao, Manjunath A. Nimmakayalu, Feiya Wang, Dekai Zhang, Robert E. Handschumacher, Patricia Bray-Ward, and Giuseppe Pizzorno
Cancer Res 1999 59: 4997-5001. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Carcinoma-associated Fibroblasts Direct Tumor Progression of Initiated Human Prostatic Epithelium

Aria F. Olumi, Gary D. Grossfeld, Simon W. Hayward, Peter R. Carroll, Thea D. Tlsty, and Gerald R. Cunha
Cancer Res 1999 59: 5002-5011. [Abstract] [Full Text] [PDF]  

In Vivo Prediction of Vascular Susceptibility to Vascular Endothelial Growth Factor Withdrawal: Magnetic Resonance Imaging of C6 Rat Glioma in Nude Mice

Rinat Abramovitch, Hagit Dafni, Eitzik Smouha, Laura E. Benjamin, and Michal Neeman
Cancer Res 1999 59: 5012-5016. [Abstract] [Full Text] [PDF]  

Paradoxical Inhibition of c-myc-induced Carcinogenesis by Bcl-2 in Transgenic Mice

Alix de La Coste, Alexandre Mignon, Monique Fabre, Emmanuelle Gilbert, Arlette Porteu, Terry Van Dyke, Axel Kahn, and Christine Perret
Cancer Res 1999 59: 5017-5022. [Abstract] [Full Text] [PDF]  

Overexpression of Fibroblast Growth Factor 1 in MCF-7 Breast Cancer Cells Facilitates Tumor Cell Dissemination but Does Not Support the Development of Macrometastases in the Lungs or Lymph Nodes

Lurong Zhang, Samir Kharbanda, Sandra W. McLeskey, and Francis G. Kern
Cancer Res 1999 59: 5023-5029. [Abstract] [Full Text] [PDF]  

Evidence for Clonal Outgrowth of Androgen-independent Prostate Cancer Cells from Androgen-dependent Tumors through a Two-Step Process

Noah Craft, Chloe Chhor, Chris Tran, Arie Belldegrun, Jean DeKernion, Owen N. Witte, Jonathan Said, Robert E. Reiter, and Charles L. Sawyers
Cancer Res 1999 59: 5030-5036. [Abstract] [Full Text] [PDF]  

Thymidine Phosphorylase Expression Is Associated with Both Increase of Intratumoral Microvessels and Decrease of Apoptosis in Human Colorectal Carcinomas

Takahiko Matsuura, Itaru Kuratate, Kazuki Teramachi, Mitsuhiko Osaki, Yasuhiko Fukuda, and Hisao Ito
Cancer Res 1999 59: 5037-5040. [Abstract] [Full Text] [PDF]  

A Soluble Transforming Growth Factor ß Type III Receptor Suppresses Tumorigenicity and Metastasis of Human Breast Cancer MDA-MB-231 Cells

Abhik Bandyopadhyay, Yong Zhu, Michael L. Cibull, LiWei Bao, Changguo Chen, and LuZhe Sun
Cancer Res 1999 59: 5041-5046. [Abstract] [Full Text] [PDF]  

Induction of Apoptosis by Arachidonic Acid in Chronic Myeloid Leukemia Cells

Maria Teresa Rizzo, Ester Regazzi, Daniela Garau, Luke Akard, Michael Dugan, H. Scott Boswell, Vittorio Rizzoli, and Carmelo Carlo-Stella
Cancer Res 1999 59: 5047-5053. [Abstract] [Full Text] [PDF]  

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