Advances in Brief:

Childhood Hepatoblastomas Frequently Carry a Mutated Degradation Targeting Box of the ß-Catenin Gene

Arend Koch, Dorota Denkhaus, Steffen Albrecht, Ivo Leuschner, Dietrich von Schweinitz, and Torsten Pietsch
Cancer Res 1999 59: 269-273. [Abstract] [Full Text] [PDF]  

Perivascular Cells Harboring Multiple Endocrine Neoplasia Type 1 Alterations Are Neoplastic Cells in Angiofibromas

Alexander O. Vortmeyer, Roland Böni, Svetlana D. Pack, Thomas N. Darling, and Zhengping Zhuang
Cancer Res 1999 59: 274-278. [Abstract] [Full Text] [PDF]  

Activation of Mitogen-Activated Protein Kinase Associated with Prostate Cancer Progression

Daniel Gioeli, James W. Mandell, Gina R. Petroni, Henry F. Frierson, Jr., and Michael J. Weber
Cancer Res 1999 59: 279-284. [Abstract] [Full Text] [PDF]  

The Multilayered Organization of Engineered Human Skin Does Not Influence the Formation of Sunlight-induced Cyclobutane Pyrimidine Dimers in Cellular DNA

Jean-Philippe Therrien, Mahmoud Rouabhia, Elliot A. Drobetsky, and Régen Drouin
Cancer Res 1999 59: 285-289. [Abstract] [Full Text] [PDF]  

Human MLH1 Deficiency Predisposes to Hematological Maligancy and Neurofibromatosis Type 1

Marie D. Ricciardone, Tayfun Özçelik, Birsen Cevher, Hilal Özdag, Murat Tuncer, Aytemiz Gürgey, Özden Uzunalimoglu, Hülya Çetinkaya, Attila Tanyeli, Eren Erken, and Mehmet Öztürk
Cancer Res 1999 59: 290-293. [Abstract] [Full Text] [PDF]  

Neurofibromatosis and Early Onset of Cancers in hMLH1-deficient children

Qing Wang, Christine Lasset, Françoise Desseigne, Didier Frappaz, Christophe Bergeron, Claudine Navarro, Eric Ruano, and Alain Puisieux
Cancer Res 1999 59: 294-297. [Abstract] [Full Text] [PDF]  

Asbestos and DNA Double Strand Breaks

Ryuichi Okayasu, Sentaro Takahashi, Shigeru Yamada, Tom K. Hei, and Robert L. Ullrich
Cancer Res 1999 59: 298-300. [Abstract] [Full Text] [PDF]  

A Superagonist Variant of Peptide MART1/Melan A_27–35 Elicits Anti-Melanoma CD8⁺ T Cells with Enhanced Functional Characteristics: Implication for More Effective Immunotherapy

Licia Rivoltini, Paola Squarcina, Douglas J. Loftus, Chiara Castelli, Paolo Tarsini, Arabella Mazzocchi, Francesca Rini, Vincenzo Viggiano, Filiberto Belli, and Giorgio Parmiani
Cancer Res 1999 59: 301-306. [Abstract] [Full Text] [PDF]  

Somatic Mutations in the Kinase Domain of the Met/Hepatocyte Growth Factor Receptor Gene in Childhood Hepatocellular Carcinomas

Won Sang Park, Seung Myung Dong, Su Young Kim, Eun Young Na, Min Sun Shin, Jae Ho Pi, Bum Jun Kim, Jeong Hoon Bae, Young Ki Hong, Kyo Sun Lee, Sug Hyung Lee, Nam Jin Yoo, Ja June Jang, Svetlana Pack, Zhengping Zhuang, Laura Schmidt, Berton Zbar, and Jung Young Lee
Cancer Res 1999 59: 307-310. [Abstract] [Full Text] [PDF]  

Deletion of Chromosome 1 Predicts Prognosis in Pancreatic Endocrine Tumors

Sam A. Ebrahimi, Eric H. Wang, Alan Wu, Rhona R. Schreck, Edward Passaro, Jr., and Mark P. Sawicki
Cancer Res 1999 59: 311-315. [Abstract] [Full Text] [PDF]  

Glioblastoma Cell-specific Expression of Fibroblast Growth Factor Receptor-1ß Requires an Intronic Repressor of RNA Splicing

Wei Jin, Weiqi Bi, Eileen S-C. Huang, and Gilbert J. Cote
Cancer Res 1999 59: 316-319. [Abstract] [Full Text] [PDF]  

Mutational Inactivation of Transforming Growth Factor ß Receptor Type II in Microsatellite Stable Colon Cancers

William M. Grady, Lois L. Myeroff, Sandra E. Swinler, Ashwani Rajput, Sam Thiagalingam, James D. Lutterbaugh, Aaron Neumann, Michael G. Brattain, Jay Chang, Seong-Jin Kim, Ken W. Kinzler, Bert Vogelstein, James K. V. Willson, and Sanford Markowitz
Cancer Res 1999 59: 320-324. [Abstract] [Full Text] [PDF]  

Loss of Adenoviral Receptor Expression in Human Bladder Cancer Cells: A Potential Impact on the Efficacy of Gene Therapy

Yingming Li, Rey-Chen Pong, Jeffrey M. Bergelson, M. Craig Hall, Arthur I. Sagalowsky, Ching-Ping Tseng, Zhi Wang, and Jer-Tsong Hsieh
Cancer Res 1999 59: 325-330. [Abstract] [Full Text] [PDF]  

Photodynamic Therapy Sensitivity Is Not Altered in Human Tumor Cells after Abrogation of p53 Function

Anita M. R. Fisher, Angela Ferrario, Natalie Rucker, Sha Zhang, and Charles J. Gomer
Cancer Res 1999 59: 331-335. [Abstract] [Full Text] [PDF]  

A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity

Nanjoo Suh, Yongping Wang, Tadashi Honda, Gordon W. Gribble, Ethan Dmitrovsky, William F. Hickey, Robert A. Maue, Andrew E. Place, Donna M. Porter, Michael J. Spinella, Charlotte R. Williams, Gengfei Wu, Andrew J. Dannenberg, Kathleen C. Flanders, John J. Letterio, David J. Mangelsdorf, Carl F. Nathan, Lananh Nguyen, Weston W. Porter, Renee F. Ren, Anita B. Roberts, Nanette S. Roche, Kotha Subbaramaiah, and Michael B. Sporn
Cancer Res 1999 59: 336-341. [Abstract] [Full Text] [PDF]  

Transcription Factor Y-Box Binding Protein 1 Binds Preferentially to Cisplatin-modified DNA and Interacts with Proliferating Cell Nuclear Antigen

Tomoko Ise, Gunji Nagatani, Toshihiro Imamura, Ken Kato, Hiroshi Takano, Minoru Nomoto, Hiroto Izumi, Haruki Ohmori, Tatsuro Okamoto, Takefumi Ohga, Takeshi Uchiumi, Michihiko Kuwano, and Kimitoshi Kohno
Cancer Res 1999 59: 342-346. [Abstract] [Full Text] [PDF]  

Biochemistry:

Increased Binding Affinity and Valence of Recombinant Antibody Fragments Lead to Improved Targeting of Tumoral Angiogenesis

Francesca Viti, Lorenzo Tarli, Leonardo Giovannoni, Luciano Zardi, and Dario Neri
Cancer Res 1999 59: 347-352. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Genotype-Phenotype Correlation in Murine Apc Mutation: Differences in Enterocyte Migration and Response to Sulindac

Najjia N. Mahmoud, Robyn T. Bilinski, Matthew R. Churchill, Winfried Edelmann, Raju Kucherlapati, and Monica M. Bertagnolli
Cancer Res 1999 59: 353-359. [Abstract] [Full Text] [PDF]  

Expression of 15-Lipoxygenase-1 in Human Colorectal Cancer

Hiroshi Ikawa, Hideki Kamitani, Benjamin F. Calvo, Julie F. Foley, and Thomas E. Eling
Cancer Res 1999 59: 360-366. [Abstract] [Full Text] [PDF]  

Interleukin 8: An Autocrine Growth Factor for Malignant Mesothelioma

Gabriella Galffy, Kamal A. Mohammed, Patrick A. Dowling, Najmunnisa Nasreen, Melissa J. Ward, and Veena B. Antony
Cancer Res 1999 59: 367-371. [Abstract] [Full Text] [PDF]  

Endocrinology:

The Pure Antiestrogen ICI 182,780 Inhibits Progestin-induced Transcription

Zafar Nawaz, George M. Stancel, and Salman M. Hyder
Cancer Res 1999 59: 372-376. [Abstract] [Full Text] [PDF]  

Steroid Sulfatase Expression Is an Independent Predictor of Recurrence in Human Breast Cancer

Toshiaki Utsumi, Noriko Yoshimura, Shinji Takeuchi, Jiro Ando, Morito Maruta, Kotaro Maeda, and Nobuhiro Harada
Cancer Res 1999 59: 377-381. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Signaling Pathway Activated during Apoptosis of the Prostate Cancer Cell Line LNCaP: Overexpression of Caspase-7 as a New Gene Therapy Strategy for Prostate Cancer

Marco Marcelli, Glenn R. Cunningham, Margaret Walkup, Zening He, Lydia Sturgis, Carolina Kagan, Roberta Mannucci, Ildo Nicoletti, BaBie Teng, and Larry Denner
Cancer Res 1999 59: 382-390. [Abstract] [Full Text] [PDF]  

Activation of c-Jun NH₂-terminal Kinase and Subsequent CPP32/Yama during Topoisomerase Inhibitor ß-Lapachone-induced Apoptosis through an Oxidation-dependent Pathway

Shine-Gwo Shiah, Shuang-En Chuang, Yat-Pang Chau, Shing-Chuan Shen, and Min-Liang Kuo
Cancer Res 1999 59: 391-398. [Abstract] [Full Text] [PDF]  

Histone Deacetylase Inhibitors as Potential Anti-Skin Cancer Agents

Nicholas Saunders, Anthony Dicker, Claudia Popa, Susan Jones, and Alison Dahler
Cancer Res 1999 59: 399-404. [Abstract] [Full Text] [PDF]  

The Use of Zn-Desferrioxamine for Radioprotection in Mice, Tissue Culture, and Isolated DNA

Yuval Samuni, Deborah Coffin, Anne Marie DeLuca, William G. DeGraff, David J. Venson, Indu Ambudkar, Mordechai Chevion, and James B. Mitchell
Cancer Res 1999 59: 405-409. [Abstract] [Full Text] [PDF]  

Therapy of Colon Cancer with Oncolytic Adenovirus Is Enhanced by the Addition of Herpes Simplex Virus-thymidine kinase

Oliver Wildner, R. Michael Blaese, and John C. Morris
Cancer Res 1999 59: 410-413. [Abstract] [Full Text] [PDF]  

Immunology:

Immune Events Associated with the Cure of Established Tumors and Spontaneous Metastases by Local and Systemic Interleukin 12

Federica Cavallo, Emma Di Carlo, Monia Butera, Roberta Verrua, Mario P. Colombo, Piero Musiani, and Guido Forni
Cancer Res 1999 59: 414-421. [Abstract] [Full Text] [PDF]  

The Pharmacokinetic Characteristics of Glycolated Humanized Anti-Tac Fabs Are Determined by Their Isoelectric Points

Hisataka Kobayashi, Nhat Le, In-sook Kim, Meyoung-Kon Kim, Jae-Eun Pie, Debra Drumm, David S. Paik, Thomas A. Waldmann, Chang H. Paik, and Jorge A. Carrasquillo
Cancer Res 1999 59: 422-430. [Abstract] [Full Text] [PDF]  

Identification of HLA-A3-restricted Cytotoxic T Lymphocyte Epitopes from Carcinoembryonic Antigen and HER-2/neu by Primary in Vitro Immunization with Peptide-pulsed Dendritic Cells

Ichiro Kawashima, Van Tsai, Scott Southwood, Kazutoh Takesako, Alessandro Sette, and Esteban Celis
Cancer Res 1999 59: 431-435. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Extensive Intra- and Interindividual Heterogeneity of ^p15INK4B Methylation in Acute Myeloid Leukemia

Anni Aggerholm, Per Guldberg, Marianne Hokland, and Peter Hokland
Cancer Res 1999 59: 436-441. [Abstract] [Full Text] [PDF]  

Tumor Suppressor PTEN Inhibition of Cell Invasion, Migration, and Growth: Differential Involvement of Focal Adhesion Kinase and p130^Cas

Masahito Tamura, Jianguo Gu, Takahisa Takino, and Kenneth M. Yamada
Cancer Res 1999 59: 442-449. [Abstract] [Full Text] [PDF]  

Comparative Genomic Hybridization and Loss of Heterozygosity Analyses Identify a Common Region of Deletion at 15q11.1–15 in Human Malignant Mesothelioma

Binaifer R. Balsara, Daphne W. Bell, Gonosuke Sonoda, Assunta De Rienzo, Stanislas du Manoir, Suresh C. Jhanwar, and Joseph R. Testa
Cancer Res 1999 59: 450-454. [Abstract] [Full Text] [PDF]  

Screening for Germ-Line Rearrangements and Regulatory Mutations in BRCA1 Led to the Identification of Four New Deletions

Nadine Puget, Dominique Stoppa-Lyonnet, Olga M. Sinilnikova, Sabine Pagès, Henry T. Lynch, Gilbert M. Lenoir, and Sylvie Mazoyer
Cancer Res 1999 59: 455-461. [Abstract] [Full Text] [PDF]  

Causes and Consequences of Microsatellite Instability in Endometrial Carcinoma

Cheryl C. Gurin, Mark G. Federici, Lan Kang, and Jeff Boyd
Cancer Res 1999 59: 462-466. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Enhanced Production and Activation of Progelatinase A Mediated by Membrane-Type 1 Matrix Metalloproteinase in Human Papillary Thyroid Carcinomas

Hiroyuki Nakamura, Hirohisa Ueno, Kaname Yamashita, Taketoshi Shimada, Etsuhide Yamamoto, Masakuni Noguchi, Noboru Fujimoto, Hiroshi Sato, Motoharu Seiki, and Yasunori Okada
Cancer Res 1999 59: 467-473. [Abstract] [Full Text] [PDF]  

12-O-Tetradecanoylphorbol-13-acetate Induces Clonal Expansion of Potentially Malignant Keratinocytes in a Tissue Model of Early Neoplastic Progression

Jeffrey Karen, Youai Wang, Ashkan Javaherian, Michael Vaccariello, Norbert E. Fusenig, and Jonathan A. Garlick
Cancer Res 1999 59: 474-481. [Abstract] [Full Text] [PDF]  

Mannosylerythritol Lipid Is a Potent Inducer of Apoptosis and Differentiation of Mouse Melanoma Cells in Culture

Xiaoxian Zhao, Yoko Wakamatsu, Miki Shibahara, Nobuhiko Nomura, Christian Geltinger, Tadaatsu Nakahara, Takehide Murata, and Kazunari K. Yokoyama
Cancer Res 1999 59: 482-486. [Abstract] [Full Text] [PDF]  

Meeting Report:

Angiogenesis and Cancer: AACR Special Conferene in Cancer Research

Michael Klagsbrun
Cancer Res 1999 59: 487 [PDF]  

Ninth Annual Pezcoller Symposium: The Biology of Tumors

Enrico Mihich and Carlo M. Croce
Cancer Res 1999 59: 491 [PDF]  

Innovative Approaches to the Prevention, Diagnosis, and Therapy of Cancer: Fourth Joint Conference of the American Association for Cancer Research (AACR) and the Japan Cancer Association (JCA)

Kaoru Abe and Edward Bresnick
Cancer Res 1999 59: 498 [PDF]  

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