Advances in Brief:

Carboxymethyl Benzylamide Dextran Blocks Angiogenesis of MDA-MB435 Breast Carcinoma Xenografted in Fat Pad and Its Lung Metastases in Nude Mice

Rozita Bagheri-Yarmand, Yamina Kourbali, Ana Maria Rath, Roger Vassy, Antoine Martin, Jacqueline Jozefonvicz, Claudine Soria, He Lu, and Michel Crépin
Cancer Res 1999 59: 507-510. [Abstract] [Full Text] [PDF]  

Identification of a Novel Gene, MASL1 within an Amplicon at 8p23.1 Detected in Malignant Fibrous Histiocytomas by Comparative Genomic Hybridization

Tomoya Sakabe, Takashi Shinomiya, Toshiki Mori, Yoji Ariyama, Yoji Fukuda, Tsutomu Fujiwara, Yusuke Nakamura, and Johji Inazawa
Cancer Res 1999 59: 511-515. [Abstract] [Full Text] [PDF]  

Functional Evidence of Novel Tumor Suppressor Genes for Cutaneous Malignant Melanoma

Christopher N. Parris, Julian D. Harris, Darren K. Griffin, Andrew P. Cuthbert, Andrew J. R. Silver, and Robert F. Newbold
Cancer Res 1999 59: 516-520. [Abstract] [Full Text] [PDF]  

Chemoprevention of Rat Prostate Carcinogenesis by 9-cis-Retinoic Acid

David L. McCormick, K. V. N. Rao, Vernon E. Steele, Ronald A. Lubet, Gary J. Kelloff, and Maarten C. Bosland
Cancer Res 1999 59: 521-524. [Abstract] [Full Text] [PDF]  

Coexpression of Estrogen Receptor and ß: Poor Prognostic Factors in Human Breast Cancer?

Valerie Speirs, Alicia T. Parkes, Michael J. Kerin, David S. Walton, Peter J. Carleton, John N. Fox, and Stephen L. Atkin
Cancer Res 1999 59: 525-528. [Abstract] [Full Text] [PDF]  

Estrogen Receptor-ß Messenger RNA Expression in Human Breast Tumor Biopsies: Relationship to Steroid Receptor Status and Regulation by Progestins

Helmut Dotzlaw, Etienne Leygue, Peter H. Watson, and Leigh C. Murphy
Cancer Res 1999 59: 529-532. [Abstract] [Full Text] [PDF]  

BNIP3: A Human Homolog of Mitochondrial Proapoptotic Protein BNIP3

Motoaki Yasuda, Jia-wen Han, Cheryl A. Dionne, Janice M. Boyd, and G. Chinnadurai
Cancer Res 1999 59: 533-537. [Abstract] [Full Text] [PDF]  

The Human MLH1 cDNA Complements DNA Mismatch Repair Defects in Mlh1-deficient Mouse Embryonic Fibroblasts

Andrew B. Buermeyer, Carmell Wilson-Van Patten, Sean M. Baker, and R. Michael Liskay
Cancer Res 1999 59: 538-541. [Abstract] [Full Text] [PDF]  

Phosphoinositide 3-Kinase Activity Is Essential for all-trans-Retinoic Acid-induced Granulocytic Differentiation of HL-60 Cells

Valeria Bertagnolo, Luca Maria Neri, Marco Marchisio, Carlo Mischiati, and Silvano Capitani
Cancer Res 1999 59: 542-546. [Abstract] [Full Text] [PDF]  

Independent Regulation of Growth and SMAD-mediated Transcription by Transforming Growth Factor ß in Human Melanoma Cells

Ulrich Rodeck, Takafumi Nishiyama, and Alain Mauviel
Cancer Res 1999 59: 547-550. [Abstract] [Full Text] [PDF]  

Cloning of Human Telomerase Catalytic Subunit (hTERT) Gene Promoter and Identification of Proximal Core Promoter Sequences Essential for Transcriptional Activation in Immortalized and Cancer Cells

Masahiro Takakura, Satoru Kyo, Taro Kanaya, Hisao Hirano, Jun Takeda, Masuo Yutsudo, and Masaki Inoue
Cancer Res 1999 59: 551-557. [Abstract] [Full Text] [PDF]  

Biochemistry:

Identification of Functional Elements of p18^INK4C Essential for Binding and Inhibition of Cyclin-dependent Kinase (CDK) 4 and CDK6

Seong J. Noh, Yan Li, Yue Xiong, and Kun-Liang Guan
Cancer Res 1999 59: 558-564. [Abstract] [Full Text] [PDF]  

Transcription of the Bone Sialoprotein Gene Is Stimulated by v-Src Acting through an Inverted CCAAT Box

Richard H. Kim and Jaro Sodek
Cancer Res 1999 59: 565-571. [Abstract] [Full Text] [PDF]  

Protein Kinase D in Small Cell Lung Cancer Cells: Rapid Activation through Protein Kinase C

Lina Paolucci and Enrique Rozengurt
Cancer Res 1999 59: 572-577. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Cancer Chemopreventive Activity Mediated by 4'-Bromoflavone, a Potent Inducer of Phase II Detoxification Enzymes

Lynda L. Song, Jerome W. Kosmeder II, Sang Kook Lee, Clarissa Gerhäuser, Daniel Lantvit, Richard C. Moon, Robert M. Moriarty, and John M. Pezzuto
Cancer Res 1999 59: 578-585. [Abstract] [Full Text] [PDF]  

Polymorphic Expression of the Glutathione Polymorphic Expression of the Glutathione S-Transferase P1 Gene and Its Susceptibility to Barrett’s Esophagus and Esophageal Carcinoma

Esther M. M. van Lieshout, Hennie M. J. Roelofs, Simone Dekker, Chris J. J. Mulder, Theo Wobbes, Jan B. M. J. Jansen, and Wilbert H. M. Peters
Cancer Res 1999 59: 586-589. [Abstract] [Full Text] [PDF]  

Quantitation of Urinary Metabolites of a Tobacco-specific Lung Carcinogen after Smoking Cessation

Stephen S. Hecht, Steven G. Carmella, Menglan Chen, J. F. Dor Koch, Andrew T. Miller, Sharon E. Murphy, Joni A. Jensen, Cheryl L. Zimmerman, and Dorothy K. Hatsukami
Cancer Res 1999 59: 590-596. [Abstract] [Full Text] [PDF]  

Chemopreventive Effect of Curcumin, a Naturally Occurring Anti-Inflammatory Agent, during the Promotion/Progression Stages of Colon Cancer

Toshihiko Kawamori, Ronald Lubet, Vernon E. Steele, Gary J. Kelloff, Robert B. Kaskey, and Chinthalapally V. Rao
Cancer Res 1999 59: 597-601. [Abstract] [Full Text] [PDF]  

Manganese Superoxide Dismutase (MnSOD) Genetic Polymorphisms, Dietary Antioxidants, and Risk of Breast Cancer

Christine B. Ambrosone, Jo L. Freudenheim, Patricia A. Thompson, Elise Bowman, John E. Vena, James R. Marshall, Saxon Graham, Rosemary Laughlin, Takuma Nemoto, and Peter G. Shields
Cancer Res 1999 59: 602-606. [Abstract] [Full Text] [PDF]  

Isoform-specific Induction of a Human Aldo-Keto Reductase by Polycyclic Aromatic Hydrocarbons (PAHs), Electrophiles, and Oxidative Stress: Implications for the Alternative Pathway of PAH Activation Catalyzed by Human Dihydrodiol Dehydrogenase

Michael E. Burczynski, Hseuh-Kung Lin, and Trevor M. Penning
Cancer Res 1999 59: 607-614. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

2-[C-11]Thymidine Imaging of Malignant Brain Tumors

Janet F. Eary, David A. Mankoff, Alexander M. Spence, Mitchel S. Berger, Adam Olshen, Jeanne M. Link, Finbarr O’Sullivan, and Kenneth A. Krohn
Cancer Res 1999 59: 615-621. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

A Flavonoid Antioxidant, Silymarin, Affords Exceptionally High Protection against Tumor Promotion in the SENCAR Mouse Skin Tumorigenesis Model

Moushumi Lahiri-Chatterjee, Santosh K. Katiyar, Rajiv R. Mohan, and Rajesh Agarwal
Cancer Res 1999 59: 622-632. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Stimulation of Tumors to Synthesize Tumor Necrosis Factor- in Situ Using 5,6-Dimethylxanthenone-4-acetic Acid: A Novel Approach to Cancer Therapy

Wayne R. Joseph, Zhihui Cao, Kathleen G. Mountjoy, Elaine S. Marshall, Bruce C. Baguley, and Lai-Ming Ching
Cancer Res 1999 59: 633-638. [Abstract] [Full Text] [PDF]  

Effects of Cationic Porphyrins as G-Quadruplex Interactive Agents in Human Tumor Cells

Elzbieta Izbicka, Richard T. Wheelhouse, Eric Raymond, Karen K. Davidson, Richard A. Lawrence, Daekyu Sun, Bradford E. Windle, Laurence H. Hurley, and Daniel D. Von Hoff
Cancer Res 1999 59: 639-644. [Abstract] [Full Text] [PDF]  

Eradication of Rat Malignant Gliomas by Retroviral-mediated, in Vivo Delivery of the Interleukin 4 Gene

Sara Benedetti, Maria Grazia Bruzzone, Bianca Pollo, Francesco DiMeco, Lorenzo Magrassi, Barbara Pirola, Nicola Cirenei, Mario P. Colombo, and Gaetano Finocchiaro
Cancer Res 1999 59: 645-652. [Abstract] [Full Text] [PDF]  

Laulimalide and Isolaulimalide, New Paclitaxel-Like Microtubule-Stabilizing Agents

Susan L. Mooberry, Georgia Tien, Anne H. Hernandez, Anuchit Plubrukarn, and Bradley S. Davidson
Cancer Res 1999 59: 653-660. [Abstract] [Full Text] [PDF]  

Radioisotope Concentrator Gene Therapy Using the Sodium/Iodide Symporter Gene

Robert B. Mandell, Leisa Z. Mandell, and Charles J. Link, Jr.
Cancer Res 1999 59: 661-668. [Abstract] [Full Text] [PDF]  

Cytotoxicity and Accumulation of Ganciclovir Triphosphate in Bystander Cells Cocultured with Herpes Simplex Virus Type 1 Thymidine Kinase-expressing Human Glioblastoma Cells

Laura Z. Rubsam, Paul D. Boucher, Patrick J. Murphy, Mark KuKuruga, and Donna S. Shewach
Cancer Res 1999 59: 669-675. [Abstract] [Full Text] [PDF]  

Immunology:

Induction of Protective Host Immunity to Carcinoembryonic Antigen (CEA), a Self-Antigen in CEA Transgenic Mice, by Immunizing with a Recombinant Vaccinia-CEA Virus

Erik Kass, Jeffrey Schlom, John Thompson, Fiorella Guadagni, Paolo Graziano, and John W. Greiner
Cancer Res 1999 59: 676-683. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Reduced Expression of the Cell Cycle Inhibitor p27^Kip1 in Non-Small Cell Lung Carcinoma: A Prognostic Factor Independent of Ras

Charles Catzavelos, Ming-Sound Tsao, Gerrit DeBoer, Nandita Bhattacharya, Frances A. Shepherd, and Joyce M. Slingerland
Cancer Res 1999 59: 684-688. [Abstract] [Full Text] [PDF]  

N-(2-Chloroethyl)-N-nitrosourea Tethered to Lexitropsin Induces Minor Groove Lesions at the p53 cDNA That Are More Cytotoxic than Mutagenic

Alberto Inga, Fa-Xian Chen, Paola Monti, Anna Aprile, Paola Campomenosi, Paola Menichini, Laura Ottaggio, Silvia Viaggi, Angelo Abbondandolo, Barry Gold, and Gilberto Fronza
Cancer Res 1999 59: 689-695. [Abstract] [Full Text] [PDF]  

Bax Is Frequently Compromised in Burkitt’s Lymphomas with Irreversible Resistance to Fas-induced Apoptosis

Marina I. Gutiérrez, Barry Cherney, Azhar Hussain, Howard Mostowski, Giovanna Tosato, Ian Magrath, and Kishor Bhatia
Cancer Res 1999 59: 696-703. [Abstract] [Full Text] [PDF]  

Yeast Proteins Related to the p40/Laminin Receptor Precursor Are Required for 20S Ribosomal RNA Processing and the Maturation of 40S Ribosomal Subunits

Christine L. Ford, Leslie Randal-Whitis, and Steven R. Ellis
Cancer Res 1999 59: 704-710. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Activation of Neurotrophin-3 Receptor TrkC Induces Apoptosis in Medulloblastomas

John Y. H. Kim, Mary E. Sutton, Diane J. Lu, Tracey A. Cho, Liliana C. Goumnerova, Lyuda Goritchenko, Jill R. Kaufman, K. K. Lam, Amy L. Billet, Nancy J. Tarbell, Julian Wu, Jeffrey C. Allen, Charles D. Stiles, Rosalind A. Segal, and Scott L. Pomeroy
Cancer Res 1999 59: 711-719. [Abstract] [Full Text] [PDF]  

Expression of Endothelin 1 and Endothelin A Receptor in Ovarian Carcinoma: Evidence for an Autocrine Role in Tumor Growth

Anna Bagnato, Debora Salani, Valeriana Di Castro, Jinshyun R. Wu-Wong, Raffaele Tecce, Maria Rita Nicotra, Aldo Venuti, and Pier Giorgio Natali
Cancer Res 1999 59: 720-727. [Abstract] [Full Text] [PDF]  

Expression of Vascular Endothelial Growth Factor and Its Receptors in Hematopoietic Malignancies

William T. Bellamy, Lynne Richter, Yvette Frutiger, and Thomas M. Grogan
Cancer Res 1999 59: 728-733. [Abstract] [Full Text] [PDF]  

Chemotherapy Augments TRAIL-induced Apoptosis in Breast Cell Lines

Maccon M. Keane, Seth A. Ettenberg, Marion M. Nau, Edward K. Russell, and Stan Lipkowitz
Cancer Res 1999 59: 734-741. [Abstract] [Full Text] [PDF]  

Stimulation of Breast Cancer Invasion and Metastasis by Synuclein

Tongli Jia, Yiliang E. Liu, Jingwen Liu, and Y. Eric Shi
Cancer Res 1999 59: 742-747. [Abstract] [Full Text] [PDF]  

Comparative Genomic Hybridization of Cancer of the Gastroesophageal Junction: Deletion of 14Q31–32.1 Discriminates between Esophageal (Barrett’s) and Gastric Cardia Adenocarcinomas

Herman van Dekken, Eric Geelen, Winand N. M. Dinjens, B. P. L. Wijnhoven, Hugo W. Tilanus, Hans J. Tanke, and Carla Rosenberg
Cancer Res 1999 59: 748-752. [Abstract] [Full Text] [PDF]  

Variants of Squamous Cell Carcinoma of the Anal Canal and Perianal Skin and Their Relation to Human Papillomaviruses

Morten Frisch, Claus Fenger, Adriaan J. C. van den Brule, Per Sørensen, Chris J. L. M. Meijer, Jan M. M. Walboomers, Hans-Olov Adami, Mads Melbye, and Bengt Glimelius
Cancer Res 1999 59: 753-757. [Abstract] [Full Text] [PDF]  

Focal Adhesion Kinase-dependent Apoptosis of Melanoma Induced by Tyrosine and Phenylalanine Deficiency

Ya-Min Fu, Zu-Xi Yu, Bertha A. Pelayo, Victor J. Ferrans, and Gary G. Meadows
Cancer Res 1999 59: 758-765. [Abstract] [Full Text] [PDF]  

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