Review:

Apoptosis, p53, and Tumor Cell Sensitivity to Anticancer Agents

J. Martin Brown and Bradly G. Wouters
Cancer Res 1999 59: 1391-1399. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Increased Expression of Cyclooxygenase-2 in Rat Lung Tumors Induced by the Tobacco-specific Nitrosamine 4-(Methylnitrosamino)-4-(3-pyridyl)-1-butanone: The Impact of a High-Fat Diet

Karam El-Bayoumy, Michael Iatropoulos, Shantu Amin, Dietrich Hoffmann, and Ernst L. Wynder
Cancer Res 1999 59: 1400-1403. [Abstract] [Full Text] [PDF]  

Heterogeneous Nuclear Ribonucleoprotein B1 as a New Marker of Early Detection for Human Lung Cancers

Eisaburo Sueoka, Yuri Goto, Naoko Sueoka, Yasuko Kai, Tomoko Kozu, and Hirota Fujiki
Cancer Res 1999 59: 1404-1407. [Abstract] [Full Text] [PDF]  

Localization of PS6K to Chromosomal Region 17q23 and Determination of Its Amplification in Breast Cancer

Fergus J. Couch, Xiao-Yang Wang, Guo-Jun Wu, Junqi Qian, Robert B. Jenkins, and C. David James
Cancer Res 1999 59: 1408-1411. [Abstract] [Full Text] [PDF]  

Comparison of Cytochrome P450- and Peroxidase-dependent Metabolic Activation of the Potent Carcinogen Dibenzo[a,l]pyrene in Human Cell Lines: Formation of Stable DNA Adducts and Absence of a Detectable Increase in Apurinic Sites

Victor J. Melendez-Colon, Andreas Luch, Albrecht Seidel, and William M. Baird
Cancer Res 1999 59: 1412-1416. [Abstract] [Full Text] [PDF]  

Superiority of Yeast over Bacterial Cytosine Deaminase for Enzyme/Prodrug Gene Therapy in Colon Cancer Xenografts

Els Kievit, Eric Bershad, Emily Ng, Phiroze Sethna, Inderjeet Dev, Theodore S. Lawrence, and Alnawaz Rehemtulla
Cancer Res 1999 59: 1417-1421. [Abstract] [Full Text] [PDF]  

Caspase-mediated Degradation of T-Cell Receptor -Chain

Brian R. Gastman, Daniel E. Johnson, Theresa L. Whiteside, and Hannah Rabinowich
Cancer Res 1999 59: 1422-1427. [Abstract] [Full Text] [PDF]  

Differential Transactivation by Alternative EWS-FLI1 Fusion Proteins Correlates with Clinical Heterogeneity in Ewing’s Sarcoma

Patrick P. Lin, Rachel I. Brody, Aimée C. Hamelin, James E. Bradner, John H. Healey, and Marc Ladanyi
Cancer Res 1999 59: 1428-1432. [Abstract] [Full Text] [PDF]  

Comparative Genomic Hybridization of Breast Tumors Stratified by Histological Grade Reveals New Insights into the Biological Progression of Breast Cancer

Rebecca Roylance, Patricia Gorman, William Harris, Rachael Liebmann, Diana Barnes, Andrew Hanby, and Denise Sheer
Cancer Res 1999 59: 1433-1436. [Abstract] [Full Text] [PDF]  

Allelotype of Gastric Adenocarcinoma

Aron S. Yustein, Jeffery C. Harper, Gina R. Petroni, Oscar W. Cummings, Christopher A. Moskaluk, and Steven M. Powell
Cancer Res 1999 59: 1437-1441. [Abstract] [Full Text] [PDF]  

ß-Catenin Mutations Are More Frequent in Small Colorectal Adenomas Than in Larger Adenomas and Invasive Carcinomas

Wade S. Samowitz, Michael D. Powers, Lisa N. Spirio, Friedel Nollet, Frans van Roy, and Martha L. Slattery
Cancer Res 1999 59: 1442-1444. [Abstract] [Full Text] [PDF]  

Novel Genes in the PAGE and GAGE Family of Tumor Antigens Found by Homology Walking in the dbEST Database

Ulrich Brinkmann, George Vasmatzis, Byungkook Lee, and Ira Pastan
Cancer Res 1999 59: 1445-1448. [Abstract] [Full Text] [PDF]  

Antiapoptotic Signaling in LNCaP Prostate Cancer Cells: A Survival Signaling Pathway Independent of Phosphatidylinositol 3'-Kinase and Akt/Protein Kinase B

Jonathan P. Carson, George Kulik, and Michael J. Weber
Cancer Res 1999 59: 1449-1453. [Abstract] [Full Text] [PDF]  

Cremophor EL-mediated Alteration of Paclitaxel Distribution in Human Blood: Clinical Pharmacokinetic Implications

Alex Sparreboom, Lia van Zuylen, Eric Brouwer, Walter J. Loos, Peter de Bruijn, Hans Gelderblom, Marrimuthoo Pillay, Kees Nooter, Gerrit Stoter, and Jaap Verweij
Cancer Res 1999 59: 1454-1457. [Abstract] [Full Text] [PDF]  

Biochemistry:

The Anticancer Prodrug CPT-11 Is a Potent Inhibitor of Acetylcholinesterase but Is Rapidly Catalyzed to SN-38 by Butyrylcholinesterase

Christopher L. Morton, Randy M. Wadkins, Mary K. Danks, and Philip M. Potter
Cancer Res 1999 59: 1458-1463. [Abstract] [Full Text] [PDF]  

Induction of Vascular Endothelial Growth Factor Expression in Endothelial Cells by Platelet-derived Growth Factor through the Activation of Phosphatidylinositol 3-Kinase

Degui Wang, H-J. Su Huang, Andrius Kazlauskas, and Webster K. Cavenee
Cancer Res 1999 59: 1464-1472. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Comparative Metabolism of 1-, 2-, and 4-Nitropyrene by Human Hepatic and Pulmonary Microsomes

Young-Heum Chae, Tom Thomas, F. Peter Guengerich, Peter P. Fu, and Karam El-Bayoumy
Cancer Res 1999 59: 1473-1480. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Increased Chromosome-Type Chromosome Aberration Frequencies as Biomarkers of Cancer Risk in a Blackfoot Endemic Area

Saou-Hsing Liou, Jia-Chyi Lung, Yeong-Hwang Chen, Tsann Yang, Ling-Ling Hsieh, Chien-Jen Chen, and Trong-Neng Wu
Cancer Res 1999 59: 1481-1484. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Induction of Lytic Epstein-Barr Virus (EBV) Infection in EBV-associated Malignancies Using Adenovirus Vectors in Vitro and in Vivo

Eva-Maria Westphal, Amy Mauser, Jennifer Swenson, Michelle G. Davis, Christine L. Talarico, and Shannon C. Kenney
Cancer Res 1999 59: 1485-1491. [Abstract] [Full Text] [PDF]  

Use of Alanosine as a Methylthioadenosine Phosphorylase-Selective Therapy for T-Cell Acute Lymphoblastic Leukemia in Vitro

Ayse Batova, Mitchell B. Diccianni, Motoko Omura-Minamisawa, John Yu, Carlos J. Carrera, Louis J. Bridgeman, Faith H. Kung, Jeanette Pullen, Michael D. Amylon, and Alice L. Yu
Cancer Res 1999 59: 1492-1497. [Abstract] [Full Text] [PDF]  

Identification of the Transcriptional Regulatory Sequences of Human Kallikrein 2 and Their Use in the Construction of Calydon Virus 764, an Attenuated Replication Competent Adenovirus for Prostate Cancer Therapy

De-Chao Yu, Gordon T. Sakamoto, and Daniel R. Henderson
Cancer Res 1999 59: 1498-1504. [Abstract] [Full Text] [PDF]  

Development of meta-Tetrahydroxyphenylchlorin-Monoclonal Antibody Conjugates for Photoimmunotherapy

Maarten B. Vrouenraets, Gerard W. M. Visser, Fiona A. Stewart, Marijke Stigter, Hugo Oppelaar, Pieter E. Postmus, Gordon B. Snow, and Guus A. M. S. van Dongen
Cancer Res 1999 59: 1505-1513. [Abstract] [Full Text] [PDF]  

Alteration of the Conserved Residue Tyrosine-158 to Histidine Renders Human O⁶-Alkylguanine-DNA Alkyltransferase Insensitive to the Inhibitor O⁶-Benzylguanine

Meng Xu-Welliver, José Leitão, Sreenivas Kanugula, and Anthony E. Pegg
Cancer Res 1999 59: 1514-1519. [Abstract] [Full Text] [PDF]  

A Fully Synthetic Immunogen Carrying a Carcinoma-associated Carbohydrate for Active Specific Immunotherapy¹

Richard Lo-Man, Sylvie Bay, Sophie Vichier-Guerre, Edith Dériaud, Danièle Cantacuzène, and Claude Leclerc
Cancer Res 1999 59: 1520-1524. [Abstract] [Full Text] [PDF]  

Immunology:

Enhancement of Graft-Versus-Tumor Activity and Graft-Versus-Host Disease by Pretransplant Immunization of Allogeneic Bone Marrow Donors with a Recipient-derived Tumor Cell Vaccine

Larry D. Anderson, Jr., Demetrios Petropoulos, Linda A. Everse, and Craig A. Mullen
Cancer Res 1999 59: 1525-1530. [Abstract] [Full Text] [PDF]  

A Critical Role for a Peritumoral Stromal Reaction in the Induction of T-Cell Migration Responsible for Interleukin-12-induced Tumor Regression

Makoto Ogawa, Kazunari Umehara, Wen-Gong Yu, Yasuhiro Uekusa, Chigusa Nakajima, Takahiro Tsujimura, Takeshi Kubo, Hiromi Fujiwara, and Toshiyuki Hamaoka
Cancer Res 1999 59: 1531-1538. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Expression of Catalytically Active Telomerase Does Not Prevent Premature Senescence Caused by Overexpression of Oncogenic Ha-Ras in Normal Human Fibroblasts

Shan Wei, Wenyi Wei, and John M. Sedivy
Cancer Res 1999 59: 1539-1543. [Abstract] [Full Text] [PDF]  

Cells Deficient in DNA Polymerase ß Are Hypersensitive to Alkylating Agent-induced Apoptosis and Chromosomal Breakage

Kirsten Ochs, Robert W. Sobol, Samuel H. Wilson, and Bernd Kaina
Cancer Res 1999 59: 1544-1551. [Abstract] [Full Text] [PDF]  

The Breast Cancer-associated MUC1 Gene Generates Both a Receptor and Its Cognate Binding Protein

Amos Baruch, Mor-li Hartmann, Merav Yoeli, Yair Adereth, Shulamit Greenstein, Yona Stadler, Yehuda Skornik, Joseph Zaretsky, Nechama I. Smorodinsky, Iafa Keydar, and Daniel H. Wreschner
Cancer Res 1999 59: 1552-1561. [Abstract] [Full Text] [PDF]  

Chromosome 13q Deletion Mapping in Pituitary Tumors: Infrequent Loss of the Retinoblastoma Susceptibility Gene (RB1) Locus Despite Loss of RB1 Protein Product in Somatotrophinomas

D. J. Simpson, J. Magnay, J. E. Bicknell, A. L. Barkan, A. M. McNicol, R. N. Clayton, and W. E. Farrell
Cancer Res 1999 59: 1562-1566. [Abstract] [Full Text] [PDF]  

Plasma DNA Microsatellites as Tumor-specific Markers and Indicators of Tumor Progression in Melanoma Patients

Yoshiyuki Fujiwara, Dorcas D. J. Chi, HeJing Wang, Pond Keleman, Donald L. Morton, Roderick Turner, and Dave S. B. Hoon
Cancer Res 1999 59: 1567-1571. [Abstract] [Full Text] [PDF]  

Transcriptional Activation of Cyclooxygenase-2in Wnt-1-transformed Mouse Mammary Epithelial Cells

Louise R. Howe, Kotha Subbaramaiah, Wen Jing Chung, Andrew J. Dannenberg, and Anthony M. C. Brown
Cancer Res 1999 59: 1572-1577. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Hypoxia-induced Up-Regulation of Angiogenin in Human Malignant Melanoma

Anke Hartmann, Manfred Kunz, Sebastian Köstlin, Reinhard Gillitzer, Atiye Toksoy, Eva-B. Bröcker, and C. Eberhard Klein
Cancer Res 1999 59: 1578-1583. [Abstract] [Full Text] [PDF]  

Initiation of Growth Arrest and Apoptosis of MCF-7 Mammary Carcinoma Cells by Tributyrin, a Triglyceride Analogue of the Short-Chain Fatty Acid Butyrate,Is Associated with Mitochondrial Activity

Barbara G. Heerdt, Michele A. Houston, Gillian M. Anthony, and Leonard H. Augenlicht
Cancer Res 1999 59: 1584-1591. [Abstract] [Full Text] [PDF]  

Tumor-derived Expression of Vascular Endothelial Growth Factor Is a Critical Factor in Tumor Expansion and Vascular Function

Jeremy Grunstein, W. Gregory Roberts, Odile Mathieu-Costello, Douglas Hanahan, and Randall S. Johnson
Cancer Res 1999 59: 1592-1598. [Abstract] [Full Text] [PDF]  

Profile of Cytokine Expression in Nasopharyngeal Carcinomas: A Distinct Expression of Interleukin 1 in Tumor and CD4⁺ T Cells

Yu-Tzu Huang, Tzung-Shiahn Sheen, Chi-Long Chen, Jean Lu, Yao Chang, Jen-Yang Chen, and Ching-Hwa Tsai
Cancer Res 1999 59: 1599-1605. [Abstract] [Full Text] [PDF]  

Tumor Necrosis Factor- Sensitizes Prostate Cancer Cells to -Irradiation-induced Apoptosis

Kotohiko Kimura, Cai Bowen, Sarah Spiegel, and Edward P. Gelmann
Cancer Res 1999 59: 1606-1614. [Abstract] [Full Text] [PDF]  

Intratumoral Distribution of Two Consecutive Injections of Chimeric Antibody G250 in Primary Renal Cell Carcinoma: Implications for Fractionated Dose Radioimmunotherapy

Martijn G. Steffens, Otto C. Boerman, Wim J. G. Oyen, Paul H. M. Kniest, J. Alfred Witjes, Gosse O. N. Oosterhof, Geert J. L. H. van Leenders, Frans M. J. Debruyne, Frans H. M. Corstens, and Egbert Oosterwijk
Cancer Res 1999 59: 1615-1619. [Abstract] [Full Text] [PDF]  

Heregulin ß1-activated Phosphatidylinositol 3-Kinase Enhances Aggregation of MCF-7 Breast Cancer Cells Independent of Extracellular Signal-regulated Kinase

Ming Tan, Rebecca Grijalva, and Dihua Yu
Cancer Res 1999 59: 1620-1625. [Abstract] [Full Text] [PDF]  

Combretastatin A-4 Phosphate as a Tumor Vascular-Targeting Agent: Early Effects in Tumors and Normal Tissues

Gillian M. Tozer, Vivien E. Prise, John Wilson, Rosalind J. Locke, Borivoj Vojnovic, Michael R. L. Stratford, Madeleine F. Dennis, and David J. Chaplin
Cancer Res 1999 59: 1626-1634. [Abstract] [Full Text] [PDF]  

Ovarian Carcinoma Regulation of Matrix Metalloproteinase-2 and Membrane Type 1 Matrix Metalloproteinase through ß1 Integrin

Shawn M. Ellerbroek, David A. Fishman, Alicia S. Kearns, Lisa M. Bafetti, and M. Sharon Stack
Cancer Res 1999 59: 1635-1641. [Abstract] [Full Text] [PDF]  

Dietary Intervention at Middle Age: Caloric Restriction but not Dehydroepiandrosterone Sulfate Increases Lifespan and Lifetime Cancer Incidence in Mice

Thomas D. Pugh, Terry D. Oberley, and Richard Weindruch
Cancer Res 1999 59: 1642-1648. [Abstract] [Full Text] [PDF]  

Interdependent Regulation of Intracellular Acidification and SHP-1 in Apoptosis

Muthusamy Thangaraju, Kamal Sharma, Danni Liu, Shi-Hsiang Shen, and Coimbatore B. Srikant
Cancer Res 1999 59: 1649-1654. [Abstract] [Full Text] [PDF]  

Prostatic Carcinoma Cell Migration via _vß₃Integrin Is Modulated by a Focal Adhesion Kinase Pathway

Duo-Qi Zheng, Amy S. Woodard, Mara Fornaro, Giovanni Tallini, and Lucia R. Languino
Cancer Res 1999 59: 1655-1664. [Abstract] [Full Text] [PDF]  

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