Advances in Brief:

HRad17, a Human Homologue of the Schizosaccharomyces pombe Checkpoint Gene rad17, Is Overexpressed in Colon Carcinoma

Shideng Bao, Mau-Sun Chang, Daniel Auclair, Yapin Sun, Youbin Wang, Wei-Kong Wong, Jinyang Zhang, Yuan Liu, Xiuqi Qian, Rebecca Sutherland, Cristina Magi-Galluzi, Ellen Weisberg, Edmond Y. S. Cheng, Luning Hao, Hidefumi Sasaki, Michael S. Campbell, Stine-Kathrein Kraeft, Massimo Loda, Kin-Ming Lo, and LanBo Chen
Cancer Res 1999 59: 2023-2028. [Abstract] [Full Text] [PDF]  

Methylation of CpG in a Small Region of the hMLH1 Promoter Invariably Correlates with the Absence of Gene Expression

Guoren Deng, Ada Chen, Joe Hong, Hiun Suk Chae, and Young S. Kim
Cancer Res 1999 59: 2029-2023. [Abstract] [Full Text] [PDF]  

Impairment of the Proapoptotic Activity of Bax by Missense Mutations Found in Gastrointestinal Cancers

Joan Gil, Hiroyuki Yamamoto, Juan M. Zapata, John C. Reed, and Manuel Perucho
Cancer Res 1999 59: 2034-2037. [Abstract] [Full Text] [PDF]  

Genetic and Functional Analyses Exclude Mortality Factor 4 (MORF4) as a Keratinocyte Senescence Gene

Steven D. Bryce, Nicholas R. Forsyth, Sara A. Fitzsimmons, Louise J. Clark, Michael J. Bertram, Andrew P. Cuthbert, Robert F. Newbold, Olivia M. Pereira-Smith, and E. Kenneth Parkinson
Cancer Res 1999 59: 2038-2040. [Abstract] [Full Text] [PDF]  

Centrosomal Kinase AIK1 Is Overexpressed in Invasive Ductal Carcinoma of the Breast

Takuji Tanaka, Masashi Kimura, Kengo Matsunaga, Daizo Fukada, Hideki Mori, and Yukio Okano
Cancer Res 1999 59: 2041-2044. [Abstract] [Full Text] [PDF]  

Promoting Effects of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on Rat Glandular Stomach Carcinogenesis Initiated with N-Methyl-N'-nitro-N-nitrosoguanidine

Akiyoshi Nishikawa, Fumio Furukawa, In-Seon Lee, Ken-ichiro Kasahara, Zen-yo Tanakamaru, Hideaki Nakamura, Makoto Miyauchi, Naohide Kinae, and Masao Hirose
Cancer Res 1999 59: 2045-2049. [Abstract] [Full Text] [PDF]  

Genetic Deletion of p21^WAF1 Enhances Papilloma Formation but not Malignant Conversion in Experimental Mouse Skin Carcinogenesis

Wendy C. Weinberg, Ester Fernandez-Salas, David L. Morgan, Aryaman Shalizi, Elena Mirosh, Eric Stanulis, Chuxia Deng, Henry Hennings, and Stuart H. Yuspa
Cancer Res 1999 59: 2050-2054. [Abstract] [Full Text] [PDF]  

Replication-competent, Nonneuroinvasive Genetically Engineered Herpes Virus Is Highly Effective in the Treatment of Therapy-resistant Experimental Human Tumors

Sunil J. Advani, Su-Mi Chung, Sze Y. Yan, G. Yancey Gillespie, James M. Markert, Richard J. Whitley, Bernard Roizman, and Ralph R. Weichselbaum
Cancer Res 1999 59: 2055-2058. [Abstract] [Full Text] [PDF]  

Elevation of 2(I) Collagen, a Suppressor of Ras Transformation, Is Required for Stable Phenotypic Reversion by Farnesyltransferase Inhibitors

Wei Du, Peter F. Lebowitz, and George C. Prendergast
Cancer Res 1999 59: 2059-2063. [Abstract] [Full Text] [PDF]  

The Pathway Regulating MDM2 Protein Degradation Can Be Altered in Human Leukemic Cells

Yi Pan and Dale S. Haines
Cancer Res 1999 59: 2064-2067. [Abstract] [Full Text] [PDF]  

Mouse p73 Gene Maps to the Distal Part of Chromosome 4 and Might Be Involved in the Progression of -Radiation-induced T-cell Lymphomas

Michel Herranz, Javier Santos, Eduardo Salido, José Ferná ndez-Piqueras, and Manuel Serrano
Cancer Res 1999 59: 2068-2071. [Abstract] [Full Text] [PDF]  

Direct Correlation between Nitric Oxide Synthase II Inducibility and Metastatic Ability of UV-2237 Murine Fibrosarcoma Cells Carrying Mutant p53

Qian Shi, Suyun Huang, Weidong Jiang, Laura S. Kutach, Honnavara N. Ananthaswamy, and Keping Xie
Cancer Res 1999 59: 2072-2075. [Abstract] [Full Text] [PDF]  

Biochemistry:

Glioma Migration Can Be Blocked by Nontoxic Inhibitors of Myosin II

G. Yancey Gillespie, Liliana Soroceanu, Timothy J. Manning, Jr., Candece L. Gladson, and Steven S. Rosenfeld
Cancer Res 1999 59: 2076-2082. [Abstract] [Full Text] [PDF]  

Mistletoe Lectin Activates Caspase-8/FLICE Independently of Death Receptor Signaling and Enhances Anticancer Drug-induced Apoptosis

Heike Bantel, Ingo H. Engels, Wolfgang Voelter, Klaus Schulze-Osthoff, and Sebastian Wesselborg
Cancer Res 1999 59: 2083-2090. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Mutagenic Potential of -(N²-Deoxyguanosinyl)tamoxifen Lesions, the Major DNA Adducts Detected in Endometrial Tissues of Patients Treated with Tamoxifen

Isamu Terashima, Naomi Suzuki, and Shinya Shibutani
Cancer Res 1999 59: 2091-2095. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Phase I Evaluation of Humanized OKT3: Toxicity and Immunomodulatory Effects of hOKT3₄

Jon Richards, Julie Auger, Donna Peace, Danielle Gale, Judy Michel, Ann Koons, Tom Haverty, Robert Zivin, Linda Jolliffe, and Jeffrey A. Bluestone
Cancer Res 1999 59: 2096-2101. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Modulation of Drug Resistance Mediated by Loss of Mismatch Repair by the DNA Polymerase Inhibitor Aphidicolin

Nicole J. Moreland, Maureen Illand, Young Tae Kim, Jim Paul, and Robert Brown
Cancer Res 1999 59: 2102-2106. [Abstract] [Full Text] [PDF]  

Paracrine Immunotherapy with Interleukin-2 and Local Chemotherapy Is Synergistic in the Treatment of Experimental Brain Tumors

Prakash Sampath, Justin Hanes, Francesco DiMeco, Betty M. Tyler, Daniel Brat, Drew M. Pardoll, and Henry Brem
Cancer Res 1999 59: 2107-2114. [Abstract] [Full Text] [PDF]  

Prostate Cancer Chemoprevention by Green Tea: In Vitro and in Vivo Inhibition of Testosterone-mediated Induction of Ornithine Decarboxylase

Sanjay Gupta, Nihal Ahmad, Rajiv R. Mohan, Mirza M. Husain, and Hasan Mukhtar
Cancer Res 1999 59: 2115-2120. [Abstract] [Full Text] [PDF]  

In Vivo Cytotoxicity of Ovarian Cancer Cells through Tumor-selective Expression of the BAX Gene

Yu-Tzu Tai, Thomas Strobel, Donald Kufe, and Stephen A. Cannistra
Cancer Res 1999 59: 2121-2126. [Abstract] [Full Text] [PDF]  

Expression of Human (1,3)Fucosyltransferase Antisense Sequences Inhibits Selectin-mediated Adhesion and Liver Metastasis of Colon Carcinoma Cells

Brent W. Weston, Kara M. Hiller, John P. Mayben, George A. Manousos, Katharine M. Bendt, Rong Liu, and James C. Cusack, Jr.
Cancer Res 1999 59: 2127-2135. [Abstract] [Full Text] [PDF]  

Prostate-specific Antigen (PSA) Promoter-driven Androgen-inducible Expression of Sodium Iodide Symporter in Prostate Cancer Cell Lines

Christine Spitzweg, Shaobo Zhang, Elizabeth R. Bergert, Maria R. Castro, Bryan McIver, Armin E. Heufelder, Donald J. Tindall, Charles Y. F. Young, and John C. Morris
Cancer Res 1999 59: 2136-2141. [Abstract] [Full Text] [PDF]  

Immunology:

Regulation of Transforming Growth Factor ß1 by Nitric Oxide

Yoram Vodovotz, Louis Chesler, Hyonkyong Chong, Seong-Jin Kim, John T. Simpson, William DeGraff, George W. Cox, Anita B. Roberts, David A. Wink, and Mary Helen Barcellos-Hoff
Cancer Res 1999 59: 2142-2149. [Abstract] [Full Text] [PDF]  

Presentation of Tumor Antigens by Phagocytic Dendritic Cell Clusters Generated from Human CD34⁺ Hematopoietic Progenitor Cells: Induction of Autologous Cytotoxic T Lymphocytes against Leukemic Cells in Acute Myelogenous Leukemia Patients

Shin-ichiro Fujii, Koji Fujimoto, Kanako Shimizu, Taichi Ezaki, Fumio Kawano, Kiyoshi Takatsuki, Makoto Kawakita, and Kenjiro Matsuno
Cancer Res 1999 59: 2150-2158. [Abstract] [Full Text] [PDF]  

Improving the Efficacy of Antibody-Interleukin 2 Fusion Proteins by Reducing Their Interaction with Fc Receptors

Stephen D. Gillies, Yan Lan, Kin-Ming Lo, Michael Super, and John Wesolowski
Cancer Res 1999 59: 2159-2166. [Abstract] [Full Text] [PDF]  

An Antigen-targeted Approach to Adoptive Transfer Therapy of Cancer

Danila Valmori, Mikaël J. Pittet, Donata Rimoldi, Danielle Liénard, Rod Dunbar, Vincenzo Cerundolo, Ferdy Lejeune, Jean-Charles Cerottini, and Pedro Romero
Cancer Res 1999 59: 2167-2173. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

ATP-dependent Steps in Apoptotic Signal Transduction

Yutaka Eguchi, Anu Srinivasan, Kevin J. Tomaselli, Shigeomi Shimizu, and Yoshihide Tsujimoto
Cancer Res 1999 59: 2174-2181. [Abstract] [Full Text] [PDF]  

The Genetic Locus NRC-1 within Chromosome 3p12 Mediates Tumor Suppression in Renal Cell Carcinoma Independently of Histological Type, Tumor Microenvironment, and VHL Mutation

Mercedes Lovell, Steven Trent Lott, Patricia Wong, Adel El-Naggar, Susan Tucker, and Ann McNeill Killary
Cancer Res 1999 59: 2182-2189. [Abstract] [Full Text] [PDF]  

Poly(ADP-ribosyl)ation of p53 during Apoptosis in Human Osteosarcoma Cells

Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, RuiBai Luo, and Mark E. Smulson
Cancer Res 1999 59: 2190-2194. [Abstract] [Full Text] [PDF]  

The JNK/SAPK Activator Mixed Lineage Kinase 3 (MLK3) Transforms NIH 3T3 Cells in a MEK-dependent Fashion

Jörg Hartkamp, Jakob Troppmair, and Ulf R. Rapp
Cancer Res 1999 59: 2195-2202. [Abstract] [Full Text] [PDF]  

Tumor Biology:

The Insulin-like Growth Factor Axis and Prostate Cancer: Lessons from the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model

Paula J. Kaplan, Subburaman Mohan, Pinchas Cohen, Barbara A. Foster, and Norman M. Greenberg
Cancer Res 1999 59: 2203-2209. [Abstract] [Full Text] [PDF]  

Transforming Growth Factor ß1 Is a Target for the von Hippel-Lindau Tumor Suppressor and a Critical Growth Factor for Clear Cell Renal Carcinoma

Subbian Ananth, Bertrand Knebelmann, Wolfram Grüning, Mohanraj Dhanabal, Gerd Walz, Isaac E. Stillman, and Vikas P. Sukhatme
Cancer Res 1999 59: 2210-2216. [Abstract] [Full Text] [PDF]  

Tumor Spectrum in ARF-deficient Mice

Takehiko Kamijo, Sara Bodner, Esther van de Kamp, David H. Randle, and Charles J. Sherr
Cancer Res 1999 59: 2217-2222. [Abstract] [Full Text] [PDF]  

Relationship of Arachidonic Acid Metabolizing Enzyme Expression in Epithelial Cancer Cell Lines to the Growth Effect of Selective Biochemical Inhibitors

Sung H. Hong, Ingalill Avis, Michele D. Vos, Alfredo Martínez, Anthony M. Treston, and James L. Mulshine
Cancer Res 1999 59: 2223-2228. [Abstract] [Full Text] [PDF]  

Overexpression of Sialomucin Complex, a Rat Homologue of MUC4, Inhibits Tumor Killing by Lymphokine-activated Killer Cells

Masanobu Komatsu, Lisa Yee, and Kermit L. Carraway
Cancer Res 1999 59: 2229-2236. [Abstract] [Full Text] [PDF]  

Overexpression of 1-6 Fucosyltransferase in Hepatoma Cells Suppresses Intrahepatic Metastasis after Splenic Injection in Athymic Mice

Eiji Miyoshi, Katsuhisa Noda, Jeong Heon Ko, Atsuko Ekuni, Takatoshi Kitada, Naofumi Uozumi, Yoshitaka Ikeda, Nariaki Matsuura, Yutaka Sasaki, Norio Hayashi, Masatsugu Hori, and Naoyuki Taniguchi
Cancer Res 1999 59: 2237-2243. [Abstract] [Full Text] [PDF]  

Deficient Activity of von Willebrand’s Factor-cleaving Protease in Patients with Disseminated Malignancies

Leslie Oleksowicz, Niyati Bhagwati, and Margie DeLeon-Fernandez
Cancer Res 1999 59: 2244-2250. [Abstract] [Full Text] [PDF]  

Meeting Report:

Third International Meeting on van Hippel-Lindau Disease

Berton Zbar, William Kaelin, Eamonn Maher, and Stephane Richard
Cancer Res 1999 59: 2251 [PDF]  

Obituary:

Raymond Latarjet

Cancer Res 1999 59: 2256 [PDF]  

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