Advances in Brief:

p53 Polymorphism in Human Papillomavirus-associated Esophageal Cancer

Hidetoshi Kawaguchi, Shinji Ohno, Koshi Araki, Mitsuhiro Miyazaki, Hiroshi Saeki, Masayuki Watanabe, Shinji Tanaka, and Keizo Sugimachi
Cancer Res 2000 60: 2753-2755. [Abstract] [Full Text] [PDF]  

Amplification in Human Breast Cancer of a Gene Encoding a c-myc mRNA-binding Protein

Glenn A. Doyle, Jeanne M. Bourdeau-Heller, Stephanie Coulthard, Lorraine F. Meisner, and Jeffrey Ross
Cancer Res 2000 60: 2756-2759. [Abstract] [Full Text] [PDF]  

Detection of Exon Deletions and Duplications of the Mismatch Repair Genes in Hereditary Nonpolyposis Colorectal Cancer Families Using Multiplex Polymerase Chain Reaction of Short Fluorescent Fragments

Françoise Charbonnier, Grégory Raux, Qing Wang, Nathalie Drouot, Frédéric Cordier, Jean-Marc Limacher, Jean-Christophe Saurin, Alain Puisieux, Sylviane Olschwang, and Thierry Frebourg
Cancer Res 2000 60: 2760-2763. [Abstract] [Full Text] [PDF]  

Functional Evidence for a Novel Human Breast Carcinoma Metastasis Suppressor, BRMS1, Encoded at Chromosome 11q13

M. Jabed Seraj, Rajeev S. Samant, Michael F. Verderame, and Danny R. Welch
Cancer Res 2000 60: 2764-2769. [Abstract] [Full Text] [PDF]  

Telomere Erosion Varies during in Vitro Aging of Normal Human Fibroblasts from Young and Adult Donors

Reynel Figueroa, Heike Lindenmaier, Manfred Hergenhahn, Kirsten Vang Nielsen, and Petra Boukamp
Cancer Res 2000 60: 2770-2774. [Abstract] [Full Text] [PDF]  

Deletion of 6q16-q21 in Human Lymphoid Malignancies: A Mapping and Deletion Analysis

Amanda Jackson, Paola Carrara, Veronique Duke, Paul Sinclair, Mary Papaioannou, Christine J. Harrison, and Letizia Foroni
Cancer Res 2000 60: 2775-2779. [Abstract] [Full Text] [PDF]  

Differential Susceptibility of Renal Carcinoma Cell Lines to Tumor Suppression by Exogenous Fhit Expression

Nicole Susann Werner, Zurab Siprashvili, Louise Y. Y. Fong, Guido Marquitan, Jan K. Schröder, Walter Bardenheuer, Siegfried Seeber, Kay Huebner, Jochen Schütte, and Bertram Opalka
Cancer Res 2000 60: 2780-2785. [Abstract] [Full Text]  

Translocation t(10;14)(q11.2;q22.1) Fusing the Kinectin to the RET Gene Creates a Novel Rearranged Form (PTC8) of the RET Proto-Oncogene in Radiation-induced Childhood Papillary Thyroid Carcinoma

Konstadinos Salassidis, Jochen Bruch, Horst Zitzelsberger, Edmund Lengfelder, Albrecht M. Kellerer, and Manfred Bauchinger
Cancer Res 2000 60: 2786-2789. [Abstract] [Full Text] [PDF]  

Oncolysis of Diffuse Hepatocellular Carcinoma by Intravascular Administration of a Replication-competent, Genetically Engineered Herpesvirus

Timothy M. Pawlik, Hideo Nakamura, Sam S. Yoon, John T. Mullen, Soundararajalu Chandrasekhar, E. Antonio Chiocca, and Kenneth K. Tanabe
Cancer Res 2000 60: 2790-2795. [Abstract] [Full Text] [PDF]  

Expression of a Repressor of Estrogen Receptor Activity in Human Breast Tumors: Relationship to Some Known Prognostic Markers

Sharon L. R. Simon, Alicia Parkes, Etienne Leygue, Helmut Dotzlaw, Linda Snell, Sandra Troup, Adewale Adeyinka, Peter H. Watson, and Leigh C. Murphy
Cancer Res 2000 60: 2796-2799. [Abstract] [Full Text] [PDF]  

Aloe-emodin Is a New Type of Anticancer Agent with Selective Activity against Neuroectodermal Tumors

Teresa Pecere, M. Vittoria Gazzola, Carla Mucignat, Cristina Parolin, Francesca Dalla Vecchia, Andrea Cavaggioni, Giuseppe Basso, Alberto Diaspro, Benedetto Salvato, Modesto Carli, and Giorgio Palù
Cancer Res 2000 60: 2800-2804. [Abstract] [Full Text] [PDF]  

A Novel Antisense Oligonucleotide Targeting Survivin Expression Induces Apoptosis and Sensitizes Lung Cancer Cells to Chemotherapy

Robert A. Olie, A. Paula Simões-Wüst, Bettina Baumann, Siân H. Leech, Doriano Fabbro, Rolf A. Stahel, and Uwe Zangemeister-Wittke
Cancer Res 2000 60: 2805-2809. [Abstract] [Full Text] [PDF]  

Peripheral Tolerance to Human Papillomavirus E7 Oncoprotein Occurs by Cross-Tolerization, Is Largely Th-2-independent, and Is Broken by Dendritic Cell Immunization

Tracy Doan, Karen A. Herd, Paul F. Lambert, Germain J. P. Fernando, Michael D. Street, and Robert W. Tindle
Cancer Res 2000 60: 2810-2815. [Abstract] [Full Text] [PDF]  

The von Hippel-Lindau Tumor Suppressor Targets to Mitochondria

Yih-Horng Shiao, James H. Resau, Kunio Nagashima, Lucy M. Anderson, and Gayatri Ramakrishna
Cancer Res 2000 60: 2816-2819. [Abstract] [Full Text] [PDF]  

Role of the von Hippel-Lindau Tumor Suppressor Protein during Neuronal Differentiation

Hiroshi Kanno, Farid Saljooque, Isao Yamamoto, Satoshi Hattori, Masahiro Yao, Taro Shuin, and Hoi-Sang U
Cancer Res 2000 60: 2820-2824. [Abstract] [Full Text] [PDF]  

Interaction between Sp1 and Cell Cycle Regulatory Proteins Is Important in Transactivation of a Differentiation-related Gene

Oliver G. Opitz and Anil K. Rustgi
Cancer Res 2000 60: 2825-2830. [Abstract] [Full Text] [PDF]  

Loss of p53 in Benzene-induced Thymic Lymphomas in p53+/- Mice: Evidence of Chromosomal Recombination

Scott E. Boley, Elizabeth E. Anderson, John E. French, Lawrence A. Donehower, Dana B. Walker, and Leslie Recio
Cancer Res 2000 60: 2831-2835. [Abstract] [Full Text] [PDF]  

A Region of Deletion on Chromosome 22q13 Is Common to Human Breast and Colorectal Cancers

Antoni Castells, James F. Gusella, Vijaya Ramesh, and Anil K. Rustgi
Cancer Res 2000 60: 2836-2839. [Abstract] [Full Text] [PDF]  

Expression of Bone Morphogenetic Protein Receptors Type-IA, -IB, and -II Correlates with Tumor Grade in Human Prostate Cancer Tissues

Isaac Yi Kim, Dong-Hyeon Lee, Han-Jong Ahn, Hideo Tokunaga, Weitao Song, Lisa M. Devereaux, Donald Jin, T. Kuber Sampath, and Ronald A. Morton
Cancer Res 2000 60: 2840-2844. [Abstract] [Full Text] [PDF]  

RET Receptor Expression in Thyroid Follicular Epithelial Cell-derived Tumors

Giuseppe Bunone, Mauro Uggeri, Piera Mondellini, Marco A. Pierotti, and Italia Bongarzone
Cancer Res 2000 60: 2845-2849. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Prostate Adenocarcinoma Cells Release the Novel Proinflammatory Polypeptide EMAP-II in Response to Stress

Georgina Barnett, Anne-Mette Jakobsen, Maarten Tas, Katherine Rice, James Carmichael, and J. Clifford Murray
Cancer Res 2000 60: 2850-2857. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Impact of Global Genome Repair versus Transcription-coupled Repair on Ultraviolet Carcinogenesis in Hairless Mice

Rob J. W. Berg, Heggert Rebel, Gijsbertus T. J. van der Horst, Henk J. van Kranen, Leon H. F. Mullenders, Willem A. van Vloten, and Frank R. de Gruijl
Cancer Res 2000 60: 2858-2863. [Abstract] [Full Text] [PDF]  

ß-Catenin Mutations and Protein Accumulation in All Hepatoblastomas Examined from B6C3F1 Mice Treated with Anthraquinone or Oxazepam

Colleen H. Anna, Robert C. Sills, Julie F. Foley, Patricia S. Stockton, Thai-Vu Ton, and Theodora R. Devereux
Cancer Res 2000 60: 2864-2868. [Abstract] [Full Text] [PDF]  

Retinoic Acid Receptor and Retinoid X Receptor Alterations in Lung Cancer Precursor Lesions

Nadine Martinet, François Alla, Guillaume Farré, Taonfika Labib, Hèlène Drouot, Reynald Vidili, Evelyne Picard, Marie-Pierre Gaube, Danielle Le Faou, Joëlle Siat, Jacques Borelly, Phillippe Vermylen, Taha Bazarbachi, Jean-Michel Vignaud, and Yves Martinet
Cancer Res 2000 60: 2869-2875. [Abstract] [Full Text] [PDF]  

Genetic Resistance to Chemical Carcinogen-induced Preneoplastic Hepatic Lesions in DRH Strain Rats

Zhao-Zhu Zeng, Shin Higashi, Wakashi Kitayama, Ayumi Denda, Ying Yan, Koichi Matsuo, Yoichi Konishi, Hiroshi Hiai, and Ken Higashi
Cancer Res 2000 60: 2876-2881. [Abstract] [Full Text] [PDF]  

In Vitro and in Vivo Studies of Methylseleninic Acid: Evidence That a Monomethylated Selenium Metabolite Is Critical for Cancer Chemoprevention

Clement Ip, Henry J. Thompson, Zongjian Zhu, and Howard E. Ganther
Cancer Res 2000 60: 2882-2886. [Abstract] [Full Text] [PDF]  

Sex Differences in the Activation of Tamoxifen to DNA Binding Species in Rat Liver in Vivo and in Rat Hepatocytes in Vitro: Role of Sulfotransferase Induction

Warren Davis, Alan Hewer, Krzysztof M. Rajkowski, Walter Meinl, Hansruedi Glatt, and David H. Phillips
Cancer Res 2000 60: 2887-2891. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Color Doppler Vascularity Index Can Predict Distant Metastasis and Survival in Colon Cancer Patients

Chiung-Nien Chen, Yung-Ming Cheng, Jin-Tung Liang, Po-Huang Lee, Fon-Jou Hsieh, Ray-Hwang Yuan, Shih-Ming Wang, Mei-Fang Chang, and King-Jen Chang
Cancer Res 2000 60: 2892-2897. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor (VEGF) in Breast Cancer: Comparison of Plasma, Serum, and Tissue VEGF and Microvessel Density and Effects of Tamoxifen

Jacqueline Adams, Pauline J. Carder, Sarah Downey, Mary A. Forbes, Kenneth MacLennan, Victoria Allgar, Sarah Kaufman, Susan Hallam, Roy Bicknell, James J. Walker, Fiona Cairnduff, Peter J. Selby, Timothy J. Perren, Mark Lansdown, and Rosamonde E. Banks
Cancer Res 2000 60: 2898-2905. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

p53 Mutations and Exposure to Environmental Tobacco Smoke in a Multicenter Study on Lung Cancer

Kirsti Husgafvel-Pursiainen, Paolo Boffetta, Annamaria Kannio, Fredrik Nyberg, Göran Pershagen, Anush Mukeria, Vali Constantinescu, Cristina Fortes, and Simone Benhamou
Cancer Res 2000 60: 2906-2911. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Enhancement of Fas-mediated Apoptosis in Renal Cell Carcinoma Cells by Adriamycin

Xiu-Xian Wu, Youichi Mizutani, Yoshiyuki Kakehi, Osamu Yoshida, and Osamu Ogawa
Cancer Res 2000 60: 2912-2918. [Abstract] [Full Text] [PDF]  

Inhibition of Translation Initiation Mediates the Anticancer Effect of the n-3 Polyunsaturated Fatty Acid Eicosapentaenoic Acid

Sangeetha S. Palakurthi, Rudolf Flückiger, Hussein Aktas, Arun K. Changolkar, Aliakbar Shahsafaei, Silvia Harneit, Ergin Kilic, and Jose A. Halperin
Cancer Res 2000 60: 2919-2925. [Abstract] [Full Text] [PDF]  

Blockade of the Epidermal Growth Factor Receptor Signaling by a Novel Tyrosine Kinase Inhibitor Leads to Apoptosis of Endothelial Cells and Therapy of Human Pancreatic Carcinoma

Christiane J. Bruns, Carmen C. Solorzano, Matthew T. Harbison, Shutaro Ozawa, Rachel Tsan, Dominic Fan, James Abbruzzese, Peter Traxler, Elisabeth Buchdunger, Robert Radinsky, and Isaiah J. Fidler
Cancer Res 2000 60: 2926-2935. [Abstract] [Full Text] [PDF]  

Therapeutic Efficacy of the Suicide Gene Driven by the Promoter of Vascular Endothelial Growth Factor Gene against Hypoxic Tumor Cells

Nobuko Koshikawa, Keizo Takenaga, Masatoshi Tagawa, and Shigeru Sakiyama
Cancer Res 2000 60: 2936-2941. [Abstract] [Full Text] [PDF]  

Benzylidene Lactam Compound, KNK437, a Novel Inhibitor of Acquisition of Thermotolerance and Heat Shock Protein Induction in Human Colon Carcinoma Cells

Shin-ichi Yokota, Mikio Kitahara, and Kazuhiro Nagata
Cancer Res 2000 60: 2942-2948. [Abstract] [Full Text] [PDF]  

Bisphosphonates Inhibit Breast and Prostate Carcinoma Cell Invasion, an Early Event in the Formation of Bone Metastases

Sandrine Boissier, Mercedes Ferreras, Olivier Peyruchaud, Sandrine Magnetto, Frank H. Ebetino, Marc Colombel, Pierre Delmas, Jean-Marie Delaissé, and Philippe Clézardin
Cancer Res 2000 60: 2949-2954. [Abstract] [Full Text] [PDF]  

Cationic Lipid:Bacterial DNA Complexes Elicit Adaptive Cellular Immunity in Murine Intraperitoneal Tumor Models

Michael Lanuti, Samantha Rudginsky, Seth D. Force, Eric S. Lambright, William M. Siders, Michael Y. Chang, Kunjlata M. Amin, Larry R. Kaiser, Ronald K. Scheule, and Steven M. Albelda
Cancer Res 2000 60: 2955-2963. [Abstract] [Full Text] [PDF]  

Discovery and Characterization of OC144-093, a Novel Inhibitor of P-Glycoprotein-mediated Multidrug Resistance

Michael J. Newman, Jennifer C. Rodarte, Khalid D. Benbatoul, Suzanne J. Romano, Chengzhi Zhang, Sonja Krane, Edmund J. Moran, Roy T. Uyeda, Ross Dixon, Emma S. Guns, and Lawrence D. Mayer
Cancer Res 2000 60: 2964-2972. [Abstract] [Full Text] [PDF]  

Porphyrin Analogues as Novel Antagonists of Fibroblast Growth Factor and Vascular Endothelial Growth Factor Receptor Binding That Inhibit Endothelial Cell Proliferation, Tumor Progression, and Metastasis

David Aviezer, Sara Cotton, Magda David, Amit Segev, Nona Khaselev, Nitsa Galili, Zeev Gross, and Avner Yayon
Cancer Res 2000 60: 2973-2980. [Abstract] [Full Text] [PDF]  

Structure, Function, and Targeting of Interleukin 4 Receptors on Human Head and Neck Cancer Cells

Koji Kawakami, Pamela Leland, and Raj K. Puri
Cancer Res 2000 60: 2981-2987. [Abstract] [Full Text] [PDF]  

Complete Regression of Xenografted Human Carcinomas by Camptothecin Analogue-Carboxymethyl Dextran Conjugate (T-0128)

Satoshi Okuno, Mitsunori Harada, Toshiro Yano, Shigeru Yano, Satoko Kiuchi, Naoki Tsuda, Yumi Sakamura, Jun Imai, Takayuki Kawaguchi, and Kenji Tsujihara
Cancer Res 2000 60: 2988-2995. [Abstract] [Full Text] [PDF]  

Inhibition of Metastatic Renal Cell Carcinomas Expressing Somatostatin Receptors by a Targeted Cytotoxic Analogue of Somatostatin AN-238

Artur Plonowski, Andrew V. Schally, Attila Nagy, Hippokratis Kiaris, Francine Hebert, and Gabor Halmos
Cancer Res 2000 60: 2996-3001. [Abstract] [Full Text] [PDF]  

Immunology:

Sequential Loss of Cytotoxic T Lymphocyte Responses to Simian Virus 40 Large T Antigen Epitopes in T Antigen Transgenic Mice Developing Osteosarcomas

Todd D. Schell, Barbara B. Knowles, and Satvir S. Tevethia
Cancer Res 2000 60: 3002-3012. [Abstract] [Full Text] [PDF]  

CD59 Expressed on a Tumor Cell Surface Modulates Decay-accelerating Factor Expression and Enhances Tumor Growth in a Rat Model of Human Neuroblastoma

Shaohua Chen, Theresa Caragine, Nai-Kong V. Cheung, and Stephen Tomlinson
Cancer Res 2000 60: 3013-3018. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

p53 Transdominance But No Gain of Function in Mouse Brain Tumor Model

Monika E. Hegi, Michael A. Klein, Daniela Rüedi, Patrick Chène, Marie-France Hamou, and Adriano Aguzzi
Cancer Res 2000 60: 3019-3024. [Abstract] [Full Text] [PDF]  

DNA Copy Number Changes in Malignant Ovarian Germ Cell Tumors

Sigrid Marie Kraggerud, Jadwiga Szymanska, Vera M. Abeler, Janne Kærn, Mette Eknæs, Sverre Heim, Manuel R. Teixeira, Claes G. Tropé, Päivi Peltomäki, and Ragnhild A. Lothe
Cancer Res 2000 60: 3025-3030. [Abstract] [Full Text] [PDF]  

Mitogenic Conversion of Transforming Growth Factor-ß1 Effect by Oncogenic Ha-Ras-induced Activation of the Mitogen-activated Protein Kinase Signaling Pathway in Human Prostate Cancer

Bum-Joon Park, Jae-Il Park, Do-Sun Byun, Jae-Hoon Park, and Sung-Gil Chi
Cancer Res 2000 60: 3031-3038. [Abstract] [Full Text] [PDF]  

Allelic Loss in the Progression of Myelodysplastic Syndrome

Naoki Mori, Roberta Morosetti, Elisabeth Hoflehner, Michael Lübbert, Hideaki Mizoguchi, and H. Phillip Koeffler
Cancer Res 2000 60: 3039-3042. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Overexpression of CDC25B Phosphatase as a Novel Marker of Poor Prognosis of Human Colorectal Carcinoma

Ichiro Takemasa, Hirofumi Yamamoto, Mitsugu Sekimoto, Masayuki Ohue, Shingo Noura, Yasuhiro Miyake, Takashi Matsumoto, Tomohiko Aihara, Naohiro Tomita, Yasuhiro Tamaki, Isao Sakita, Nobuteru Kikkawa, Nariaki Matsuura, Hitoshi Shiozaki, and Morito Monden
Cancer Res 2000 60: 3043-3050. [Abstract] [Full Text] [PDF]  

Tumor Necrosis Factor-related Apoptosis-inducing Ligand Retains Its Apoptosis-inducing Capacity on Bcl-2- or Bcl-x_L-overexpressing Chemotherapy-resistant Tumor Cells

Henning Walczak, Axel Bouchon, Heiko Stahl, and Peter H. Krammer
Cancer Res 2000 60: 3051-3057. [Abstract] [Full Text] [PDF]  

Castration-induced Up-Regulation of Insulin-like Growth Factor Binding Protein-5 Potentiates Insulin-like Growth Factor-I Activity and Accelerates Progression to Androgen Independence in Prostate Cancer Models

Hideaki Miyake, Michael Pollak, and Martin E. Gleave
Cancer Res 2000 60: 3058-3064. [Abstract] [Full Text] [PDF]  

Arsenic Trioxide-mediated Growth Inhibition in MC/CAR Myeloma Cells via Cell Cycle Arrest in Association with Induction of Cyclin-dependent Kinase Inhibitor, p21, and Apoptosis

Woo H. Park, Jae G. Seol, Eun S. Kim, Jung M. Hyun, Chul W. Jung, Chung C. Lee, Byoung K. Kim, and Young Y. Lee
Cancer Res 2000 60: 3065-3071. [Abstract] [Full Text] [PDF]  

Expression of Polysialic Acid and STX, a Human Polysialyltransferase, Is Correlated with Tumor Progression in Non-Small Cell Lung Cancer

Fumihiro Tanaka, Yosuke Otake, Tatsuo Nakagawa, Yozo Kawano, Ryo Miyahara, Mio Li, Kazuhiro Yanagihara, Jun Nakayama, Ichiro Fujimoto, Kazuhiro Ikenaka, and Hiromi Wada
Cancer Res 2000 60: 3072-3080. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor vIII Enhances Tumorigenicity in Human Breast Cancer

Careen K. Tang, Xiao-Qi Gong, David K. Moscatello, Albert J. Wong, and Marc E. Lippman
Cancer Res 2000 60: 3081-3087. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor/KDR Activated Microvessel Density versus CD31 Standard Microvessel Density in Non-Small Cell Lung Cancer

Michael I. Koukourakis, Alexandra Giatromanolaki, Philip E. Thorpe, Rolf A. Brekken, Efthimios Sivridis, Stelios Kakolyris, Vassilis Georgoulias, Kevin C. Gatter, and Adrian L. Harris
Cancer Res 2000 60: 3088-3095. [Abstract] [Full Text] [PDF]  

In Vivo Induction of Insulin-like Growth Factor-I Receptor and CD44v6 Confers Homing and Adhesion to Murine Multiple Myeloma Cells

Kewal Asosingh, Ursula Günthert, Marleen H. C. Bakkus, Hendrik De Raeve, Eva Goes, Ivan Van Riet, Ben Van Camp, and Karin Vanderkerken
Cancer Res 2000 60: 3096-3104. [Abstract] [Full Text] [PDF]  

Vasoactive Intestinal Peptide/Pituitary Adenylate Cyclase-activating Peptide Receptor Subtypes in Human Tumors and Their Tissues of Origin¹

Jean Claude Reubi, Ursula Läderach, Beatrice Waser, Jan-O. Gebbers, Patrick Robberecht, and Jean A. Laissue
Cancer Res 2000 60: 3105-3112. [Abstract] [Full Text] [PDF]  

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