Advances in Brief:

Pancreatic Duct Cell Carcinomas Express High Levels of High Mobility Group I(Y) Proteins

Nobutsugu Abe, Takashi Watanabe, Tadahiko Masaki, Toshiyuki Mori, Masanori Sugiyama, Hidemasa Uchimura, Yasunori Fujioka, Gennaro Chiappetta, Alfredo Fusco, and Yutaka Atomi
Cancer Res 2000 60: 3117-3122. [Abstract] [Full Text] [PDF]  

Inhibition of Angiogenesis and Induction of Apoptosis Are Involved in E1A-mediated Bystander Effect and Tumor Suppression

Ruping Shao, Weiya Xia, and Mien-Chie Hung
Cancer Res 2000 60: 3123-3126. [Abstract] [Full Text] [PDF]  

The Pyrido[2,3-d]pyrimidine Derivative PD180970 Inhibits p210^Bcr-Abl Tyrosine Kinase and Induces Apoptosis of K562 Leukemic Cells

Jay F. Dorsey, Richard Jove, Alan J. Kraker, and Jie Wu
Cancer Res 2000 60: 3127-3131. [Abstract] [Full Text] [PDF]  

Vaccine-induced Apoptosis: A Novel Clinical Trial End Point?

Schwann Amin, R. Adrian Robins, Charles A. Maxwell-Armstrong, John H. Scholefield, and Lindy G. Durrant
Cancer Res 2000 60: 3132-3136. [Abstract] [Full Text] [PDF]  

A Novel Histone Deacetylase Inhibitor Identified by High-Throughput Transcriptional Screening of a Compound Library

Gloria H. Su, Taylor A. Sohn, Byungwoo Ryu, and Scott E. Kern
Cancer Res 2000 60: 3137-3142. [Abstract] [Full Text] [PDF]  

Genomic Structure of the Human ING1 Gene and Tumor-specific Mutations Detected in Head and Neck Squamous Cell Carcinomas

Mehmet Gunduz, Mamoru Ouchida, Kunihiro Fukushima, Hiroko Hanafusa, Tsutomu Etani, Shinji Nishioka, Kazunori Nishizaki, and Kenji Shimizu
Cancer Res 2000 60: 3143-3146. [Abstract] [Full Text] [PDF]  

Functional Evaluation of PTEN Missense Mutations Using in Vitro Phosphoinositide Phosphatase Assay

Shuang-Yin Han, Hideaki Kato, Shunsuke Kato, Takao Suzuki, Hiroyuki Shibata, Seiichi Ishii, Ken-ichi Shiiba, Seiki Matsuno, Ryunosuke Kanamaru, and Chikashi Ishioka
Cancer Res 2000 60: 3147-3151. [Abstract] [Full Text] [PDF]  

Cysteine 230 Modulates Tumor Necrosis Factor-related Apoptosis-inducing Ligand Activity

Dai-Wu Seol and Timothy R. Billiar
Cancer Res 2000 60: 3152-3154. [Abstract] [Full Text] [PDF]  

Alcohol Consumption and Cigarette Smoking Increase the Frequency of p53 Mutations in Non-Small Cell Lung Cancer

Steven A. Ahrendt, John T. Chow, Stephen C. Yang, Li Wu, Mei-Jie Zhang, Jin Jen, and David Sidransky
Cancer Res 2000 60: 3155-3159. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Consistent and Fast Inhibition of Colon Carcinogenesis by Polyethylene Glycol in Mice and Rats Given Various Carcinogens

Denis E. Corpet, Géraldine Parnaud, Maxence Delverdier, Ginette Peiffer, and Sylviane Taché
Cancer Res 2000 60: 3160-3164. [Abstract] [Full Text] [PDF]  

Instability of X Chromosome Methylation in Aberrant Crypt Foci of the Human Colon

Nobuyuki Sakurazawa, Noritake Tanaka, Masahiko Onda, and Hiroyasu Esumi
Cancer Res 2000 60: 3165-3169. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Detection of Germ-Cell Tumor Cells in the Peripheral Blood by Nested Reverse Transcription-Polymerase Chain Reaction for -Fetoprotein-Messenger RNA and ß Human Chorionic Gonadotropin-Messenger RNA

Andreas L. A. Hautkappe, Mengji Lu, Hendrik Mueller, Axel Bex, Andreas Harstrick, Michael Roggendorf, and Herbert Ruebben
Cancer Res 2000 60: 3170-3174. [Abstract] [Full Text] [PDF]  

Endocrinology:

Expression of Estrogen Receptor (ER)- and ER-ß in Normal and Malignant Prostatic Epithelial Cells: Regulation by Methylation and Involvement in Growth Regulation

Kin-Mang Lau, Mark LaSpina, John Long, and Shuk-Mei Ho
Cancer Res 2000 60: 3175-3182. [Abstract] [Full Text] [PDF]  

Identification of Functional Estrogen Response Elements in the Gene Coding for the Potent Angiogenic Factor Vascular Endothelial Growth Factor

Salman M. Hyder, Zafar Nawaz, Constance Chiappetta, and George M. Stancel
Cancer Res 2000 60: 3183-3190. [Abstract] [Full Text] [PDF]  

Epidemiology:

Chemopreventive Effects of Dietary Folate on Intestinal Polyps in Apc+/- Msh2-/- Mice

Jacquelin Song, Kyoung-Jin Sohn, Alan Medline, Colleen Ash, Steven Gallinger, and Young-In Kim
Cancer Res 2000 60: 3191-3199. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Regrowth of 5-Fluorouracil-treated Human Colon Cancer Cells Is Prevented by the Combination of Interferon , Indomethacin, and Phenylbutyrate

Yicong Huang, Curt M. Horvath, and Samuel Waxman
Cancer Res 2000 60: 3200-3206. [Abstract] [Full Text] [PDF]  

Addition of Matrix Metalloproteinase Inhibition to Conventional Cytotoxic Therapy Reduces Tumor Implantation and Prolongs Survival in a Murine Model of Human Pancreatic Cancer

Mahmudul Haq, Alexis Shafii, Emmanuel E. Zervos, and Alexander S. Rosemurgy
Cancer Res 2000 60: 3207-3211. [Abstract] [Full Text] [PDF]  

Mitochondrial Amplification of Death Signals Determines Thymidine Kinase/Ganciclovir-triggered Activation of Apoptosis

Christian Beltinger, Simone Fulda, Thomas Kammertoens, Wolfgang Uckert, and Klaus-Michael Debatin
Cancer Res 2000 60: 3212-3217. [Abstract] [Full Text] [PDF]  

Cancer Gene Therapy by Thyroid Hormone-mediated Expression of Toxin Genes

Verónica Martín, Maria Luisa Cortés, Pablo de Felipe, Antonella Farsetti, Nora B. Calcaterra, and Marta Izquierdo
Cancer Res 2000 60: 3218-3224. [Abstract] [Full Text] [PDF]  

Agonistic Properties and in Vivo Antitumor Activity of the Anti-CD40 Antibody SGN-14

Joseph A. Francisco, Karen L. Donaldson, Dana Chace, Clay B. Siegall, and Alan F. Wahl
Cancer Res 2000 60: 3225-3231. [Abstract] [Full Text] [PDF]  

In Vivo Antitumor Activity and Host Toxicity of Methoxymorpholinyl Doxorubicin: Role of Cytochrome P450 3A

Luigi Quintieri, Antonio Rosato, Eleonora Napoli, Francesco Sola, Cristina Geroni, Maura Floreani, and Paola Zanovello
Cancer Res 2000 60: 3232-3238. [Abstract] [Full Text] [PDF]  

Immunology:

Differences in Dendritic Cells Stimulated in Vivo by Tumors Engineered to Secrete Granulocyte-Macrophage Colony-stimulating Factor or Flt3-Ligand

Nicolas Mach, Silke Gillessen, S. Brian Wilson, Christine Sheehan, Martin Mihm, and Glenn Dranoff
Cancer Res 2000 60: 3239-3246. [Abstract] [Full Text] [PDF]  

Genetically Modified Dendritic Cells Prime Autoreactive T Cells through a Pathway Independent of CD40L and Interleukin 12: Implications for Cancer Vaccines

Yonghong Wan, Jonathan Bramson, Andrew Pilon, Qing Zhu, and Jack Gauldie
Cancer Res 2000 60: 3247-3253. [Abstract] [Full Text] [PDF]  

Construction, Production, and Characterization of Humanized Anti-Lewis Y Monoclonal Antibody 3S193 for Targeted Immunotherapy of Solid Tumors

Andrew M. Scott, Detlef Geleick, Michael Rubira, Kerrie Clarke, Edouard C. Nice, Fiona E. Smyth, Elisabeth Stockert, Elizabeth C. Richards, Frank J. Carr, William J. Harris, Kathryn L. Armour, Jeff Rood, Anna Kypridis, Veronika Kronina, Roger Murphy, F-T. Lee, Zhanqi Liu, Kunio Kitamura, Gerd Ritter, Katrina Laughton, Eric Hoffman, Antony W. Burgess, and Lloyd J. Old
Cancer Res 2000 60: 3254-3261. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Epigenetic Regulation of the MGMT and hMSH6 DNA Repair Genes in Cells Resistant to Methylating Agents

Alessandra Bearzatto, Marta Szadkowski, Peter Macpherson, Josef Jiricny, and Peter Karran
Cancer Res 2000 60: 3262-3270. [Abstract] [Full Text] [PDF]  

Unique Anti-Activator Protein-1 Activity of Retinoic Acid Receptor ß

Feng Lin, Dongmei Xiao, Siva Kumar Kolluri, and Xiao-kun Zhang
Cancer Res 2000 60: 3271-3280. [Abstract] [Full Text] [PDF]  

Rapid and Reliable Quantification of Minimal Residual Disease in Acute Lymphoblastic Leukemia Using Rearranged Immunoglobulin and T-Cell Receptor Loci by LightCycler Technology

Makoto Nakao, Johannes W. G. Janssen, Thomas Flohr, and Claus R. Bartram
Cancer Res 2000 60: 3281-3289. [Abstract] [Full Text] [PDF]  

Inhibition of the Interferon-/Signal Transducers and Activators of Transcription (STAT) Pathway by Hypermethylation at a STAT-binding Site in the p21^WAF1 Promoter Region

Bin Chen, Ling He, Van H. Savell, Jesse J. Jenkins, and David M. Parham
Cancer Res 2000 60: 3290-3298. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Role for ATM in DNA Damage-induced Phosphorylation of BRCA1

Magtouf Gatei, Shaun P. Scott, Igor Filippovitch, Natasha Soronika, Martin F. Lavin, Barbara Weber, and Kum Kum Khanna
Cancer Res 2000 60: 3299-3304. [Abstract] [Full Text] [PDF]  

Arginase Activity in Human Breast Cancer Cell Lines: N-Hydroxy-L-arginine Selectively Inhibits Cell Proliferation and Induces Apoptosis in MDA-MB-468 Cells

Rajan Singh, Shehla Pervin, Ardeshir Karimi, Stephen Cederbaum, and Gautam Chaudhuri
Cancer Res 2000 60: 3305-3312. [Abstract] [Full Text] [PDF]  

New Evidence for an Extra-Hepatic Role of N-acetylglucosaminyltransferase III in the Progression of Diethylnitrosamine-induced Liver Tumors in Mice

Xiaoping Yang, Mantu Bhaumik, Riddhi Bhattacharyya, Shih Gong, Charles E. Rogler, and Pamela Stanley
Cancer Res 2000 60: 3313-3319. [Abstract] [Full Text] [PDF]  

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