Advances in Brief:

Frequent ß-Catenin Gene Mutations and Accumulations of the Protein in the Putative Preneoplastic Lesions Lacking Macroscopic Aberrant Crypt Foci Appearance, in Rat Colon Carcinogenesis

Yasuhiro Yamada, Naoki Yoshimi, Yoshinobu Hirose, Kunihiro Kawabata, Kengo Matsunaga, Masahito Shimizu, Akira Hara, and Hideki Mori
Cancer Res 2000 60: 3323-3327. [Abstract] [Full Text] [PDF]  

The Epidermal Growth Factor Receptor Is Required to Maintain the Proliferative Population in the Basal Compartment of Epidermal Tumors

Laura A. Hansen, Roderick L. Woodson, II, Sherry Holbus, Kathryn Strain, You-Chein Lo, and Stuart H. Yuspa
Cancer Res 2000 60: 3328-3332. [Abstract] [Full Text] [PDF]  

Increased p53 Mutation Load in Noncancerous Colon Tissue from Ulcerative Colitis: A Cancer-prone Chronic Inflammatory Disease

S. Perwez Hussain, Paul Amstad, Kamran Raja, Stefan Ambs, Makoto Nagashima, William P. Bennett, Peter G. Shields, Amy-Joan Ham, James A. Swenberg, Aizen J. Marrogi, and Curtis C. Harris
Cancer Res 2000 60: 3333-3337. [Abstract] [Full Text] [PDF]  

Exisulind Induction of Apoptosis Involves Guanosine 3',5'-Cyclic Monophosphate Phosphodiesterase Inhibition, Protein Kinase G Activation, and Attenuated ß-Catenin

W. Joseph Thompson, Gary A. Piazza, Han Li, Li Liu, John Fetter, Bing Zhu, Gerhard Sperl, Dennis Ahnen, and Rifat Pamukcu
Cancer Res 2000 60: 3338-3342. [Abstract] [Full Text] [PDF]  

Inhibition of Metastatic Tumor Growth in Nude Mice by Portal Vein Infusions of Matrix-targeted Retroviral Vectors Bearing a Cytocidal Cyclin G1 Construct

Erlinda M. Gordon, Peng Xuan Liu, Zhen Hai Chen, Ling Liu, Michelle D. Whitley, Conway Gee, Susan Groshen, David R. Hinton, Robert W. Beart, and Frederick L. Hall
Cancer Res 2000 60: 3343-3347. [Abstract] [Full Text] [PDF]  

High Resolution Allelotype of Microdissected Primary Nasopharyngeal Carcinoma

Kwok-Wai Lo, Peter M. L. Teo, Angela Bik-Yu Hui, Ka-Fai To, Yuen-Shan Tsang, Sylvia Yat-Yee Chan, Ko-Fung Mak, Joseph C. K. Lee, and Dolly P. Huang
Cancer Res 2000 60: 3348-3353. [Abstract] [Full Text] [PDF]  

Isolation and Characterization of a Novel Human Gene, DRCTNNB1A, the Expression of Which Is Down-Regulated by ß-Catenin

Teru Kawasoe, Yoichi Furukawa, Yataro Daigo, Tadashi Nishiwaki, Hideyuki Ishiguro, Manabu Fujita, Seiji Satoh, Nobutomo Miwa, Yutaka Nagasawa, Yasuo Miyoshi, Michio Ogawa, and Yusuke Nakamura
Cancer Res 2000 60: 3354-3358. [Abstract] [Full Text] [PDF]  

Down-Regulation of HP1^Hs Expression Is Associated with the Metastatic Phenotype in Breast Cancer

Dawn A. Kirschmann, Ruth A. Lininger, Lynn M. G. Gardner, Elisabeth A. Seftor, Valerie A. Odero, Alexandra M. Ainsztein, William C. Earnshaw, Lori L. Wallrath, and Mary J. C. Hendrix
Cancer Res 2000 60: 3359-3363. [Abstract] [Full Text] [PDF]  

Front-Cell-specific Expression of Membrane-Type 1 Matrix Metalloproteinase and Gelatinase A during Cohort Migration of Colon Carcinoma Cells Induced by Hepatocyte Growth Factor/Scatter Factor

Kazuki Nabeshima, Teruhiko Inoue, Yoshiya Shimao, Yasunori Okada, Yoshifumi Itoh, Motoharu Seiki, and Masashi Koono
Cancer Res 2000 60: 3364-3369. [Abstract] [Full Text] [PDF]  

Frequent Alteration of p63 Expression in Human Primary Bladder Carcinomas

Bum-Joon Park, Seung-Jae Lee, Jin Il Kim, Sun-Ju Lee, Choong-Hyun Lee, Sung-Goo Chang, Jae-Hoon Park, and Sung-Gil Chi
Cancer Res 2000 60: 3370-3374. [Abstract] [Full Text] [PDF]  

Carcinogenic Metals Induce Hypoxia-inducible Factor-stimulated Transcription by Reactive Oxygen Species-independent Mechanism

Konstantin Salnikow, Weicheng Su, Mikhail V. Blagosklonny, and Max Costa
Cancer Res 2000 60: 3375-3378. [Abstract] [Full Text] [PDF]  

Differential Formation of ß-Catenin/Lymphoid Enhancer Factor-1 DNA Binding Complex Induced by Nitric Oxide in Mouse Colonic Epithelial Cells Differing in Adenomatous Polyposis Coli (Apc) Genotype

Jay M. Mei, Norman G. Hord, Dolores F. Winterstein, Steven P. Donald, and James M. Phang
Cancer Res 2000 60: 3379-3383. [Abstract] [Full Text] [PDF]  

Tumor-inhibitory Antibodies to HER-2/ErbB-2 May Act by Recruiting c-Cbl and Enhancing Ubiquitination of HER-2

Leah N. Klapper, Hadassa Waterman, Michael Sela, and Yosef Yarden
Cancer Res 2000 60: 3384-3388. [Abstract] [Full Text] [PDF]  

Liposomal Encapsulation of Topotecan Enhances Anticancer Efficacy in Murine and Human Xenograft Models

Paul Tardi, Edward Choice, Dana Masin, Thomas Redelmeier, Marcel Bally, and Thomas D. Madden
Cancer Res 2000 60: 3389-3393. [Abstract] [Full Text] [PDF]  

In Vivo Inhibition of Estrone Sulfatase Activity and Growth of Nitrosomethylurea-induced Mammary Tumors by 667 COUMATE

Atul Purohit, Lawrence W. L. Woo, Barry V. L. Potter, and Michael J. Reed
Cancer Res 2000 60: 3394-3396. [Abstract] [Full Text] [PDF]  

Identification of New Minimally Lost Regions on 18q in Head and Neck Squamous Cell Carcinoma

Satoru Takebayashi, Tetsuya Ogawa, Kwang-Yoon Jung, Ariege Muallem, Hiroyuki Mineta, Susan G. Fisher, Reidar Grenman, and Thomas E. Carey
Cancer Res 2000 60: 3397-3403. [Abstract] [Full Text] [PDF]  

Biallelic Methylation and Silencing of Mouse Aprt in Normal Kidney Cells

Jennifer A. Rose, Phillip A. Yates, James Simpson, Jay A. Tischfield, Peter J. Stambrook, and Mitchell S. Turker
Cancer Res 2000 60: 3404-3408. [Abstract] [Full Text] [PDF]  

BCR-ABL Mediates Arsenic Trioxide-induced Apoptosis Independently of Its Aberrant Kinase Activity

Elena Puccetti, Saskia Güller, Anette Orleth, Nicole Brüggenolte, Dieter Hoelzer, Oliver Gerhard Ottmann, and Martin Ruthardt
Cancer Res 2000 60: 3409-3413. [Abstract] [Full Text] [PDF]  

Reproductive State of Rat Mammary Gland Stroma Modulates Human Breast Cancer Cell Migration and Invasion

Lynne T. Bemis and Pepper Schedin
Cancer Res 2000 60: 3414-3418. [Abstract] [Full Text] [PDF]  

Human Carcinoembryonic Antigen Functions as a General Inhibitor of Anoikis

Cosme Ordoñez, Robert A. Screaton, Chris Ilantzis, and Clifford P. Stanners
Cancer Res 2000 60: 3419-3424. [Abstract] [Full Text] [PDF]  

Loss of Cell Cycle Control Allows Selective Microtubule-active Drug-induced Bcl-2 Phosphorylation and Cytotoxicity in Autonomous Cancer Cells

Mikhail V. Blagosklonny, Philippe C. Bishop, Robert Robey, Tito Fojo, and Susan E. Bates
Cancer Res 2000 60: 3425-3428. [Abstract] [Full Text] [PDF]  

Differential Expression of Cell Surface Molecules in Prostate Cancer Cells

Alvin Y. Liu
Cancer Res 2000 60: 3429-3434. [Abstract] [Full Text] [PDF]  

Heat-induced Gene Expression as a Novel Targeted Cancer Gene Therapy Strategy

Qian Huang, Jim K. Hu, Frank Lohr, Li Zhang, Rod Braun, Jennifer Lanzen, John B. Little, Mark W. Dewhirst, and Chuan-Yuan Li
Cancer Res 2000 60: 3435-3439. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Cytochrome P450 1B1 (CYP1B1) Pharmacogenetics: Association of Polymorphisms with Functional Differences in Estrogen Hydroxylation Activity

Imad H. Hanna, Sheila Dawling, Nady Roodi, F. Peter Guengerich, and Fritz F. Parl
Cancer Res 2000 60: 3440-3444. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Arsenic Mediates Cell Proliferation and Gene Expression in the Bladder Epithelium: Association with Activating Protein-1 Transactivation

Petia P. Simeonova, Shiyi Wang, Wataru Toriuma, Vera Kommineni, Joanna Matheson, Nyseo Unimye, Fujio Kayama, Dan Harki, Min Ding, Val Vallyathan, and Michael I. Luster
Cancer Res 2000 60: 3445-3453. [Abstract] [Full Text] [PDF]  

Cytochrome P4501B1 Mediates Induction of Bone Marrow Cytotoxicity and Preleukemia Cells in Mice Treated with 7,12-Dimethylbenz[a]anthracene

Shawn M. Heidel, Peter S. MacWilliams, William M. Baird, W. Mohaiza Dashwood, Jeroen T. M. Buters, Frank J. Gonzalez, Michele C. Larsen, Charles J. Czuprynski, and Colin R. Jefcoate
Cancer Res 2000 60: 3454-3460. [Abstract] [Full Text] [PDF]  

Mice Heterozygous for a Brca1 or Brca2 Mutation Display Distinct Mammary Gland and Ovarian Phenotypes in Response to Diethylstilbestrol

L. Michelle Bennett, Kimberly A. McAllister, Jason Malphurs, Toni Ward, N. Keith Collins, John C. Seely, Lori C. Gowen, Beverly H. Koller, Barbara J. Davis, and Roger W. Wiseman
Cancer Res 2000 60: 3461-3469. [Abstract] [Full Text] [PDF]  

Endocrinology:

A Plasmin-derived Hexapeptide from the Carboxyl End of Osteocalcin Counteracts Oxytocin-mediated Growth of Inhibition of Osteosarcoma Cells

J. F. Novak, M. B. Judkins, M. I. Chernin, P. Cassoni, G. Bussolati, J. A. Nitche, and S. K. Nishimoto
Cancer Res 2000 60: 3470-3476. [Abstract] [Full Text] [PDF]  

Epidemiology:

Chemopreventive Properties of trans-Resveratrol Are Associated with Inhibition of Activation of the IB Kinase

Minnie Holmes-McNary and Albert S. Baldwin, Jr.
Cancer Res 2000 60: 3477-3483. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Adenovirus-mediated Transfer of the Thyroid Sodium/Iodide Symporter Gene into Tumors for a Targeted Radiotherapy

Anne Boland, Marcel Ricard, Paule Opolon, Jean-Michel Bidart, Patrice Yeh, Sebastiano Filetti, Martin Schlumberger, and Michel Perricaudet
Cancer Res 2000 60: 3484-3492. [Abstract] [Full Text] [PDF]  

dUTP Nucleotidohydrolase Isoform Expression in Normal and Neoplastic Tissues: Association with Survival and Response to 5-Fluorouracil in Colorectal Cancer

Robert D. Ladner, Frank J. Lynch, Susan Groshen, Yi Ping Xiong, Andrew Sherrod, Salvatore J. Caradonna, Jan Stoehlmacher, and Heinz-Josef Lenz
Cancer Res 2000 60: 3493-3503. [Abstract] [Full Text] [PDF]  

A Direct Linkage between the Phosphoinositide 3-Kinase-AKT Signaling Pathway and the Mammalian Target of Rapamycin in Mitogen-stimulated and Transformed Cells

Aleksandar Sekulic, Christine C. Hudson, James L. Homme, Peng Yin, Diane M. Otterness, Larry M. Karnitz, and Robert T. Abraham
Cancer Res 2000 60: 3504-3513. [Abstract] [Full Text] [PDF]  

Methotrexate Cross-Resistance in a Mitoxantrone-selected Multidrug-resistant MCF7 Breast Cancer Cell Line Is Attributable to Enhanced Energy-dependent Drug Efflux

Erin L. Volk, Kristin Rohde, Myung Rhee, John J. McGuire, L. Austin Doyle, Douglas D. Ross, and Erasmus Schneider
Cancer Res 2000 60: 3514-3521. [Abstract] [Full Text] [PDF]  

Differential Signaling by an Anti-p185^HER2 Antibody and Heregulin

Xiao-Feng Le, Ratna Vadlamudi, Amanda McWatters, Duk Soo Bae, Gordon B. Mills, Rakesh Kumar, and Robert C. Bast, Jr.
Cancer Res 2000 60: 3522-3531. [Abstract] [Full Text] [PDF]  

Intracellular Acidification of Human Melanoma Xenografts by the Respiratory Inhibitor m-Iodobenzylguanidine Plus Hyperglycemia: A ³¹P Magnetic Resonance Spectroscopy Study

Rong Zhou, Navin Bansal, Dennis B. Leeper, and Jerry D. Glickson
Cancer Res 2000 60: 3532-3536. [Abstract] [Full Text] [PDF]  

Taxol and Anti-Stathmin Therapy: A Synergistic Combination that Targets the Mitotic Spindle

Camelia Iancu, Sucharita J. Mistry, Steven Arkin, and George F. Atweh
Cancer Res 2000 60: 3537-3541. [Abstract] [Full Text] [PDF]  

Immunology:

Generation of Tumor-specific T Lymphocytes by Cross-Priming with Human Dendritic Cells Ingesting Apoptotic Tumor Cells

Thomas K. Hoffmann, Norbert Meidenbauer, Grzegorz Dworacki, Hiroaki Kanaya, and Theresa L. Whiteside
Cancer Res 2000 60: 3542-3549. [Abstract] [Full Text] [PDF]  

Identification of a New Endoplasmic Reticulum-resident Protein Recognized by HLA-A24-restricted Tumor-infiltrating Lymphocytes of Lung Cancer

Kouichiro Kawano, Shinya Gomi, Koji Tanaka, Naotake Tsuda, Toshiharu Kamura, Kyogo Itoh, and Akira Yamada
Cancer Res 2000 60: 3550-3558. [Abstract] [Full Text] [PDF]  

Peripheral Burst of Tumor-specific Cytotoxic T Lymphocytes and Infiltration of Metastatic Lesions by Memory CD8⁺ T Cells in Melanoma Patients Receiving Interleukin 12

Roberta Mortarini, Alessandra Borri, Gabrina Tragni, Ilaria Bersani, Claudia Vegetti, Emilio Bajetta, Silvana Pilotti, Vincenzo Cerundolo, and Andrea Anichini
Cancer Res 2000 60: 3559-3568. [Abstract] [Full Text] [PDF]  

HER-2/neu Is a Tumor Rejection Target in Tolerized HER-2/neu Transgenic Mice

R. Todd Reilly, Morris B. C. Gottlieb, Anne M. Ercolini, Jean-Pascal H. Machiels, Colin E. Kane, Francesca I. Okoye, William J. Muller, Katharine H. Dixon, and Elizabeth M. Jaffee
Cancer Res 2000 60: 3569-3576. [Abstract] [Full Text] [PDF]  

Differences of Biodistribution, Pharmacokinetics, and Tumor Targeting between Interleukins 2 and 15

Hisataka Kobayashi, Jorge A. Carrasquillo, Chang H. Paik, Thomas A. Waldmann, and Yutaka Tagaya
Cancer Res 2000 60: 3577-3583. [Abstract] [Full Text] [PDF]  

Serological Cloning of a Melanocyte rab Guanosine 5'-Triphosphate-binding Protein and a Chromosome Condensation Protein from a Melanoma Complementary DNA Library

Dirk Jäger, Elisabeth Stockert, Elke Jäger, Ali O. Güre, Matthew J. Scanlan, Alexander Knuth, Lloyd J. Old, and Yao-Tseng Chen
Cancer Res 2000 60: 3584-3591. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Fusion of H4/D10S170 to the Platelet-derived Growth Factor Receptor ß in BCR-ABL-negative Myeloproliferative Disorders with a t(5;10)(q33;q21)

Shashikant Kulkarni, Carol Heath, Sally Parker, Andrew Chase, Sameena Iqbal, Christopher F. Pocock, Jaspal Kaeda, Kate Cwynarski, John M. Goldman, and Nicholas C. P. Cross
Cancer Res 2000 60: 3592-3598. [Abstract] [Full Text] [PDF]  

Correlation of p53 and the Proto-Oncogene eIF4E in Larynx Cancers: Prognostic Implications

Cherie-Ann O. Nathan, Kenneth Sanders, Fleurette W. Abreo, Raja Nassar, and Jonathan Glass
Cancer Res 2000 60: 3599-3604. [Abstract] [Full Text] [PDF]  

High Incidence of Breast and Endometrial Neoplasia Resembling Human Cowden Syndrome in pten^+/- Mice

Vuk Stambolic, Ming-Sound Tsao, David Macpherson, Akira Suzuki, William B. Chapman, and Tak W. Mak
Cancer Res 2000 60: 3605-3611. [Abstract] [Full Text] [PDF]  

Proliferation-associated SNF2-like Gene (PASG): A SNF2 Family Member Altered in Leukemia¹

David W. Lee, Kejian Zhang, Zhi-Qiang Ning, Eric H. Raabe, Suzanne Tintner, Regina Wieland, Benjamin J. Wilkins, Julia M. Kim, Ruthann I. Blough, and Robert J. Arceci
Cancer Res 2000 60: 3612-3622. [Abstract] [Full Text] [PDF]  

Methylation of the Androgen Receptor Minimal Promoter Silences Transcription in Human Prostate Cancer

Hidefumi Kinoshita, Yan Shi, Carol Sandefur, Lorraine F. Meisner, Chawnshang Chang, Aung Choon, Catherine R. Reznikoff, G. Steven Bova, Andreas Friedl, and David F. Jarrard
Cancer Res 2000 60: 3623-3630. [Abstract] [Full Text] [PDF]  

Mirk Protein Kinase Is a Mitogen-activated Protein Kinase Substrate That Mediates Survival of Colon Cancer Cells

Kangmoon Lee, Xiaobing Deng, and Eileen Friedman
Cancer Res 2000 60: 3631-3637. [Abstract] [Full Text] [PDF]  

Increased Tumor Necrosis Factor- Sensitivity of MCF-7 Cells Transfected with NAD(P)H:Quinone Reductase

Linda M. Siemankowski, Jeanne Morreale, Brent D. Butts, and Margaret M. Briehl
Cancer Res 2000 60: 3638-3644. [Abstract] [Full Text] [PDF]  

Identification and Fine Mapping of a Region Showing a High Frequency of Allelic Imbalance on Chromosome 16q23.2 That Corresponds to a Prostate Cancer Susceptibility Locus

Pamela L. Paris, John S. Witte, Patrick A. Kupelian, Howard Levin, Eric A. Klein, William J. Catalona, and Graham Casey
Cancer Res 2000 60: 3645-3649. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Cadherin Switching in Human Prostate Cancer Progression

Kyoichi Tomita, Adrie van Bokhoven, Geert J. L. H. van Leenders, Emiel T. G. Ruijter, Cornelius F. J. Jansen, Marion J. G. Bussemakers, and Jack A. Schalken
Cancer Res 2000 60: 3650-3654. [Abstract] [Full Text] [PDF]  

Wild-Type p53 Suppresses Angiogenesis in Human Leiomyosarcoma and Synovial Sarcoma by Transcriptional Suppression of Vascular Endothelial Growth Factor Expression

Lianglin Zhang, Dihua Yu, Mei Hu, Shunbin Xiong, Aiqing Lang, Lee M. Ellis, and Raphael E. Pollock
Cancer Res 2000 60: 3655-3661. [Abstract] [Full Text] [PDF]  

The Value of Platelet-derived Endothelial Cell Growth Factor as a Novel Predictor of Advancement of Uterine Cervical Cancers

Jiro Fujimoto, Hideki Sakaguchi, Ikumi Aoki, and Teruhiko Tamaya
Cancer Res 2000 60: 3662-3665. [Abstract] [Full Text] [PDF]  

Corrections:

Correction for vol. 59, p. 5815

Cancer Res 2000 60: 3668 [Full Text] [PDF]  

Erratum:

Correction for vol. 60, p. 2104

Cancer Res 2000 60: 3668 [Full Text] [PDF]  

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