Perspectives in Cancer Research:

Fractals and Cancer

James W. Baish and Rakesh K. Jain
Cancer Res 2000 60: 3683-3688. [Abstract] [Full Text] [PDF]  

Special Lecture:

The Pezcoller Lecture: Cancer Cell Cycles Revisited

Charles J. Sherr
Cancer Res 2000 60: 3689-3695. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Human Mesothelioma Samples Overexpress Both Cyclooxygenase-2 (COX-2) and Inducible Nitric Oxide Synthase (NOS2): In Vitro Antiproliferative Effects of a COX-2 Inhibitor

Aizen Marrogi, Harvey I. Pass, Mohammed Khan, Linda J. Metheny-Barlow, Curtis C. Harris, and Brenda I. Gerwin
Cancer Res 2000 60: 3696-3700. [Abstract] [Full Text] [PDF]  

Vaccination against Gonadotropin-releasing Hormone (GnRH) Using Toxin Receptor-binding Domain-conjugated GnRH Repeats

Chia-Tse Hsu, Chun-Yuan Ting, Chun-Jen Ting, Tzong-Yueh Chen, Chia-Po Lin, Jacqueline Whang-Peng, and Jaulang Hwang
Cancer Res 2000 60: 3701-3705. [Abstract] [Full Text] [PDF]  

A Genome-wide Map Showing Common Regions of Loss of Heterozygosity/Allelic Imbalance in Breast Cancer

Robert J. Osborne and Marion G. Hamshere
Cancer Res 2000 60: 3706-3712. [Abstract] [Full Text] [PDF]  

Suppressing Effects of Dietary Supplementation of the Organoselenium 1,4-Phenylenebis(methylene)selenocyanate and the Citrus Antioxidant Auraptene on Lung Metastasis of Melanoma Cells in Mice

Takuji Tanaka, Hiroyuki Kohno, Manabu Murakami, Seiko Kagami, and Karam El-Bayoumy
Cancer Res 2000 60: 3713-3716. [Abstract] [Full Text] [PDF]  

Synergistic Antitumor Activity of Irinotecan in Combination with 5-Fluorouracil in Rats Bearing Advanced Colorectal Cancer: Role of Drug Sequence and Dose

Shousong Cao and Youcef M. Rustum
Cancer Res 2000 60: 3717-3721. [Abstract] [Full Text] [PDF]  

Identification of Fractalkine, a CX3C-type Chemokine, as a Direct Target of p53

Kenji Shiraishi, Seisuke Fukuda, Toshiki Mori, Koichi Matsuda, Tatsuya Yamaguchi, Chizu Tanikawa, Michio Ogawa, Yusuke Nakamura, and Hirofumi Arakawa
Cancer Res 2000 60: 3722-3726. [Abstract] [Full Text] [PDF]  

Tyrosine 1062 of RET-MEN2A Mediates Activation of Akt (Protein Kinase B) and Mitogen-activated Protein Kinase Pathways Leading to PC12 Cell Survival

Gabriella De Vita, Rosa Marina Melillo, Francesca Carlomagno, Roberta Visconti, Maria Domenica Castellone, Alfonso Bellacosa, Marc Billaud, Alfredo Fusco, Philip N. Tsichlis, and Massimo Santoro
Cancer Res 2000 60: 3727-3731. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Highly Selective Isolation of Unknown Mutations in Diverse DNA Fragments: Toward New Multiplex Screening in Cancer

Subrata Chakrabarti, Brendan D. Price, Sotirios Tetradis, Edward A. Fox, Yuzhi Zhang, Gautam Maulik, and G. Mike Makrigiorgos
Cancer Res 2000 60: 3732-3737. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Accelerated Ultraviolet Radiation-induced Carcinogenesis in Hepatocyte Growth Factor/Scatter Factor Transgenic Mice

Frances P. Noonan, Toshiyuki Otsuka, Stacey Bang, Miriam R. Anver, and Glenn Merlino
Cancer Res 2000 60: 3738-3743. [Abstract] [Full Text] [PDF]  

Epidemiology:

Plasma Insulin-like Growth Factor (IGF) I, IGF-binding Protein 3, and Mammographic Density

Celia Byrne, Graham A. Colditz, Walter C. Willett, Frank E. Speizer, Michael Pollak, and Susan E. Hankinson
Cancer Res 2000 60: 3744-3748. [Abstract] [Full Text] [PDF]  

Cigarette Smoking, CYP1A1 MspI and GSTM1 Genotypes, and Colorectal Adenomas

Hisako Inoue, Chikako Kiyohara, Tomomi Marugame, Sachiko Shinomiya, Emiko Tsuji, Koichi Handa, Hitomi Hayabuchi, Kazuya Onuma, Hiroaki Hamada, Hiroko Koga, and Suminori Kono
Cancer Res 2000 60: 3749-3752. [Abstract] [Full Text] [PDF]  

Dietary Heterocyclic Amines and the Risk of Lung Cancer among Missouri Women

Rashmi Sinha, Martin Kulldorff, Christine A. Swanson, Jane Curtin, Ross C. Brownson, and Michael C. R. Alavanja
Cancer Res 2000 60: 3753-3756. [Abstract] [Full Text] [PDF]  

Patterns of Tumor Initiation in Choroidal Melanoma

Wenjun Li, Heidi Judge, Evangelos S. Gragoudas, Johanna M. Seddon, and Kathleen M. Egan
Cancer Res 2000 60: 3757-3760. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Combination of the Bioreductive Drug Tirapazamine with the Chemotherapeutic Prodrug Cyclophosphamide for P450/P450-Reductase-based Cancer Gene Therapy

Youssef Jounaidi and David J. Waxman
Cancer Res 2000 60: 3761-3769. [Abstract] [Full Text] [PDF]  

In Vivo Site Specificity and Human Isoenzyme Selectivity of Two Topoisomerase II-poisoning Anthracyclines

Monica Binaschi, Rosalba Farinosi, M. Evelina Borgnetto, and Giovanni Capranico
Cancer Res 2000 60: 3770-3776. [Abstract] [Full Text] [PDF]  

Cooperative Effects of Mycobacterium tuberculosis Ag38 Gene Transduction and Interleukin 12 in Vaccination against Spontaneous Tumor Development in Proto-neu Transgenic Mice

Lucia Sfondrini, Monica Rodolfo, Mahavir Singh, Mario P. Colombo, Maria I. Colnaghi, Sylvie Ménard, and Andrea Balsari
Cancer Res 2000 60: 3777-3781. [Abstract] [Full Text] [PDF]  

Prevention of Mammary Tumors with a Chimeric HER-2 B-cell Epitope Peptide Vaccine

Naveen K. Dakappagari, Donna B. Douglas, Pierre L. Triozzi, Vernon C. Stevens, and Pravin T. P. Kaumaya
Cancer Res 2000 60: 3782-3789. [Abstract] [Full Text] [PDF]  

Antigene and Antiproliferative Effects of a c-myc-targeting Phosphorothioate Triple Helix-forming Oligonucleotide in Human Leukemia Cells

Eileen M. McGuffie, Daniel Pacheco, Giuseppina M. R. Carbone, and Carlo V. Catapano
Cancer Res 2000 60: 3790-3799. [Abstract] [Full Text] [PDF]  

Use of Phosphorous-31 Nuclear Magnetic Resonance Spectroscopy to Determine Safe Timing of Chemotherapy after Hepatic Resection

David A. Kooby, Kristen L. Zakian, Surya N. Challa, Cornelia Matei, Henrik Petrowsky, Hyok-Hee Yoo, Jason A. Koutcher, and Yuman Fong
Cancer Res 2000 60: 3800-3806. [Abstract] [Full Text] [PDF]  

Cardiac Glycosides Stimulate Ca²⁺ Increases and Apoptosis in Androgen-independent, Metastatic Human Prostate Adenocarcinoma Cells

David J. McConkey, Yun Lin, Leta K. Nutt, Huseyin Z. Ozel, and Robert A. Newman
Cancer Res 2000 60: 3807-3812. [Abstract] [Full Text] [PDF]  

In Vivo Cancer Gene Therapy by Adenovirus-mediated Transfer of a Bifunctional Yeast Cytosine Deaminase/Uracil Phosphoribosyltransferase Fusion Gene

Philippe Erbs, Etienne Regulier, Jacqueline Kintz, Pierre Leroy, Yves Poitevin, Françoise Exinger, Richard Jund, and Majid Mehtali
Cancer Res 2000 60: 3813-3822. [Abstract] [Full Text] [PDF]  

Dietary Flavone Is a Potent Apoptosis Inducer in Human Colon Carcinoma Cells

Uwe Wenzel, Sabine Kuntz, Mathias D. Brendel, and Hannelore Daniel
Cancer Res 2000 60: 3823-3831. [Abstract] [Full Text] [PDF]  

In Situ Tumor Vaccination with Interleukin-12-encapsulated Biodegradable Microspheres: Induction of Tumor Regression and Potent Antitumor Immunity

Nejat K. Egilmez, Yong S. Jong, Michael S. Sabel, Jules S. Jacob, Edith Mathiowitz, and Richard B. Bankert
Cancer Res 2000 60: 3832-3837. [Abstract] [Full Text] [PDF]  

Immunology:

Oleandrin Suppresses Activation of Nuclear Transcription Factor-B, Activator Protein-1, and c-Jun NH₂-Terminal Kinase

Sunil K. Manna, Nand K. Sah, Robert A. Newman, Angela Cisneros, and Bharat B. Aggarwal
Cancer Res 2000 60: 3838-3847. [Abstract] [Full Text] [PDF]  

Identification on a Human Sarcoma of Two New Genes with Tumor-specific Expression

Valérie Martelange, Charles De Smet, Etienne De Plaen, Christophe Lurquin, and Thierry Boon
Cancer Res 2000 60: 3848-3855. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

The Extracellular Region of Heregulin Is Sufficient to Promote Mammary Gland Proliferation and Tumorigenesis but not Apoptosis

Edward J. Weinstein and Philip Leder
Cancer Res 2000 60: 3856-3861. [Abstract] [Full Text] [PDF]  

Different Combinations of Genetic/Epigenetic Alterations Inactivate the p53 and pRb Pathways in Invasive Human Bladder Cancers

Somdatta Sarkar, Knut P. Jülicher, Melissa S. Burger, Véronique Della Valle, Christian-Jacques Larsen, Thomas R. Yeager, Timothy B. Grossman, Robert W. Nickells, Chris Protzel, David F. Jarrard, and Catherine A. Reznikoff
Cancer Res 2000 60: 3862-3871. [Abstract] [Full Text] [PDF]  

The Human T-Cell Transcription Factor-4 Gene: Structure, Extensive Characterization of Alternative Splicings, and Mutational Analysis in Colorectal Cancer Cell Lines

Alex Duval, Sandra Rolland, Emmanuel Tubacher, Hung Bui, Gilles Thomas, and Richard Hamelin
Cancer Res 2000 60: 3872-3879. [Abstract] [Full Text] [PDF]  

Deletion at 13q21 Is Associated with Aggressive Prostate Cancers

Jin-Tang Dong, Ceshi Chen, Brian G. Stultz, John T. Isaacs, and Henry F. Frierson, Jr.
Cancer Res 2000 60: 3880-3883. [Abstract] [Full Text] [PDF]  

Genome-wide Search for Loss of Heterozygosity Using Laser Capture Microdissected Tissue of Breast Carcinoma: An Implication for Mutator Phenotype and Breast Cancer Pathogenesis

Chen-Yang Shen, Jyh-Cherng Yu, Yen-Li Lo, Chia-Hui Kuo, Chung-Tai Yue, Yuh-Shan Jou, Chiun-Sheng Huang, Jia-Chyi Lung, and Cheng-Wen Wu
Cancer Res 2000 60: 3884-3892. [Abstract] [Full Text] [PDF]  

A Case-Control Study Confirms That Microsatellite Assay Can Identify Patients at Risk of Developing Oral Squamous Cell Carcinoma within a Field of Cancerization

Maxine Partridge, Stelios Pateromichelakis, Elaine Phillips, Gracy G. Emilion, Roger P. A’Hern, and John D. Langdon
Cancer Res 2000 60: 3893-3898. [Abstract] [Full Text] [PDF]  

Tumor Biology:

DNA Sequence Copy Number Changes in Gastrointestinal Stromal Tumors: Tumor Progression and Prognostic Significance

Wa’el El-Rifai, Maarit Sarlomo-Rikala, Leif C. Andersson, Sakari Knuutila, and Markku Miettinen
Cancer Res 2000 60: 3899-3903. [Abstract] [Full Text] [PDF]  

Down-Regulation of neu/HER-2 by Interferon- in Prostate Cancer Cells

Scott L. Kominsky, Amy C. Hobeika, Faith A. Lake, Barbara A. Torres, and Howard M. Johnson
Cancer Res 2000 60: 3904-3908. [Abstract] [Full Text] [PDF]  

Activation of Insulin-like Growth Factor I Receptor Signaling Pathway Is Critical for Mouse Plasma Cell Tumor Growth

Weiqun Li, Teresa Hyun, Mary Heller, Alan Yam, Lawrence Flechner, Jacalyn H. Pierce, and Stuart Rudikoff
Cancer Res 2000 60: 3909-3915. [Abstract] [Full Text] [PDF]  

Akt/Protein Kinase B Promotes Survival and Hormone-independent Proliferation of Thyroid Cells in the Absence of Dedifferentiating and Transforming Effects

Gabriella De Vita, Maria Teresa Berlingieri, Roberta Visconti, Maria Domenica Castellone, Giuseppe Viglietto, Gustavo Baldassarre, Mariastella Zannini, Alfonso Bellacosa, Philip N. Tsichlis, Alfredo Fusco, and Massimo Santoro
Cancer Res 2000 60: 3916-3920. [Abstract] [Full Text] [PDF]  

Histone H3 and Heat Shock Protein GRP78 Are Selectively Cross-Linked to DNA by Photoactivated Gilvocarcin V in Human Fibroblasts

Akira Matsumoto and Philip C. Hanawalt
Cancer Res 2000 60: 3921-3926. [Abstract] [Full Text] [PDF]  

The Role of Cellular Glutathione Peroxidase Redox Regulation in the Suppression of Tumor Cell Growth by Manganese Superoxide Dismutase

Shijun Li, Tao Yan, Ji-Qin Yang, Terry D. Oberley, and Larry W. Oberley
Cancer Res 2000 60: 3927-3939. [Abstract] [Full Text] [PDF]  

Inhibition of Hsp90 Function by Ansamycins Causes Retinoblastoma Gene Product-dependent G₁ Arrest

Mary Srethapakdi, Franklin Liu, Ranjana Tavorath, and Neal Rosen
Cancer Res 2000 60: 3940-3946. [Abstract] [Full Text] [PDF]  

Metabolic Inhibitors Sensitize for CD95 (APO-1/Fas)-induced Apoptosis by Down-Regulating Fas-associated Death Domain-like Interleukin 1-Converting Enzyme Inhibitory Protein Expression

Simone Fulda, Eric Meyer, and Klaus-Michael Debatin
Cancer Res 2000 60: 3947-3956. [Abstract] [Full Text] [PDF]  

E1A Overcomes the Apoptosis Block in BCR-ABL+ Leukemia Cells and Renders Cells Susceptible to Induction of Apoptosis by Chemotherapeutic Agents

Thorsten Stiewe, Keiarasch Parssanedjad, Helmut Esche, Bertram Opalka, and Brigitte M. Pützer
Cancer Res 2000 60: 3957-3964. [Abstract] [Full Text] [PDF]  

Dnmt1^N/+ Reduces the Net Growth Rate and Multiplicity of Intestinal Adenomas in C57BL/6-Multiple Intestinal Neoplasia (Min)/+ Mice Independently of p53 but Demonstrates Strong Synergy with the Modifier of Min 1^AKR Resistance Allele

Robert T. Cormier and William F. Dove
Cancer Res 2000 60: 3965-3970. [Abstract] [Full Text] [PDF]  

STAT5 Activation Is Required for Interleukin-9-dependent Growth and Transformation of Lymphoid Cells

Jean-Baptiste Demoulin, Catherine Uyttenhove, Diane Lejeune, Alice Mui, Bernd Groner, and Jean-Christophe Renauld
Cancer Res 2000 60: 3971-3977. [Abstract] [Full Text] [PDF]  

Cimetidine Inhibits Cancer Cell Adhesion to Endothelial Cells and Prevents Metastasis by Blocking E-selectin Expression

Ken-ichi Kobayashi, Sumio Matsumoto, Takashi Morishima, Takumi Kawabe, and Takashi Okamoto
Cancer Res 2000 60: 3978-3984. [Abstract] [Full Text] [PDF]  

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