Review:

Bystander Effect in Herpes Simplex Virus-Thymidine Kinase/Ganciclovir Cancer Gene Therapy: Role of Gap-junctional Intercellular Communication¹

Marc Mesnil and Hiroshi Yamasaki
Cancer Res 2000 60: 3989-3999. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Overexpression of Cyclin B1 in Early-Stage Non-Small Cell Lung Cancer and Its Clinical Implication

Jean-Charles Soria, Se Jin Jang, Fadlo R. Khuri, Khaled Hassan, Diane Liu, Waun Ki Hong, and Li Mao
Cancer Res 2000 60: 4000-4004. [Abstract] [Full Text] [PDF]  

Constitutive Achaete-Scute Homologue-1 Promotes Airway Dysplasia and Lung Neuroendocrine Tumors in Transgenic Mice

R. Ilona Linnoila, Bihong Zhao, Janet L. DeMayo, Barry D. Nelkin, Stephen B. Baylin, Franco J. DeMayo, and Douglas W. Ball
Cancer Res 2000 60: 4005-4009. [Abstract] [Full Text] [PDF]  

Hypoxia-inducible Factor-1 Is a Positive Factor in Solid Tumor Growth

Heather E. Ryan, Michelle Poloni, Wayne McNulty, David Elson, Max Gassmann, Jeffery M. Arbeit, and Randall S. Johnson
Cancer Res 2000 60: 4010-4015. [Abstract] [Full Text] [PDF]  

Down-Regulation of p63 Is Required for Epidermal UV-B-induced Apoptosis

Kristin M. Liefer, Maranke I. Koster, Xiao-Jing Wang, Annie Yang, Frank McKeon, and Dennis R. Roop
Cancer Res 2000 60: 4016-4020. [Abstract] [Full Text] [PDF]  

Genetic and Epigenetic Alterations in Normal Bladder Epithelium in Patients with Metachronous Bladder Cancer

Satoru Muto, Shigeo Horie, Satoru Takahashi, Kyoichi Tomita, and Tadaichi Kitamura
Cancer Res 2000 60: 4021-4025. [Abstract] [Full Text] [PDF]  

A Hypersensitive Estrogen Receptor- Mutation in Premalignant Breast Lesions

Suzanne A. W. Fuqua, Christoph Wiltschke, Qui X. Zhang, Åke Borg, Carl G. Castles, William E. Friedrichs, Torsten Hopp, Sue Hilsenbeck, Syed Mohsin, Peter O’Connell, and D. Craig Allred
Cancer Res 2000 60: 4026-4029. [Abstract] [Full Text] [PDF]  

Renal Failure in the Denys-Drash and Wilms’ Tumor-Aniridia Syndromes

Norman E. Breslow, Janice R. Takashima, Michael L. Ritchey, Louise C. Strong, and Daniel M. Green
Cancer Res 2000 60: 4030-4032. [Abstract] [Full Text] [PDF]  

Prostate Cancer and Other Xenografts from Cells in Peripheral Blood of Patients

Thomas G. Pretlow, Stuart Schwartz, Joseph M. Giaconia, Alison L. Wright, Heather A. Grimm, Nancy L. Edgehouse, John R. Murphy, Sanford D. Markowitz, James M. Jamison, Jack L. Summers, Clive R. Hamlin, Gregory T. MacLennan, Martin I. Resnick, Theresa P. Pretlow, and Cindylou F. Connell
Cancer Res 2000 60: 4033-4036. [Abstract] [Full Text] [PDF]  

Cancer Gene Discovery Using Digital Differential Display

Daniela Scheurle, Maurice Phil DeYoung, David M. Binninger, Holly Page, Mohammad Jahanzeb, and Ramaswamy Narayanan
Cancer Res 2000 60: 4037-4043. [Abstract] [Full Text] [PDF]  

Aberrant Methylation of the Cyclooxygenase 2 CpG Island in Colorectal Tumors

Minoru Toyota, Lanlan Shen, Mutsumi Ohe-Toyota, Stanley R. Hamilton, Frank A. Sinicrope, and Jean-Pierre J. Issa
Cancer Res 2000 60: 4044-4048. [Abstract] [Full Text] [PDF]  

Novel Transcripts of Fibroblast Growth Factor Receptor 3 Reveal Aberrant Splicing and Activation of Cryptic Splice Sequences in Colorectal Cancer

Jun-Hyeog Jang, Ki-Hyuk Shin, Young-Jin Park, Richard J. Lee, Wallace L. McKeehan, and Jae-Gahb Park
Cancer Res 2000 60: 4049-4052. [Abstract] [Full Text] [PDF]  

Glutathione S-Transferase p Elicits Protection against H₂O₂-induced Cell Death via Coordinated Regulation of Stress Kinases

Zhimin Yin, Vladimir N. Ivanov, Hasem Habelhah, Kenneth Tew, and Ze’ev Ronai
Cancer Res 2000 60: 4053-4057. [Abstract] [Full Text] [PDF]  

Detection of t(4;14)(p16.3;q32) Chromosomal Translocation in Multiple Myeloma by Reverse Transcription-Polymerase Chain Reaction Analysis of IGH-MMSET Fusion Transcripts

Ursula Malgeri, Luca Baldini, Vittorio Perfetti, Sonia Fabris, Maurizio Colli Vignarelli, Gualtiero Colombo, Valentina Lotti, Silvana Compasso, Silvia Bogni, Luigia Lombardi, Anna Teresa Maiolo, and Antonino Neri
Cancer Res 2000 60: 4058-4061. [Abstract] [Full Text] [PDF]  

Dominant Negative Isoform of the Ikaros Gene in Patients with Adult B-Cell Acute Lymphoblastic Leukemia

Koichi Nakase, Fumihiko Ishimaru, Nicole Avitahl, Hiromichi Dansako, Keitaro Matsuo, Keiko Fujii, Nobuo Sezaki, Hiroyuki Nakayama, Tomofumi Yano, Shunnichi Fukuda, Kenji Imajoh, Makoto Takeuchi, Akira Miyata, Masamichi Hara, Masaki Yasukawa, Isao Takahashi, Hirokuni Taguchi, Kosei Matsue, Shinji Nakao, Yoshiyuki Niho, Katsuto Takenaka, Katsuji Shinagawa, Kazuma Ikeda, Kenji Niiya, and Mine Harada
Cancer Res 2000 60: 4062-4065. [Abstract] [Full Text] [PDF]  

Antiangiogenic Treatment Enhances Photodynamic Therapy Responsiveness in a Mouse Mammary Carcinoma

Angela Ferrario, Karl F. von Tiehl, Natalie Rucker, Margaret A. Schwarz, Parkash S. Gill, and Charles J. Gomer
Cancer Res 2000 60: 4066-4069. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Invasive Properties of Murine Squamous Carcinoma Cells: Secretion of Matrix-degrading Cathepsins Is Attributable to a Deficiency in the Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor

Kim Lorenzo, Phuong Ton, Jason L. Clark, Sogué Coulibaly, and Lukas Mach
Cancer Res 2000 60: 4070-4076. [Abstract] [Full Text] [PDF]  

Apoptotic Response of HL-60 Human Leukemia Cells to the Antitumor Drug TAS-103

Jérôme Kluza, Amélie Lansiaux, Nicole Wattez, Christine Mahieu, Neil Osheroff, and Christian Bailly
Cancer Res 2000 60: 4077-4084. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Nuclear Factor B Subunits Induce Epithelial Cell Growth Arrest

Cornelia S. Seitz, Helen Deng, Kaede Hinata, Qun Lin, and Paul A. Khavari
Cancer Res 2000 60: 4085-4092. [Abstract] [Full Text] [PDF]  

Efficacious Chemoprevention of Primary Prostate Cancer by Flutamide in an Autochthonous Transgenic Model

Sharan Raghow, Emin Kuliyev, Marjorie Steakley, Norman Greenberg, and Mitchell S. Steiner
Cancer Res 2000 60: 4093-4097. [Abstract] [Full Text] [PDF]  

Mutagenesis Induced by a Single 1,N⁶-Ethenodeoxyadenosine Adduct in Human Cells

Robert L. Levine, In-Young Yang, Munfarah Hossain, Gagan A. Pandya, Arthur P. Grollman, and Masaaki Moriya
Cancer Res 2000 60: 4098-4104. [Abstract] [Full Text] [PDF]  

Malignant Transformation of Human Fibroblast Cell Strain MSU-1.1 by N-Methyl-N-nitrosourea: Evidence of Elimination of p53 by Homologous Recombination

Scott E. Boley, Terrence P. McManus, Veronica M. Maher, and J. Justin McCormick
Cancer Res 2000 60: 4105-4111. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Decreased Ovarian Hormones during a Soya Diet: Implications for Breast Cancer Prevention

Lee-Jane W. Lu, Karl E. Anderson, James J. Grady, Fortune Kohen, and Manubai Nagamani
Cancer Res 2000 60: 4112-4121. [Abstract] [Full Text] [PDF]  

Endocrinology:

Thyroid Carcinoma Cells Are Resistant to FAS-mediated Apoptosis But Sensitive to Tumor Necrosis Factor-related Apoptosis-inducing Ligand

Nicholas Mitsiades, Vassiliki Poulaki, Sophia Tseleni-Balafouta, Demetrios A. Koutras, and Ivan Stamenkovic
Cancer Res 2000 60: 4122-4129. [Abstract] [Full Text] [PDF]  

Long-Term Hydroxytamoxifen Treatment of an MCF-7-derived Breast Cancer Cell Line Irreversibly Inhibits the Expression of Estrogenic Genes through Chromatin Remodeling

Eric Badia, Marie-Josèphe Duchesne, Abdelhabib Semlali, Maryse Fuentes, Claire Giamarchi, Hélène Richard-Foy, Jean-Claude Nicolas, and Michel Pons
Cancer Res 2000 60: 4130-4138. [Abstract] [Full Text] [PDF]  

Epidemiology:

Cell Cycle Arrest and Apoptosis of Melanoma Cells by Docosahexaenoic Acid: Association with Decreased pRb Phosphorylation

Anthony P. Albino, Gloria Juan, Frank Traganos, Lisa Reinhart, Jeanne Connolly, David P. Rose, and Zbigniew Darzynkiewicz
Cancer Res 2000 60: 4139-4145. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

The Suppression of Human Prostate Tumor Growth in Mice by the Intratumoral Injection of a Slow-Release Polymeric Paste Formulation of Paclitaxel

John K. Jackson, Martin E. Gleave, Virginia Yago, Eliana Beraldi, William L. Hunter, and Helen M. Burt
Cancer Res 2000 60: 4146-4151. [Abstract] [Full Text] [PDF]  

SU6668 Is a Potent Antiangiogenic and Antitumor Agent That Induces Regression of Established Tumors

A. Douglas Laird, Peter Vajkoczy, Laura K. Shawver, Andreas Thurnher, Congxin Liang, Moosa Mohammadi, Joseph Schlessinger, Axel Ullrich, Stevan R. Hubbard, Robert A. Blake, T. Annie T. Fong, Laurie M. Strawn, Li Sun, Cho Tang, Rachael Hawtin, Flora Tang, Narmada Shenoy, K. Peter Hirth, Gerald McMahon, and Julie M. Cherrington
Cancer Res 2000 60: 4152-4160. [Abstract] [Full Text] [PDF]  

Monitoring the Expression Profiles of Doxorubicin-induced and Doxorubicin-resistant Cancer Cells by cDNA Microarray

Kazuya Kudoh, Manasi Ramanna, Roald Ravatn, Abdel G. Elkahloun, Michael L. Bittner, Paul S. Meltzer, Jeffrey M. Trent, William S. Dalton, and Khew-Voon Chin
Cancer Res 2000 60: 4161-4166. [Abstract] [Full Text] [PDF]  

The Role of the E1B 55 kDa Gene Product in Oncolytic Adenoviral Vectors Expressing Herpes Simplex Virus-tk: Assessment of Antitumor Efficacy and Toxicity

Oliver Wildner and John C. Morris
Cancer Res 2000 60: 4167-4174. [Abstract] [Full Text] [PDF]  

One-Step Single-Chain Fv Recombinant Antibody-based Purification of gp96 for Vaccine Development

Danièle Arnold-Schild, Christian Kleist, Martin Welschof, Gerhard Opelz, Hans-Georg Rammensee, Hansjörg Schild, and Peter Terness
Cancer Res 2000 60: 4175-4178. [Abstract] [Full Text] [PDF]  

Bioactivation of 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by Human NAD(P)H Quinone Oxidoreductase 2: A Novel Co-substrate-mediated Antitumor Prodrug Therapy

Richard J. Knox, Terence C. Jenkins, Stephen M. Hobbs, Shiuan Chen, Roger G. Melton, and Philip J. Burke
Cancer Res 2000 60: 4179-4186. [Abstract] [Full Text] [PDF]  

Role of Poly(ADP-ribosyl)ation in the Killing of Chronic Lymphocytic Leukemia Cells by Purine Analogues

Andrew R. Pettitt, Paul D. Sherrington, and John C. Cawley
Cancer Res 2000 60: 4187-4193. [Abstract] [Full Text] [PDF]  

Regulation of Targeted Chemotherapy with Cytotoxic Lutenizing Hormone-releasing Hormone Analogue by Epidermal Growth Factor

Linda J. Krebs, Xiaopeng Wang, Haridas E. Pudavar, Earl J. Bergey, Andrew V. Schally, Attila Nagy, Paras N. Prasad, and Charles Liebow
Cancer Res 2000 60: 4194-4199. [Abstract] [Full Text] [PDF]  

Experimental Photoimmunotherapy of Hepatic Metastases of Colorectal Cancer with a 17.1A Chlorin_e6 Immunoconjugate

Marco Del Governatore, Michael R. Hamblin, Christopher R. Shea, Imran Rizvi, Kelly G. Molpus, Kenneth K. Tanabe, and Tayyaba Hasan
Cancer Res 2000 60: 4200-4205. [Abstract] [Full Text] [PDF]  

Activation of CPT-11 in Mice: Identification and Analysis of a Highly Effective Plasma Esterase

Christopher L. Morton, Monika Wierdl, LaGora Oliver, Margaret K. Ma, Mary K. Danks, Clinton F. Stewart, Julie L. Eiseman, and Philip M. Potter
Cancer Res 2000 60: 4206-4210. [Abstract] [Full Text] [PDF]  

Immunology:

Adoptive Immunotherapy by Avidin-driven Cytotoxic T Lymphocyte- Tumor Bridging

Maria Guttinger, Fabrizio Guidi, Marco Chinol, Eva Reali, Fabrizio Veglia, Giovanna Viale, Giovanni Paganelli, Angelo Corti, and Antonio G. Siccardi
Cancer Res 2000 60: 4211-4215. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

hMLH1 and hMSH2 Expression Correlates with Allelic Imbalance on Chromosome 3p in Non-Small Cell Lung Carcinomas

George Xinarianos, Triantafillos Liloglou, Wendy Prime, Paul Maloney, Jill Callaghan, Patricia Fielding, John R. Gosney, and John K. Field
Cancer Res 2000 60: 4216-4221. [Abstract] [Full Text] [PDF]  

Stabilization of the Ras Oncoprotein by the Insulin-like Growth Factor 1 Receptor during Anchorage-independent Growth

Martina Gatzka, Marco Prisco, and Renato Baserga
Cancer Res 2000 60: 4222-4230. [Abstract] [Full Text] [PDF]  

Nuclear and Mitochondrial Genome Instability in Human Breast Cancer

Silvina M. Richard, Graciela Bailliet, Gerardo L. Páez, Martha S. Bianchi, Päivi Peltomäki, and Néstor O. Bianchi
Cancer Res 2000 60: 4231-4237. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Increased Resistance to Anticancer Therapy of Mouse Cells Lacking the Poly(ADP-ribose) Polymerase Attributable to Up-Regulation of the Multidrug Resistance Gene Product P-Glycoprotein

Gabriele Wurzer, Zdenko Herceg, and Józefa Wsierska-Gadek
Cancer Res 2000 60: 4238-4244. [Abstract] [Full Text] [PDF]  

Increased Expression of Fibroblast Growth Factor 6 in Human Prostatic Intraepithelial Neoplasia and Prostate Cancer

Frederic Ropiquet, Dipak Giri, Bernard Kwabi-Addo, Alka Mansukhani, and Michael Ittmann
Cancer Res 2000 60: 4245-4250. [Abstract] [Full Text] [PDF]  

Oncotic Pressure in Solid Tumors Is Elevated

Manfred Stohrer, Yves Boucher, Manfred Stangassinger, and Rakesh K. Jain
Cancer Res 2000 60: 4251-4255. [Abstract] [Full Text] [PDF]  

The Oncogenic Properties of the HMG-I Gene Family

Lisa J. Wood, Joseph F. Maher, Tracie E. Bunton, and Linda M. S. Resar
Cancer Res 2000 60: 4256-4261. [Abstract] [Full Text] [PDF]  

Cytokines Prevent Dexamethasone-induced Apoptosis via the Activation of Mitogen-activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in a New Multiple Myeloma Cell Line

Megumu Ogawa, Tetsuo Nishiura, Kenji Oritani, Hitoshi Yoshida, Masafumi Yoshimura, Yu Okajima, Jun Ishikawa, Koji Hashimoto, Itaru Matsumura, Yoshiaki Tomiyama, and Yuji Matsuzawa
Cancer Res 2000 60: 4262-4269. [Abstract] [Full Text] [PDF]  

Characterization of Bile Salt-induced Apoptosis in Colon Cancer Cell Lines

Klaus Schlottmann, Frank-Peter Wachs, René Christian Krieg, Frank Kullmann, Jürgen Schölmerich, and Gerhard Rogler
Cancer Res 2000 60: 4270-4276. [Abstract] [Full Text] [PDF]  

Scatter Factor/Hepatocyte Growth Factor Protects against Cytotoxic Death in Human Glioblastoma via Phosphatidylinositol 3-Kinase- and AKT-dependent Pathways

Daniel C. Bowers, Saijun Fan, Kevin A. Walter, Roger Abounader, Jeffery A. Williams, Eliot M. Rosen, and John Laterra
Cancer Res 2000 60: 4277-4283. [Abstract] [Full Text] [PDF]  

Effects of a Pure Antiestrogen on Apoptosis and Proliferation within Human Breast Ductal Carcinoma in Situ

Ashu Gandhi, Philip A. Holland, W. Fiona Knox, Christopher S. Potten, and Nigel J. Bundred
Cancer Res 2000 60: 4284-4288. [Abstract] [Full Text] [PDF]  

Virology:

Human Papillomavirus Type 16 E6 and E7 Proteins Inhibit Differentiation-dependent Expression of Transforming Growth Factor-ß2 in Cervical Keratinocytes

Matthias Nees, Joel M. Geoghegan, Peter Munson, Vinayakumar Prabhu, Yun Liu, Elliot Androphy, and Craig D. Woodworth
Cancer Res 2000 60: 4289-4298. [Abstract] [Full Text] [PDF]  

Errata:

R. Figueroa et al., Cancer Res., 60:2770–2774, 2000

Cancer Res 2000 60: 4301 [Full Text] [PDF]  

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