Advances in Brief:

Midkine Promoter-based Adenoviral Vector Gene Delivery for Pediatric Solid Tumors

Yasuo Adachi, Paul N. Reynolds, Masato Yamamoto, William E. Grizzle, Ken Overturf, Shyuichiro Matsubara, Takashi Muramatsu, and David T. Curiel
Cancer Res 2000 60: 4305-4310. [Abstract] [Full Text] [PDF]  

Inhibition of Tumor Angiogenesis by a Single-chain Antibody Directed against Vascular Endothelial Growth Factor

Alessandra Vitaliti, Mariana Wittmer, Rudolf Steiner, Lorenza Wyder, Dario Neri, and Roman Klemenz
Cancer Res 2000 60: 4311-4314. [Abstract] [Full Text] [PDF]  

Loss of Caspase-8 Expression in Highly Malignant Human Neuroblastoma Cells Correlates with Resistance to Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis

Sally Hopkins-Donaldson, Jean-Luc Bodmer, Katia Balmas Bourloud, Christine Beretta Brognara, Jürg Tschopp, and Nicole Gross
Cancer Res 2000 60: 4315-4319. [Abstract] [Full Text] [PDF]  

Inactivation of Retinoblastoma Protein in Uveal Melanoma by Phosphorylation of Sites in the COOH-Terminal Region

Milam A. Brantley, Jr. and J. William Harbour
Cancer Res 2000 60: 4320-4323. [Abstract] [Full Text] [PDF]  

Absence of Functional Lymphatics within a Murine Sarcoma: A Molecular and Functional Evaluation

Anders J. Leu, David A. Berk, Athina Lymboussaki, Kari Alitalo, and Rakesh K. Jain
Cancer Res 2000 60: 4324-4327. [Abstract] [Full Text] [PDF]  

Mutations of the bak Gene in Human Gastric and Colorectal Cancers

Shinya Kondo, Yasuhisa Shinomura, Yoshiji Miyazaki, Tatsuya Kiyohara, Shusaku Tsutsui, Shinji Kitamura, Yutaka Nagasawa, Masanori Nakahara, Shuji Kanayama, and Yuji Matsuzawa
Cancer Res 2000 60: 4328-4330. [Abstract] [Full Text] [PDF]  

Fenretinide-induced Caspase 3 Activity Involves Increased Protein Stability in a Mechanism Distinct from Reactive Oxygen Species Elevation

Anna M. DiPietrantonio, Tze-Chen Hsieh, Gloria Juan, Frank Traganos, Zbigniew Darzynkiewicz, and Joseph M. Wu
Cancer Res 2000 60: 4331-4335. [Abstract] [Full Text] [PDF]  

Cure of Burkitt’s Lymphoma in Severe Combined Immunodeficiency Mice by T Cells, Tetravalent CD3 x CD19 Tandem Diabody, and CD28 Costimulation

Björn Cochlovius, Sergey M. Kipriyanov, Marike J. J. G. Stassar, Jochen Schuhmacher, Axel Benner, Gerhard Moldenhauer, and Melvyn Little
Cancer Res 2000 60: 4336-4341. [Abstract] [Full Text] [PDF]  

A Deficiency in DNA Repair and DNA-PKcs Expression in the Radiosensitive BALB/c Mouse

Ryuichi Okayasu, Katsutoshi Suetomi, Yongjia Yu, Andy Silver, Joel S. Bedford, Roger Cox, and Robert L. Ullrich
Cancer Res 2000 60: 4342-4345. [Abstract] [Full Text] [PDF]  

Aberrant Methylation of the Estrogen Receptor and E-Cadherin 5' CpG Islands Increases with Malignant Progression in Human Breast Cancer

Sharyl J. Nass, James G. Herman, Edward Gabrielson, Philip W. Iversen, Fritz F. Parl, Nancy E. Davidson, and Jeremy R. Graff
Cancer Res 2000 60: 4346-4348. [Abstract] [Full Text] [PDF]  

Genomic Instability at the BUB1 Locus in Colorectal Cancer, but not in Non-Small Cell Lung Cancer¹

Ross G. Jaffrey, Stuart C. Pritchard, Caroline Clark, Graeme I. Murray, James Cassidy, Keith M. Kerr, Marianne C. Nicolson, and Howard L. McLeod
Cancer Res 2000 60: 4349-4352. [Abstract] [Full Text] [PDF]  

Inactivation of the 14-3-3 Gene Is Associated with 5' CpG Island Hypermethylation in Human Cancers

Hiromu Suzuki, Fumio Itoh, Minoru Toyota, Takefumi Kikuchi, Hideki Kakiuchi, and Kohzoh Imai
Cancer Res 2000 60: 4353-4357. [Abstract] [Full Text] [PDF]  

Bcl-2 Overexpression Results in Enhanced Capacitative Calcium Entry and Resistance to SKF-96395-induced Apoptosis

Scott S. Williams, John N. French, Mark Gilbert, Arun A. Rangaswami, Jan Walleczek, and Susan J. Knox
Cancer Res 2000 60: 4358-4361. [Abstract] [Full Text] [PDF]  

Effect of Endostatin on Spontaneous Tumorigenesis of Mammary Adenocarcinomas in a Transgenic Mouse Model

Yumi Yokoyama, Jeffrey E. Green, Vikas P. Sukhatme, and S. Ramakrishnan
Cancer Res 2000 60: 4362-4365. [Abstract] [Full Text] [PDF]  

Analysis of Adenomatous Polyposis Coli Promoter Hypermethylation in Human Cancer

Manel Esteller, Andrew Sparks, Minoru Toyota, Montserrat Sanchez-Cespedes, Gabriel Capella, Miguel Angel Peinado, Sara Gonzalez, Gemma Tarafa, David Sidransky, Stephen J. Meltzer, Stephen B. Baylin, and James G. Herman
Cancer Res 2000 60: 4366-4371. [Abstract] [Full Text] [PDF]  

Diminished DNA Repair and Elevated Mutagenesis in Mammalian Cells Exposed to Hypoxia and Low pH

Jianling Yuan, Latha Narayanan, Sara Rockwell, and Peter M. Glazer
Cancer Res 2000 60: 4372-4376. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Human THP-1 Monocytic Leukemic Cells Induced to Undergo Monocytic Differentiation by Bryostatin 1 Are Refractory to Proteasome Inhibitor-induced Apoptosis

Catheryne Chen, Hong Lin, Chachata Karanes, George R. Pettit, and Ben D. Chen
Cancer Res 2000 60: 4377-4385. [Abstract] [Full Text] [PDF]  

Caspase-3 Is Essential for Procaspase-9 Processing and Cisplatin-induced Apoptosis of MCF-7 Breast Cancer Cells

Céline Blanc, Quinn L. Deveraux, Stanislaw Krajewski, Reiner U. Jänicke, Alan G. Porter, John C. Reed, Rolf Jaggi, and Andreas Marti
Cancer Res 2000 60: 4386-4390. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

A Role for Protein Kinase C- in the Regulation of Ornithine Decarboxylase Expression by Oxidative Stress

Monicah A. Otieno and Thomas W. Kensler
Cancer Res 2000 60: 4391-4396. [Abstract] [Full Text] [PDF]  

Targeted Disruption of the Epidermal Growth Factor Receptor Inhibits Development of Papillomas and Carcinomas from Human Papillomavirus-immortalized Keratinocytes

Craig D. Woodworth, Darci Gaiotti, Evan Michael, Laura Hansen, and Matthias Nees
Cancer Res 2000 60: 4397-4402. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Human Acute Myeloid Leukemia CD34⁺/CD38^- Progenitor Cells Have Decreased Sensitivity to Chemotherapy and Fas-induced Apoptosis, Reduced Immunogenicity, and Impaired Dendritic Cell Transformation Capacities

Régis T. Costello, Françoise Mallet, Béatrice Gaugler, Danielle Sainty, Christine Arnoulet, Jean-Albert Gastaut, and Daniel Olive
Cancer Res 2000 60: 4403-4411. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

The Vitamin D Analogue EB 1089 Prevents Skeletal Metastasis and Prolongs Survival Time in Nude Mice Transplanted with Human Breast Cancer Cells

Khadija El Abdaimi, Natalie Dion, Vasilios Papavasiliou, Patrice-Etienne Cardinal, Lise Binderup, David Goltzman, Louis-Georges Ste-Marie, and Richard Kremer
Cancer Res 2000 60: 4412-4418. [Abstract] [Full Text] [PDF]  

Growth Inhibition of Prostate Cancer by an Adenovirus Expressing a Novel Tumor Suppressor Gene, pHyde

Mitchell S. Steiner, Xiongwen Zhang, Ying Wang, and Yi Lu
Cancer Res 2000 60: 4419-4425. [Abstract] [Full Text] [PDF]  

Nuclear Factor-B/IB Signaling Pathway May Contribute to the Mediation of Paclitaxel-induced Apoptosis in Solid Tumor Cells

Yi Huang, Korey R. Johnson, James S. Norris, and Weimin Fan
Cancer Res 2000 60: 4426-4432. [Abstract] [Full Text] [PDF]  

Metabolism and Pharmacokinetics of N ,N¹¹-Diethylnorspermine in a Cebus apella Primate Model

Raymond J. Bergeron, Ronald L. Merriman, Stephen G. Olson, Jan Wiegand, John Bender, Richard R. Streiff, and William R. Weimar
Cancer Res 2000 60: 4433-4439. [Abstract] [Full Text] [PDF]  

Hyperthermia Enables Tumor-specific Nanoparticle Delivery: Effect of Particle Size

Garheng Kong, Rod D. Braun, and Mark W. Dewhirst
Cancer Res 2000 60: 4440-4445. [Abstract] [Full Text] [PDF]  

Dendritic Cells Containing Apoptotic Melanoma Cells Prime Human CD8⁺ T Cells for Efficient Tumor Cell Lysis

Lars Jenne, Jean-François Arrighi, Helmut Jonuleit, Jean-Hilaire Saurat, and Conrad Hauser
Cancer Res 2000 60: 4446-4452. [Abstract] [Full Text] [PDF]  

Radioiodination via D-Amino Acid Peptide Enhances Cellular Retention and Tumor Xenograft Targeting of an Internalizing Anti-Epidermal Growth Factor Receptor Variant III Monoclonal Antibody

Catherine F. Foulon, Craig J. Reist, Darell D. Bigner, and Michael R. Zalutsky
Cancer Res 2000 60: 4453-4460. [Abstract] [Full Text] [PDF]  

2-5A Antisense Telomerase RNA Therapy for Intracranial Malignant Gliomas

Shigehiko Mukai, Yasuko Kondo, Shoji Koga, Tadashi Komata, Barbara P. Barna, and Seiji Kondo
Cancer Res 2000 60: 4461-4467. [Abstract] [Full Text] [PDF]  

Sphingosine Enhances Apoptosis of Radiation-resistant Prostate Cancer Cells

Victor E. Nava, Olivier Cuvillier, Lisa C. Edsall, Kotohiko Kimura, Sheldon Milstien, Edward P. Gelmann, and Sarah Spiegel
Cancer Res 2000 60: 4468-4474. [Abstract] [Full Text] [PDF]  

Immunology:

Targeting and Therapy of Carcinoembryonic Antigen-expressing Tumors in Transgenic Mice with an Antibody-Interleukin 2 Fusion Protein

Xiaochuan Xu, Patrick Clarke, György Szalai, John E. Shively, Lawrence E. Williams, Yu Shyr, Ergang Shi, and F. James Primus
Cancer Res 2000 60: 4475-4484. [Abstract] [Full Text] [PDF]  

Tumor Necrosis Factor and CD40 Ligand Antagonize the Inhibitory Effects of Interleukin 10 on T-Cell Stimulatory Capacity of Dendritic Cells

Peter Brossart, Anke Zobywalski, Frank Grünebach, Lars Behnke, Gernot Stuhler, Volker L. Reichardt, Lothar Kanz, and Wolfram Brugger
Cancer Res 2000 60: 4485-4492. [Abstract] [Full Text] [PDF]  

Immunotherapy with Dendritic Cells and Tumor Major Histocompatibility Complex Class I-derived Peptides Requires a High Density of Antigen on Tumor Cells

Pisana Rawson, Ian F. Hermans, Stephanie P. Huck, Joanna M. Roberts, Hanspeter Pircher, and Franca Ronchese
Cancer Res 2000 60: 4493-4498. [Abstract] [Full Text] [PDF]  

Naturally Occurring Human Lymphocyte Antigen-A2 Restricted CD8⁺ T-Cell Response to the Cancer Testis Antigen NY-ESO-1 in Melanoma Patients

Danila Valmori, Valérie Dutoit, Danielle Liénard, Donata Rimoldi, Mikaël J. Pittet, Patrick Champagne, Kim Ellefsen, Ugur Sahin, Daniel Speiser, Ferdy Lejeune, Jean-Charles Cerottini, and Pedro Romero
Cancer Res 2000 60: 4499-4506. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Analysis of Specific Gene Mutations in the Transforming Growth Factor-ß Signal Transduction Pathway in Human Ovarian Cancer

Dan Wang, Tatsuya Kanuma, Hideki Mizunuma, Fumiko Takama, Yoshito Ibuki, Norio Wake, Akira Mogi, Yoshinori Shitara, and Seiichi Takenoshita
Cancer Res 2000 60: 4507-4512. [Abstract] [Full Text] [PDF]  

The Frequency of Germ-line Mutations in the Breast Cancer Predisposition Genes BRCA1 AND BRCA2 in Familial Prostate Cancer

Simon A. Gayther, Karen A. F. de Foy, Patricia Harrington, Paul Pharoah, William D. Dunsmuir, Stephen M. Edwards, Cheryl Gillett, Audrey Ardern-Jones, David P. Dearnaley, Douglas F. Easton, Deborah Ford, Robert J. Shearer, Roger S. Kirby, Anna L. Dowe, Joanne Kelly, Michael R. Stratton, Bruce A. J. Ponder, Diana Barnes, and Rosalind A. Eeles
Cancer Res 2000 60: 4513-4518. [Abstract] [Full Text] [PDF]  

Comparative Genomic Hybridization Analysis of 38 Breast Cancer Cell Lines: A Basis for Interpreting Complementary DNA Microarray Data

Farahnaz Forozan, Eija H. Mahlamäki, Outi Monni, Yidong Chen, Robin Veldman, Yuan Jiang, Gerald C. Gooden, Stephen P. Ethier, Anne Kallioniemi, and Olli-P. Kallioniemi
Cancer Res 2000 60: 4519-4525. [Abstract] [Full Text] [PDF]  

Delineation of the 6p22 Amplification Unit in Urinary Bladder Carcinoma Cell Lines

Jochen Bruch, Wolfgang A. Schulz, Jürgen Häussler, Ingo Melzner, Silke Brüderlein, Peter Möller, Ralf Kemmerling, Walther Vogel, and Horst Hameister
Cancer Res 2000 60: 4526-4530. [Abstract] [Full Text] [PDF]  

Transforming Growth Factor-ß1 Recruits Histone Deacetylase 1 to a p130 Repressor Complex in Transgenic Mice in Vivo

Boumediene Bouzahzah, Maofu Fu, Antonio Iavarone, Valentina M. Factor, Snorri S. Thorgeirsson, and Richard G. Pestell
Cancer Res 2000 60: 4531-4537. [Abstract] [Full Text] [PDF]  

p53 Dependence of Topoisomerase I Recruitment in Vivo

Yinghui Mao, Shoshiro Okada, Long-Sheng Chang, and Mark T. Muller
Cancer Res 2000 60: 4538-4543. [Abstract] [Full Text] [PDF]  

Induction of Retinoic Acid Receptor- by Granulocyte Macrophage Colony-stimulating Factor in Human Myeloid Leukemia Cell Lines

Takahisa Shimizu and Ken Takeda
Cancer Res 2000 60: 4544-4549. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Suppression of Human Prostate Cancer Cell Growth By 1-Adrenoceptor Antagonists Doxazosin and Terazosin via Induction of Apoptosis

Natasha Kyprianou and Cynthia M. Benning
Cancer Res 2000 60: 4550-4555. [Abstract] [Full Text] [PDF]  

Tumor Oxygenation in Hormone-Dependent Tumors During Vascular Endothelial Growth Factor Receptor-2 Blockade, Hormone Ablation, and Chemotherapy

Nils Hansen-Algenstaedt, Brian R. Stoll, Timothy P. Padera, Dennis E. J. G. J. Dolmans, Daniel J. Hicklin, Dai Fukumura, and Rakesh K. Jain
Cancer Res 2000 60: 4556-4560. [Abstract] [Full Text] [PDF]  

Genetic Reprogramming in Pathways of Colonic Cell Maturation Induced by Short Chain Fatty Acids: Comparison with Trichostatin A, Sulindac, and Curcumin and Implications for Chemoprevention of Colon Cancer

John M. Mariadason, Georgia A. Corner, and Leonard H. Augenlicht
Cancer Res 2000 60: 4561-4572. [Abstract] [Full Text] [PDF]  

Insulin-like Growth Factor-I Is an Autocrine Regulator of Chromogranin A Secretion and Growth in Human Neuroendocrine Tumor Cells

Götz von Wichert, Peter M. Jehle, Andreas Hoeflich, Stefan Koschnick, Henning Dralle, Eckhard Wolf, Bertram Wiedenmann, Bernhard O. Boehm, Guido Adler, and Thomas Seufferlein
Cancer Res 2000 60: 4573-4581. [Abstract] [Full Text] [PDF]  

Scintigraphic Imaging of the Hypoxia Marker ^99mTechnetium-labeled 2,2'-(1,4-Diaminobutane)bis(2-methyl-3-butanone) Dioxime (^99mTc-labeled HL-91; Prognox): Noninvasive Detection of Tumor Response to the Antivascular Agent 5,6-Dimethylxanthenone-4-acetic Acid

Bronwyn G. Siim, Wilda T. Laux, Michael D. Rutland, Barry N. Palmer, and William R. Wilson
Cancer Res 2000 60: 4582-4588. [Abstract] [Full Text] [PDF]  

Early Deregulation of the p16^ink4a-Cyclin D1/Cyclin-dependent Kinase 4-Retinoblastoma Pathway in Cell Proliferation-driven Esophageal Tumorigenesis in Zinc-deficient Rats

Louise Y. Y. Fong, Vu T. Nguyen, John L. Farber, Kay Huebner, and Peter N. Magee
Cancer Res 2000 60: 4589-4595. [Abstract] [Full Text] [PDF]  

The N-myc Oncogene in Human Neuroblastoma Cells: Down-Regulation of an Angiogenesis Inhibitor Identified as Activin A

Stephen Breit, Keith Ashman, Jörg Wilting, Jochen Rössler, Elissavet Hatzi, Theodore Fotsis, and Lothar Schweigerer
Cancer Res 2000 60: 4596-4601. [Abstract] [Full Text] [PDF]  

Mutational and Nonmutational Activation of p21^ras in Rat Colonic Azoxymethane-induced Tumors: Effects on Mitogen-activated Protein Kinase, Cyclooxygenase-2, and Cyclin D1

Marc Bissonnette, Sharad Khare, Friederike C. von Lintig, Ramesh K. Wali, Lan Nguyen, Yingchun Zhang, John Hart, Susan Skarosi, Nissi Varki, Gerry R. Boss, and Thomas A. Brasitus
Cancer Res 2000 60: 4602-4609. [Abstract] [Full Text] [PDF]  

Acidic pH-induced Elevation in Interleukin 8 Expression by Human Ovarian Carcinoma Cells

Lei Xu and Isaiah J. Fidler
Cancer Res 2000 60: 4610-4616. [Abstract] [Full Text] [PDF]  

Evaluation of Microsatellite Analysis in Urine Sediment for Diagnosis of Bladder Cancer

Anne Schneider, Stéphane Borgnat, Hervé Lang, Odile Régine, Véronique Lindner, Maysoun Kassem, Christian Saussine, Pierre Oudet, Didier Jacqmin, and Marie Pierre Gaub
Cancer Res 2000 60: 4617-4622. [Abstract] [Full Text] [PDF]  

The DNA of Annexin V-binding Apoptotic Cells Is Highly Fragmented

Zsolt Bacsó, Richard B. Everson, and James F. Eliason
Cancer Res 2000 60: 4623-4628. [Abstract] [Full Text] [PDF]  

Inhibitors of Prostaglandin Synthesis Inhibit Human Prostate Tumor Cell Invasiveness and Reduce the Release of Matrix Metalloproteinases

Fadwa A. Attiga, Patricia M. Fernandez, Ashani T. Weeraratna, Michael J. Manyak, and Steven R. Patierno
Cancer Res 2000 60: 4629-4637. [Abstract] [Full Text] [PDF]  

p53 Promotes Selection for Fas-mediated Apoptotic Resistance

Heather L. Maecker, Constantinos Koumenis, and Amato J. Giaccia
Cancer Res 2000 60: 4638-4644. [Abstract] [Full Text] [PDF]  

The Effect of Exogenous Prostaglandin Administration on Tumor Size and Yield in Min/+ Mice

James W. Wilson and Christopher S. Potten
Cancer Res 2000 60: 4645-4653. [Abstract] [Full Text] [PDF]  

Deregulated Manganese Superoxide Dismutase Expression and Resistance to Oxidative Injury in p53-deficient Cells

Giovanni Pani, Barbara Bedogni, Rosanna Anzevino, Renata Colavitti, Bernardetta Palazzotti, Silvia Borrello, and Tommaso Galeotti
Cancer Res 2000 60: 4654-4660. [Abstract] [Full Text] [PDF]  

Errata:

J. F. Novak et al., Cancer Res., 60:3470–3476, 2000.

Cancer Res 2000 60: 4661-4663. [Full Text] [PDF]  

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