Review:

Mammary Expression of Xenobiotic Metabolizing Enzymes and Their Potential Role in Breast Cancer

J. Andrew Williams and David H. Phillips
Cancer Res 2000 60: 4667-4677. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Inhibition of Epidermal Growth Factor Receptor Tyrosine Kinase Fails to Suppress Adenoma Formation in Apc^Min Mice but Induces Duodenal Injury

Steve R. Ritland, Sandra J. Gendler, Lawrence J. Burgart, David W. Fry, James M. Nelson, Alexander J. Bridges, Larry Andress, and William E. Karnes, Jr.
Cancer Res 2000 60: 4678-4681. [Abstract] [Full Text] [PDF]  

Increased Expression of H/T-Cadherin in Tumor-penetrating Blood Vessels

Lorenza Wyder, Alessandra Vitaliti, Henriette Schneider, Lionel W. Hebbard, Dirk R. Moritz, Mariana Wittmer, Malek Ajmo, and Roman Klemenz
Cancer Res 2000 60: 4682-4688. [Abstract] [Full Text] [PDF]  

Histological Type-selective, Tumor-predominant Expression of a Novel CHK1 Isoform and Infrequent in Vivo Somatic CHK2 Mutation in Small Cell Lung Cancer

Nobuhiro Haruki, Hiroko Saito, Yoshio Tatematsu, Hiroyuki Konishi, Tomoko Harano, Akira Masuda, Hirotaka Osada, Yoshitaka Fujii, and Takashi Takahashi
Cancer Res 2000 60: 4689-4692. [Abstract] [Full Text] [PDF]  

Overexpression of Hypoxia-inducible Factor 1 Is a Marker for an Unfavorable Prognosis in Early-Stage Invasive Cervical Cancer

Peter Birner, Monika Schindl, Andreas Obermair, Christina Plank, Gerhard Breitenecker, and Georg Oberhuber
Cancer Res 2000 60: 4693-4696. [Abstract] [Full Text] [PDF]  

Aberrant Transcripts of the Cyclin-dependent Kinase-associated Protein Phosphatase in Hepatocellular Carcinoma

Chau-Ting Yeh, Su-Chuan Lu, Tse-Ching Chen, Cheng-Yuan Peng, and Yun-Fan Liaw
Cancer Res 2000 60: 4697-4700. [Abstract] [Full Text] [PDF]  

Frequent Frameshift Mutations of RIZ in Sporadic Gastrointestinal and Endometrial Carcinomas with Microsatellite Instability

Zhe Piao, Wei Fang, Sergei Malkhosyan, Hoguen Kim, Akira Horii, Manuel Perucho, and Shi Huang
Cancer Res 2000 60: 4701-4704. [Abstract] [Full Text] [PDF]  

Genetic Disruption of Ptgs-1, as well as of Ptgs-2, Reduces Intestinal Tumorigenesis in Min Mice

Patricia C. Chulada, Morrow B. Thompson, Joel F. Mahler, Christine M. Doyle, Beth W. Gaul, Christopher Lee, Howard F. Tiano, Scott G. Morham, Oliver Smithies, and Robert Langenbach
Cancer Res 2000 60: 4705-4708. [Abstract] [Full Text] [PDF]  

ß-Catenin Affects Androgen Receptor Transcriptional Activity and Ligand Specificity

Cristina I. Truica, Stephen Byers, and Edward P. Gelmann
Cancer Res 2000 60: 4709-4713. [Abstract] [Full Text] [PDF]  

Tumor Prevention and Antitumor Immunity with Heat Shock Protein 70 Induced by 15-Deoxy-^12,14-prostaglandin J₂ in Transgenic Adenocarcinoma of Mouse Prostate Cells

Donkena Krishna Vanaja, Michael E. Grossmann, Esteban Celis, and Charles Y. F. Young
Cancer Res 2000 60: 4714-4718. [Abstract] [Full Text] [PDF]  

Fibrinogen E-fragment Inhibits the Migration and Tubule Formation of Human Dermal Microvascular Endothelial Cells in Vitro

Carolyn A. Bootle-Wilbraham, S. Tazzyman, J. M. Marshall, and Claire E. Lewis
Cancer Res 2000 60: 4719-4724. [Abstract] [Full Text] [PDF]  

Proficient Metabolism of Irinotecan by a Human Intestinal Carboxylesterase

Ruchi Khanna, Christopher L. Morton, Mary K. Danks, and Philip M. Potter
Cancer Res 2000 60: 4725-4728. [Abstract] [Full Text] [PDF]  

Isolation and Mapping of a Human Septin Gene to a Region on Chromosome 17q, Commonly Deleted in Sporadic Epithelial Ovarian Tumors

S. E. Hilary Russell, Michael A. McIlhatton, James F. Burrows, Paul G. Donaghy, Severine Chanduloy, Elizabeth M. Petty, Linda M. Kalikin, Stewart W. Church, Stephen McIlroy, D. Paul Harkin, Gillian W. Keilty, Aaron N. Cranston, Jean Weissenbach, Ivor Hickey, and Patrick G. Johnston
Cancer Res 2000 60: 4729-4734. [Abstract] [Full Text] [PDF]  

Identification of a Novel Gene, GASC1, within an Amplicon at 9p23–24 Frequently Detected in Esophageal Cancer Cell Lines

Zeng-Quan Yang, Issei Imoto, Yoji Fukuda, Atiphan Pimkhaokham, Yutaka Shimada, Masayuki Imamura, Sumio Sugano, Yusuke Nakamura, and Johji Inazawa
Cancer Res 2000 60: 4735-4739. [Abstract] [Full Text] [PDF]  

Alterations of the DNA Repair Gene OGG1 in Human Clear Cell Carcinomas of the Kidney

Marc Audebert, Sylvie Chevillard, Céline Levalois, Gabor Gyapay, Annick Vieillefond, Jerzy Klijanienko, Philippe Vielh, Adel K. El Naggar, Stéphane Oudard, Serge Boiteux, and J. Pablo Radicella
Cancer Res 2000 60: 4740-4744. [Abstract] [Full Text] [PDF]  

Matrilysin-2, a New Matrix Metalloproteinase Expressed in Human Tumors and Showing the Minimal Domain Organization Required for Secretion, Latency, and Activity

José A. Uría and Carlos López-Otín
Cancer Res 2000 60: 4745-4751. [Abstract] [Full Text] [PDF]  

XAGE-1, A New Gene That Is Frequently Expressed in Ewing’s Sarcoma

Xiu Fen Liu, Lee J. Helman, Choy Yeung, Tapan K. Bera, Byungkook Lee, and Ira Pastan
Cancer Res 2000 60: 4752-4755. [Abstract] [Full Text] [PDF]  

Suppression of Ethylnitrosourea-induced Schwannoma Development Involves Elimination of neu/erbB-2 Mutant Premalignant Cells in the Resistant BDIV Rat Strain

Andrea Kindler-Röhrborn, André B. Kind, Bernd U. Koelsch, Christine Fischer, and Manfred F. Rajewsky
Cancer Res 2000 60: 4756-4760. [Abstract] [Full Text] [PDF]  

Transactivation of the Multidrug Resistance 1 Gene by T-Cell Factor 4/ß-Catenin Complex in Early Colorectal Carcinogenesis

Tesshi Yamada, Asako S. Takaoka, Yasuyoshi Naishiro, Reiko Hayashi, Keiji Maruyama, Chihaya Maesawa, Atsushi Ochiai, and Setsuo Hirohashi
Cancer Res 2000 60: 4761-4766. [Abstract] [Full Text] [PDF]  

Astrocytes Contribute to the Brain-metastatic Specificity of Melanoma Cells by Producing Heparanase

Dario Marchetti, John Li, and Ruijun Shen
Cancer Res 2000 60: 4767-4770. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

The Surface of Prostate Carcinoma DU145 Cells Mediates the Inhibition of Urokinase-type Plasminogen Activator by Maspin

Richard McGowen, Hector Biliran, Jr., Ruth Sager, and Shijie Sheng
Cancer Res 2000 60: 4771-4778. [Abstract] [Full Text] [PDF]  

Transport of Amphipathic Anions by Human Multidrug Resistance Protein 3

Hao Zeng, Guosheng Liu, Philip A. Rea, and Gary D. Kruh
Cancer Res 2000 60: 4779-4784. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Stimulatory Effect of Oral Administration of Green Tea or Caffeine on Ultraviolet Light-induced Increases in Epidermal Wild-Type p53, p21(WAF1/CIP1), and Apoptotic Sunburn Cells in SKH-1 Mice

Yao-Ping Lu, You-Rong Lou, Xiang Hong Li, Jian Guo Xie, Douglas Brash, Mou-Tuan Huang, and Allan H. Conney
Cancer Res 2000 60: 4785-4791. [Abstract] [Full Text] [PDF]  

Preventive Potential of Wheat Bran Fractions against Experimental Colon Carcinogenesis: Implications for Human Colon Cancer Prevention

Bandaru S. Reddy, Yoshinobu Hirose, Leonard A. Cohen, Barbara Simi, Indrane Cooma, and Chinthalapally V. Rao
Cancer Res 2000 60: 4792-4797. [Abstract] [Full Text] [PDF]  

Oxidants from Nicotinamide Adenine Dinucleotide Phosphate Oxidase Are Involved in Triggering Cell Proliferation in the Liver Due to Peroxisome Proliferators

Ivan Rusyn, Shunhei Yamashina, Brahm H. Segal, Robert Schoonhoven, Steven M. Holland, Russell C. Cattley, James A. Swenberg, and Ronald G. Thurman
Cancer Res 2000 60: 4798-4803. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

In Vivo Biodistribution of a Humanized Anti-Lewis Y Monoclonal Antibody (hu3S193) in MCF-7 Xenografted BALB/c Nude Mice

Kerrie Clarke, Fook-Thean Lee, Martin W. Brechbiel, Fiona E. Smyth, Lloyd J. Old, and Andrew M. Scott
Cancer Res 2000 60: 4804-4811. [Abstract] [Full Text] [PDF]  

Differential Expression of Drug Resistance Genes and Chemosensitivity in Glial Cell Lineages Correlate with Differential Response of Oligodendrogliomas and Astrocytomas to Chemotherapy

Catherine L. Nutt, Mark Noble, Ann F. Chambers, and J. Gregory Cairncross
Cancer Res 2000 60: 4812-4818. [Abstract] [Full Text] [PDF]  

Effects of PTK787/ZK 222584, a Specific Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, on Primary Tumor, Metastasis, Vessel Density, and Blood Flow in a Murine Renal Cell Carcinoma Model

Joachim Drevs, Inga Hofmann, Harald Hugenschmidt, Christine Wittig, Helmut Madjar, Marianne Müller, Jeanette Wood, Georg Martiny-Baron, Clemens Unger, and Dieter Marmé
Cancer Res 2000 60: 4819-4824. [Abstract] [Full Text] [PDF]  

Applicability of Carcinoembryonic Antigen-specific Monoclonal Antibodies to Radioimmunoguided Surgery for Human Colorectal Carcinoma

Jin C. Kim, Wan S. Kim, Jin S. Ryu, Seung J. Oh, Dong H. Lee, Kum H. Koo, Sun A. Roh, Hee C. Kim, Chang S. Yu, Gyeong H. Kang, and Walter F. Bodmer
Cancer Res 2000 60: 4825-4829. [Abstract] [Full Text] [PDF]  

Immunology:

A New Tumor-Rejection Antigen Recognized by Cytotoxic T Lymphocytes Infiltrating into a Lung Adenocarcinoma

Shinya Nishizaka, Shinya Gomi, Kenji Harada, Kotaro Oizumi, Kyogo Itoh, and Shigeki Shichijo
Cancer Res 2000 60: 4830-4837. [Abstract] [Full Text] [PDF]  

Rapid Generation of Potent and Tumor-specific Cytotoxic T Lymphocytes by Interleukin 18 Using Dendritic Cells and Natural Killer Cells

Fumiaki Tanaka, Wataru Hashimoto, Haruki Okamura, Paul D. Robbins, Michael T. Lotze, and Hideaki Tahara
Cancer Res 2000 60: 4838-4844. [Abstract] [Full Text] [PDF]  

Generation of Survivin-specific CD8⁺ T Effector Cells by Dendritic Cells Pulsed with Protein or Selected Peptides

Marc Schmitz, Petra Diestelkoetter, Bernd Weigle, Florian Schmachtenberg, Stefan Stevanovic, Detlef Ockert, Hans-Georg Rammensee, and Ernst Peter Rieber
Cancer Res 2000 60: 4845-4849. [Abstract] [Full Text] [PDF]  

Natural T-cell Response against MHC Class I Epitopes of Epithelial Cell Adhesion Molecule, her-2/neu, and Carcinoembryonic Antigen in Patients with Colorectal Cancer

Dirk Nagorsen, Ulrich Keilholz, Licia Rivoltini, Alexander Schmittel, Anne Letsch, Anne Marie Asemissen, Gerd Berger, Heinz-Johannes Buhr, Eckhard Thiel, and Carmen Scheibenbogen
Cancer Res 2000 60: 4850-4854. [Abstract] [Full Text] [PDF]  

Identification of a Tumor-specific Shared Antigen Derived From an Eph Receptor and Presented to CD4 T Cells on HLA Class II Molecules

Rita Chiari, Gérald Hames, Vincent Stroobant, Catherine Texier, Bernard Maillère, Thierry Boon, and Pierre G. Coulie
Cancer Res 2000 60: 4855-4863. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Microsatellite Instability in Inflammatory Bowel Disease-associated Neoplastic Lesions Is Associated with Hypermethylation and Diminished Expression of the DNA Mismatch Repair Gene, hMLH1

A. Steven Fleisher, Manel Esteller, Noam Harpaz, Anatoly Leytin, Asma Rashid, Yan Xu, Jing Liang, O. Colin Stine, Jing Yin, Tong-Tong Zou, John M. Abraham, Dehe Kong, Keith T. Wilson, Stephen P. James, James G. Herman, and Stephen J. Meltzer
Cancer Res 2000 60: 4864-4868. [Abstract] [Full Text] [PDF]  

PLAG1 Fusion Oncogenes in Lipoblastoma

Michele K. Hibbard, Harry P. Kozakewich, Paola Dal Cin, Raf Sciot, Xiaolian Tan, Sheng Xiao, and Jonathan A. Fletcher
Cancer Res 2000 60: 4869-4872. [Abstract] [Full Text] [PDF]  

The Kaposi’s Sarcoma-associated Herpes Virus G Protein-coupled Receptor Up-Regulates Vascular Endothelial Growth Factor Expression and Secretion through Mitogen-activated Protein Kinase and p38 Pathways Acting on Hypoxia-inducible Factor 1

Akrit Sodhi, Silvia Montaner, Vyomesh Patel, Muriel Zohar, Carlos Bais, Enrique A. Mesri, and J. Silvio Gutkind
Cancer Res 2000 60: 4873-4880. [Abstract] [Full Text] [PDF]  

Radiosensitivity in Nijmegen Breakage Syndrome Cells Is Attributable to a Repair Defect and not Cell Cycle Checkpoint Defects

Pierre-Marie Girard, Nicolas Foray, Markus Stumm, Alistair Waugh, Enriqueta Riballo, Richard S. Maser, William P. Phillips, John Petrini, Colin F. Arlett, and Penny A. Jeggo
Cancer Res 2000 60: 4881-4888. [Abstract] [Full Text] [PDF]  

Ionizing Radiation-induced Apoptosis via Separate Pms2- and p53-dependent Pathways

Ming Zeng, Latha Narayanan, Xiaoxin S. Xu, Tomas A. Prolla, R. Michael Liskay, and Peter M. Glazer
Cancer Res 2000 60: 4889-4893. [Abstract] [Full Text] [PDF]  

Genome-wide Allelotyping of Lung Cancer Identifies New Regions of Allelic Loss, Differences between Small Cell Lung Cancer and Non-Small Cell Lung Cancer, and Loci Clustering

Luc Girard, Sabine Zöchbauer-Müller, Arvind K. Virmani, Adi F. Gazdar, and John D. Minna
Cancer Res 2000 60: 4894-4906. [Abstract] [Full Text] [PDF]  

The Gene for a Novel Transmembrane Protein Containing Epidermal Growth Factor and Follistatin Domains Is Frequently Hypermethylated in Human Tumor Cells

Gangning Liang, Keith D. Robertson, Cathy Talmadge, Janos Sumegi, and Peter A. Jones
Cancer Res 2000 60: 4907-4912. [Abstract] [Full Text] [PDF]  

The Human ARHI Tumor Suppressor Gene Inhibits Lactation and Growth in Transgenic Mice

Fengji Xu, Weiya Xia, Robert Z. Luo, Hongqi Peng, Shulei Zhao, Jianyu Dai, Yan Long, Linglong Zou, Weidong Le, Jinsong Liu, Albert F. Parlow, Mien-Chie Hung, Robert C. Bast, Jr., and Yinhua Yu
Cancer Res 2000 60: 4913-4920. [Abstract] [Full Text] [PDF]  

Specificity of Mutations Induced by the Food-associated Heterocyclic Amine 2-Amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine in Colon Cancer Cell Lines Defective in Mismatch Repair

Warren E. Glaab, Kristy L. Kort, and Thomas R. Skopek
Cancer Res 2000 60: 4921-4925. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Expression of Cyclooxygenase 2 (COX-2) in Human Glioma and in Vitro Inhibition by a Specific COX-2 Inhibitor, NS-398

Tatsuhiro Joki, Oliver Heese, Demetrios C. Nikas, Lorenzo Bello, Jianping Zhang, Stine-Kathrein Kraeft, Nicholas T. Seyfried, Toshiaki Abe, Lan Bo Chen, Rona S. Carroll, and Peter M. Black
Cancer Res 2000 60: 4926-4931. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor, Interleukin 8, Platelet-derived Endothelial Cell Growth Factor, and Basic Fibroblast Growth Factor Promote Angiogenesis and Metastasis in Human Melanoma Xenografts

Einar K. Rofstad and Ellen F. Halsør
Cancer Res 2000 60: 4932-4938. [Abstract] [Full Text] [PDF]  

Human T-Cell Leukemia Virus Type I Tax Activates Transcription of the Human Monocyte Chemoattractant Protein-1 Gene through Two Nuclear Factor-B Sites

Naoki Mori, Atsuhisa Ueda, Shuichi Ikeda, Yoshihiro Yamasaki, Yasuaki Yamada, Masao Tomonaga, Shigeru Morikawa, Romas Geleziunas, Teizo Yoshimura, and Naoki Yamamoto
Cancer Res 2000 60: 4939-4945. [Abstract] [Full Text] [PDF]  

NY-ESO-1 Encodes DRB1*0401-restricted Epitopes Recognized by Melanoma-reactive CD4+ T Cells

Hassane M. Zarour, Walter J. Storkus, Vladimir Brusic, Eileen Williams, and John M. Kirkwood
Cancer Res 2000 60: 4946-4952. [Abstract] [Full Text] [PDF]  

In Vivo Imaging of Proteolytic Enzyme Activity Using a Novel Molecular Reporter

Ching-Hsuan Tung, Umar Mahmood, Sebastian Bredow, and Ralph Weissleder
Cancer Res 2000 60: 4953-4958. [Abstract] [Full Text] [PDF]  

Expression of Vascular Endothelial Growth Factor Is Necessary but not Sufficient for Production and Growth of Brain Metastasis

Seiji Yano, Hisashi Shinohara, Roy S. Herbst, Hiroki Kuniyasu, Corazon D. Bucana, Lee M. Ellis, Darren W. Davis, David J. McConkey, and Isaiah J. Fidler
Cancer Res 2000 60: 4959-4967. [Abstract] [Full Text] [PDF]  

Protein Metabolism in the Small Intestine during Cancer Cachexia and Chemotherapy in Mice

Susan E. Samuels, Andrew L. Knowles, Thomas Tilignac, Eric Debiton, Jean Claude Madelmont, and Didier Attaix
Cancer Res 2000 60: 4968-4974. [Abstract] [Full Text] [PDF]  

Correction:

A. Bateman, et al, Cancer Res., 60: 2492–2497, 2000.

Andrew Bateman, Francis Bullough, Stephen Murphy, Lisa Emiliusen, Dimitri Lavillette, François-Loic Cosset, Roberto Cattaneo, Stephen J. Russell, and Richard G. Vile
Cancer Res 2000 60: 4975-4978. [Full Text] [PDF]  

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