Review:

Estrogens, BRCA1, and Breast Cancer

Leena Hilakivi-Clarke
Cancer Res 2000 60: 4993-5001. [Abstract] [Full Text] [PDF]  

Advances in Brief:

p53 Is Essential for Chemotherapy-induced Hair Loss

Vladimir A. Botchkarev, Elena A. Komarova, Frank Siebenhaar, Natalia V. Botchkareva, Pavel G. Komarov, Marcus Maurer, Barbara A. Gilchrest, and Andrei V. Gudkov
Cancer Res 2000 60: 5002-5006. [Abstract] [Full Text] [PDF]  

Identification by cDNA Microarray of Genes Involved in Ovarian Carcinogenesis

Kenji Ono, Toshihiro Tanaka, Tatsuhiko Tsunoda, Osamu Kitahara, Chikashi Kihara, Aikou Okamoto, Kazunori Ochiai, Toshihisa Takagi, and Yusuke Nakamura
Cancer Res 2000 60: 5007-5011. [Abstract] [Full Text] [PDF]  

Micropthalmia Transcription Factor: A New Prognostic Marker in Intermediate-thickness Cutaneous Malignant Melanoma

George I. Salti, Taline Manougian, Miguel Farolan, Anne Shilkaitis, Dibyen Majumdar, and Tapas K. Das Gupta
Cancer Res 2000 60: 5012-5016. [Abstract] [Full Text] [PDF]  

Population-based Mapping of Pulmonary Adenoma Susceptibility 1 Locus

Tommaso A. Dragani, Setsuo Hirohashi, Takeo Juji, Kaname Kawajiri, Masahiro Kihara, Masako Ono-Kihara, Giacomo Manenti, Tomoko Nomoto, Haruhiko Sugimura, Keiichiro Genka, Jun Yokota, Takashi Takahashi, Tetsuya Mitsudomi, and Minako Nagao
Cancer Res 2000 60: 5017-5020. [Abstract] [Full Text] [PDF]  

Fields of Aberrant CpG Island Hypermethylation in Barrett’s Esophagus and Associated Adenocarcinoma

Cindy A. Eads, Reginald V. Lord, Soudamini K. Kurumboor, Kumari Wickramasinghe, Margaret L. Skinner, Tiffany I. Long, Jeffrey H. Peters, Tom R. DeMeester, Kathleen D. Danenberg, Peter V. Danenberg, Peter W. Laird, and Kristin A. Skinner
Cancer Res 2000 60: 5021-5026. [Abstract] [Full Text] [PDF]  

Pleiotropic Resistance to DNA-interactive Drugs Is Associated with Increased Expression of Genes Involved in DNA Replication, Repair, and Stress Response

Irina A. Davidovich and Igor B. Roninson
Cancer Res 2000 60: 5027-5030. [Abstract] [Full Text] [PDF]  

The Dual Impact of Coxsackie and Adenovirus Receptor Expression on Human Prostate Cancer Gene Therapy

Takatsugu Okegawa, Yingming Li, Rey-Chen Pong, Jeffrey M. Bergelson, Jian Zhou, and Jer-Tsong Hsieh
Cancer Res 2000 60: 5031-5036. [Abstract] [Full Text] [PDF]  

Ataxia Telangiectasia-related Protein Is Involved in the Phosphorylation of BRCA1 following Deoxyribonucleic Acid Damage

Junjie Chen
Cancer Res 2000 60: 5037-5039. [Abstract] [Full Text] [PDF]  

The Cyclooxygenase-2 Inhibitor Celecoxib Is a Potent Preventive and Therapeutic Agent in the Min Mouse Model of Adenomatous Polyposis

Russell F. Jacoby, Karen Seibert, Carolyn E. Cole, Gary Kelloff, and Ronald A. Lubet
Cancer Res 2000 60: 5040-5044. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Novel Actions of the Antitumor Drugs Vinflunine and Vinorelbine on Microtubules

Vivian K. Ngan, Krista Bellman, Dulal Panda, Bridget T. Hill, Mary Ann Jordan, and Leslie Wilson
Cancer Res 2000 60: 5045-5051. [Abstract] [Full Text] [PDF]  

Cell-based Screen for Antimitotic Agents and Identification of Analogues of Rhizoxin, Eleutherobin, and Paclitaxel in Natural Extracts

Michel Roberge, Bruno Cinel, Hilary J. Anderson, Lynette Lim, Xiuxian Jiang, Lin Xu, Cristina M. Bigg, Michael T. Kelly, and Raymond J. Andersen
Cancer Res 2000 60: 5052-5058. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Inhibitory Effect of Citrus Nobiletin on Phorbol Ester-induced Skin Inflammation, Oxidative Stress, and Tumor Promotion in Mice

Akira Murakami, Yoshimasa Nakamura, Koji Torikai, Takuji Tanaka, Teruaki Koshiba, Koichi Koshimizu, Shigeru Kuwahara, Yasuo Takahashi, Kazunori Ogawa, Masamichi Yano, Harukuni Tokuda, Hoyoku Nishino, Yoshihiro Mimaki, Yutaka Sashida, Susumu Kitanaka, and Hajime Ohigashi
Cancer Res 2000 60: 5059-5066. [Abstract] [Full Text] [PDF]  

Differential Activation of c-Jun NH₂-terminal Kinase and p38 Mitogen-activated Protein Kinases by Methyl Methanesulfonate in the Liver and Brain of Rats: Implication for Organ-specific Carcinogenesis

Yousin Suh, Ung Gu Kang, Yong Sik Kim, Woo-Ho Kim, Sang-Chul Park, and Joo-Bae Park
Cancer Res 2000 60: 5067-5073. [Abstract] [Full Text] [PDF]  

Human Cytochrome P450 CYP2A13: Predominant Expression in the Respiratory Tract and Its High Efficiency Metabolic Activation of a Tobacco-specific Carcinogen, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

Ting Su, Ziping Bao, Qing-Yu Zhang, Theresa J. Smith, Jun-Yan Hong, and Xinxin Ding
Cancer Res 2000 60: 5074-5079. [Abstract] [Full Text] [PDF]  

Increased Mutant Frequency and Altered Mutation Spectrum of the lacI Transgene in Wilson Disease Rats with Hepatitis

Hideko Sone, Ying Jie Li, Mayumi Ishizuka, Yasunobu Aoki, and Minako Nagao
Cancer Res 2000 60: 5080-5086. [Abstract] [Full Text] [PDF]  

Lack of Phenobarbital-mediated Promotion of Hepatocarcinogenesis in Connexin32-Null Mice

Oliver Moennikes, Albrecht Buchmann, Alessandro Romualdi, Thomas Ott, Jürgen Werringloer, Klaus Willecke, and Michael Schwarz
Cancer Res 2000 60: 5087-5091. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Early Resistance to Therapy during Induction in Childhood Acute Lymphoblastic Leukemia

Michael J. Brisco, Pamela J. Sykes, Gaynor Dolman, Elizabeth Hughes, Sim-Hee Neoh, Liming Peng, Lesley E. Snell, Ian R. G. Toogood, Michael S. Rice, and Alexander A. Morley
Cancer Res 2000 60: 5092-5096. [Abstract] [Full Text] [PDF]  

Endocrinology:

Allosteric Silencing of Activating Function 1 in the 4-Hydroxytamoxifen Estrogen Receptor Complex Is Induced by Substituting Glycine for Aspartate at Amino Acid 351

Jennifer MacGregor Schafer, Hong Liu, David J. Bentrem, James W. Zapf, and V. Craig Jordan
Cancer Res 2000 60: 5097-5105. [Abstract] [Full Text] [PDF]  

Epidemiology:

Serum Testosterone:Estradiol Ratio and the Development of Hepatocellular Carcinoma among Male Cirrhotic Patients

Keitaro Tanaka, Hironori Sakai, Makoto Hashizume, and Tomio Hirohata
Cancer Res 2000 60: 5106-5110. [Abstract] [Full Text] [PDF]  

Polymorphic CAG and GGN Repeat Lengths in the Androgen Receptor Gene and Prostate Cancer Risk: A Population-based Case-Control Study in China

Ann W. Hsing, Yu-Tang Gao, Guan Wu, Xin Wang, Jie Deng, Yuh-Ling Chen, Isabell A. Sesterhenn, F. Kash Mostofi, Jacques Benichou, and Chawnshang Chang
Cancer Res 2000 60: 5111-5116. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Selective Inhibition of Vascular Endothelial Growth Factor (VEGF) Receptor 2 (KDR/Flk-1) Activity by a Monoclonal Anti-VEGF Antibody Blocks Tumor Growth in Mice

Rolf A. Brekken, Jay P. Overholser, Victor A. Stastny, Johannes Waltenberger, John D. Minna, and Philip E. Thorpe
Cancer Res 2000 60: 5117-5124. [Abstract] [Full Text] [PDF]  

Chemoprevention of Prostate Carcinogenesis by -Difluoromethylornithine in TRAMP Mice

Sanjay Gupta, Nihal Ahmad, Susan R. Marengo, Gregory T. MacLennan, Norman M. Greenberg, and Hasan Mukhtar
Cancer Res 2000 60: 5125-5133. [Abstract] [Full Text] [PDF]  

CD99 Engagement: An Effective Therapeutic Strategy for Ewing Tumors

Katia Scotlandi, Nicola Baldini, Vanessa Cerisano, Maria Cristina Manara, Stefania Benini, Massimo Serra, Pier-Luigi Lollini, Patrizia Nanni, Giordano Nicoletti, Ghislaine Bernard, Alain Bernard, and Piero Picci
Cancer Res 2000 60: 5134-5142. [Abstract] [Full Text] [PDF]  

Intracranial Inhibition of Platelet-derived Growth Factor-mediated Glioblastoma Cell Growth by an Orally Active Kinase Inhibitor of the 2-Phenylaminopyrimidine Class

Turker Kilic, John A. Alberta, Pawel R. Zdunek, Melih Acar, Palma Iannarelli, Terence O’Reilly, Elisabeth Buchdunger, Peter M. Black, and Charles D. Stiles
Cancer Res 2000 60: 5143-5150. [Abstract] [Full Text] [PDF]  

Uroguanylin Treatment Suppresses Polyp Formation in the Apc^Min/+ Mouse and Induces Apoptosis in Human Colon Adenocarcinoma Cells via Cyclic GMP

Kunwar Shailubhai, Helen H. Yu, Kanthasamy Karunanandaa, Joan Y. Wang, Sammy L. Eber, Yuan Wang, Nam Soo Joo, Hyun Dju Kim, Brent W. Miedema, S. Zaheer Abbas, Sekhar S. Boddupalli, Mark G. Currie, and Leonard R. Forte
Cancer Res 2000 60: 5151-5157. [Abstract] [Full Text] [PDF]  

Human Carbonyl Reductase Overexpression in the Heart Advances the Development of Doxorubicin-induced Cardiotoxicity in Transgenic Mice

Gerald L. Forrest, Basilio Gonzalez, William Tseng, XiuLi Li, and Jeffrey Mann
Cancer Res 2000 60: 5158-5164. [Abstract] [Full Text] [PDF]  

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Suppresses the Growth of Prostate Cancer Cells in Vitro and in Vivo

Lisa M. Butler, David B. Agus, Howard I. Scher, Brian Higgins, Adam Rose, Carlos Cordon-Cardo, Howard T. Thaler, Richard A. Rifkind, Paul A. Marks, and Victoria M. Richon
Cancer Res 2000 60: 5165-5170. [Abstract] [Full Text] [PDF]  

Taxol Mediates Serine Phosphorylation of the 66-kDa Shc Isoform

Chia-Ping Huang Yang and Susan Band Horwitz
Cancer Res 2000 60: 5171-5178. [Abstract] [Full Text] [PDF]  

Noninvasive Real-Time Monitoring of Intracellular Cancer Cell Metabolism and Response to Lonidamine Treatment Using Diffusion Weighted Proton Magnetic Resonance Spectroscopy

Yael Mardor, Ofer Kaplan, Marina Sterin, Jesus Ruiz-Cabello, Elissa Ash, Yiftach Roth, Israel Ringel, and Jack S. Cohen
Cancer Res 2000 60: 5179-5186. [Abstract] [Full Text] [PDF]  

Direct Reversal of DNA Damage by Mutant Methyltransferase Protein Protects Mice against Dose-intensified Chemotherapy and Leads to in Vivo Selection of Hematopoietic Stem Cells

Susanne Ragg, Meng Xu-Welliver, Jeff Bailey, Maria D’Souza, Ryan Cooper, Saurabh Chandra, Roopa Seshadri, Anthony E. Pegg, and David A. Williams
Cancer Res 2000 60: 5187-5195. [Abstract] [Full Text] [PDF]  

Role of CYP1A1 in Modulation of Antitumor Properties of the Novel Agent 2-(4-Amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in Human Breast Cancer Cells

Mei-Sze Chua, Eiji Kashiyama, Tracey D. Bradshaw, Sherman F. Stinson, Eileen Brantley, Edward A. Sausville, and Malcolm F. G. Stevens
Cancer Res 2000 60: 5196-5203. [Abstract] [Full Text] [PDF]  

Pharmacological Inhibition of Phosphatidylcholine Biosynthesis Is Associated with Induction of Phosphatidylinositol Accumulation and Cytolysis of Neoplastic Cell Lines

Robert E. Finney, Edward Nudelman, Thayer White, Stuart Bursten, Peter Klein, Laura L. Leer, Nu Wang, David Waggoner, Jack W. Singer, and Robert A. Lewis
Cancer Res 2000 60: 5204-5213. [Abstract] [Full Text] [PDF]  

MT-21 Is a Synthetic Apoptosis Inducer That Directly Induces Cytochrome c Release from Mitochondria

Masahiko Watabe, Kiyotaka Machida, and Hiroyuki Osada
Cancer Res 2000 60: 5214-5222. [Abstract] [Full Text] [PDF]  

Immunology:

Use of Two Predictive Algorithms of the World Wide Web for the Identification of Tumor-reactive T-Cell Epitopes

Jun Lu and Esteban Celis
Cancer Res 2000 60: 5223-5227. [Abstract] [Full Text] [PDF]  

Defining Promiscuous MHC Class II Helper T-Cell Epitopes for the HER2/neu Tumor Antigen

Hiroya Kobayashi, Monique Wood, Yongsheng Song, Ettore Appella, and Esteban Celis
Cancer Res 2000 60: 5228-5236. [Abstract] [Full Text] [PDF]  

In Vitro Characterization of Radiolabeled Monoclonal Antibodies Specific for the Extracellular Domain of Prostate-specific Membrane Antigen

Peter M. Smith-Jones, Shankar Vallabahajosula, Stanley J. Goldsmith, Vincent Navarro, Catherine J. Hunter, Diego Bastidas, and Neil H. Bander
Cancer Res 2000 60: 5237-5243. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Loss of p27^Kip1 from Cyclin E/Cyclin-dependent Kinase (CDK) 2 but not from Cyclin D1/CDK4 Complexes in Cells Transformed by Polyamine Biosynthetic Enzymes

Kirsi Ravanko, Kristiina Järvinen, Aino Paasinen-Sohns, and Erkki Hölttä
Cancer Res 2000 60: 5244-5253. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Tissue-specific Carcinogenesis in Transgenic Mice Expressing the RET Proto-Oncogene with a Multiple Endocrine Neoplasia Type 2A Mutation

Kumi Kawai, Toshihide Iwashita, Hideki Murakami, Noriko Hiraiwa, Atsushi Yoshiki, Moriaki Kusakabe, Kenzo Ono, Ken-ichi Iida, Atsuo Nakayama, and Masahide Takahashi
Cancer Res 2000 60: 5254-5260. [Abstract] [Full Text] [PDF]  

Involvement of Cell Surface Glycans in Adhesion of Human Colon Carcinoma Cells to Liver Tissue in a Frozen Section Assay: Role of Endo-ß-galactosidase-sensitive Structures

Masayuki Ota, Noriaki Takamura, and Tatsuro Irimura
Cancer Res 2000 60: 5261-5268. [Abstract] [Full Text] [PDF]  

Specific Detection of Multidrug Resistance Proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-Glycoprotein with a Panel of Monoclonal Antibodies

George L. Scheffer, Marcel Kool, Marc Heijn, Marcel de Haas, Adriana C. L. M. Pijnenborg, Jan Wijnholds, Ardy van Helvoort, Mariska C. de Jong, Jan H. Hooijberg, Carla A. A. M. Mol, Marcel van der Linden, J. Marleen L. de Vree, Paul van der Valk, Ronald P. J. Oude Elferink, Piet Borst, and Rik J. Scheper
Cancer Res 2000 60: 5269-5277. [Abstract] [Full Text] [PDF]  

Increased Expression of Insulin-like Growth Factor I Receptor in Malignant Cells Expressing Aberrant p53: Functional Impact

Leonard Girnita, Ada Girnita, Bertha Brodin, Yuntao Xie, Gunnar Nilsson, Anica Dricu, Joakim Lundeberg, Johan Wejde, Armando Bartolazzi, Klas G. Wiman, and Olle Larsson
Cancer Res 2000 60: 5278-5283. [Abstract] [Full Text] [PDF]  

Pleiotrophin Can Be Rate-limiting for Pancreatic Cancer Cell Growth

Dirk Weber, Hans-Jürgen Klomp, Frank Czubayko, Anton Wellstein, and Hartmut Juhl
Cancer Res 2000 60: 5284-5288. [Abstract] [Full Text] [PDF]  

Mechanism for the Antitumor and Anticachectic Effects of n-3 Fatty Acids

Leonard A. Sauer, Robert T. Dauchy, and David E. Blask
Cancer Res 2000 60: 5289-5295. [Abstract] [Full Text] [PDF]  

PCD1, a Novel Gene Containing PDZ and LIM Domains, Is Overexpressed in Several Human Cancers

Sanmao Kang, Haidong Xu, Xiaozhu Duan, Jing-Jie Liu, Zhijun He, Fang Yu, Siliang Zhou, Xian-Qin Meng, Manqiu Cao, and Giulia C. Kennedy
Cancer Res 2000 60: 5296-5302. [Abstract] [Full Text] [PDF]  

Prevention of Phosphatidylinositol 3'-Kinase-Akt Survival Signaling Pathway during Topotecan-induced Apoptosis

Ayako Nakashio, Naoya Fujita, Susumu Rokudai, Saori Sato, and Takashi Tsuruo
Cancer Res 2000 60: 5303-5309. [Abstract] [Full Text] [PDF]  

Transactivation of the Epidermal Growth Factor Receptor in Endothelin-1-induced Mitogenic Signaling in Human Ovarian Carcinoma Cells

Fabrizio Vacca, Anna Bagnato, Kevin J. Catt, and Raffaele Tecce
Cancer Res 2000 60: 5310-5317. [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.