Advances in Brief:

MYB Oncogene Amplification in Hereditary BRCA1 Breast Cancer

Päivikki Kauraniemi, Ingrid Hedenfalk, Karin Persson, David J. Duggan, Minna Tanner, Oskar Johannsson, Håkan Olsson, Jeffrey M. Trent, Jorma Isola, and Åke Borg
Cancer Res 2000 60: 5323-5328. [Abstract] [Full Text] [PDF]  

BRCA1 Promoter Region Hypermethylation in Ovarian Carcinoma: A Population-based Study

Rae Lynn Baldwin, Elizabeta Nemeth, Hang Tran, Hyun Shvartsman, Ilana Cass, Steven Narod, and Beth Y. Karlan
Cancer Res 2000 60: 5329-5333. [Abstract] [Full Text] [PDF]  

Blockade of Nuclear Factor-B Signaling Inhibits Angiogenesis and Tumorigenicity of Human Ovarian Cancer Cells by Suppressing Expression of Vascular Endothelial Growth Factor and Interleukin 8

Suyun Huang, Jubilee B. Robinson, Ariel DeGuzman, Corazon D. Bucana, and Isaiah J. Fidler
Cancer Res 2000 60: 5334-5339. [Abstract] [Full Text] [PDF]  

Multiple Genes at 17q23 Undergo Amplification and Overexpression in Breast Cancer

Maarit Bärlund, Outi Monni, Juha Kononen, Robert Cornelison, Joachim Torhorst, Guido Sauter, Olli-P. Kallioniemi, and Anne Kallioniemi
Cancer Res 2000 60: 5340-5344. [Abstract] [Full Text] [PDF]  

Suppression of Metastasis by Thymidine Phosphorylase Inhibitor

Sonshin Takao, Shin-ichi Akiyama, Akihiro Nakajo, Hiroyoshi Yoh, Masaki Kitazono, Shoji Natsugoe, Kazutaka Miyadera, Masakazu Fukushima, Yuji Yamada, and Takashi Aikou
Cancer Res 2000 60: 5345-5348. [Abstract] [Full Text] [PDF]  

Paclitaxel Induces Release of Cytochrome c from Mitochondria Isolated from Human Neuroblastoma Cells

Nicolas André, Diane Braguer, Gaël Brasseur, Anthony Gonçalves, Danielle Lemesle-Meunier, Stéphanie Guise, Mary Ann Jordan, and Claudette Briand
Cancer Res 2000 60: 5349-5353. [Abstract] [Full Text] [PDF]  

Bcl-2 Antisense Oligodeoxynucleotide Therapy of Epstein-Barr Virus-associated Lymphoproliferative Disease in Severe Combined Immunodeficient Mice

Mary E. Guinness, Jamie L. Kenney, Michael Reiss, and Jill Lacy
Cancer Res 2000 60: 5354-5358. [Abstract] [Full Text] [PDF]  

Tumor-specific Transgene Expression from the Human Telomerase Reverse Transcriptase Promoter Enables Targeting of the Therapeutic Effects of the Bax Gene to Cancers

Jian Gu, Shunsuke Kagawa, Masahiro Takakura, Satoru Kyo, Masaki Inoue, Jack A. Roth, and Bingliang Fang
Cancer Res 2000 60: 5359-5364. [Abstract] [Full Text] [PDF]  

High Frequency of Chromosome 3p Deletion in Histologically Normal Nasopharyngeal Epithelia from Southern Chinese

Andrew Siu Chung Chan, Ka Fai To, Kwok Wai Lo, Ko Fung Mak, Wai Pak, Brian Chiu, Gary M. K. Tse, Min Ding, Xianghong Li, Joseph Chuen Kwun Lee, and Dolly Poon Huang
Cancer Res 2000 60: 5365-5370. [Abstract] [Full Text] [PDF]  

17q23 Amplifications in Breast Cancer Involve the PAT1, RAD51C, PS6K, and SIGMA1B Genes

Guo-Jun Wu, Colleen S. Sinclair, John Paape, James N. Ingle, Patrick C. Roche, C. David James, and Fergus J. Couch
Cancer Res 2000 60: 5371-5375. [Abstract] [Full Text] [PDF]  

Progesterone Regulates Human Telomerase Reverse Transcriptase Gene Expression via Activation of Mitogen-activated Protein Kinase Signaling Pathway

Zhuo Wang, Satoru Kyo, Masahiro Takakura, Masaaki Tanaka, Noriyuki Yatabe, Yoshiko Maida, Masayoshi Fujiwara, Jun Hayakawa, Masahide Ohmichi, Koji Koike, and Masaki Inoue
Cancer Res 2000 60: 5376-5381. [Abstract] [Full Text] [PDF]  

An Approach to Analysis of Large-Scale Correlations between Genome Changes and Clinical Endpoints in Ovarian Cancer

Seiji Suzuki, Dan H. Moore, II, David G. Ginzinger, Tony E. Godfrey, John Barclay, Bethan Powell, Daniel Pinkel, Charles Zaloudek, Karen Lu, Gordon Mills, Andrew Berchuck, and Joe W. Gray
Cancer Res 2000 60: 5382-5385. [Abstract] [Full Text] [PDF]  

Regulation of Gli Activity by All-trans Retinoic Acid in Mouse Keratinocytes

Philippe Goyette, Deborah Allan, Pascal Peschard, Chang Feng Chen, Wei Wang, and David Lohnes
Cancer Res 2000 60: 5386-5389. [Abstract] [Full Text] [PDF]  

The Phosphatidylinositol 3-Kinase/AKT Signal Transduction Pathway Plays a Critical Role in the Expression of p21^{WAF1/CIP1/SDI1} Induced by Cisplatin and Paclitaxel

Yasuhiro Mitsuuchi, Steven W. Johnson, Muthu Selvakumaran, Stephen J. Williams, Thomas C. Hamilton, and Joseph R. Testa
Cancer Res 2000 60: 5390-5394. [Abstract] [Full Text] [PDF]  

Tamoxifen-induced Enhancement of Calcium Signaling in Glioma and MCF-7 Breast Cancer Cells

Wei Zhang, William T. Couldwell, Hua Song, Takahiro Takano, Jane H. C. Lin, and Maiken Nedergaard
Cancer Res 2000 60: 5395-5400. [Abstract] [Full Text] [PDF]  

The Collection of the Motile Population of Cells from a Living Tumor

Jeffrey B. Wyckoff, Jeffrey E. Segall, and John S. Condeelis
Cancer Res 2000 60: 5401-5404. [Abstract] [Full Text] [PDF]  

Measurement of DNA Copy Number at Microsatellite Loci Using Quantitative PCR Analysis

David G. Ginzinger, Tony E. Godfrey, Janice Nigro, Dan H. Moore, II, Seiji Suzuki, Maria G. Pallavicini, Joe W. Gray, and Ronald H. Jensen
Cancer Res 2000 60: 5405-5409. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Endostatin Inhibits Endothelial and Tumor Cellular Invasion by Blocking the Activation and Catalytic Activity of Matrix Metalloproteinase 2

Young-Mi Kim, Jin-Wook Jang, Ok-Hee Lee, Jungheum Yeon, Eu-Yul Choi, Kyu-Won Kim, Seung-Taek Lee, and Young-Guen Kwon
Cancer Res 2000 60: 5410-5413. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Ovarian Tumors in Rats Induced by Chronic 2,3,7,8-Tetrachlorodibenzo-p- Dioxin Treatment

Barbara J. Davis, Elizabeth A. McCurdy, Brian D. Miller, George W. Lucier, and Angelika M. Tritscher
Cancer Res 2000 60: 5414-5419. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Reconstitution of Endogenous Interferon by Recombinant Interferon in Hairy Cell Leukemia

Medhat Shehata, Josef D. Schwarzmeier, Son Tho Nguyen, Martin Hilgarth, Rudolf Berger, Rainer Hubmann, Sonja Kickmaier, and Thomas Decker
Cancer Res 2000 60: 5420-5426. [Abstract] [Full Text] [PDF]  

Polyadenylate Polymerase Enzymatic Activity in Mammary Tumor Cytosols: A New Independent Prognostic Marker in Primary Breast Cancer

Andreas Scorilas, Maroulio Talieri, Alexandros Ardavanis, Nelly Courtis, Euthymios Dimitriadis, Julia Yotis, Chris Milton Tsiapalis, and Theoni Trangas
Cancer Res 2000 60: 5427-5433. [Abstract] [Full Text] [PDF]  

Epidemiology:

Effects of Dietary Folate on Intestinal Tumorigenesis in the Apc^Min Mouse

Jacquelin Song, Alan Medline, Joel B. Mason, Steven Gallinger, and Young-In Kim
Cancer Res 2000 60: 5434-5440. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Differential Effects of Estrone and Estrone-3-O-Sulfamate Derivatives on Mitotic Arrest, Apoptosis, and Microtubule Assembly in Human Breast Cancer Cells

Lucy MacCarthy-Morrogh, Paul A. Townsend, Atul Purohit, Hatem A. M. Hejaz, Barry V. L. Potter, Michael J. Reed, and Graham Packham
Cancer Res 2000 60: 5441-5450. [Abstract] [Full Text] [PDF]  

Inhibition of Phosphatidylinositide 3-Kinase Enhances Gemcitabine-induced Apoptosis in Human Pancreatic Cancer Cells

Sylvia S. W. Ng, Ming-Sound Tsao, Sue Chow, and David W. Hedley
Cancer Res 2000 60: 5451-5455. [Abstract] [Full Text] [PDF]  

Adenoviral Vectors Targeted to CD40 Enhance the Efficacy of Dendritic Cell-based Vaccination against Human Papillomavirus 16-induced Tumor Cells in a Murine Model

Bryan W. Tillman, Traci L. Hayes, Tanja D. deGruijl, Joanne T. Douglas, and David T. Curiel
Cancer Res 2000 60: 5456-5463. [Abstract] [Full Text] [PDF]  

Effect of O⁶-Benzylguanine on Alkylating Agent-induced Toxicity and Mutagenicity in Chinese Hamster Ovary Cells Expressing Wild-Type and Mutant O⁶-Alkylguanine-DNA Alkyltransferases

Yingna Cai, Michael H. Wu, Meng Xu-Welliver, Anthony E. Pegg, Susan M. Ludeman, and M. Eileen Dolan
Cancer Res 2000 60: 5464-5469. [Abstract] [Full Text] [PDF]  

Comparison of Different Busulfan Analogues for Depletion of Hematopoietic Stem Cells and Promotion of Donor-Type Chimerism in Murine Bone Marrow Transplant Recipients

G. Robbin Westerhof, Rob E. Ploemacher, Adrie Boudewijn, Irene Blokland, Jan H. Dillingh, Alan T. McGown, John A. Hadfield, Martin J. Dawson, and Julian D. Down
Cancer Res 2000 60: 5470-5478. [Abstract] [Full Text] [PDF]  

Activation of Retinoic Acid Receptor Is Sufficient for Full Induction of Retinoid Responses in SK-BR-3 and T47D Human Breast Cancer Cells

Sonja M. Schneider, Martin Offterdinger, Heinz Huber, and Thomas W. Grunt
Cancer Res 2000 60: 5479-5487. [Abstract] [Full Text] [PDF]  

Experimental Cancer Cachexia: The Role of Host-derived Cytokines Interleukin (IL)-6, IL-12, Interferon-, and Tumor Necrosis Factor Evaluated in Gene Knockout, Tumor-bearing Mice on C57 Bl Background and Eicosanoid-dependent Cachexia

Christian Cahlin, A. Körner, H. Axelsson, Wenhua Wang, Kent Lundholm, and Elisabeth Svanberg
Cancer Res 2000 60: 5488-5493. [Abstract] [Full Text] [PDF]  

Down-Regulation of Prostate-specific Antigen Expression by Ligands for Peroxisome Proliferator-activated Receptor in Human Prostate Cancer

Jun-ichi Hisatake, Takeyuki Ikezoe, Michael Carey, Stuart Holden, Shigeru Tomoyasu, and H. Phillip Koeffler
Cancer Res 2000 60: 5494-5498. [Abstract] [Full Text] [PDF]  

Immunology:

Tk, a New Colon Tumor-associated Antigen Resulting from Altered O-Glycosylation

Marc Meichenin, Jezabel Rocher, Oxana Galanina, Nicolai Bovin, Nikolay Nifant’ev, Andrei Sherman, Elisabeth Cassagnau, Marie Francoise Heymann, Jacques Bara, Robin H. Fraser, and Jacques Le Pendu
Cancer Res 2000 60: 5499-5507. [Abstract] [Full Text] [PDF]  

High Steady-State Levels of p53 Are Not a Prerequisite for Tumor Eradication by Wild-Type p53-specific Cytotoxic T Lymphocytes

Michel P. M. Vierboom, Sander Zwaveling, Gerard M. J. Bos, Marlies Ooms, G. Menno Krietemeijer, Cornelis J. M. Melief, and Rienk Offringa
Cancer Res 2000 60: 5508-5513. [Abstract] [Full Text] [PDF]  

Therapeutic Efficacy of OX-40 Receptor Antibody Depends on Tumor Immunogenicity and Anatomic Site of Tumor Growth

Jørgen Kjærgaard, Junta Tanaka, Julian A. Kim, Kevin Rothchild, Andrew Weinberg, and Suyu Shu
Cancer Res 2000 60: 5514-5521. [Abstract] [Full Text] [PDF]  

Prostate Stem Cell Antigen Is a Promising Candidate for Immunotherapy of Advanced Prostate Cancer

Jens Dannull, Pierre-André Diener, Ladislav Prikler, Gregor Fürstenberger, Thomas Cerny, Ulrico Schmid, Daniel K. Ackermann, and Marcus Groettrup
Cancer Res 2000 60: 5522-5528. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

A Putative Oncogenic Role for MPP11 in Head and Neck Squamous Cell Cancer

Vicente A. Resto, Otavia L. Caballero, Martin R. Buta, William H. Westra, Li Wu, Joanne M. Westendorf, Jin Jen, Philip Hieter, and David Sidransky
Cancer Res 2000 60: 5529-5535. [Abstract] [Full Text] [PDF]  

Survey of Genetic Alterations in Gastrinomas

Fang Yu, Robert T. Jensen, Irina A. Lubensky, Eija H. Mahlamaki, Yun-Ling Zheng, Alison M. Herr, and Lance J. Ferrin
Cancer Res 2000 60: 5536-5542. [Abstract] [Full Text] [PDF]  

Defects in Methylthioadenosine Phosphorylase Are Associated with but not Responsible for Methionine-dependent Tumor Cell Growth

Baiqing Tang, Yunan N. Li, and Warren D. Kruger
Cancer Res 2000 60: 5543-5547. [Abstract] [Full Text] [PDF]  

BRCA1 and BRCA2 Are Necessary for the Transcription-Coupled Repair of the Oxidative 8-Oxoguanine Lesion in Human Cells

Florence Le Page, Voahangy Randrianarison, Didier Marot, Jeannine Cabannes, Michel Perricaudet, Jean Feunteun, and Alain Sarasin
Cancer Res 2000 60: 5548-5552. [Abstract] [Full Text] [PDF]  

Screening of the MEN1 Gene and Discovery of Germ-Line and Somatic Mutations in Apparently Sporadic Parathyroid Tumors

Shinya Uchino, Shiro Noguchi, Mari Sato, Hiroto Yamashita, Hiroyuki Yamashita, Shin Watanabe, Tsukasa Murakami, Masakatsu Toda, Akira Ohshima, Tetsuhiro Futata, Tsunenori Mizukoshi, Eisuke Koike, Keisuke Takatsu, Kyoichi Terao, Shigeko Wakiya, Miho Nagatomo, and Mitsuo Adachi
Cancer Res 2000 60: 5553-5557. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Activation of Peroxisome Proliferator-activated Receptor by Troglitazone Inhibits Cell Growth through the Increase of p27^Kip1 in Human Pancreatic Carcinoma Cells

Wataru Motomura, Toshikatsu Okumura, Nobuhiko Takahashi, Takeshi Obara, and Yutaka Kohgo
Cancer Res 2000 60: 5558-5564. [Abstract] [Full Text] [PDF]  

Anti-Vascular Endothelial Growth Factor Treatment Augments Tumor Radiation Response under Normoxic or Hypoxic Conditions

Chang-Geol Lee, Marcus Heijn, Emmanuelle di Tomaso, Genevieve Griffon-Etienne, M. Ancukiewicz, Chieko Koike, K. R. Park, Napoleone Ferrara, Rakesh K. Jain, Herman D. Suit, and Yves Boucher
Cancer Res 2000 60: 5565-5570. [Abstract] [Full Text] [PDF]  

The CaM Kinase, Pnck, Is Spatially and Temporally Regulated during Murine Mammary Gland Development and May Identify an Epithelial Cell Subtype Involved in Breast Cancer

Heather Perry Gardner, Seung I. Ha, Carol Reynolds, and Lewis A. Chodosh
Cancer Res 2000 60: 5571-5577. [Abstract] [Full Text] [PDF]  

Expression of a Novel Factor, com1, Is Regulated by 1,25-Dihydroxyvitamin D₃ in Breast Cancer Cells

Åse Bratland, Karianne Risberg, Gunhild M. Mælandsmo, Kristine Bjerve Gützkow, Øyvind E. Olsen, Amir Moghaddam, Meng-yu Wang, Christina Mørk Hansen, Heidi Kiil Blomhoff, Jens P. Berg, Øystein Fodstad, and Anne Hansen Ree
Cancer Res 2000 60: 5578-5583. [Abstract] [Full Text] [PDF]  

Virology:

Expression of BARF1 Gene Encoded by Epstein-Barr Virus in Nasopharyngeal Carcinoma Biopsies

Gisèle Decaussin, Fatima Sbih-Lammali, Mireille de Turenne-Tessier, Abdelmadjide Bouguermouh, and Tadamasa Ooka
Cancer Res 2000 60: 5584-5588. [Abstract] [Full Text] [PDF]  

Differences in the Immunogenicity of Latent Membrane Protein 1 (LMP1) Encoded by Epstein-Barr Virus Genomes Derived from LMP1-positive and -negative Nasopharyngeal Carcinoma

Lifu Hu, Boris Troyanovsky, Xiangning Zhang, Pankaj Trivedi, Ingemar Ernberg, and George Klein
Cancer Res 2000 60: 5589-5593. [Abstract] [Full Text] [PDF]  

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