Advances in Brief:

Celecoxib Inhibits N-Butyl-N-(4-hydroxybutyl)-nitrosamine-induced Urinary Bladder Cancers in Male B6D2F1 Mice and Female Fischer-344 Rats

Clinton J. Grubbs, Ronald A. Lubet, Alane T. Koki, Kathleen M. Leahy, Jaime L. Masferrer, Vernon E. Steele, Gary J. Kelloff, D. L. Hill, and Karen Seibert
Cancer Res 2000 60: 5599-5602. [Abstract] [Full Text] [PDF]  

Expression and Function of CYR61, an Angiogenic Factor, in Breast Cancer Cell Lines and Tumor Biopsies

Miaw-Sheue Tsai, Ann E. Hornby, Johnathon Lakins, and Ruth Lupu
Cancer Res 2000 60: 5603-5607. [Abstract] [Full Text] [PDF]  

Chromosomal Instability in Unirradiated Cells Induced in Vivo by a Bystander Effect of Ionizing Radiation

Gwyneth E. Watson, Sally A. Lorimore, Denise A. Macdonald, and Eric G. Wright
Cancer Res 2000 60: 5608-5611. [Abstract] [Full Text] [PDF]  

A Variant within the DNA Repair Gene XRCC3 Is Associated with the Development of Melanoma Skin Cancer

Samantha L. Winsey, Neil A. Haldar, Howard P. Marsh, Mike Bunce, Sara E. Marshall, Adrian L. Harris, Fenella Wojnarowska, and Ken I. Welsh
Cancer Res 2000 60: 5612-5616. [Abstract] [Full Text] [PDF]  

Silibinin Up-Regulates Insulin-like Growth Factor-Binding Protein 3 Expression and Inhibits Proliferation of Androgen-independent Prostate Cancer Cells

Xiaolin Zi, Jianchun Zhang, Rajesh Agarwal, and Michael Pollak
Cancer Res 2000 60: 5617-5620. [Abstract] [Full Text] [PDF]  

Association between Survival after Treatment for Breast Cancer and Glutathione S-Transferase P1 Ile¹⁰⁵Val Polymorphism

Carol Sweeney, Gail Y. McClure, Manal Y. Fares, Angie Stone, Brian F. Coles, Patricia A. Thompson, Soheila Korourian, Laura F. Hutchins, Fred F. Kadlubar, and Christine B. Ambrosone
Cancer Res 2000 60: 5621-5624. [Abstract] [Full Text] [PDF]  

Scavenging of Reactive Oxygen Species Leads to Diminished Peritoneal Tumor Recurrence

Marie-Elma E. van Rossen, Wim Sluiter, Fred Bonthuis, Hans Jeekel, Richard L. Marquet, and Casper H. J. van Eijck
Cancer Res 2000 60: 5625-5629. [Abstract] [Full Text] [PDF]  

Hyperinducibility of Hypoxia-responsive Genes without p53/p21-dependent Checkpoint in Aggressive Prostate Cancer

Konstantin Salnikow, Max Costa, William D. Figg, and Mikhail V. Blagosklonny
Cancer Res 2000 60: 5630-5634. [Abstract] [Full Text] [PDF]  

Alcohol Stimulates Estrogen Receptor Signaling in Human Breast Cancer Cell Lines

Saijun Fan, Qinghui Meng, Bin Gao, Jason Grossman, Michael Yadegari, Itzhak D. Goldberg, and Eliot M. Rosen
Cancer Res 2000 60: 5635-5639. [Abstract] [Full Text] [PDF]  

Somatic Mutations of the CD95 Gene in Hodgkin and Reed-Sternberg Cells

Markus Müschen, Daniel Re, Andreas Bräuninger, Jürgen Wolf, Martin-Leo Hansmann, Volker Diehl, Ralf Küppers, and Klaus Rajewsky
Cancer Res 2000 60: 5640-5643. [Abstract] [Full Text] [PDF]  

BCL-6 Mutations Are Associated with Immunoglobulin Variable Heavy Chain Mutations in B-Cell Chronic Lymphocytic Leukemia

Laura Pasqualucci, Antonino Neri, Luca Baldini, Riccardo Dalla-Favera, and Anna Migliazza
Cancer Res 2000 60: 5644-5648. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Melanoma-targeting Properties of ^99mTechnetium-labeled Cyclic -Melanocyte-stimulating Hormone Peptide Analogues

JianQing Chen, Zhen Cheng, Timothy J. Hoffman, Silvia S. Jurisson, and Thomas P. Quinn
Cancer Res 2000 60: 5649-5658. [Abstract] [Full Text] [PDF]  

Down-Regulation of X-linked Inhibitor of Apoptosis Protein Induces Apoptosis in Chemoresistant Human Ovarian Cancer Cells

Hiromasa Sasaki, YingLun Sheng, Fumikazu Kotsuji, and Benjamin K. Tsang
Cancer Res 2000 60: 5659-5666. [Abstract] [Full Text] [PDF]  

Histone H1 and H3 Dephosphorylation Are Differentially Regulated by Radiation-induced Signal Transduction Pathways

Chang Y. Guo, Craig Mizzen, Yu Wang, and James M. Larner
Cancer Res 2000 60: 5667-5672. [Abstract] [Full Text] [PDF]  

Interferon- Treatment Elevates Caspase-8 Expression and Sensitizes Human Breast Tumor Cells to a Death Receptor-induced Mitochondria-operated Apoptotic Program

Carmen Ruiz-Ruiz, Cristina Muñoz-Pinedo, and Abelardo López-Rivas
Cancer Res 2000 60: 5673-5680. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

The Relationship between Benzo[a]pyrene-induced Mutagenesis and Carcinogenesis in Repair-deficient Cockayne Syndrome Group B Mice

Susan W. P. Wijnhoven, Hanneke J. M. Kool, Conny T. M. van Oostrom, Rudolf B. Beems, Leon H. F. Mullenders, Albert A. van Zeeland, Gijsbertus T. J. van der Horst, Harry Vrieling, and Harry van Steeg
Cancer Res 2000 60: 5681-5687. [Abstract] [Full Text] [PDF]  

Both (±)syn- and (±)anti-7,12-Dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides Initiate Tumors in Mouse Skin That Possess -CAA- to -CTA- Mutations at Codon 61 of c-H-ras

Moon-shong Tang, Suryanarayana V. Vulimiri, Aurora Viaje, James X. Chen, Deepa S. Bilolikar, Rebecca J. Morris, Ronald G. Harvey, Tom J. Slaga, and John DiGiovanni
Cancer Res 2000 60: 5688-5695. [Abstract] [Full Text] [PDF]  

Inhibition of Ornithine Decarboxylase (ODC) Decreases Tumor Vascularization and Reverses Spontaneous Tumors in ODC/Ras Transgenic Mice

Li Lan, Carol Trempus, and Susan K. Gilmour
Cancer Res 2000 60: 5696-5703. [Abstract] [Full Text] [PDF]  

Endocrinology:

Estrogenic and Antiproliferative Properties of Glabridin from Licorice in Human Breast Cancer Cells

Snait Tamir, Mark Eizenberg, Dalia Somjen, Naftali Stern, Rayah Shelach, Alvin Kaye, and Jacob Vaya
Cancer Res 2000 60: 5704-5709. [Abstract] [Full Text] [PDF]  

Epidemiology:

Increased Risk of Prostate Cancer and Benign Prostatic Hyperplasia Associated with a CYP17 Gene Polymorphism with a Gene Dosage Effect

Tomonori Habuchi, Zhang Liqing, Takehiro Suzuki, Ryusei Sasaki, Norihiko Tsuchiya, Hiroshi Tachiki, Naotake Shimoda, Shigeru Satoh, Kazunari Sato, Yoshiyuki Kakehi, Toshiyuki Kamoto, Osamu Ogawa, and Tetsuro Kato
Cancer Res 2000 60: 5710-5713. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Role of the Immune Response during Neuro-attenuated Herpes Simplex Virus-mediated Tumor Destruction in a Murine Intracranial Melanoma Model

Cathie G. Miller and Nigel W. Fraser
Cancer Res 2000 60: 5714-5722. [Abstract] [Full Text] [PDF]  

Treatment of Colorectal Liver Metastases by Adenoviral Transfer of Tissue Inhibitor of Metalloproteinases-2 into the Liver Tissue

Karsten Brand, Andrew H. Baker, Alejandra Perez-Cantó, Alexandra Possling, Michael Sacharjat, Martina Geheeb, and Wolfgang Arnold
Cancer Res 2000 60: 5723-5730. [Abstract] [Full Text] [PDF]  

The Human Leukemic T-Cell Line, TALL-104, Is Cytotoxic to Human Malignant Brain Tumors and Traffics through Brain Tissue: Implications for Local Adoptive Immunotherapy

Carol A. Kruse, Sophie Visonneau, Bette K. Kleinschmidt-DeMasters, Carol J. Gup, German G. Gomez, David B. Paul, and Daniela Santoli
Cancer Res 2000 60: 5731-5739. [Abstract] [Full Text] [PDF]  

CM101 Treatment Overrides Tumor-induced Immunoprivilege Leading to Apoptosis

F. Michael Yakes, Barbara D. Wamil, Fenglei Sun, He-Ping Yan, Clint E. Carter, and Carl G. Hellerqvist
Cancer Res 2000 60: 5740-5746. [Abstract] [Full Text] [PDF]  

Changes in Subcellular Distribution of Topoisomerase II Correlate with Etoposide Resistance in Multicell Spheroids and Xenograft Tumors

Arusha Oloumi, Susan H. MacPhail, Peter J. Johnston, Judit P. Banáth, and Peggy L. Olive
Cancer Res 2000 60: 5747-5753. [Abstract] [Full Text] [PDF]  

Apo2 Ligand/TNF-related Apoptosis-inducing Ligand and Death Receptor 5 Mediate the Apoptotic Signaling Induced by Ionizing Radiation in Leukemic Cells

Bendi Gong and Alex Almasan
Cancer Res 2000 60: 5754-5760. [Abstract] [Full Text] [PDF]  

Extensive Contribution of the Multidrug Transporters P-Glycoprotein and Mrp1 to Basal Drug Resistance

John D. Allen, Remco F. Brinkhuis, Liesbeth van Deemter, Jan Wijnholds, and Alfred H. Schinkel
Cancer Res 2000 60: 5761-5766. [Abstract] [Full Text] [PDF]  

Selective Inhibition of Cyclooxygenase-2 Suppresses Growth and Induces Apoptosis in Human Esophageal Adenocarcinoma Cells

Rhonda F. Souza, Kenneth Shewmake, David G. Beer, Byron Cryer, and Stuart Jon Spechler
Cancer Res 2000 60: 5767-5772. [Abstract] [Full Text] [PDF]  

Selective Radiosensitization of Drug-resistant MutS Homologue-2 (MSH2) Mismatch Repair-deficient Cells by Halogenated Thymidine (dThd) Analogues: Msh2 Mediates dThd Analogue DNA Levels and the Differential Cytotoxicity and Cell Cycle Effects of the dThd Analogues and 6-Thioguanine

Suzanne E. Berry, Thomas W. Davis, Jane E. Schupp, Hwa-Shin Hwang, Niels de Wind, and Timothy J. Kinsella
Cancer Res 2000 60: 5773-5780. [Abstract] [Full Text] [PDF]  

Activation of Lytic Epstein-Barr Virus (EBV) Infection by Radiation and Sodium Butyrate in Vitro and in Vivo: A Potential Method for Treating EBV-positive Malignancies

Eva M. Westphal, William Blackstock, Wenhai Feng, Bruce Israel, and Shannon C. Kenney
Cancer Res 2000 60: 5781-5788. [Abstract] [Full Text] [PDF]  

Immunology:

Loss of Interferon- Inducibility of TAP1 and LMP2 in a Renal Cell Carcinoma Cell Line

Susan E. Dovhey, Nilanjan S. Ghosh, and Kenneth L. Wright
Cancer Res 2000 60: 5789-5796. [Abstract] [Full Text] [PDF]  

Pretransplant Tumor Antigen-specific Immunization of Allogeneic Bone Marrow Transplant Donors Enhances Graft-versus-Tumor Activity without Exacerbation of Graft-versus-Host Disease

Larry D. Anderson, Jr., Shahram Mori, Savita Mann, Cherylyn A. Savary, and Craig A. Mullen
Cancer Res 2000 60: 5797-5802. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Hormone-dependent Tumor Regression in Vivo by an Inducible Transcriptional Repressor Directed at the PAX3-FKHR Oncogene

Kasirajan Ayyanathan, William J. Fredericks, Carola Berking, Meenhard Herlyn, Christopher Balakrishnan, Edward Gunther, and Frank J. Rauscher, III
Cancer Res 2000 60: 5803-5814. [Abstract] [Full Text] [PDF]  

Apoptosis Induced by DNA Damage O -Methylguanine Is Bcl-2 and Caspase-9/3 Regulated and Fas/Caspase-8 Independent

Kirsten Ochs and Bernd Kaina
Cancer Res 2000 60: 5815-5824. [Abstract] [Full Text] [PDF]  

Ligand-independent Activation of the Androgen Receptor by the Differentiation Agent Butyrate in Human Prostate Cancer Cells

Marianne D. Sadar and Martin E. Gleave
Cancer Res 2000 60: 5825-5831. [Abstract] [Full Text] [PDF]  

Tumor Biology:

RhoC GTPase, a Novel Transforming Oncogene for Human Mammary Epithelial Cells That Partially Recapitulates the Inflammatory Breast Cancer Phenotype

Kenneth L. van Golen, Zhi-Fen Wu, Xiao Tan Qiao, Li Wei Bao, and Sofia D. Merajver
Cancer Res 2000 60: 5832-5838. [Abstract] [Full Text] [PDF]  

Tumor Development Is Retarded in Mice Lacking the Gene for Urokinase-Type Plasminogen Activator or Its Inhibitor, Plasminogen Activator Inhibitor-1

Linda S. Gutierrez, Alexis Schulman, Teresa Brito-Robinson, Francisco Noria, Victoria A. Ploplis, and Francis J. Castellino
Cancer Res 2000 60: 5839-5847. [Abstract] [Full Text] [PDF]  

A New M_r 55,000 Surface Protein Implicated in Melanoma Progression: Association with a Metastatic Phenotype

Habib Boukerche, Patrick Baril, Eric Tabone, Frédéric Bérard, Kamel Sanhadji, Brigitte Balme, François Wolf, Henri Perrot, and Luc Thomas
Cancer Res 2000 60: 5848-5856. [Abstract] [Full Text] [PDF]  

Reduced Infiltration of Tumor-associated Macrophages in Human Prostate Cancer: Association with Cancer Progression

Satoru Shimura, Guang Yang, Shin Ebara, Thomas M. Wheeler, Anna Frolov, and Timothy C. Thompson
Cancer Res 2000 60: 5857-5861. [Abstract] [Full Text] [PDF]  

B16 Melanoma Cell Arrest in the Mouse Liver Induces Nitric Oxide Release and Sinusoidal Cytotoxicity: A Natural Hepatic Defense against Metastasis

Hui Helen Wang, Alan R. McIntosh, Brian B. Hasinoff, Edward S. Rector, Naeem Ahmed, Dwight M. Nance, and F. William Orr
Cancer Res 2000 60: 5862-5869. [Abstract] [Full Text] [PDF]  

Caveolin-1 Levels Are Down-Regulated in Human Colon Tumors, and Ectopic Expression of Caveolin-1 in Colon Carcinoma Cell Lines Reduces Cell Tumorigenicity

Florent C. Bender, Marc A. Reymond, Claude Bron, and Andrew F. G. Quest
Cancer Res 2000 60: 5870-5878. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor Transcriptionally Up-Regulates Vascular Endothelial Growth Factor Expression in Human Glioblastoma Cells via a Pathway Involving Phosphatidylinositol 3'-Kinase and Distinct from That Induced by Hypoxia

Amit Maity, Nabendu Pore, Jerry Lee, Don Solomon, and Donald M. O’Rourke
Cancer Res 2000 60: 5879-5886. [Abstract] [Full Text] [PDF]  

Inhibition of HER2/neu (erbB-2) and Mitogen-activated Protein Kinases Enhances Tamoxifen Action against HER2-overexpressing, Tamoxifen-resistant Breast Cancer Cells

Hirokazu Kurokawa, Anne E. G. Lenferink, Jean F. Simpson, Paul I. Pisacane, Mark X. Sliwkowski, James T. Forbes, and Carlos L. Arteaga
Cancer Res 2000 60: 5887-5894. [Abstract] [Full Text] [PDF]  

A Modified p53 Overcomes mdm2-mediated Oncogenic Transformation: A Potential Cancer Therapeutic Agent

Jiayuh Lin, Xiaohong Jin, Carmen Page, Vernon K. Sondak, Guihua Jiang, and R. Kevin Reynolds
Cancer Res 2000 60: 5895-5901. [Abstract] [Full Text] [PDF]  

Antiserum Raised against an Epitope of the Cholecystokinin B/Gastrin Receptor Inhibits Hepatic Invasion of a Human Colon Tumor

Susan A. Watson, Philip A. Clarke, Teresa M. Morris, and Martyn E. Caplin
Cancer Res 2000 60: 5902-5907. [Abstract] [Full Text] [PDF]  

Correction:

F. Hayes et al., Cancer Res: 60: 2411–2418, 2000

Cancer Res 2000 60: 5908-5910. [Full Text] [PDF]  

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