Advances in Brief:

NAD(P)H:Quinone Oxidoreductase 1 Deficiency Increases Susceptibility to Benzo(a)pyrene-induced Mouse Skin Carcinogenesis

Delwin J. Long, II, Rebekah L. Waikel, Xiao-Jing Wang, Laszlo Perlaky, Dennis R. Roop, and Anil K. Jaiswal
Cancer Res 2000 60: 5913-5915. [Abstract] [Full Text] [PDF]  

Human Papillomavirus Type 16 Integrations in Cervical Tumors Frequently Occur in Common Fragile Sites

Erik C. Thorland, Shannon L. Myers, David H. Persing, Gobinda Sarkar, Renee M. McGovern, Bobbie S. Gostout, and David I. Smith
Cancer Res 2000 60: 5916-5921. [Abstract] [Full Text] [PDF]  

Identification of c-Myc Responsive Genes Using Rat cDNA Microarray

Qingbin M. Guo, Renae L. Malek, Sunkyu Kim, Chia Chiao, Mei He, Mauro Ruffy, Krishna Sanka, Norman H. Lee, Chi V. Dang, and Edison T. Liu
Cancer Res 2000 60: 5922-5928. [Abstract] [Full Text] [PDF]  

Id Proteins Are Dynamically Expressed in Normal Epidermis and Dysregulated in Squamous Cell Carcinoma

Kenneth Langlands, Gareth A. Down, and Terence Kealey
Cancer Res 2000 60: 5929-5933. [Abstract] [Full Text] [PDF]  

Threonine 68 Phosphorylation by Ataxia Telangiectasia Mutated Is Required for Efficient Activation of Chk2 in Response to Ionizing Radiation

Joon-Young Ahn, Julie K. Schwarz, Helen Piwnica-Worms, and Christine E. Canman
Cancer Res 2000 60: 5934-5936. [Abstract] [Full Text] [PDF]  

Chloroquinoxaline Sulfonamide (NSC 339004) Is a Topoisomerase II/ß Poison

Hanlin Gao, Edith F. Yamasaki, Kenneth K. Chan, Linus L. Shen, and Robert M. Snapka
Cancer Res 2000 60: 5937-5940. [Abstract] [Full Text] [PDF]  

Fluorescent Methylation-specific Polymerase Chain Reaction for DNA-based Detection of Prostate Cancer in Bodily Fluids

Carsten Goessl, Hans Krause, Markus Müller, Rüdiger Heicappell, Mark Schrader, Jana Sachsinger, and Kurt Miller
Cancer Res 2000 60: 5941-5945. [Abstract] [Full Text] [PDF]  

Breast Cancer Susceptibility Gene 1 (BRCA1) Is a Coactivator of the Androgen Receptor

John J. Park, Ryan A. Irvine, Grant Buchanan, Stephen S. Koh, Jinha M. Park, Wayne D. Tilley, Michael R. Stallcup, Michael F. Press, and Gerhard A. Coetzee
Cancer Res 2000 60: 5946-5949. [Abstract] [Full Text] [PDF]  

Induction of bcl-x_L Expression in Mammary Epithelial Cells Is Glucocorticoid-dependent but not Signal Transducer and Activator of Transcription 5-dependent

Kristel Schorr and Priscilla A. Furth
Cancer Res 2000 60: 5950-5953. [Abstract] [Full Text] [PDF]  

Predicting Lung Cancer by Detecting Aberrant Promoter Methylation in Sputum

William A. Palmisano, Kevin K. Divine, Geno Saccomanno, Frank D. Gilliland, Stephen B. Baylin, James G. Herman, and Steven A. Belinsky
Cancer Res 2000 60: 5954-5958. [Abstract] [Full Text] [PDF]  

Mitomycin C Resistance Induced by TCF-3 Overexpression in Gastric Cancer Cell Line MKN28 Is Associated with DT-diaphorase Down-Regulation

Norihiko Sagara and Masaru Katoh
Cancer Res 2000 60: 5959-5962. [Abstract] [Full Text] [PDF]  

Somatic von Hippel-Lindau Gene Mutations Detected in Sporadic Endolymphatic Sac Tumors

Alexander O. Vortmeyer, Steve C. Huang, Christian A. Koch, Lance Governale, Rob D. Dickerman, Paul E. McKeever, Edward H. Oldfield, and Zhengping Zhuang
Cancer Res 2000 60: 5963-5965. [Abstract] [Full Text] [PDF]  

Schwann Cell-conditioned Medium Inhibits Angiogenesis

Donghui Huang, J. Lynn Rutkowski, Garrett M. Brodeur, Pauline M. Chou, Janet L. Kwiatkowski, Angela Babbo, and Susan L. Cohn
Cancer Res 2000 60: 5966-5971. [Abstract] [Full Text] [PDF]  

E2F-1 Gene Transfer Enhances Invasiveness of Human Head and Neck Carcinoma Cell Lines

Shi Yu Zhang, Shao Chen Liu, David G. Johnson, and Andres J. P. Klein-Szanto
Cancer Res 2000 60: 5972-5976. [Abstract] [Full Text] [PDF]  

Effects of Estrogen on Global Gene Expression: Identification of Novel Targets of Estrogen Action

April H. Charpentier, Andrzej K. Bednarek, Rachael L. Daniel, Kathleen A. Hawkins, Kendra J. Laflin, Sara Gaddis, Michael C. MacLeod, and C. Marcelo Aldaz
Cancer Res 2000 60: 5977-5983. [Abstract] [Full Text] [PDF]  

Up-Regulation of Clusterin during Phthalocyanine 4 Photodynamic Therapy-mediated Apoptosis of Tumor Cells and Ablation of Mouse Skin Tumors

Katrin Kalka, Nihal Ahmad, Tracy Criswell, David Boothman, and Hasan Mukhtar
Cancer Res 2000 60: 5984-5987. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Inhibition of BAD Phosphorylation Either at Serine 112 via Extracellular Signal-regulated Protein Kinase Cascade or at Serine 136 via Akt Cascade Sensitizes Human Ovarian Cancer Cells to Cisplatin

Jun Hayakawa, Masahide Ohmichi, Hirohisa Kurachi, Yuki Kanda, Koji Hisamoto, Yukihiro Nishio, Kazushige Adachi, Keiichi Tasaka, Toru Kanzaki, and Yuji Murata
Cancer Res 2000 60: 5988-5994. [Abstract] [Full Text] [PDF]  

Activation of Caspase-3 and c-Jun NH₂-terminal Kinase-1 Signaling Pathways in Tamoxifen-induced Apoptosis of Human Breast Cancer Cells

Sandhya Mandlekar, Rong Yu, Tse-Hua Tan, and Ah-Ng Tony Kong
Cancer Res 2000 60: 5995-6000. [Abstract] [Full Text] [PDF]  

Bisphosphonates Directly Regulate Cell Proliferation, Differentiation, and Gene Expression in Human Osteoblasts

Gregory G. Reinholz, Barbara Getz, Larry Pederson, Emily S. Sanders, Malayannan Subramaniam, James N. Ingle, and Thomas C. Spelsberg
Cancer Res 2000 60: 6001-6007. [Abstract] [Full Text] [PDF]  

Carcinogeniesis:

Sex Hormone-induced Carcinogenesis in Rb-deficient Prostate Tissue

Yuzhuo Wang, Simon W. Hayward, Anne A. Donjacour, Peter Young, Tyler Jacks, Julien Sage, Rajvir Dahiya, Robert D. Cardiff, Mark L. Day, and Gerald R. Cunha
Cancer Res 2000 60: 6008-6017. [Abstract] [Full Text] [PDF]  

Connexin43 Suppresses MFG-E8 While Inducing Contact Growth Inhibition of Glioma Cells

Gary S. Goldberg, John F. Bechberger, Youichi Tajima, Mary Merritt, Yasufumi Omori, Mary Ann Gawinowicz, Ramaswamy Narayanan, Yi Tan, Yutaka Sanai, Hiroshi Yamasaki, Christian C. G. Naus, Hiroyuki Tsuda, and Bruce J. Nicholson
Cancer Res 2000 60: 6018-6026. [Abstract] [Full Text] [PDF]  

Epidemiology:

A Prospective Study Showing Long-Term Infection with Human Papillomavirus 16 before the Development of Cervical Carcinoma in Situ

Nathalie Ylitalo, Agnetha Josefsson, Mads Melbye, Per Sörensen, Morten Frisch, Per Kragh Andersen, Pär Sparén, Margit Gustafsson, Patrik Magnusson, Jan Pontén, Ulf Gyllensten, and Hans-Olov Adami
Cancer Res 2000 60: 6027-6032. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Induction of Adipocyte-specific Gene Expression Is Correlated with Mammary Tumor Regression by the Retinoid X Receptor-Ligand LGD1069 (Targretin)

Veena R. Agarwal, Eric D. Bischoff, Thomas Hermann, and William W. Lamph
Cancer Res 2000 60: 6033-6038. [Abstract] [Full Text] [PDF]  

Reversal of Drug Resistance in Human Tumor Xenografts by 2'-Deoxy-5-azacytidine-induced Demethylation of the hMLH1 Gene Promoter

Jane A. Plumb, Gordon Strathdee, Julieann Sludden, Stanley B. Kaye, and Robert Brown
Cancer Res 2000 60: 6039-6044. [Abstract] [Full Text] [PDF]  

Celecoxib Prevents Tumor Growth in Vivo without Toxicity to Normal Gut: Lack of Correlation between in Vitro and in Vivo Models

Christopher S. Williams, Alastair J. M. Watson, Hongmiao Sheng, Rania Helou, Jinyi Shao, and Raymond N. DuBois
Cancer Res 2000 60: 6045-6051. [Abstract] [Full Text] [PDF]  

Bcl-xL in Prostate Cancer Cells: Effects of Overexpression and Down-Regulation on Chemosensitivity

Irina Lebedeva, Robert Rando, Joshua Ojwang, Paul Cossum, and C. A. Stein
Cancer Res 2000 60: 6052-6060. [Abstract] [Full Text] [PDF]  

Tumor Cell-selective Cytotoxicity of Matrix Metalloproteinase-activated Anthrax Toxin

Shihui Liu, Sarah Netzel-Arnett, Henning Birkedal-Hansen, and Stephen H. Leppla
Cancer Res 2000 60: 6061-6067. [Abstract] [Full Text] [PDF]  

Apicidin, a Histone Deacetylase Inhibitor, Inhibits Proliferation of Tumor Cells via Induction of p21^WAF1/Cip1 and Gelsolin

Jeung-Whan Han, Seong Hoon Ahn, Seung Hee Park, So Young Wang, Gyu-Un Bae, Dong-Wan Seo, Hyoung-Keun Kwon, Sungyoul Hong, Hoi Young Lee, Yin-Won Lee, and Hyang-Woo Lee
Cancer Res 2000 60: 6068-6074. [Abstract] [Full Text] [PDF]  

Equilibrative-Sensitive Nucleoside Transporter and Its Role in Gemcitabine Sensitivity

David R. Rauchwerger, Patricia S. Firby, David W. Hedley, and Malcolm J. Moore
Cancer Res 2000 60: 6075-6079. [Abstract] [Full Text] [PDF]  

The Role of Cell Cycle Progression in Radiosensitization by 2',2'-Difluoro-2'-deoxycytidine

Leo J. Ostruszka and Donna S. Shewach
Cancer Res 2000 60: 6080-6088. [Abstract] [Full Text] [PDF]  

Targeted Therapy of Experimental Renal Cell Carcinoma with a Novel Conjugate of Monoclonal Antibody 138H11 and Calicheamicin ^I₁

Katrin Knoll, Wolfgang Wrasidlo, Jürgen E. Scherberich, Gerhard Gaedicke, and Peter Fischer
Cancer Res 2000 60: 6089-6094. [Abstract] [Full Text] [PDF]  

Immunology:

An -Particle Emitting Antibody ([²¹³Bi]J591) for Radioimmunotherapy of Prostate Cancer

Michael R. McDevitt, Els Barendswaard, Dangshe Ma, Lawrence Lai, Michael J. Curcio, George Sgouros, Åse M. Ballangrud, Wei-Hong Yang, Ronald D. Finn, Virginia Pellegrini, Maurits W. Geerlings, Jr., Mona Lee, Martin W. Brechbiel, Neil H. Bander, Carlos Cordon-Cardo, and David A. Scheinberg
Cancer Res 2000 60: 6095-6100. [Abstract] [Full Text] [PDF]  

Molecular Biology & Genetics:

An Informatics Approach Identifying Markers of Chemosensitivity in Human Cancer Cell Lines

Sally A. Amundson, Timothy G. Myers, Dominic Scudiero, Shinichi Kitada, John C. Reed, and Albert J. Fornace, Jr.
Cancer Res 2000 60: 6101-6110. [Abstract] [Full Text] [PDF]  

Loss of NKX3.1 Expression in Human Prostate Cancers Correlates with Tumor Progression^1,2

Cai Bowen, Lukas Bubendorf, H. James Voeller, Rebecca Slack, Niels Willi, Guido Sauter, Thomas C. Gasser, Pasi Koivisto, Ernest E. Lack, Juha Kononen, Olli-P. Kallioniemi, and Edward P. Gelmann
Cancer Res 2000 60: 6111-6115. [Abstract] [Full Text] [PDF]  

The 630-kb Lung Cancer Homozygous Deletion Region on Human Chromosome 3p21.3: Identification and Evaluation of the Resident Candidate Tumor Suppressor Genes

Michael I. Lerman and John D. Minna
Cancer Res 2000 60: 6116-6133. [Abstract] [Full Text] [PDF]  

Dysregulated Expression of Androgen-responsive and Nonresponsive Genes in the Androgen-independent Prostate Cancer Xenograft Model CWR22-R

Lukas C. Amler, David B. Agus, Carrie LeDuc, M. Lisa Sapinoso, William D. Fox, Suzanne Kern, Dori Lee, Vivian Wang, Maurice Leysens, Brian Higgins, Jason Martin, William Gerald, Nicholas Dracopoli, Carlos Cordon-Cardo, Howard I. Scher, and Garret M. Hampton
Cancer Res 2000 60: 6134-6141. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Tumor Endothelium-specific Transgene Expression Directed by Vascular Endothelial Growth Factor Receptor-2 (Flk-1) Promoter/Enhancer Sequences^1,2

Regina Heidenreich, Andreas Kappel, and Georg Breier
Cancer Res 2000 60: 6142-6147. [Abstract] [Full Text] [PDF]  

Activation of Hepatocyte Growth Factor/Scatter Factor in Colorectal Carcinoma

Hiroaki Kataoka, Ryouichi Hamasuna, Hiroshi Itoh, Naomi Kitamura, and Masashi Koono
Cancer Res 2000 60: 6148-6159. [Abstract] [Full Text] [PDF]  

Induction of Cell Death by Basic Fibroblast Growth Factor in Ewing’s Sarcoma

Lisa-Marie Sturla, Georgina Westwood, Peter J. Selby, Ian J. Lewis, and Susan A. Burchill
Cancer Res 2000 60: 6160-6170. [Abstract] [Full Text] [PDF]  

BRG1, a Component of the SWI-SNF Complex, Is Mutated in Multiple Human Tumor Cell Lines

Alexander K. C. Wong, Frances Shanahan, Yuan Chen, Lubing Lian, Phuong Ha, Kristin Hendricks, Siavash Ghaffari, Diana Iliev, Brandon Penn, Anne-Marie Woodland, Richard Smith, Grant Salada, Arlene Carillo, Kirsten Laity, Jamila Gupte, Brad Swedlund, Sean V. Tavtigian, David H-F. Teng, and Emma Lees
Cancer Res 2000 60: 6171-6177. [Abstract] [Full Text] [PDF]  

Tumor Induction by the c-Myc Target Genes rcl and Lactate Dehydrogenase A

Brian C. Lewis, Julia E. Prescott, Susan E. Campbell, Hyunsuk Shim, Robert Z. Orlowski, and Chi V. Dang
Cancer Res 2000 60: 6178-6183. [Abstract] [Full Text] [PDF]  

UV but not Irradiation Accelerates p53-induced Apoptosis of Teratocarcinoma Cells by Repressing MDM2 Transcription

Xiaoya Zeng, David Keller, Lin Wu, and Hua Lu
Cancer Res 2000 60: 6184-6188. [Abstract] [Full Text] [PDF]  

Coordinate Up-Regulation of Hypoxia Inducible Factor (HIF)-1 and HIF-1 Target Genes during Multi-Stage Epidermal Carcinogenesis and Wound Healing

David A. Elson, Heather E. Ryan, Jonathan W. Snow, Randall Johnson, and Jeffrey M. Arbeit
Cancer Res 2000 60: 6189-6195. [Abstract] [Full Text] [PDF]  

Unfractionated and Low Molecular Weight Heparin Affect Fibrin Structure and Angiogenesis in Vitro

Annemie Collen, Susanne M. Smorenburg, Erna Peters, Florea Lupu, Pieter Koolwijk, Cornelis Van Noorden, and Victor W. M. van Hinsbergh
Cancer Res 2000 60: 6196-6200. [Abstract] [Full Text] [PDF]  

Remarkable Tolerance of Tumor Cells to Nutrient Deprivation: Possible New Biochemical Target for Cancer Therapy

Kunihiko Izuishi, Kazuyoshi Kato, Tsutomu Ogura, Taira Kinoshita, and Hiroyasu Esumi
Cancer Res 2000 60: 6201-6207. [Abstract] [Full Text] [PDF]  

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