Advances in Brief:

Duplication of the Mutant RET Allele in Trisomy 10 or Loss of the Wild-Type Allele in Multiple Endocrine Neoplasia Type 2-associated Pheochromocytomas

Steve C. Huang, Christian A. Koch, Alexander O. Vortmeyer, Svetlana D. Pack, Urs D. Lichtenauer, Poonam Mannan, Irina A. Lubensky, George P. Chrousos, Robert F. Gagel, Karel Pacak, and Zhengping Zhuang
Cancer Res 2000 60: 6223-6226. [Abstract] [Full Text] [PDF]  

t(9;11)(p22;p15) in Acute Myeloid Leukemia Results in a Fusion between NUP98 and the Gene Encoding Transcriptional Coactivators p52 and p75-Lens Epithelium-derived Growth Factor (LEDGF)

Harish G. Ahuja, Jianming Hong, Peter D. Aplan, Lucene Tcheurekdjian, Stephen J. Forman, and Marilyn L. Slovak
Cancer Res 2000 60: 6227-6229. [Abstract] [Full Text] [PDF]  

Frequent Amplification of the Telomerase Reverse Transcriptase Gene in Human Tumors

Anju Zhang, Chengyun Zheng, Charlotta Lindvall, Mi Hou, Jessica Ekedahl, Rolf Lewensohn, Zhongqun Yan, Xiaoyan Yang, Marie Henriksson, Elisabeth Blennow, Magnus Nordenskjöld, Anders Zetterberg, Magnus Björkholm, Astrid Gruber, and Dawei Xu
Cancer Res 2000 60: 6230-6235. [Abstract] [Full Text] [PDF]  

TMS1, a Novel Proapoptotic Caspase Recruitment Domain Protein, Is a Target of Methylation-induced Gene Silencing in Human Breast Cancers

Kerry E. Conway, Beth B. McConnell, Claire E. Bowring, Carlton D. Donald, Stephen T. Warren, and Paula M. Vertino
Cancer Res 2000 60: 6236-6242. [Abstract] [Full Text] [PDF]  

Activation of a Caspase-9-mediated Apoptotic Pathway by Subcellular Redistribution of the Novel Caspase Recruitment Domain Protein TMS1

Beth B. McConnell and Paula M. Vertino
Cancer Res 2000 60: 6243-6247. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor (VEGF) Modulation by Targeting Hypoxia-inducible Factor-1 Hypoxia Response Element VEGF Cascade Differentially Regulates Vascular Response and Growth Rate in Tumors

Yoshikazu Tsuzuki, Dai Fukumura, Bert Oosthuyse, Chieko Koike, Peter Carmeliet, and Rakesh K. Jain
Cancer Res 2000 60: 6248-6252. [Abstract] [Full Text] [PDF]  

Complete Inhibition of Rhabdomyosarcoma Xenograft Growth and Neovascularization Requires Blockade of Both Tumor and Host Vascular Endothelial Growth Factor

Hans-Peter Gerber, Joe Kowalski, Daniel Sherman, David A. Eberhard, and Napoleone Ferrara
Cancer Res 2000 60: 6253-6258. [Abstract] [Full Text] [PDF]  

The Caspase 9 Inhibitor Z-LEHD-FMK Protects Human Liver Cells while Permitting Death of Cancer Cells Exposed to Tumor Necrosis Factor-related Apoptosis-inducing Ligand

Nesrin Özören, Kunhong Kim, Timothy F. Burns, David T. Dicker, A. David Moscioni, and Wafik S. El-Deiry
Cancer Res 2000 60: 6259-6265. [Abstract] [Full Text] [PDF]  

Altered Expression of Estrogen Receptor Coregulators during Human Breast Tumorigenesis

Leigh C. Murphy, Sharon L. R. Simon, Alicia Parkes, Etienne Leygue, Helmut Dotzlaw, Linda Snell, Sandra Troup, Adewale Adeyinka, and Peter H. Watson
Cancer Res 2000 60: 6266-6271. [Abstract] [Full Text] [PDF]  

A MAGE-A3 Peptide Presented by HLA-DP4 Is Recognized on Tumor Cells by CD4⁺ Cytolytic T Lymphocytes

Erwin S. Schultz, Bernard Lethé, César L. Cambiaso, Jacques Van Snick, Pascal Chaux, Jurgen Corthals, Carlo Heirman, Kris Thielemans, Thierry Boon, and Pierre van der Bruggen
Cancer Res 2000 60: 6272-6275. [Abstract] [Full Text] [PDF]  

Activation of the Transcription Factor Oct-1 in Response to DNA Damage

Hongcheng Zhao, Shunqian Jin, Feiyue Fan, Wenhong Fan, Tong Tong, and Qimin Zhan
Cancer Res 2000 60: 6276-6280. [Abstract] [Full Text] [PDF]  

Large-Scale Serial Analysis of Gene Expression Reveals Genes Differentially Expressed in Ovarian Cancer

Colleen D. Hough, Cheryl A. Sherman-Baust, Ellen S. Pizer, F. J. Montz, Dwight D. Im, Neil B. Rosenshein, Kathleen R. Cho, Gregory J. Riggins, and Patrice J. Morin
Cancer Res 2000 60: 6281-6287. [Abstract] [Full Text] [PDF]  

Frequent Association of ß-Catenin and WT1 Mutations in Wilms Tumors

Sourindra Maiti, Rita Alam, Christopher I. Amos, and Vicki Huff
Cancer Res 2000 60: 6288-6292. [Abstract] [Full Text] [PDF]  

Loss of Annexin 1 Correlates with Early Onset of Tumorigenesis in Esophageal and Prostate Carcinoma

Cloud P. Paweletz, David K. Ornstein, Mark J. Roth, Verena E. Bichsel, John W. Gillespie, Valerie S. Calvert, Cathy D. Vocke, Stephen M. Hewitt, Paul H. Duray, Judi Herring, Quan-Hong Wang, Nan Hu, W. Marston Linehan, Phillip R. Taylor, Lance A. Liotta, Michael R. Emmert-Buck, and Emanuel F. Petricoin, III
Cancer Res 2000 60: 6293-6297. [Abstract] [Full Text] [PDF]  

Thymidine Phosphorylase Induces Carcinoma Cell Oxidative Stress and Promotes Secretion of Angiogenic Factors

Nicholas S. Brown, Adam Jones, Chisato Fujiyama, Adrian L. Harris, and Roy Bicknell
Cancer Res 2000 60: 6298-6302. [Abstract] [Full Text] [PDF]  

The Oncogenic Potential of the High Mobility Group Box Protein Sox3

Yu Xia, Nancy Papalopulu, Peter K. Vogt, and Jian Li
Cancer Res 2000 60: 6303-6306. [Abstract] [Full Text] [PDF]  

O⁶-Benzylguanine Potentiates the Antitumor Effect of Locally Delivered Carmustine against an Intracranial Rat Glioma

Laurence D. Rhines, Prakash Sampath, M. Eileen Dolan, Betty M. Tyler, Henry Brem, and Jon Weingart
Cancer Res 2000 60: 6307-6310. [Abstract] [Full Text] [PDF]  

Somatic Mutations of LKB1 and ß-Catenin Genes in Gastrointestinal Polyps from Patients with Peutz-Jeghers Syndrome

Michiko Miyaki, Takeru Iijima, Keiko Hosono, Reiko Ishii, Masamichi Yasuno, Takeo Mori, Masakazu Toi, Tsunekazu Hishima, Nobuyuki Shitara, Kazuo Tamura, Joji Utsunomiya, Naoyuki Kobayashi, Toshio Kuroki, and Takeo Iwama
Cancer Res 2000 60: 6311-6313. [Abstract] [Full Text] [PDF]  

Functional Analysis of Human Ornithine Decarboxylase Alleles

Yongjun Guo, Robin B. Harris, Dan Rosson, David Boorman, and Thomas G. O’Brien
Cancer Res 2000 60: 6314-6317. [Abstract] [Full Text] [PDF]  

Bax Is a Transcriptional Target and Mediator of c-Myc-induced Apoptosis

Kyran O. Mitchell, M. Stacey Ricci, Toshiyuki Miyashita, David T. Dicker, Zhaoyu Jin, John C. Reed, and Wafik S. El-Deiry
Cancer Res 2000 60: 6318-6325. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Nitric Oxide Synthase Is Induced in Tumor Promoter-sensitive, but not Tumor Promoter-resistant, JB6 Mouse Epidermal Cells Cocultured with Interferon- -stimulated RAW 264.7 Cells: The Role of Tumor Necrosis Factor-

Akira Murakami, Kyuichi Kawabata, Teruaki Koshiba, Guanxin Gao, Yoshimasa Nakamura, Koichi Koshimizu, and Hajime Ohigashi
Cancer Res 2000 60: 6326-6331. [Abstract] [Full Text] [PDF]  

Activator Protein 1 Transcription Factors Are Fundamental to v-ras^Ha-induced Changes in Gene Expression in Neoplastic Keratinocytes

Susan E. Rutberg, Tracey L. Adams, Adam Glick, Maria T. Bonovich, Charles Vinson, and Stuart H. Yuspa
Cancer Res 2000 60: 6332-6338. [Abstract] [Full Text] [PDF]  

Carcinogeniesis:

The RB1 Gene Is the Target of Chromosome 13 Deletions in Malignant Fibrous Histiocytoma

Frédéric Chibon, Aline Mairal, Paul Fréneaux, Philippe Terrier, Jean-Michel Coindre, Xavier Sastre, and Alain Aurias
Cancer Res 2000 60: 6339-6345. [Abstract] [Full Text] [PDF]  

Arsenite Induces p53 Accumulation through an ATM-dependent Pathway in Human Fibroblasts

Ling-Huei Yih and Te-Chang Lee
Cancer Res 2000 60: 6346-6352. [Abstract] [Full Text] [PDF]  

Oleate Activates Phosphatidylinositol 3-Kinase and Promotes Proliferation and Reduces Apoptosis of MDA-MB-231 Breast Cancer Cells, Whereas Palmitate Has Opposite Effects¹

Serge Hardy, Yves Langelier, and Marc Prentki
Cancer Res 2000 60: 6353-6358. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Selective Replication and Oncolysis in p53 Mutant Tumors with ONYX-015, an E1B-55kD Gene-deleted Adenovirus, in Patients with Advanced Head and Neck Cancer: A Phase II Trial

John Nemunaitis, Ian Ganly, Fadlo Khuri, James Arseneau, Joseph Kuhn, Todd McCarty, Stephen Landers, Phillip Maples, Larry Romel, Britta Randlev, Tony Reid, Sam Kaye, and David Kirn
Cancer Res 2000 60: 6359-6366. [Abstract] [Full Text] [PDF]  

Endocrinology:

PDZK1 and GREB1 Are Estrogen-regulated Genes Expressed in Hormone-responsive Breast Cancer^{1, 2}

Malavika G. Ghosh, Devon A. Thompson, and Ronald J. Weigel
Cancer Res 2000 60: 6367-6375. [Abstract] [Full Text] [PDF]  

Epidemiology:

Risk for Gastric Cancer after Antibiotic Prophylaxis in Patients Undergoing Hip Replacement

Katja Akre, Lisa B. Signorello, Lars Engstrand, Reinhold Bergström, Sune Larsson, Bengt I. Eriksson, and Olof Nyrén
Cancer Res 2000 60: 6376-6380. [Abstract] [Full Text] [PDF]  

Glutathione Peroxidase Codon 198 Polymorphism Variant Increases Lung Cancer Risk

Duminda Ratnasinghe, Joseph A. Tangrea, Mark R. Andersen, Michael J. Barrett, Jarmo Virtamo, Philip R. Taylor, and Demetrius Albanes
Cancer Res 2000 60: 6381-6383. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Predicting Tumor Responses to Mitomycin C on the Basis of DT-Diaphorase Activity or Drug Metabolism by Tumor Homogenates: Implications for Enzyme-directed Bioreductive Drug Development

Roger M. Phillips, Angelika M. Burger, Paul M. Loadman, Claire M. Jarrett, David J. Swaine, and Heinz-Herbert Fiebig
Cancer Res 2000 60: 6384-6390. [Abstract] [Full Text] [PDF]  

Tumor Regression Induced by Intratumor Administration of Adenovirus Vector Expressing CD40 Ligand and Naive Dendritic Cells

Toshiaki Kikuchi, Naoki Miyazawa, Malcolm A. S. Moore, and Ronald G. Crystal
Cancer Res 2000 60: 6391-6395. [Abstract] [Full Text] [PDF]  

Viral Fusogenic Membrane Glycoprotein Expression Causes Syncytia Formation with Bioenergetic Cell Death: Implications for Gene Therapy

Hajime Higuchi, Steven F. Bronk, Andrew Bateman, Kevin Harrington, Richard G. Vile, and Gregory J. Gores
Cancer Res 2000 60: 6396-6402. [Abstract] [Full Text] [PDF]  

Modulation of Mitogen-activated Protein Kinases and Phosphorylation of Bcl-2 by Vinblastine Represent Persistent Forms of Normal Fluctuations at G₂-M

Meiyun Fan, Lihua Du, Albert A. Stone, Kathleen M. Gilbert, and Timothy C. Chambers
Cancer Res 2000 60: 6403-6407. [Abstract] [Full Text] [PDF]  

The Role of c-jun Kinase in the Apoptotic Response to Nucleoside Analogue-induced DNA Damage

Deepa Sampath and William Plunkett
Cancer Res 2000 60: 6408-6415. [Abstract] [Full Text] [PDF]  

Antitumor Activity of Tumor Necrosis Factor- Conjugated with Polyvinylpyrrolidone on Solid Tumors in Mice

Haruhiko Kamada, Yasuo Tsutsumi, Yoko Yamamoto, Tetsunari Kihira, Yoshihisa Kaneda, Yu Mu, Hiroshi Kodaira, Shin-ichi Tsunoda, Shinsaku Nakagawa, and Tadanori Mayumi
Cancer Res 2000 60: 6416-6420. [Abstract] [Full Text] [PDF]  

Immunology:

Cystathionine-ß-Synthase cDNA Transfection Alters the Sensitivity and Metabolism of 1-ß-D-Arabinofuranosylcytosine in CCRF-CEM Leukemia Cells in Vitro and in Vivo: A Model of Leukemia in Down Syndrome

Jeffrey W. Taub, Xi Huang, Yubin Ge, Julie A. Dutcher, Mark L. Stout, Ramzi M. Mohammad, Yaddanapudi Ravindranath, and Larry H. Matherly
Cancer Res 2000 60: 6421-6426. [Abstract] [Full Text] [PDF]  

Superior Tumor Protection Induced by a Cellular Vaccine Carrying a Tumor-specific T Helper Epitope by Genetic Exchange of the Class II-associated Invariant Chain Peptide

Jeroen van Bergen, Marcel Camps, Rienk Offringa, Cornelis J. M. Melief, Ferry Ossendorp, and Frits Koning
Cancer Res 2000 60: 6427-6433. [Abstract] [Full Text] [PDF]  

Targeting of Bivalent Anti-ErbB2 Diabody Antibody Fragments to Tumor Cells Is Independent of the Intrinsic Antibody Affinity

Ulrik B. Nielsen, Gregory P. Adams, Louis M. Weiner, and James D. Marks
Cancer Res 2000 60: 6434-6440. [Abstract] [Full Text] [PDF]  

Dead or Alive: Immunogenicity of Human Melanoma Cells When Presented by Dendritic Cells

Munitta Shaif-Muthana, Catherine McIntyre, Karen Sisley, Ian Rennie, and Anna Murray
Cancer Res 2000 60: 6441-6447. [Abstract] [Full Text] [PDF]  

A Novel Melanoma Gene (MG50) Encoding the Interleukin 1 Receptor Antagonist and Six Epitopes Recognized by Human Cytolytic T Lymphocytes

Malcolm S. Mitchell, June Kan-Mitchell, Boris Minev, Carl Edman, and Robert J. Deans
Cancer Res 2000 60: 6448-6456. [Abstract] [Full Text] [PDF]  

Adenovirus-Interleukin-12-mediated Tumor Regression in a Murine Hepatocellular Carcinoma Model Is Not Dependent on CD1-restricted Natural Killer T Cells

Kahlil J. Andrews, Antoni Ribas, Lisa H. Butterfield, Charles M. Vollmer, Fritz C. Eilber, Vivian B. Dissette, Scott D. Nelson, Peter Shintaku, Shahram Mekhoubad, Toshinori Nakayama, Masaru Taniguchi, John A. Glaspy, William H. McBride, and James S. Economou
Cancer Res 2000 60: 6457-6464. [Abstract] [Full Text] [PDF]  

Molecular Biology & Genetics:

Differential Effects of Theaflavin Monogallates on Cell Growth, Apoptosis, and Cox-2 Gene Expression in Cancerous versus Normal Cells

Jiebo Lu, Chi-Tang Ho, Geetha Ghai, and Kuang Yu Chen
Cancer Res 2000 60: 6465-6471. [Abstract] [Full Text] [PDF]  

Prognostic Value of Genetically Diagnosed Lymph Node Micrometastasis in Non-Small Cell Lung Carcinoma Cases

Takehisa Hashimoto, Yasuhito Kobayashi, Yuichi Ishikawa, Shigehiro Tsuchiya, Sakae Okumura, Ken Nakagawa, Yoshio Tokuchi, Moriaki Hayashi, Kazunori Nishida, Shin-ichi Hayashi, Jun-ichi Hayashi, and Eiju Tsuchiya
Cancer Res 2000 60: 6472-6478. [Abstract] [Full Text] [PDF]  

Two Percent of Finnish Prostate Cancer Patients Have a Germ-line Mutation in the Hormone-binding Domain of the Androgen Receptor Gene

Nina Mononen, Kirsi Syrjäkoski, Mika Matikainen, Teuvo L. J. Tammela, Johanna Schleutker, Olli-P. Kallioniemi, Jan Trapman, and Pasi A. Koivisto
Cancer Res 2000 60: 6479-6481. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Induction of Mammary Differentiation by Mammary-derived Growth Inhibitor-related Gene That Interacts with an -3 Fatty Acid on Growth Inhibition of Breast Cancer Cells

Mingsheng Wang, Yiliang E. Liu, Jian Ni, Banu Aygun, Itzhak D. Goldberg, and Y. Eric Shi
Cancer Res 2000 60: 6482-6487. [Abstract] [Full Text] [PDF]  

Increase of GKLF Messenger RNA and Protein Expression during Progression of Breast Cancer

K. Wade Foster, Andra R. Frost, Peggy McKie-Bell, Chin-Yu Lin, Jeffrey A. Engler, William E. Grizzle, and J. Michael Ruppert
Cancer Res 2000 60: 6488-6495. [Abstract] [Full Text] [PDF]  

Visualization of the Timing of Gene Amplification during Multistep Head and Neck Tumorigenesis

Hwan J. Roh, Dong M. Shin, Jin S. Lee, Jae Y. Ro, Michael A. Tainsky, Waun K. Hong, and Walter N. Hittelman
Cancer Res 2000 60: 6496-6502. [Abstract] [Full Text] [PDF]  

Construction of Evolutionary Tree Models for Renal Cell Carcinoma from Comparative Genomic Hybridization Data

Feng Jiang, Richard Desper, Christos H. Papadimitriou, Alejandro A. Schäffer, Olli-P. Kallioniemi, Jan Richter, Peter Schraml, Guido Sauter, Michael J. Mihatsch, and Holger Moch
Cancer Res 2000 60: 6503-6509. [Abstract] [Full Text] [PDF]  

Clonal Selection versus Genetic Instability as the Driving Force in Neoplastic Transformation

Ming Chow and Harry Rubin
Cancer Res 2000 60: 6510-6518. [Abstract] [Full Text] [PDF]  

Involvement of the Ets-1 Gene in Overexpression of Matrilysin in Human Hepatocellular Carcinoma

Iwata Ozaki, Toshihiko Mizuta, Gang Zhao, Hiroaki Yotsumoto, Toshiya Hara, Susumu Kajihara, Akitaka Hisatomi, Takahiro Sakai, and Kyosuke Yamamoto
Cancer Res 2000 60: 6519-6525. [Abstract] [Full Text] [PDF]  

Treatment of Prostate Cancer by Radioiodine Therapy after Tissue-specific Expression of the Sodium Iodide Symporter

Christine Spitzweg, Michael K. O’Connor, Elizabeth R. Bergert, Donald J. Tindall, Charles Y. F. Young, and John C. Morris
Cancer Res 2000 60: 6526-6530. [Abstract] [Full Text] [PDF]  

Sp1 Decoy Transfected to Carcinoma Cells Suppresses the Expression of Vascular Endothelial Growth Factor, Transforming Growth Factor ß₁, and Tissue Factor and Also Cell Growth and Invasion Activities

Hiroaki Ishibashi, Kazunori Nakagawa, Mitsuho Onimaru, Emilio J Castellanous, Yasufumi Kaneda, Yutaka Nakashima, Kanemitsu Shirasuna, and Katsuo Sueishi
Cancer Res 2000 60: 6531-6536. [Abstract] [Full Text] [PDF]  

Induction of Fas Expression and Augmentation of Fas/Fas Ligand-mediated Apoptosis by the Synthetic Retinoid CD437 in Human Lung Cancer Cells

Shi-Yong Sun, Ping Yue, Waun Ki Hong, and Reuben Lotan
Cancer Res 2000 60: 6537-6543. [Abstract] [Full Text] [PDF]  

Errata:

Errata

Cancer Res 2000 60: 6544-6547. [Full Text]  

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