Advances in Brief:

Isolation of a Peptide for Targeted Drug Delivery into Human Head and Neck Solid Tumors

Frank D. Hong and Gary L. Clayman
Cancer Res 2000 60: 6551-6556. [Abstract] [Full Text] [PDF]  

Tumor Metastasis and the Reciprocal Regulation of Prometastatic and Antimetastatic Factors by Nuclear Factor B

Valentine B. Andela, Edward M. Schwarz, J. Edward Puzas, Regis J. O’Keefe, and Randy N. Rosier
Cancer Res 2000 60: 6557-6562. [Abstract] [Full Text] [PDF]  

WISH-PC2: A Unique Xenograft Model of Human Prostatic Small Cell Carcinoma

Jehonathan H. Pinthus, Tova Waks, Daniel G. Schindler, Alon Harmelin, Jonathan W. Said, Arie Belldegrun, Jacob Ramon, and Zelig Eshhar
Cancer Res 2000 60: 6563-6567. [Abstract] [Full Text] [PDF]  

PSGR, a Novel Prostate-specific Gene with Homology to a G Protein-coupled Receptor, Is Overexpressed in Prostate Cancer

Linda L. Xu, Bennett G. Stackhouse, Kim Florence, Wei Zhang, Naga Shanmugam, Iasbell A. Sesterhenn, Zhiqiang Zou, Vasantha Srikantan, Meena Augustus, Viktor Roschke, Kenneth Carter, David G. McLeod, Judd W. Moul, Dan Soppett, and Shiv Srivastava
Cancer Res 2000 60: 6568-6572. [Abstract] [Full Text] [PDF]  

In Vitro Sensitivity of T-Cell Lymphoblastic Leukemia to UCN-01 (7-Hydroxystaurosporine) Is Dependent on p16 Protein Status: A Pediatric Oncology Group Study

Motoko Omura-Minamisawa, Mitchell B. Diccianni, Ayse Batova, Ray C. Chang, Louis J. Bridgeman, John Yu, Esther de Wit, Faith H. Kung, Jeanette D. Pullen, and Alice L. Yu
Cancer Res 2000 60: 6573-6576. [Abstract] [Full Text] [PDF]  

Activity of a Novel Camptothecin Analogue, Homocamptothecin, in Camptothecin-resistant Cell Lines with Topoisomerase I Alterations

Yoshimasa Urasaki, Yuji Takebayashi, and Yves Pommier
Cancer Res 2000 60: 6577-6580. [Abstract] [Full Text] [PDF]  

DLC-1 Is Deleted in Primary Hepatocellular Carcinoma and Exerts Inhibitory Effects on the Proliferation of Hepatoma Cell Lines with Deleted DLC-1

Irene Oi-lin Ng, Zheng-dong Liang, Liang Cao, and Terence Kin-wah Lee
Cancer Res 2000 60: 6581-6584. [Abstract] [Full Text] [PDF]  

RB18A, Whose Gene Is Localized on Chromosome 17q12-q21.1, Regulates in Vivo p53 Transactivating Activity

Raymond Frade, Michelle Balbo, and Monique Barel
Cancer Res 2000 60: 6585-6589. [Abstract] [Full Text] [PDF]  

Neutral Endopeptidase Promotes Phorbol Ester-induced Apoptosis in Prostate Cancer Cells by Inhibiting Neuropeptide-induced Protein Kinase C Degradation

Makoto Sumitomo, Ruoqian Shen, Jonathan S. Goldberg, Jie Dai, Daniel Navarro, and David M. Nanus
Cancer Res 2000 60: 6590-6596. [Abstract] [Full Text] [PDF]  

Direct Evidence for the Contribution of Activated N-ras and K-ras Oncogenes to Increased Intrinsic Radiation Resistance in Human Tumor Cell Lines

Eric J. Bernhard, Eric J. Stanbridge, Swati Gupta, Anjali K. Gupta, Daniel Soto, Vincent J. Bakanauskas, George J. Cerniglia, Ruth J. Muschel, and W. Gillies McKenna
Cancer Res 2000 60: 6597-6600. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Pharmacodynamics of Tamoxifen and Its 4-Hydroxy and N-Desmethyl Metabolites: Activation of Caspases and Induction of Apoptosis in Rat Mammary Tumors and in Human Breast Cancer Cell Lines

Sandhya Mandlekar, Vidya Hebbar, Konstantin Christov, and A-N. Tony Kong
Cancer Res 2000 60: 6601-6606. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Sulindac Sulfone Inhibits K-ras-dependent Cyclooxygenase-2 Expression in Human Colon Cancer Cells

Michele T. Taylor, Kathryn R. Lawson, Natalia A. Ignatenko, Sarah E. Marek, David E. Stringer, Beth A. Skovan, and Eugene W. Gerner
Cancer Res 2000 60: 6607-6610. [Abstract] [Full Text] [PDF]  

Mutations of Adenomatous Polyposis Coli and ß-Catenin Genes during Progression of Lung Tumors Induced by N-Nitrosobis(2-hydroxypropyl)amine in Rats

Toshifumi Tsujiuchi, Masahiro Tsutsumi, Yasutaka Sasaki, Nao Murata, and Yoichi Konishi
Cancer Res 2000 60: 6611-6616. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Identification of Differentially Expressed Genes in Human Gliomas by DNA Microarray and Tissue Chip Techniques

Satu-Leena Sallinen, Pauli K. Sallinen, Hannu K. Haapasalo, Heikki J. Helin, Pauli T. Helén, Peter Schraml, Olli-P. Kallioniemi, and Juha Kononen
Cancer Res 2000 60: 6617-6622. [Abstract] [Full Text] [PDF]  

Allelic Deletions of Cell Growth Regulators during Progression of Bladder Cancer

Hanne Primdahl, Hans von der Maase, Mariann Christensen, Hans Wolf, and Torben F. Ørntoft
Cancer Res 2000 60: 6623-6629. [Abstract] [Full Text] [PDF]  

Endocrinology:

Antiandrogenic Effects of Novel Androgen Synthesis Inhibitors on Hormone-dependent Prostate Cancer

Brian J. Long, Dmitry N. Grigoryev, Ivo P. Nnane, Yang Liu, Yang-Zhi Ling, and Angela M. Brodie
Cancer Res 2000 60: 6630-6640. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Locoregional Cancer Treatment with Magnetic Drug Targeting

Christoph Alexiou, Wolfgang Arnold, Roswitha J. Klein, Fritz G. Parak, Peter Hulin, Christian Bergemann, Wolfgang Erhardt, Stefan Wagenpfeil, and Andreas S. Lübbe
Cancer Res 2000 60: 6641-6648. [Abstract] [Full Text] [PDF]  

Yeast Cytosine Deaminase Improves Radiosensitization and Bystander Effect by 5-Fluorocytosine of Human Colorectal Cancer Xenografts

Els Kievit, Mukesh K. Nyati, Emily Ng, Lauren D. Stegman, Josh Parsels, Brian D. Ross, Alnawaz Rehemtulla, and Theodore S. Lawrence
Cancer Res 2000 60: 6649-6655. [Abstract] [Full Text] [PDF]  

Tyrosinase Mutants Are Capable of Prodrug Activation in Transfected Nonmelanotic Cells

Maria Simonova, Alexander Wall, Ralph Weissleder, and Alexei Bogdanov, Jr.
Cancer Res 2000 60: 6656-6662. [Abstract] [Full Text] [PDF]  

A Tetravalent Single-chain Antibody-Streptavidin Fusion Protein for Pretargeted Lymphoma Therapy

Jody Schultz, Yukang Lin, James Sanderson, Yuting Zuo, Diane Stone, Robert Mallett, Sibylle Wilbert, and Donald Axworthy
Cancer Res 2000 60: 6663-6669. [Abstract] [Full Text] [PDF]  

Molecular Biology & Genetics:

Suppression of Ganglioside GD3 Expression in a Rat F-11 Tumor Cell Line Reduces Tumor Growth, Angiogenesis, and Vascular Endothelial Growth Factor Production

Guichao Zeng, Luoyi Gao, Stéphane Birklé, and Robert K. Yu
Cancer Res 2000 60: 6670-6676. [Abstract] [Full Text] [PDF]  

Identification of a 6-cM Minimal Deletion at 11q23.1–23.2 and Exclusion of PPP2R1B Gene as a Deletion Target in Cervical Cancer

Hugo Arias Pulido, Mohamed J. Fakruddin, Anupam Chatterjee, Edward D. Esplin, Nestor Beleño, Gilberto Martínez, Hector Posso, Glen A. Evans, and V. V. V. S. Murty
Cancer Res 2000 60: 6677-6682. [Abstract] [Full Text] [PDF]  

Down-Regulation of Monocyte Chemotactic Protein-3 by Activated ß-Catenin

Manabu Fujita, Yoichi Furukawa, Yutaka Nagasawa, Michio Ogawa, and Yusuke Nakamura
Cancer Res 2000 60: 6683-6687. [Abstract] [Full Text] [PDF]  

Thioredoxin Nuclear Translocation and Interaction with Redox Factor-1 Activates the Activator Protein-1 Transcription Factor in Response to Ionizing Radiation

S. Jack Wei, Ana Botero, Kiichi Hirota, C. Matthew Bradbury, Stephanie Markovina, Andrei Laszlo, Douglas R. Spitz, Prabhat C. Goswami, Junji Yodoi, and David Gius
Cancer Res 2000 60: 6688-6695. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Mice Vaccination with Interleukin 12-transduced Colon Cancer Cells Potentiates Rejection of Syngeneic Non-Organ-related Tumor Cells

Soraya Adris, Eduardo Chuluyan, Alicia Bravo, Mariana Berenstein, Slovodanka Klein, Maria Jasnis, Cecilia Carbone, Yuti Chernajovsky, and Osvaldo L. Podhajcer
Cancer Res 2000 60: 6696-6703. [Abstract] [Full Text] [PDF]  

Dissociation of Staurosporine-induced Apoptosis from G₂-M Arrest in SW620 Human Colonic Carcinoma Cells: Initiation of the Apoptotic Cascade Is Associated with Elevation of the Mitochondrial Membrane Potential (_m)

Barbara G. Heerdt, Michele A. Houston, John M. Mariadason, and Leonard H. Augenlicht
Cancer Res 2000 60: 6704-6713. [Abstract] [Full Text] [PDF]  

The CD24/P-selectin Binding Pathway Initiates Lung Arrest of Human A125 Adenocarcinoma Cells

Jan Friederichs, Yvonka Zeller, Ali Hafezi-Moghadam, Hermann-Josef Gröne, Klaus Ley, and Peter Altevogt
Cancer Res 2000 60: 6714-6722. [Abstract] [Full Text] [PDF]  

Antiangiogenic Effects of Latent Antithrombin through Perturbed Cell-Matrix Interactions and Apoptosis of Endothelial Cells

Helena Larsson, Tobias Sjöblom, Johan Dixelius, Arne Östman, Karin Ylinenjärvi, Ingemar Björk, and Lena Claesson-Welsh
Cancer Res 2000 60: 6723-6729. [Abstract] [Full Text] [PDF]  

The Effect of Fibroblast Growth Factor 8, Isoform b, on the Biology of Prostate Carcinoma Cells and Their Interaction with Stromal Cells

Zhigang Song, William C. Powell, Noriyuki Kasahara, Adriaan van Bokhoven, Gary J. Miller, and Pradip Roy-Burman
Cancer Res 2000 60: 6730-6736. [Abstract] [Full Text] [PDF]  

HGF/NK4, a Four-Kringle Antagonist of Hepatocyte Growth Factor, Is an Angiogenesis Inhibitor that Suppresses Tumor Growth and Metastasis in Mice

Keiji Kuba, Kunio Matsumoto, Kazuhiko Date, Hideo Shimura, Masao Tanaka, and Toshikazu Nakamura
Cancer Res 2000 60: 6737-6743. [Abstract] [Full Text] [PDF]  

Differential Gene Expression between Normal and Tumor-derived Ovarian Epithelial Cells

Rubina S. Ismail, Rae Lynn Baldwin, Junguo Fang, Damaris Browning, Beth Y. Karlan, Judith C. Gasson, and David D. Chang
Cancer Res 2000 60: 6744-6749. [Abstract] [Full Text] [PDF]  

K-ras Codon 12 Mutation Induces Higher Level of Resistance to Apoptosis and Predisposition to Anchorage-independent Growth Than Codon 13 Mutation or Proto-Oncogene Overexpression

Sílvia Guerrero, Isolda Casanova, Lourdes Farré, Adela Mazo, Gabriel Capellà, and Ramon Mangues
Cancer Res 2000 60: 6750-6756. [Abstract] [Full Text] [PDF]  

Modulation of Tumor Angiogenesis by Stem Cell Factor

Wei Zhang, George Stoica, Serban I. Tasca, Katherine A. Kelly, and Cynthia J. Meininger
Cancer Res 2000 60: 6757-6762. [Abstract] [Full Text] [PDF]  

The Phosphatidylinositol 3-Kinase/AKT Kinase Pathway in Multiple Myeloma Plasma Cells: Roles in Cytokine-dependent Survival and Proliferative Responses

Yiping Tu, Agnes Gardner, and Alan Lichtenstein
Cancer Res 2000 60: 6763-6770. [Abstract] [Full Text] [PDF]  

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