Advances in Brief:

A Calcitriol Analogue, EB1089, Inhibits the Growth of LNCaP Tumors in Nude Mice

Sarah E. Blutt, Tara C. Polek, LaMonica V. Stewart, Michael W. Kattan, and Nancy L. Weigel
Cancer Res 2000 60: 779-782. [Abstract] [Full Text] [PDF]  

Osteoprotegerin Prevents and Reverses Hypercalcemia in a Murine Model of Humoral Hypercalcemia of Malignancy

Casey Capparelli, Paul J. Kostenuik, Sean Morony, Charlie Starnes, Bernadette Weimann, Gwyneth Van, Sheila Scully, Meiying Qi, David L. Lacey, and Colin R. Dunstan
Cancer Res 2000 60: 783-787. [Abstract] [Full Text] [PDF]  

Adenoviral Bak Overexpression Mediates Caspase-dependent Tumor Killing

Abujiang Pataer, Bingliang Fang, Robert Yu, Shunsuke Kagawa, Kelly K. Hunt, Timothy J. McDonnell, Jack A. Roth, and Stephen G. Swisher
Cancer Res 2000 60: 788-792. [Abstract] [Full Text] [PDF]  

A New Variant Anaplastic Lymphoma Kinase (ALK)-Fusion Protein (ATIC-ALK) in a Case of ALK-positive Anaplastic Large Cell Lymphoma

Mirella Trinei, Luisa Lanfrancone, Elias Campo, Karen Pulford, David Y. Mason, Pier-Giuseppe Pelicci, and Brunangelo Falini
Cancer Res 2000 60: 793-798. [Abstract] [Full Text] [PDF]  

Detection of Gene Amplification by Genomic Hybridization to cDNA Microarrays

Mervi A. Heiskanen, Michael L. Bittner, Yidong Chen, Javed Khan, Karl E. Adler, Jeffrey M. Trent, and Paul S. Meltzer
Cancer Res 2000 60: 799-802. [Abstract] [Full Text] [PDF]  

The DNA Mismatch Repair Genes Msh3 and Msh6 Cooperate in Intestinal Tumor Suppression

Winfried Edelmann, Asad Umar, Kan Yang, Joerg Heyer, Melanie Kucherlapati, Marie Lia, Burkhard Kneitz, Elena Avdievich, Kunhua Fan, Edmund Wong, Gray Crouse, Thomas Kunkel, Martin Lipkin, Richard D. Kolodner, and Raju Kucherlapati
Cancer Res 2000 60: 803-807. [Abstract] [Full Text] [PDF]  

Expression of the Wilms’ Tumor Suppressor Gene, WT1, Reduces the Tumorigenicity of the Leukemic Cell Line M1 in C.B-17 scid/scid Mice

Shirley I. Smith, Michelle Down, Andrew W. Boyd, and Chung L. Li
Cancer Res 2000 60: 808-814. [Abstract] [Full Text] [PDF]  

Enhanced Nuclear Diacylglycerol Kinase Activity in Response to a Mitogenic Stimulation of Quiescent Swiss 3T3 Cells with Insulin-like Growth Factor I

Alberto M. Martelli, Giovanna Tabellini, Roberta Bortul, Lucia Manzoli, Renato Bareggi, Giovanna Baldini, Vittorio Grill, Marina Zweyer, Paola Narducci, and Lucio Cocco
Cancer Res 2000 60: 815-821. [Abstract] [Full Text] [PDF]  

FasL:Fas Ratio–A Prognostic Factor in Breast Carcinomas

Toralf Reimer, Christina Herrnring, Dirk Koczan, Dagmar Richter, Bernd Gerber, Dieter Kabelitz, Klaus Friese, and Hans-Jürgen Thiesen
Cancer Res 2000 60: 822-828. [Abstract] [Full Text] [PDF]  

Dendritic Cell-based Immunotherapy of Prostate Cancer: Immune Monitoring of a Phase II Clinical Trial

Patricia A. Lodge, Lori A. Jones, Robert A. Bader, Gerald P. Murphy, and Michael L. Salgaller
Cancer Res 2000 60: 829-833. [Abstract] [Full Text] [PDF]  

Overexpression of Insulin-like Growth Factor-binding Protein-2 Results in Increased Tumorigenic Potential in Y-1 Adrenocortical Tumor Cells

Andreas Hoeflich, Olga Fettscher, Harald Lahm, Werner F. Blum, Helmut J. Kolb, Dieter Engelhardt, Eckhard Wolf, and Matthias M. Weber
Cancer Res 2000 60: 834-838. [Abstract] [Full Text] [PDF]  

Susceptibility to Prostate Cancer: Interaction between Genotypes at the Androgen Receptor and Prostate-specific Antigen Loci

Wenmei Xue, Ryan A. Irvine, Mimi C. Yu, Ronald K. Ross, Gerhard A. Coetzee, and Sue Ann Ingles
Cancer Res 2000 60: 839-841. [Abstract] [Full Text] [PDF]  

IDN5109, a Taxane with Oral Bioavailability and Potent Antitumor Activity

Maria Ines Nicoletti, Tina Colombo, Cosmo Rossi, Caterina Monardo, Stefania Stura, Massimo Zucchetti, Antonella Riva, Paolo Morazzoni, Maria Benedetta Donati, Ezio Bombardelli, Maurizio D’Incalci, and Raffaella Giavazzi
Cancer Res 2000 60: 842-846. [Abstract] [Full Text] [PDF]  

Increased Death Receptor 5 Expression by Chemotherapeutic Agents in Human Gliomas Causes Synergistic Cytotoxicity with Tumor Necrosis Factor-related Apoptosis-inducing Ligand in Vitro and in Vivo

Motoo Nagane, Guohua Pan, Jessie J. Weddle, Vishva M. Dixit, Webster K. Cavenee, and H.-J. Su Huang
Cancer Res 2000 60: 847-853. [Abstract] [Full Text] [PDF]  

Length and Loss of Heterozygosity of an Intron 1 Polymorphic Sequence of egfr Is Related to Cytogenetic Alterations and Epithelial Growth Factor Receptor Expression

Horst Buerger, Frank Gebhardt, Hartmut Schmidt, Alf Beckmann, Kirsten Hutmacher, Ronald Simon, Ralph Lelle, Werner Boecker, and Burkhard Brandt
Cancer Res 2000 60: 854-857. [Abstract] [Full Text] [PDF]  

PART-1: A Novel Human Prostate-specific, Androgen-regulated Gene that Maps to Chromosome 5q12

Biaoyang Lin, James T. White, Camari Ferguson, Roger Bumgarner, Cynthia Friedman, Barbara Trask, William Ellis, Paul Lange, Leroy Hood, and Peter S. Nelson
Cancer Res 2000 60: 858-863. [Abstract] [Full Text] [PDF]  

Methylation Patterns in Human Androgen Receptor Gene and Clonality Analysis

Se Jin Jang and Li Mao
Cancer Res 2000 60: 864-866. [Abstract] [Full Text] [PDF]  

The Glucocorticoid Receptor Mediates a Survival Signal in Human Mammary Epithelial Cells

Timothy J. Moran, Stacy Gray, Christina A. Mikosz, and Suzanne D. Conzen
Cancer Res 2000 60: 867-872. [Abstract] [Full Text] [PDF]  

A Single Nucleotide Polymorphism in the E-cadherin Gene Promoter Alters Transcriptional Activities

Long-Cheng Li, Richard M. Chui, Masahiro Sasaki, Koichi Nakajima, Geetha Perinchery, Harry C. Au, Dana Nojima, Peter Carroll, and Rajvir Dahiya
Cancer Res 2000 60: 873-876. [Abstract] [Full Text] [PDF]  

Human MT6-Matrix Metalloproteinase: Identification, Progelatinase A Activation, and Expression in Brain Tumors

Gloria Velasco, Santiago Cal, Anna Merlos-Suárez, Adolfo A. Ferrando, Sonsoles Alvarez, Atsuhisa Nakano, Joaquín Arribas, and Carlos López-Otín
Cancer Res 2000 60: 877-882. [Abstract] [Full Text] [PDF]  

Candidate Genes for the Hypoxic Tumor Phenotype

Albert C. Koong, Nicholas C. Denko, Karen M. Hudson, Cornelia Schindler, Lillian Swiersz, Cameron Koch, Sydney Evans, Hani Ibrahim, Quynh T. Le, David J. Terris, and Amato J. Giaccia
Cancer Res 2000 60: 883-887. [Abstract] [Full Text] [PDF]  

EMMPRIN (CD147), an Inducer of Matrix Metalloproteinase Synthesis, Also Binds Interstitial Collagenase to the Tumor Cell Surface

Huiming Guo, Rongsong Li, Stanley Zucker, and Bryan P. Toole
Cancer Res 2000 60: 888-891. [Abstract] [Full Text] [PDF]  

Gene Promoter Hypermethylation in Tumors and Serum of Head and Neck Cancer Patients

Montserrat Sanchez-Cespedes, Manel Esteller, Li Wu, Homaira Nawroz-Danish, George H. Yoo, Wayne M. Koch, Jin Jen, James G. Herman, and David Sidransky
Cancer Res 2000 60: 892-895. [Abstract] [Full Text] [PDF]  

p53 Phosphorylation and Association with Murine Double Minute 2, c-Jun NH₂-Terminal Kinase, p14^ARF, and p300/CBP during the Cell Cycle and after Exposure to Ultraviolet Irradiation

Thomas Buschmann, Victor Adler, Ekaterina Matusevich, Serge Y. Fuchs, and Ze’ev Ronai
Cancer Res 2000 60: 896-900. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

A Germ-Line p53 Mutation Accelerates Pulmonary Tumorigenesis: p53-independent Efficacy of Chemopreventive Agents Green Tea or Dexamethasone/myo-Inositol and Chemotherapeutic Agents Taxol or Adriamycin

Zhongqiu Zhang, Qing Liu, Laura E. Lantry, Yian Wang, Gary J. Kelloff, Marshall W. Anderson, Roger W. Wiseman, Ronald A. Lubet, and Ming You
Cancer Res 2000 60: 901-907. [Abstract] [Full Text] [PDF]  

Genotoxic Polycyclic Aromatic Hydrocarbon ortho-Quinones Generated by Aldo-Keto Reductases Induce CYP1A1 via Nuclear Translocation of the Aryl Hydrocarbon Receptor

Michael E. Burczynski and Trevor M. Penning
Cancer Res 2000 60: 908-915. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

High Lactate Levels Predict Likelihood of Metastases, Tumor Recurrence, and Restricted Patient Survival in Human Cervical Cancers

Stefan Walenta, Michael Wetterling, Michael Lehrke, Georg Schwickert, Kolbein Sundfør, Einar K. Rofstad, and Wolfgang Mueller-Klieser
Cancer Res 2000 60: 916-921. [Abstract] [Full Text] [PDF]  

Endocrinology:

A Novel SMAD4 Gene Mutation in Seminoma Germ Cell Tumors

Mourad Bouras, Eric Tabone, Jacques Bertholon, Pascal Sommer, Raymonde Bouvier, Jean-Pierre Droz, and Mohamed Benahmed
Cancer Res 2000 60: 922-928. [Abstract] [Full Text] [PDF]  

Down-Regulation of Transforming Growth Factor ß Receptors by Androgen in Ovarian Cancer Cells

Andreas Evangelou, Sangita K. Jindal, Theodore J. Brown, and Michelle Letarte
Cancer Res 2000 60: 929-935. [Abstract] [Full Text] [PDF]  

The 4-Pregnene and 5-Pregnane Progesterone Metabolites Formed in Nontumorous and Tumorous Breast Tissue Have Opposite Effects on Breast Cell Proliferation and Adhesion

John P. Wiebe, David Muzia, Juncai Hu, David Szwajcer, Scott A. Hill, and Jennifer L. Seachrist
Cancer Res 2000 60: 936-943. [Abstract] [Full Text] [PDF]  

Androgen Receptor Mutations in Prostate Cancer

Marco Marcelli, Michael Ittmann, Stefania Mariani, Richard Sutherland, Rajni Nigam, Lata Murthy, Yali Zhao, Dino DiConcini, Efisio Puxeddu, Adel Esen, James Eastham, Nancy L. Weigel, and Dolores J. Lamb
Cancer Res 2000 60: 944-949. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Genetic Polymorphisms in Uridine Diphospho-Glucuronosyltransferase 1A1 and Association with Breast Cancer among African Americans

Chantal Guillemette, Robert C. Millikan, Beth Newman, and David E. Housman
Cancer Res 2000 60: 950-956. [Abstract] [Full Text] [PDF]  

Chemoprevention of Aflatoxin B₁ Hepatocarcinogenesis by Coumarin, a Natural Benzopyrone That Is a Potent Inducer of Aflatoxin B₁-Aldehyde Reductase, the Glutathione S-Transferase A5 and P1 Subunits, and NAD(P)H:Quinone Oxidoreductase in Rat Liver

Vincent P. Kelly, Elizabeth M. Ellis, Margaret M. Manson, Simon A. Chanas, Graeme J. Moffat, Ronald McLeod, David J. Judah, Gordon E. Neal, and John D. Hayes
Cancer Res 2000 60: 957-969. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

ZD4190: An Orally Active Inhibitor of Vascular Endothelial Growth Factor Signaling with Broad-Spectrum Antitumor Efficacy

Stephen R. Wedge, Donald J. Ogilvie, Michael Dukes, Jane Kendrew, Jon O. Curwen, Laurent F. Hennequin, Andrew P. Thomas, Elaine S. E. Stokes, Brenda Curry, Graham H. P. Richmond, and Peter F. Wadsworth
Cancer Res 2000 60: 970-975. [Abstract] [Full Text] [PDF]  

Retroviral Immunotoxin Gene Therapy of Acute Myelogenous Leukemia in Mice Using Cytotoxic T Cells Transduced with an Interleukin 4/Diphtheria Toxin Gene

Daniel A. Vallera, Ni Jin, James M. R. Baldrica, Angela Panoskaltsis-Mortari, Si-Yi Chen, and Bruce R. Blazar
Cancer Res 2000 60: 976-984. [Abstract] [Full Text] [PDF]  

Microtubule Disruption Induced in Vivo by Alkylation of ß-Tubulin by 1-Aryl-3- (2-Chloroethyl)Ureas, a Novel Class of Soft Alkylating Agents

Jean Legault, Jean-François Gaulin, Emmanuelle Mounetou, Sébastien Bolduc, Jacques Lacroix, Patrick Poyet, and René C.-Gaudreault
Cancer Res 2000 60: 985-992. [Abstract] [Full Text] [PDF]  

Evaluation of HSV-tk Gene Therapy in a Rat Model of Chemically Induced Hepatocellular Carcinoma by Intratumoral and Intrahepatic Artery Routes

René Gerolami, Jorge Cardoso, Maïté Lewin, Marie-Pierre Bralet, Antonio SaCunha, Olivier Clément, Christian Bréchot, and Phuong-Lan Tran
Cancer Res 2000 60: 993-1001. [Abstract] [Full Text] [PDF]  

Inhibition of Human Prostate Cancer Proliferation in Vitro and in a Mouse Model by a Compound Synthesized to Block Ca²⁺ Entry

Doris M. Haverstick, Tiffany N. Heady, Timothy L. Macdonald, and Lloyd S. Gray
Cancer Res 2000 60: 1002-1008. [Abstract] [Full Text] [PDF]  

ONYX-015 Works Synergistically with Chemotherapy in Lung Cancer Cell Lines and Primary Cultures Freshly Made from Lung Cancer Patients

Liang You, Cheng-Ta Yang, and David M. Jablons
Cancer Res 2000 60: 1009-1013. [Abstract] [Full Text] [PDF]  

Apoptosis Induction of Human Myeloid Leukemic Cells by Ultrasound Exposure

Hagit Ashush, Leon A. Rozenszajn, Michal Blass, Mira Barda-Saad, Damir Azimov, Judith Radnay, Dov Zipori, and Uri Rosenschein
Cancer Res 2000 60: 1014-1020. [Abstract] [Full Text] [PDF]  

Immunology:

APRIL/TRDL-1, a Tumor Necrosis Factor-like Ligand, Stimulates Cell Death

Kimberly Kelly, Elizabeth Manos, Gregory Jensen, Lincoln Nadauld, and David A. Jones
Cancer Res 2000 60: 1021-1027. [Abstract] [Full Text] [PDF]  

Induction of Tumor Immunity and Cytotoxic T Lymphocyte Responses Using Dendritic Cells Transfected with Messenger RNA Amplified from Tumor Cells

David Boczkowski, Smita K. Nair, Jong-Hee Nam, H. Kim Lyerly, and Eli Gilboa
Cancer Res 2000 60: 1028-1034. [Abstract] [Full Text] [PDF]  

Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to an HSP70 Gene

Chien-Hung Chen, Tian-Li Wang, Chien-Fu Hung, Yanqin Yang, Richard A. Young, Drew M. Pardoll, and T-C. Wu
Cancer Res 2000 60: 1035-1042. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Increasing Methylation of the CDKN2A Gene Is Associated with the Progression of Adult T-Cell Leukemia

Kisato Nosaka, Michiyuki Maeda, Sadahiro Tamiya, Tatsunori Sakai, Hiroaki Mitsuya, and Masao Matsuoka
Cancer Res 2000 60: 1043-1048. [Abstract] [Full Text] [PDF]  

Alterations of the FHIT Gene in Human Hepatocellular Carcinoma

Bao-Zhu Yuan, Catherine Keck-Waggoner, Drazen B. Zimonjic, Snorri S. Thorgeirsson, and Nicholas C. Popescu
Cancer Res 2000 60: 1049-1053. [Abstract] [Full Text] [PDF]  

Mage-b4, a Novel Melanoma Antigen (MAGE) Gene Specifically Expressed during Germ Cell Differentiation

Christina Österlund, Virpi Töhönen, Karin Öhman Forslund, and Katarina Nordqvist
Cancer Res 2000 60: 1054-1061. [Abstract] [Full Text] [PDF]  

Elevated Frequency and Functional Activity of a Specific Germ-Line p53 Intron Mutation in Familial Breast Cancer

Teresa A. Lehman, Bruce G. Haffty, Christopher J. Carbone, Lisa R. Bishop, Andrew A. Gumbs, Shiva Krishnan, Peter G. Shields, Rama Modali, and Bruce C. Turner
Cancer Res 2000 60: 1062-1069. [Abstract] [Full Text] [PDF]  

Insulin-like Growth Factor II Supply Modifies Growth of Intestinal Adenoma in Apc^Min/+ Mice

A. Bassim Hassan and Julie A. Howell
Cancer Res 2000 60: 1070-1076. [Abstract] [Full Text] [PDF]  

Relating Genotype and Phenotype in Breast Cancer: An Analysis of the Prognostic Significance of Amplification at Eight Different Genes or Loci and of p53 Mutations

Marguerite Cuny, Andrew Kramar, Frank Courjal, Vala Johannsdottir, Barry Iacopetta, Hélène Fontaine, Jean Grenier, Stéphane Culine, and Charles Theillet
Cancer Res 2000 60: 1077-1083. [Abstract] [Full Text] [PDF]  

Transcriptional Regulation of Cyclooxygenase-2 Gene Expression: Novel Effects of Nonsteroidal Anti-Inflammatory Drugs

Chiun-Jye Yuan, Asim K. Mandal, Zhongjian Zhang, and Anil B. Mukherjee
Cancer Res 2000 60: 1084-1091. [Abstract] [Full Text] [PDF]  

Chromosomal Mapping of Genes Controlling Development, Histological Grade, Depth of Invasion, and Size of Rat Stomach Carcinomas

Toshikazu Ushijima, Masami Yamamoto, Masumi Suzui, Takashi Kuramoto, Yukinari Yoshida, Tomoko Nomoto, Masae Tatematsu, Takashi Sugimura, and Minako Nagao
Cancer Res 2000 60: 1092-1096. [Abstract] [Full Text] [PDF]  

The c-Fes Protein-Tyrosine Kinase Suppresses Cytokine-independent Outgrowth of Myeloid Leukemia Cells Induced by Bcr-Abl

Jack M. Lionberger and Thomas E. Smithgall
Cancer Res 2000 60: 1097-1103. [Abstract] [Full Text] [PDF]  

Tumor Biology:

The M_r 193,000 Vault Protein Is Up-Regulated in Multidrug-resistant Cancer Cell Lines

Anouk B. Schroeijers, Amara C. Siva, George L. Scheffer, Mariska C. de Jong, Sophie C. E. Bolick, Danny F. Dukers, Jerry W. Slootstra, Rob H. Meloen, Erik Wiemer, Valerie A. Kickhoefer, Leonard H. Rome, and Rik J. Scheper
Cancer Res 2000 60: 1104-1110. [Abstract] [Full Text] [PDF]  

Direct in Vitro Evidence and in Vivo Analysis of the Antiangiogenesis Effects of Interleukin 12

Dan Gabriel Duda, Makoto Sunamura, Lucian Lozonschi, Tomohiro Kodama, Shin-ichi Egawa, Gaku Matsumoto, Hiromune Shimamura, Kazuhiko Shibuya, Kazunori Takeda, and Seiki Matsuno
Cancer Res 2000 60: 1111-1116. [Abstract] [Full Text] [PDF]  

Nuclear Matrix of Calreticulin in Hepatocellular Carcinoma

Ghil-Suk Yoon, Hojung Lee, Yusun Jung, Eunsil Yu, Hee-Bom Moon, Kyuyoung Song, and Inchul Lee
Cancer Res 2000 60: 1117-1120. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor-like Ligands Differentially Up-Regulate Matrix Metalloproteinase 9 in Head and Neck Squamous Carcinoma Cells

Pornchai O-charoenrat, Helmout Modjtahedi, Peter Rhys-Evans, William J. Court, Gary M. Box, and Suzanne A. Eccles
Cancer Res 2000 60: 1121-1128. [Abstract] [Full Text] [PDF]  

Induction of Differentiation and Apoptosis by Ligands of Peroxisome Proliferator-activated Receptor in Non-Small Cell Lung Cancer

Tsg-Hui Chang and Eva Szabo
Cancer Res 2000 60: 1129-1138. [Abstract] [Full Text] [PDF]  

SN-1, A Novel Leukemic Cell Line with t(11;16)(q23;p13): Myeloid Characteristics and Resistance to Retinoids and Vitamin D₃

Yasuhide Hayashi, Yoshio Honma, Nozomi Niitsu, Tomohiko Taki, Fumio Bessho, Masahiro Sako, Taijiro Mori, Masayoshi Yanagisawa, Kohichiro Tsuji, and Tatsutoshi Nakahata
Cancer Res 2000 60: 1139-1145. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Letter

Wendla Paile
Cancer Res 2000 60: 1146 [Full Text] [PDF]  

Errata:

Errata

Cancer Res 2000 60: 1150 [Full Text] [PDF]  

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