Advances in Brief:

Chemotherapeutic DNA-damaging Drugs Activate Interferon Regulatory Factor-7 by the Mitogen-activated Protein Kinase Kinase-4-c-Jun NH₂-Terminal Kinase Pathway

Tae Kook Kim, Taeil Kim, Tae Young Kim, Woo Ghil Lee, and Jeongbin Yim
Cancer Res 2000 60: 1153-1156. [Abstract] [Full Text] [PDF]  

Antitumor Effect of Adenovirus-mediated Bax Gene Transfer on p53-sensitive and p53-resistant Cancer Lines

Shunsuke Kagawa, Jian Gu, Stephen G. Swisher, Lin Ji, Jack A. Roth, Dejian Lai, L. Clifton Stephens, and Bingliang Fang
Cancer Res 2000 60: 1157-1161. [Abstract] [Full Text] [PDF]  

Association of the Bloom Syndrome Protein with Topoisomerase III in Somatic and Meiotic Cells

F. Brad Johnson, David B. Lombard, Norma F. Neff, Mary-Ann Mastrangelo, William Dewolf, Nathan A. Ellis, Robert A. Marciniak, Yizhong Yin, Rudolf Jaenisch, and Leonard Guarente
Cancer Res 2000 60: 1162-1167. [Abstract] [Full Text] [PDF]  

Interleukin-13 Receptor Chain: A Novel Tumor-associated Transmembrane Protein in Primary Explants of Human Malignant Gliomas

Bharat H. Joshi, Gregory E. Plautz, and Raj K. Puri
Cancer Res 2000 60: 1168-1172. [Abstract] [Full Text] [PDF]  

Carbonyl Reductase: A Novel Metastasis-modulating Function

Endom Ismail, Fahd Al-Mulla, Shigeki Tsuchida, Kohji Suto, Paul Motley, Paul R. Harrison, and George D. Birnie
Cancer Res 2000 60: 1173-1176. [Abstract] [Full Text] [PDF]  

Altered Expression of Fhit in Carcinoma and Precarcinomatous Lesions of the Esophagus

Masaki Mori, Koshi Mimori, Takeshi Shiraishi, Hansjuerg Alder, Hiroshi Inoue, Yoichi Tanaka, Keizo Sugimachi, Kay Huebner, and Carlo M. Croce
Cancer Res 2000 60: 1177-1182. [Abstract] [Full Text] [PDF]  

Transforming Growth Factor ß₂ Promotes Glucose Carbon Incorporation into Nucleic Acid Ribose through the Nonoxidative Pentose Cycle in Lung Epithelial Carcinoma Cells

Laszlo G. Boros, John S. Torday, Shu Lim, Sara Bassilian, Marta Cascante, and Wai-Nang Paul Lee
Cancer Res 2000 60: 1183-1185. [Abstract] [Full Text] [PDF]  

Further Evidence That the Radioprotective Aminothiol, WR-1065, Catalytically Inactivates Mammalian Topoisomerase II

Ronald D. Snyder and David J. Grdina
Cancer Res 2000 60: 1186-1188. [Abstract] [Full Text] [PDF]  

Characterization of CPT-11 Hydrolysis by Human Liver Carboxylesterase Isoforms hCE-1 and hCE-2

Rod Humerickhouse, Karen Lohrbach, Lin Li, William F. Bosron, and M. Eileen Dolan
Cancer Res 2000 60: 1189-1192. [Abstract] [Full Text] [PDF]  

In Vivo Antitumor Activity of ONYX-015 Is Influenced by p53 Status and Is Augmented by Radiotherapy

Kenneth R. Rogulski, Svend O. Freytag, Kang Zhang, Jeff D. Gilbert, Dell L. Paielli, Jae Ho Kim, Carla C. Heise, and David H. Kirn
Cancer Res 2000 60: 1193-1196. [Abstract] [Full Text] [PDF]  

A New Temperature-sensitive Liposome for Use with Mild Hyperthermia: Characterization and Testing in a Human Tumor Xenograft Model

David Needham, Gopal Anyarambhatla, Garheng Kong, and Mark W. Dewhirst
Cancer Res 2000 60: 1197-1201. [Abstract] [Full Text] [PDF]  

Nuclear Factor-B/Rel Is Apoptogenic in Cytokine Withdrawal-induced Programmed Cell Death

U. Shivraj Sohur, Chih-Li Chen, Donna J. Hicks, Fiona E. Yull, and Lawrence D. Kerr
Cancer Res 2000 60: 1202-1205. [Abstract] [Full Text] [PDF]  

Major Improvement in the Efficacy of BRCA1 Mutation Screening Using Morphoclinical Features of Breast Cancer

Rosette Lidereau, François Eisinger, Marie-Hélène Champème, Catherine Noguès, Ivan Bièche, Daniel Birnbaum, Claude Pallud, Jocelyne Jacquemier, and Hagay Sobol
Cancer Res 2000 60: 1206-1210. [Abstract] [Full Text] [PDF]  

Loss of pRb Expression in Pituitary Adenomas Is Associated with Methylation of the RB1 CpG Island

David J. Simpson, Nigel A. Hibberts, Anne Marie McNicol, Richard N. Clayton, and William E. Farrell
Cancer Res 2000 60: 1211-1216. [Abstract] [Full Text] [PDF]  

CD95 (Fas/APO-1) and p53 Signal Apoptosis Independently in Diverse Cell Types

Liam O’Connor, Alan W. Harris, and Andreas Strasser
Cancer Res 2000 60: 1217-1220. [Abstract] [Full Text] [PDF]  

Fibroblast Growth Factor Receptor-1 -Exon Exclusion and Polypyrimidine Tract-binding Protein in Glioblastoma Multiforme Tumors

Wei Jin, Ian E. McCutcheon, Gregory N. Fuller, Eileen S-C. Huang, and Gilbert J. Cote
Cancer Res 2000 60: 1221-1224. [Abstract] [Full Text] [PDF]  

Inhibition of Constitutively Activated Stat3 Signaling Pathway Suppresses Growth of Prostate Cancer Cells

Zuyao Ni, Wei Lou, Eddy S. Leman, and Allen C. Gao
Cancer Res 2000 60: 1225-1228. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Tetrocarcin A Inhibits Mitochondrial Functions of Bcl-2 and Suppresses Its Anti-apoptotic Activity

Takayuki Nakashima, Masayuki Miura, and Mitsunobu Hara
Cancer Res 2000 60: 1229-1235. [Abstract] [Full Text] [PDF]  

The Tumor Growth-inhibiting Cell Adhesion Molecule CEACAM1 (C-CAM) Is Differently Expressed in Proliferating and Quiescent Epithelial Cells and Regulates Cell Proliferation

Bernhard B. Singer, Inka Scheffrahn, and Björn Öbrink
Cancer Res 2000 60: 1236-1244. [Abstract] [Full Text] [PDF]  

DNA-dependent Protein Kinase Stimulates an Independently Active, Nonhomologous, End-Joining Apparatus

Steven J. DiBiase, Zhao-Chong Zeng, Richard Chen, Terry Hyslop, Walter J. Curran, Jr., and George Iliakis
Cancer Res 2000 60: 1245-1253. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Irradiated Mammary Gland Stroma Promotes the Expression of Tumorigenic Potential by Unirradiated Epithelial Cells

Mary Helen Barcellos-Hoff and Shraddha A. Ravani
Cancer Res 2000 60: 1254-1260. [Abstract] [Full Text] [PDF]  

Overexpression of Human Aspartyl (Asparaginyl) ß-Hydroxylase Is Associated with Malignant Transformation

Nedim Ince, Suzanne M. de la Monte, and Jack R. Wands
Cancer Res 2000 60: 1261-1266. [Abstract] [Full Text] [PDF]  

Sensitivity of the Cervical Transformation Zone to Estrogen-induced Squamous Carcinogenesis

David A. Elson, Rebeccah R. Riley, Ama Lacey, Gudmundur Thordarson, Frank J. Talamantes, and Jeffrey M. Arbeit
Cancer Res 2000 60: 1267-1275. [Abstract] [Full Text] [PDF]  

Detection of DNA Alkylphosphotriesters by ³²P Postlabeling: Evidence for the Nonrandom Manifestation of Phosphotriester Lesions in Vivo

Yves Guichard, George D. D. Jones, and Peter B. Farmer
Cancer Res 2000 60: 1276-1282. [Abstract] [Full Text] [PDF]  

The Food-derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Activates S-Phase Checkpoint and Apoptosis, and Induces Gene Mutation in Human Lymphoblastoid TK6 Cells

Huijun Zhu, Alan R. Boobis, and Nigel J Gooderham
Cancer Res 2000 60: 1283-1289. [Abstract] [Full Text] [PDF]  

Factors Underlying the Cell Growth-related Bystander Responses to Particles

Rashi Iyer and Bruce E. Lehnert
Cancer Res 2000 60: 1290-1298. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Increased Urinary Excretion of 2-Hydroxyestrone but not 16-Hydroxyestrone in Premenopausal Women during a Soya Diet Containing Isoflavones

Lee-Jane W. Lu, Melanie Cree, Shylaja Josyula, Manubai Nagamani, James J. Grady, and Karl E. Anderson
Cancer Res 2000 60: 1299-1305. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Antiangiogenic and Antitumor Activities of Cyclooxygenase-2 Inhibitors

Jaime L. Masferrer, Kathleen M. Leahy, Alane T. Koki, Ben S. Zweifel, Steven L. Settle, B. Mark Woerner, Dorothy A. Edwards, Amy G. Flickinger, Rosalyn J. Moore, and Karen Seibert
Cancer Res 2000 60: 1306-1311. [Abstract] [Full Text] [PDF]  

Copper-transporting P-Type Adenosine Triphosphatase (ATP7B) Is Associated with Cisplatin Resistance

Masaharu Komatsu, Tomoyuki Sumizawa, Masato Mutoh, Zhe-Sheng Chen, Kunihiko Terada, Tatsuhiko Furukawa, Xiao-Li Yang, Hui Gao, Naoyuki Miura, Toshihiro Sugiyama, and Shin-ichi Akiyama
Cancer Res 2000 60: 1312-1316. [Abstract] [Full Text] [PDF]  

Cdc25 Inhibition and Cell Cycle Arrest by a Synthetic Thioalkyl Vitamin K Analogue

Kenji Tamura, Eileen C. Southwick, Jeffrey Kerns, Katherine Rosi, Brian I. Carr, Craig Wilcox, and John S. Lazo
Cancer Res 2000 60: 1317-1325. [Abstract] [Full Text] [PDF]  

Preferential Enhancement of Tumor Radioresponse by a Cyclooxygenase-2 Inhibitor

Kazushi Kishi, Sven Petersen, Cordula Petersen, Nancy Hunter, Kathryn Mason, Jaime L. Masferrer, Philip J. Tofilon, and Luka Milas
Cancer Res 2000 60: 1326-1331. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

A Role for Id-1 in the Aggressive Phenotype and Steroid Hormone Response of Human Breast Cancer Cells

Claudia Qiao Lin, Jarnail Singh, Kenji Murata, Yoko Itahana, Simona Parrinello, Scott H. Liang, Cheryl E. Gillett, Judith Campisi, and Pierre-Yves Desprez
Cancer Res 2000 60: 1332-1340. [Abstract] [Full Text] [PDF]  

A Minimal Critical Region of the 8p22–23 Amplicon in Esophageal Adenocarcinomas Defined Using Sequence Tagged Site-Amplification Mapping and Quantitative Polymerase Chain Reaction Includes the GATA-4 Gene

Lin Lin, Sanjeev Aggarwal, Thomas W. Glover, Mark B. Orringer, Samir Hanash, and David G. Beer
Cancer Res 2000 60: 1341-1347. [Abstract] [Full Text] [PDF]  

Prostate-specific Transcription Factor hPSE Is Translated Only in Normal Prostate Epithelial Cells

Masahiro Nozawa, Kentaro Yomogida, Nobufumi Kanno, Norio Nonomura, Tsuneharu Miki, Akihiko Okuyama, Yoshitake Nishimune, and Masami Nozaki
Cancer Res 2000 60: 1348-1352. [Abstract] [Full Text] [PDF]  

Identification of a Human Glioma-associated Growth Factor Gene, granulin, Using Differential Immuno-absorption

Linda M. Liau, Roger L. Lallone, Robert S. Seitz, Alexei Buznikov, Jeff P. Gregg, Harley I. Kornblum, Stanley F. Nelson, and Jeff M. Bronstein
Cancer Res 2000 60: 1353-1360. [Abstract] [Full Text] [PDF]  

BRCA1-related Papillary Serous Carcinoma of the Peritoneum Has a Unique Molecular Pathogenesis

John O. Schorge, Michael G. Muto, Sandra J. Lee, Lee-Wen Huang, William R. Welch, Debra A. Bell, Emily Z. Keung, Ross S. Berkowitz, and Samuel C. Mok
Cancer Res 2000 60: 1361-1364. [Abstract] [Full Text] [PDF]  

High Levels of Tyrosine Phosphorylated Proto-Ret in Sporadic Pheochromocytomas

Hervé Le Hir, Luca G. Colucci-D’Amato, Nicolas Charlet-Berguerand, Pierre-François Plouin, Xavier Bertagna, Vittorio de Franciscis, and Claude Thermes
Cancer Res 2000 60: 1365-1370. [Abstract] [Full Text] [PDF]  

BRCA1 and BRCA2 Have a Limited Role in Familial Prostate Cancer

Colleen Schehl Sinclair, Rebecca Berry, Daniel Schaid, Stephen N. Thibodeau, and Fergus J. Couch
Cancer Res 2000 60: 1371-1375. [Abstract] [Full Text] [PDF]  

Class A Helix-Loop-Helix Proteins Are Positive Regulators of Several Cyclin-dependent Kinase Inhibitors’ Promoter Activity and Negatively Affect Cell Growth

Alfredo Pagliuca, Pasquale Gallo, Pasquale De Luca, and Luigi Lania
Cancer Res 2000 60: 1376-1382. [Abstract] [Full Text] [PDF]  

Diversity and Frequency of Epidermal Growth Factor Receptor Mutations in Human Glioblastomas

Lori Frederick, Xiao-Yang Wang, Greg Eley, and C. David James
Cancer Res 2000 60: 1383-1387. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Heterogeneity of Angiogenesis and Blood Vessel Maturation in Human Tumors: Implications for Antiangiogenic Tumor Therapies

Anne Eberhard, Sebastian Kahlert, Valentin Goede, Bernhard Hemmerlein, Karl H. Plate, and Hellmut G. Augustin
Cancer Res 2000 60: 1388-1393. [Abstract] [Full Text] [PDF]  

Autocrine Stimulatory Mechanism by Transforming Growth Factor ß in Human Hepatocellular Carcinoma

Koichi Matsuzaki, Masataka Date, Fukiko Furukawa, Yoshiya Tahashi, Masanori Matsushita, Kazushige Sakitani, Noriyo Yamashiki, Toshihito Seki, Hidetsugu Saito, Mikio Nishizawa, Junichi Fujisawa, and Kyoichi Inoue
Cancer Res 2000 60: 1394-1402. [Abstract] [Full Text] [PDF]  

Identification of the Putative Brain Tumor Antigen BF7/GE2 as the (De)Toxifying Enzyme Microsomal Epoxide Hydrolase

Reto Kessler, Marie-France Hamou, Michele Albertoni, Nicolas de Tribolet, Michael Arand, and Erwin G. Van Meir
Cancer Res 2000 60: 1403-1409. [Abstract] [Full Text] [PDF]  

Expression of Sialyl 6-Sulfo Lewis X Is Inversely Correlated with Conventional Sialyl Lewis X Expression in Human Colorectal Cancer

Mineko Izawa, Kensuke Kumamoto, Chikako Mitsuoka, Akiko Kanamori, Katsuyuki Ohmori, Hiroji Ishida, Shigeo Nakamura, Kazumi Kurata-Miura, Katsutoshi Sasaki, Tatsunari Nishi, and Reiji Kannagi
Cancer Res 2000 60: 1410-1416. [Abstract] [Full Text] [PDF]  

A Mechanistic, Predictive Model of Dose-Response Curves for Cell Cycle Phase-specific and -nonspecific Drugs

Shea N. Gardner
Cancer Res 2000 60: 1417-1425. [Abstract] [Full Text] [PDF]  

Sulforaphane, a Naturally Occurring Isothiocyanate, Induces Cell Cycle Arrest and Apoptosis in HT29 Human Colon Cancer Cells

Laurence Gamet-Payrastre, Pengfei Li, Solange Lumeau, Georges Cassar, Marie-Ange Dupont, Sylvie Chevolleau, Nicole Gasc, Jacques Tulliez, and François Tercé
Cancer Res 2000 60: 1426-1433. [Abstract] [Full Text] [PDF]  

Estrogen Receptors in Human Myeloma Cells

Takemi Otsuki, Osamu Yamada, Junichi Kurebayashi, Takuya Moriya, Haruko Sakaguchi, Hironori Kunisue, Kenichiro Yata, Masako Uno, Yoshihito Yawata, and Ayako Ueki
Cancer Res 2000 60: 1434-1441. [Abstract] [Full Text] [PDF]  

Local Imbalance of Proangiogenic and Antiangiogenic Factors: A Potential Mechanism of Focal Necrosis and Dormancy in Tumors

Saroja Ramanujan, Gerald C. Koenig, Timothy P. Padera, Brian R. Stoll, and Rakesh K. Jain
Cancer Res 2000 60: 1442-1448. [Abstract] [Full Text] [PDF]  

Restoration of (1,2) Fucosyltransferase Activity Decreases Adhesive and Metastatic Properties of Human Pancreatic Cancer Cells

Muriel Aubert, Laurence Panicot, Christian Crotte, Patrick Gibier, Dominique Lombardo, Marie-Odile Sadoulet, and Eric Mas
Cancer Res 2000 60: 1449-1456. [Abstract] [Full Text] [PDF]  

Virology:

Overexpression of PTEN/MMAC1 and Decreased Activation of Akt in Human Papillomavirus-infected Laryngeal Papillomas

Ping Zhang and Bettie M. Steinberg
Cancer Res 2000 60: 1457-1462. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: Q-R. Chen et al., Liposomes Complexed to Plasmids Encoding Angiostatin and Endostatin Inhibit Breast Cancer in Nude Mice. Cancer Res., 59: 3308–3312, 1999.

Andrew L. Feldman, Steven K. Libutti, and A. James Mixson
Cancer Res 2001 60: 1463-1464. [Full Text] [PDF]  

Meeting Reports:

Summary of the International Cancer Microenvironment from Meeting in Pittsburgh, Pennsylvania on October 3–6, 1999

Ronald B. Herberman and Theresa L. Whiteside
Cancer Res 2000 60: 1465-1469. [Full Text] [PDF]  

Errata:

A. P. McGlynn et al. 59: 5912–5916

Cancer Res 2000 60: 1472 [Full Text] [PDF]  

A. Bonati et al. 60: 728–732

Cancer Res 2000 60: 1472 [Full Text] [PDF]  

Correction:

S. Bettuzi et al. 60: 28–34

Cancer Res 2000 60: 1472 [Full Text] [PDF]  

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