Review:

Genetics and Biology of Adult Human Male Germ Cell Tumors

R. S. K. Chaganti and Jane Houldsworth
Cancer Res 2000 60: 1475-1482. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Nuclear Expression of the c-erbB-4/HER-4 Growth Factor Receptor in Invasive Breast Cancers

Radhika Srinivasan, Cheryl E. Gillett, Diana M. Barnes, and William J. Gullick
Cancer Res 2000 60: 1483-1487. [Abstract] [Full Text] [PDF]  

Monitoring of Herpes Simplex Virus Thymidine Kinase Enzyme Activity Using Positron Emission Tomography

Geke A. P. Hospers, Anna Calogero, Aren van Waarde, Petra Doze, Willem Vaalburg, Nanno H. Mulder, and Erik F. J. de Vries
Cancer Res 2000 60: 1488-1491. [Abstract] [Full Text] [PDF]  

Fusogenic Membrane Glycoproteins As a Novel Class of Genes for the Local and Immune-mediated Control of Tumor Growth

Andrew Bateman, Francis Bullough, Stephen Murphy, Lisa Emiliusen, Dimitri Lavillette, François-Loic Cosset, Roberto Cattaneo, Stephen J. Russell, and Richard G. Vile
Cancer Res 2000 60: 1492-1497. [Abstract] [Full Text] [PDF]  

Cell Permeable Bcl-2 Binding Peptides: A Chemical Approach to Apoptosis Induction in Tumor Cells

Jia-Lun Wang, Zhi-Jia Zhang, Swati Choksi, Simei Shan, Zhixian Lu, Carlo M. Croce, Emad S. Alnemri, Robert Korngold, and Ziwei Huang
Cancer Res 2000 60: 1498-1502. [Abstract] [Full Text] [PDF]  

Antiangiogenic Gene Therapy of Cancer Utilizing a Recombinant Adenovirus to Elevate Systemic Endostatin Levels in Mice

Andrew L. Feldman, Nicholas P. Restifo, H. Richard Alexander, David L. Bartlett, Patrick Hwu, Prem Seth, and Steven K. Libutti
Cancer Res 2000 60: 1503-1506. [Abstract] [Full Text] [PDF]  

Deoxyguanosine Adducts of t-4-Hydroxy-2-nonenal Are Endogenous DNA Lesions in Rodents and Humans: Detection and Potential Sources

Fung-Lung Chung, Raghu G. Nath, Joseph Ocando, Akiyoshi Nishikawa, and Lei Zhang
Cancer Res 2000 60: 1507-1511. [Abstract] [Full Text] [PDF]  

Eradication Diminishes Enhancing Effects of Helicobacter pylori Infection on Glandular Stomach Carcinogenesis in Mongolian Gerbils

Nobuyuki Shimizu, Yuzuru Ikehara, Ken-ichi Inada, Hayao Nakanishi, Tetsuya Tsukamoto, Koji Nozaki, Michio Kaminishi, Shu Kuramoto, Atsushi Sugiyama, Tsutomu Katsuyama, and Masae Tatematsu
Cancer Res 2000 60: 1512-1514. [Abstract] [Full Text] [PDF]  

Eradication of Disseminated Lymphomas with CpG-DNA Activated T Helper Type 1 Cells from Nontransgenic Mice

Oliver Egeter, Ralph Mocikat, Kamran Ghoreschi, Andreas Dieckmann, and Martin Röcken
Cancer Res 2000 60: 1515-1520. [Abstract] [Full Text] [PDF]  

Abnormal RNA Expression of 11p15 Imprinted Genes and Kidney Developmental Genes in Wilms’ Tumor

Christine Schwienbacher, Adriano Angioni, Rosaria Scelfo, Angelo Veronese, George A. Calin, Gabriella Massazza, Izumo Hatada, Giuseppe Barbanti-Brodano, and Massimo Negrini
Cancer Res 2000 60: 1521-1525. [Abstract] [Full Text] [PDF]  

Layered Expression Scanning: Rapid Molecular Profiling of Tumor Samples

Chad R. Englert, Galina V. Baibakov, and Michael R. Emmert-Buck
Cancer Res 2000 60: 1526-1530. [Abstract] [Full Text] [PDF]  

Potential Role of BRCA2 in a Mitotic Checkpoint after Phosphorylation by hBUBR1

Manabu Futamura, Hirofumi Arakawa, Koichi Matsuda, Toyomasa Katagiri, Shigetoyo Saji, Yoshio Miki, and Yusuke Nakamura
Cancer Res 2000 60: 1531-1535. [Abstract] [Full Text] [PDF]  

EWS-FLI1, EWS-ERG, and EWS-ETV1 Oncoproteins of Ewing Tumor Family All Suppress Transcription of Transforming Growth Factor ß Type II Receptor Gene

Young-Hyuck Im, Heung Tae Kim, Cecile Lee, Danielle Poulin, Scott Welford, Poul H. B. Sorensen, Christopher T. Denny, and Seong-Jin Kim
Cancer Res 2000 60: 1536-1540. [Abstract] [Full Text] [PDF]  

Modulation of Hypoxia-inducible Factor 1 Expression by the Epidermal Growth Factor/Phosphatidylinositol 3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for Tumor Angiogenesis and Therapeutics

Hua Zhong, Kelly Chiles, David Feldser, Erik Laughner, Colleen Hanrahan, Maria-Magdalena Georgescu, Jonathan W. Simons, and Gregg L. Semenza
Cancer Res 2000 60: 1541-1545. [Abstract] [Full Text] [PDF]  

Coordinate Up-Regulation of Sp1 DNA-binding Activity and Urokinase Receptor Expression in Breast Carcinoma

Antonella Zannetti, Silvana Del Vecchio, Maria V. Carriero, Rosa Fonti, Paola Franco, Gerardo Botti, Giuseppe D’Aiuto, M. Patrizia Stoppelli, and Marco Salvatore
Cancer Res 2000 60: 1546-1551. [Abstract] [Full Text] [PDF]  

Transfection of Constitutively Active Mitogen-activated Protein/Extracellular Signal-regulated Kinase Kinase Confers Tumorigenic and Metastatic Potentials to NIH3T3 Cells

Danny R. Welch, Toshiyuki Sakamaki, Ralph Pioquinto, Timothy O. Leonard, Steven F. Goldberg, Qiufang Hon, Raymond L. Erikson, Manuel Rieber, Mary Strasberg Rieber, Deana J. Hicks, Joseph V. Bonventre, and Alessandro Alessandrini
Cancer Res 2000 60: 1552-1556. [Abstract] [Full Text] [PDF]  

Adenovirus E1A Does Not Induce the Ewing Tumor-associated Gene Fusion EWS-FLI1

Heinrich Kovar, Frits J. Fallaux, Ingrid Pribill, Dragana Jugovic, Stefan Bartl, Peter F. Ambros, Dave N. T. Aryee, Joop C. A. G. Wiegant, and Rob C. Hoeben
Cancer Res 2000 60: 1557-1560. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Constitutive Expression of Insulin-like Growth Factor-1 in Epidermal Basal Cells of Transgenic Mice Leads to Spontaneous Tumor Promotion

John DiGiovanni, David K. Bol, Erik Wilker, Linda Beltrán, Steve Carbajal, Samantha Moats, Angel Ramirez, José Jorcano, and Kaoru Kiguchi
Cancer Res 2000 60: 1561-1570. [Abstract] [Full Text] [PDF]  

Genotype-specific Trp53 Mutational Analysis in Ultraviolet B Radiation-induced Skin Cancers in Xpc and Xpc Trp53 Mutant Mice

Antonio M. Reis, David L. Cheo, Lisiane B. Meira, Marc S. Greenblatt, Jeffrey P. Bond, Dorit Nahari, and Errol C. Friedberg
Cancer Res 2000 60: 1571-1579. [Abstract] [Full Text] [PDF]  

Ultraviolet B Radiation-induced Skin Cancer in Mice Defective in the Xpc, Trp53, and Apex (HAP1) Genes: Genotype-specific Effects on Cancer Predisposition and Pathology of Tumors

David L. Cheo, Lisiane B. Meira, Dennis K. Burns, Antonio M. Reis, Tony Issac, and Errol C. Friedberg
Cancer Res 2000 60: 1580-1584. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Prognostic Significance of p53 Nuclear Accumulation in Localized Prostate Cancer Treated with Radical Prostatectomy

David I. Quinn, Susan M. Henshall, Darren R. Head, David Golovsky, J. David Wilson, Phillip C. Brenner, Jennifer J. Turner, Warick Delprado, John F. Finlayson, Phillip D. Stricker, John J. Grygiel, and Robert L. Sutherland
Cancer Res 2000 60: 1585-1594. [Abstract] [Full Text] [PDF]  

Prognostic Significance of the Metastasis-inducing Protein S100A4 (p9Ka) in Human Breast Cancer

Philip S. Rudland, Angela Platt-Higgins, Christine Renshaw, Christopher R. West, John H. R. Winstanley, Lynne Robertson, and Roger Barraclough
Cancer Res 2000 60: 1595-1603. [Abstract] [Full Text] [PDF]  

Endocrinology:

Peroxisome Proliferator-activated Receptor Ligands Inhibit Estrogen Biosynthesis in Human Breast Adipose Tissue: Possible Implications for Breast Cancer Therapy

Gary L. Rubin, Ying Zhao, Allan M. Kalus, and Evan R. Simpson
Cancer Res 2000 60: 1604-1608. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Normal Bronchial Epithelial Cell Expression of Glutathione Transferase P1, Glutathione Transferase M3, and Glutathione Peroxidase Is Low in Subjects with Bronchogenic Carcinoma

Erin L. Crawford, Sadik A. Khuder, Samual J. Durham, Mark Frampton, Mark Utell, William G. Thilly, David A. Weaver, William J. Ferencak, Constance A. Jennings, Jeffrey R. Hammersley, Daniel A. Olson, and James C. Willey
Cancer Res 2000 60: 1609-1618. [Abstract] [Full Text] [PDF]  

Chromosomal Aberrations in Lymphocytes Predict Human Cancer Independently of Exposure to Carcinogens

Stefano Bonassi, Lars Hagmar, Ulf Strömberg, Alicia Huici Montagud, Håkan Tinnerberg, Alessandra Forni, Pirjo Heikkilä, Saskia Wanders, Peter Wilhardt, Inger-Lise Hansteen, Lisbeth E. Knudsen, and Hannu Norppa
Cancer Res 2000 60: 1619-1625. [Abstract] [Full Text] [PDF]  

Association of SRD5A2 Genotype and Pathological Characteristics of Prostate Tumors

Julie M. Jaffe, S. Bruce Malkowicz, Amy H. Walker, Sam MacBride, Richard Peschel, John Tomaszewski, Keith Van Arsdalen, Alan J. Wein, and Timothy R. Rebbeck
Cancer Res 2000 60: 1626-1630. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Synergistic Enhancement of Herpes Simplex Virus Thymidine Kinase/Ganciclovir-mediated Cytotoxicity by Hydroxyurea

Paul D. Boucher, Leo J. Ostruszka, and Donna S. Shewach
Cancer Res 2000 60: 1631-1636. [Abstract] [Full Text] [PDF]  

Photodynamic Therapy-mediated Oxidative Stress as a Molecular Switch for the Temporal Expression of Genes Ligated to the Human Heat Shock Promoter

Marian C. Luna, Angela Ferrario, Sam Wong, Anita M. R. Fisher, and Charles J. Gomer
Cancer Res 2000 60: 1637-1644. [Abstract] [Full Text] [PDF]  

The Role of Apaf-1, Caspase-9, and Bid Proteins in Etoposide- or Paclitaxel-induced Mitochondrial Events during Apoptosis

Charles L. Perkins, Guofu Fang, Caryn Nae Kim, and Kapil N. Bhalla
Cancer Res 2000 60: 1645-1653. [Abstract] [Full Text] [PDF]  

Immunology:

Heterogeneous Expression of the SSX Cancer/Testis Antigens in Human Melanoma Lesions and Cell Lines

Nuno R. dos Santos, Ruurd Torensma, Teunis J. de Vries, Marco W. J. Schreurs, Diederik R. H. de Bruijn, Ellen Kater-Baats, Dirk J. Ruiter, Gosse J. Adema, Goos N. P. van Muijen, and Ad Geurts van Kessel
Cancer Res 2000 60: 1654-1662. [Abstract] [Full Text] [PDF]  

Preclinical Evaluation of "Whole" Cell Vaccines for Prophylaxis and Therapy Using a Disabled Infectious Single Cycle-Herpes Simplex Virus Vector to Transduce Cytokine Genes

S. A. Ali, C. S. McLean, M. E. G. Boursnell, G. Martin, C. L. Holmes, S. Reeder, C. Entwisle, D. M. Blakeley, J. G. Shields, S. Todryk, R. Vile, R. A. Robins, and R. C. Rees
Cancer Res 2000 60: 1663-1670. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

The ß-Catenin Binding Domain of Adenomatous Polyposis Coli Is Sufficient for Tumor Suppression

Ie-Ming Shih, Jian Yu, Tong-Chuan He, Bert Vogelstein, and Kenneth W. Kinzler
Cancer Res 2000 60: 1671-1676. [Abstract] [Full Text] [PDF]  

Identification of Differentially Expressed Genes in Human Prostate Cancer Using Subtraction and Microarray

Jiangchun Xu, John A. Stolk, Xinqun Zhang, Sandra J. Silva, Raymond L. Houghton, Masazumi Matsumura, Thomas S. Vedvick, Kevin B. Leslie, Roberto Badaro, and Steven G. Reed
Cancer Res 2000 60: 1677-1682. [Abstract] [Full Text] [PDF]  

Chromosomal Fragile Site FRA16D and DNA Instability in Cancer

Marie Mangelsdorf, Karin Ried, Erica Woollatt, Sonia Dayan, Helen Eyre, Merran Finnis, Lynne Hobson, Julie Nancarrow, Deon Venter, Elizabeth Baker, and Robert I. Richards
Cancer Res 2000 60: 1683-1689. [Abstract] [Full Text] [PDF]  

A 700-kb Physical Map of a Region of 16q23.2 Homozygously Deleted in Multiple Cancers and Spanning the Common Fragile Site FRA16D

Adam J. W. Paige, Karen J. Taylor, Aengus Stewart, John G. Sgouros, Hani Gabra, Grant C. Sellar, John F. Smyth, David J. Porteous, and J. E. Vivienne Watson
Cancer Res 2000 60: 1690-1697. [Abstract] [Full Text] [PDF]  

Somatic Mutation Rates and Specificities at TC/AG and GT/CA Microsatellite Sequences in Nontumorigenic Human Lymphoblastoid Cells

Suzanne E. Hile, Guang Yan, and Kristin A. Eckert
Cancer Res 2000 60: 1698-1703. [Abstract] [Full Text] [PDF]  

DMBT1 Encodes a Protein Involved in the Immune Defense and in Epithelial Differentiation and Is Highly Unstable in Cancer

Jan Mollenhauer, Stephan Herbertz, Uffe Holmskov, Markus Tolnay, Inge Krebs, Adrian Merlo, Henrik Daa Schrøder, Daniel Maier, Frank Breitling, Stefan Wiemann, Hermann-Josef Gröne, and Annemarie Poustka
Cancer Res 2000 60: 1704-1710. [Abstract] [Full Text] [PDF]  

A DNA Damage Signal Is Required for p53 to Activate gadd45

Gu Xiao, Agustin Chicas, Magali Olivier, Yoichi Taya, Sanjay Tyagi, Fred Rusell Kramer, and Jill Bargonetti
Cancer Res 2000 60: 1711-1719. [Abstract] [Full Text] [PDF]  

Both Normal and Transforming PCPH Proteins Have Guanosine Diphosphatase Activity But Only the Oncoprotein Cooperates with Ras in Activating Extracellular Signal-regulated Kinase ERK1

Juan A. Recio, J. Guillermo Páez, Baishali Maskeri, Mark Loveland, Juan A. Velasco, and Vicente Notario
Cancer Res 2000 60: 1720-1728. [Abstract] [Full Text] [PDF]  

Respective Roles of Cyclobutane Pyrimidine Dimers, (6–4)Photoproducts, and Minor Photoproducts in Ultraviolet Mutagenesis of Repair-deficient Xeroderma Pigmentosum A Cells

Eriko Otoshi, Takashi Yagi, Toshio Mori, Tsukasa Matsunaga, Osamu Nikaido, Sang-Tae Kim, Kenichi Hitomi, Mituo Ikenaga, and Takeshi Todo
Cancer Res 2000 60: 1729-1735. [Abstract] [Full Text] [PDF]  

TSG101 Protein Steady-State Level Is Regulated Posttranslationally by an Evolutionarily Conserved COOH-Terminal Sequence

Guo Hong Feng, Chih-Jian Lih, and Stanley N. Cohen
Cancer Res 2000 60: 1736-1741. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Effect of Cyclooxygenase and Nitric Oxide Synthase Inhibitors on Tumor Growth in Mouse Tumor Models with and without Cancer Cachexia Related to Prostanoids

Christian Cahlin, Johan Gelin, Dick Delbro, Christina Lönnroth, Chiharu Doi, and Kent Lundholm
Cancer Res 2000 60: 1742-1749. [Abstract] [Full Text] [PDF]  

Frequency and Prognostic Impact of Microsatellite Instability in a Large Population-based Study of Endometrial Carcinomas

Nicola D. MacDonald, Helga B. Salvesen, Andrew Ryan, Ole-Erik Iversen, Lars A. Akslen, and Ian J. Jacobs
Cancer Res 2000 60: 1750-1752. [Abstract] [Full Text] [PDF]  

Role of Mitogen-activated Protein Kinases in the Induction of Parathyroid Hormone-related Peptide

Fasika Aklilu, Julienne Gladu, David Goltzman, and Shafaat A. Rabbani
Cancer Res 2000 60: 1753-1760. [Abstract] [Full Text] [PDF]  

Continuous Administration of Angiostatin Inhibits Accelerated Growth of Colorectal Liver Metastases after Partial Hepatectomy

Tom A. Drixler, Inne H. M. Borel Rinkes, Ewan D. Ritchie, Theo J. M. V. van Vroonhoven, Martijn F. B. G. Gebbink, and Emile E. Voest
Cancer Res 2000 60: 1761-1765. [Abstract] [Full Text] [PDF]  

Fas Drives Cell Cycle Progression in Glioma Cells via Extracellular Signal-regulated Kinase Activation

Hisaaki Shinohara, Hideo Yagita, Yoji Ikawa, and Naoki Oyaizu
Cancer Res 2000 60: 1766-1772. [Abstract] [Full Text] [PDF]  

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