Review:

Nuclear Structure-Gene Expression Interrelationships: Implications for Aberrant Gene Expression in Cancer

Gary S. Stein, Martin Montecino, André J. van Wijnen, Janet L. Stein, and Jane B. Lian
Cancer Res 2000 60: 2067-2076. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Adenoma-specific Alterations of Protein Kinase C Isozyme Expression in Apc^MIN Mice

Irene K. Klein, Steven R. Ritland, Lawrence J. Burgart, Steven C. Ziesmer, Patrick C. Roche, Sandra J. Gendler, and William E. Karnes, Jr.
Cancer Res 2000 60: 2077-2080. [Abstract] [Full Text] [PDF]  

Flt3-Ligand Induces Transient Tumor Regression in an Ectopic Treatment Model of Major Histocompatibility Complex-negative Prostate Cancer

Richard P. Ciavarra, Kenneth D. Somers, Roy R. Brown, William F. Glass, Patricia J. deAngelis Consolvo, George L. Wright, and Paul F. Schellhammer
Cancer Res 2000 60: 2081-2084. [Abstract] [Full Text] [PDF]  

Sulindac and Exisulind Exhibit a Significant Antiproliferative Effect and Induce Apoptosis in Human Hepatocellular Carcinoma Cell Lines

Md Atiqur Rahman, Dipok Kumar Dhar, Reiko Masunaga, Akira Yamanoi, Hitoshi Kohno, and Naofumi Nagasue
Cancer Res 2000 60: 2085-2089. [Abstract] [Full Text] [PDF]  

Identification of a Geldanamycin Dimer That Induces the Selective Degradation of HER-Family Tyrosine Kinases

Fuzhong F. Zheng, Scott D. Kuduk, Gabriela Chiosis, Pamela N. Münster, Laura Sepp-Lorenzino, Samuel J. Danishefsky, and Neal Rosen
Cancer Res 2000 60: 2090-2094. [Abstract] [Full Text] [PDF]  

Regulation of TCL1 Expression in B- and T-Cell Lymphomas and Reactive Lymphoid Tissues

Maria Grazia Narducci, Edoardo Pescarmona, Cristina Lazzeri, Sabina Signoretti, Anna Maria Lavinia, Daniele Remotti, Enrico Scala, Carlo David Baroni, Antonella Stoppacciaro, Carlo Maria Croce, and Giandomenico Russo
Cancer Res 2000 60: 2095-2100. [Abstract] [Full Text] [PDF]  

Chemoprevention of Breast Cancer in Rats by Celecoxib, a Cyclooxygenase 2 Inhibitor

Randall E. Harris, Galal A. Alshafie, Hussein Abou-Issa, and Karen Seibert
Cancer Res 2000 60: 2101-2103. [Abstract] [Full Text] [PDF]  

U0126 Reverses Ki-ras-mediated Transformation by Blocking Both Mitogen-activated Protein Kinase and p70 S6 Kinase Pathways

Hidesuke Fukazawa and Yoshimasa Uehara
Cancer Res 2000 60: 2104-2107. [Abstract] [Full Text] [PDF]  

The Radiosensitizing Agent 7-Hydroxystaurosporine (UCN-01) Inhibits the DNA Damage Checkpoint Kinase hChk1

Ericka C. Busby, Dru F. Leistritz, Robert T. Abraham, Larry M. Karnitz, and Jann N. Sarkaria
Cancer Res 2000 60: 2108-2112. [Abstract] [Full Text] [PDF]  

Alterations of the INK4a/ARF Locus in Human Intracranial Germ Cell Tumors

Masayuki Iwato, Osamu Tachibana, Yasuo Tohma, Yasuaki Arakawa, Hisashi Nitta, Mitsuhiro Hasegawa, Junkoh Yamashita, and Yutaka Hayashi
Cancer Res 2000 60: 2113-2115. [Abstract] [Full Text] [PDF]  

Expression of the hTERT Gene Is Regulated at the Level of Transcriptional Initiation and Repressed by Mad1

Çagatay Günes, Serge Lichtsteiner, Alain P. Vasserot, and Christoph Englert
Cancer Res 2000 60: 2116-2121. [Abstract] [Full Text] [PDF]  

Metabolites of 2'-Fluoro-2'-deoxy-D-glucose Detected by ¹⁹F Magnetic Resonance Spectroscopy in Vivo Predict Response of Murine RIF-1 Tumors to 5-Fluorouracil

Paul M. J. McSheehy, Martin O. Leach, Ian R. Judson, and John R. Griffiths
Cancer Res 2000 60: 2122-2127. [Abstract] [Full Text] [PDF]  

Irradiation of a Primary Tumor, Unlike Surgical Removal, Enhances Angiogenesis Suppression at a Distal Site: Potential Role of Host-Tumor Interaction

Alan C. Hartford, Takeshi Gohongi, Dai Fukumura, and Rakesh K. Jain
Cancer Res 2000 60: 2128-2131. [Abstract] [Full Text] [PDF]  

Interleukin 6 Activates Androgen Receptor-mediated Gene Expression through a Signal Transducer and Activator of Transcription 3-dependent Pathway in LNCaP Prostate Cancer Cells

Taosheng Chen, Li Hua Wang, and William L. Farrar
Cancer Res 2000 60: 2132-2135. [Abstract] [Full Text] [PDF]  

cdr2, a Target Antigen of Naturally Occurring Human Tumor Immunity, Is Widely Expressed in Gynecological Tumors

Jennifer C. Darnell, Matthew L. Albert, and Robert B. Darnell
Cancer Res 2000 60: 2136-2139. [Abstract] [Full Text] [PDF]  

WWOX, a Novel WW Domain-containing Protein Mapping to Human Chromosome 16q23.3–24.1, a Region Frequently Affected in Breast Cancer

Andrzej K. Bednarek, Kendra J. Laflin, Rachael L. Daniel, Qiaoyin Liao, Kathleen A. Hawkins, and C. Marcelo Aldaz
Cancer Res 2000 60: 2140-2145. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Expression of Proteins Coincident with Inducible Radioprotection in Human Lung Epithelial Cells

Simon C. Gamble, Michael J. Dunn, Colin H. Wheeler, Michael C. Joiner, Anita Adu-Poku, and Janet E. Arrand
Cancer Res 2000 60: 2146-2151. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Prognosis of Primary Testicular Seminoma: A Report on 57 New Cases

Keita Fujikawa, Yoshiyuki Matsui, Hiroya Oka, Shigeki Fukuzawa, Miharu Sasaki, and Hideo Takeuchi
Cancer Res 2000 60: 2152-2154. [Abstract] [Full Text] [PDF]  

Complete Sequencing of TP53 Predicts Poor Response to Systemic Therapy of Advanced Breast Cancer

Els M. J. J. Berns, John A. Foekens, Rolf Vossen, Maxime P. Look, Peter Devilee, Sonja C. Henzen-Logmans, Iris L. van Staveren, Wim L. J. van Putten, Mats Inganäs, Marion E. Meijer-van Gelder, Cees Cornelisse, Cassandra J. C. Claassen, Henk Portengen, Bert Bakker, and Jan G. M. Klijn
Cancer Res 2000 60: 2155-2162. [Abstract] [Full Text] [PDF]  

Endocrinology:

Cytochrome c Is Involved in Fas-mediated Apoptosis of Prostatic Carcinoma Cell Lines

Andreas Gewies, Oskar W. Rokhlin, and Michael B. Cohen
Cancer Res 2000 60: 2163-2168. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Suppression of Tumor Angiogenesis and Growth by Gene Transfer of a Soluble Form of Vascular Endothelial Growth Factor Receptor into a Remote Organ

Koichi Takayama, Hikaru Ueno, Yoichi Nakanishi, Taiji Sakamoto, Koji Inoue, Kiyoshi Shimizu, Hideya Oohashi, and Nobuyuki Hara
Cancer Res 2000 60: 2169-2177. [Abstract] [Full Text] [PDF]  

PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration

Jeanette M. Wood, Guido Bold, Elizabeth Buchdunger, Robert Cozens, Stefano Ferrari, Jörg Frei, Francesco Hofmann, Jürgen Mestan, Helmut Mett, Terence O’Reilly, Elke Persohn, Johannes Rösel, Christian Schnell, David Stover, Andreas Theuer, Harry Towbin, Fritz Wenger, Kathie Woods-Cook, Andreas Menrad, Gerhard Siemeister, Michael Schirner, Karl-Heinz Thierauch, Martin R. Schneider, Joachim Drevs, Georg Martiny-Baron, Frank Totzke, and Dieter Marmé
Cancer Res 2000 60: 2178-2189. [Abstract] [Full Text] [PDF]  

Synergy between Angiostatin and Endostatin: Inhibition of Ovarian Cancer Growth

Yumi Yokoyama, Mohanraj Dhanabal, Arjan W. Griffioen, Vikas P. Sukhatme, and S. Ramakrishnan
Cancer Res 2000 60: 2190-2196. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor-mediated Targeting of Chlorin e₆ Selectively Potentiates Its Photodynamic Activity

Antoon Gijsens, Ludwig Missiaen, Wilfried Merlevede, and Peter de Witte
Cancer Res 2000 60: 2197-2202. [Abstract] [Full Text] [PDF]  

E-7869 (R-Flurbiprofen) Inhibits Progression of Prostate Cancer in the TRAMP Mouse

William J. Wechter, Douglas D. Leipold, E. David Murray, Jr., David Quiggle, John D. McCracken, Robert S. Barrios, and Norman M. Greenberg
Cancer Res 2000 60: 2203-2208. [Abstract] [Full Text] [PDF]  

Immunology:

CC Chemokine Receptor-7 on Dendritic Cells Is Induced after Interaction with Apoptotic Tumor Cells: Critical Role in Migration from the Tumor Site to Draining Lymph Nodes

Motohiro Hirao, Nobuyuki Onai, Kazumasa Hiroishi, Simon C. Watkins, Kouji Matsushima, Paul D. Robbins, Michael T. Lotze, and Hideaki Tahara
Cancer Res 2000 60: 2209-2217. [Abstract] [Full Text] [PDF]  

Immune Deviation and Fas-mediated Deletion Limit Antitumor Activity after Multiple Dendritic Cell Vaccinations in Mice

Antoni Ribas, Lisa H. Butterfield, Billy Hu, Vivian B. Dissette, Wilson S. Meng, Andrew Koh, Kahlil J. Andrews, Maggie Lee, Saral N. Amar, John A. Glaspy, William H. McBride, and James S. Economou
Cancer Res 2000 60: 2218-2224. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

hMSH6 Alterations in Patients with Microsatellite Instability-Low Colorectal Cancer

Yann R. Parc, Kevin C. Halling, Liang Wang, Eric R. Christensen, Julie M. Cunningham, Amy J. French, Lawrence J. Burgart, Tammy L. Price-Troska, Patrick C. Roche, and Stephen N. Thibodeau
Cancer Res 2000 60: 2225-2231. [Abstract] [Full Text] [PDF]  

Linking Gene Expression Patterns to Therapeutic Groups in Breast Cancer

Katherine J. Martin, Brian M. Kritzman, Laura M. Price, Brian Koh, Chi-Pong Kwan, Xiaohong Zhang, Alan Mackay, Michael J. O’Hare, Carolyn M. Kaelin, George L. Mutter, Arthur B. Pardee, and Ruth Sager
Cancer Res 2000 60: 2232-2238. [Abstract] [Full Text] [PDF]  

The Normal patched Allele Is Expressed in Medulloblastomas from Mice with Heterozygous Germ-Line Mutation of patched

Cynthia Wetmore, Derek E. Eberhart, and Tom Curran
Cancer Res 2000 60: 2239-2246. [Abstract] [Full Text] [PDF]  

Ubiquitin/Proteasome Pathway Regulates Levels of Retinoic Acid Receptor and Retinoid X Receptor in Human Keratinocytes

Mohamed Boudjelal, Zengquan Wang, John J. Voorhees, and Gary J. Fisher
Cancer Res 2000 60: 2247-2252. [Abstract] [Full Text] [PDF]  

Molecular Markers in Blood as Surrogate Prognostic Indicators of Melanoma Recurrence

Dave S. B. Hoon, Peter Bostick, Christine Kuo, Tetsuro Okamoto, He-Jing Wang, Robert Elashoff, and Donald L. Morton
Cancer Res 2000 60: 2253-2257. [Abstract] [Full Text] [PDF]  

Dihydrotestosterone as a Selective Cellular/Nuclear Localization Vector for Anti-Gene Peptide Nucleic Acid in Prostatic Carcinoma Cells

Lidia C. Boffa, Sonia Scarfi’, Maria Rita Mariani, Gianluca Damonte, Vincent G. Allfrey, Umberto Benatti, and Patricia L. Morris
Cancer Res 2000 60: 2258-2262. [Abstract] [Full Text] [PDF]  

Insulin-like Growth Factor I Receptor Signaling in Differentiation of Neuronal H19-7 Cells

Andrea Morrione, Gaetano Romano, Magali Navarro, Krzysztof Reiss, Barbara Valentinis, Michael Dews, Eva Eves, Marsha Rich Rosner, and Renato Baserga
Cancer Res 2000 60: 2263-2272. [Abstract] [Full Text] [PDF]  

Enhanced Sensitivity to anti-Benzo(a)pyrene-diol-epoxide DNA Damage Correlates with Decreased Global Genomic Repair Attributable to Abrogated p53 Function in Human Cells

Manzoor A. Wani, Qianzheng Zhu, Mohammed El-Mahdy, Sundaresan Venkatachalam, and Altaf A. Wani
Cancer Res 2000 60: 2273-2280. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Thioredoxin Reductase, a Redox-active Selenoprotein, Is Secreted by Normal and Neoplastic Cells: Presence in Human Plasma

Anita Söderberg, Bita Sahaf, and Anders Rosén
Cancer Res 2000 60: 2281-2289. [Abstract] [Full Text] [PDF]  

Interleukin 8 Expression Regulates Tumorigenicity and Metastasis in Human Bladder Cancer

Keiji Inoue, Joel W. Slaton, Sun Jin Kim, Paul Perrotte, Beryl Y. Eve, Menashe Bar-Eli, Robert Radinsky, and Colin P. N. Dinney
Cancer Res 2000 60: 2290-2299. [Abstract] [Full Text] [PDF]  

Human Glioblastoma Cell Lines: Levels of Low-Density Lipoprotein Receptor and Low-Density Lipoprotein Receptor-related Protein

Lenka Maletínská, Eleanor A. Blakely, Kathleen A. Bjornstad, Dennis F. Deen, Laura J. Knoff, and Trudy M. Forte
Cancer Res 2000 60: 2300-2303. [Abstract] [Full Text] [PDF]  

Apoptosis Is Induced by the Active Metabolite of Vitamin D₃ and Its Analogue EB1089 in Colorectal Adenoma and Carcinoma Cells: Possible Implications for Prevention and Therapy

G. Darío Díaz, Christos Paraskeva, Mike G. Thomas, Lise Binderup, and Angela Hague
Cancer Res 2000 60: 2304-2312. [Abstract] [Full Text] [PDF]  

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