Advances in Brief:

Ligand Responsiveness in Human Prostate Cancer: Structural Analysis of Mutant Androgen Receptors from LNCaP and CWR22 Tumors

Shawn McDonald, Lars Brive, David B. Agus, Howard I. Scher, and Kathryn R. Ely
Cancer Res 2000 60: 2317-2322. [Abstract] [Full Text] [PDF]  

Inducible Chemoresistance to 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) in Colorectal Cancer Cells and a Xenograft Model Is Overcome by Inhibition of Nuclear Factor-B Activation

James C. Cusack, Jr., Rong Liu, and Albert S. Baldwin, Jr.
Cancer Res 2000 60: 2323-2330. [Abstract] [Full Text] [PDF]  

Nijmegen Breakage Syndrome Disease Protein and MRE11 at PML Nuclear Bodies and Meiotic Telomeres

David B. Lombard and Leonard Guarente
Cancer Res 2000 60: 2331-2334. [Abstract] [Full Text] [PDF]  

Molecular Anatomy of BCL6 Translocations Revealed by Long-Distance Polymerase Chain Reaction-based Assays

Hiroshi Akasaka, Takashi Akasaka, Masayuki Kurata, Chiyoko Ueda, Akira Shimizu, Takashi Uchiyama, and Hitoshi Ohno
Cancer Res 2000 60: 2335-2341. [Abstract] [Full Text] [PDF]  

The Fhit Tumor Suppressor Protein Regulates the Intracellular Concentration of Diadenosine Triphosphate but not Diadenosine Tetraphosphate

Gillian A. Murphy, Deborah Halliday, and Alexander G. McLennan
Cancer Res 2000 60: 2342-2344. [Abstract] [Full Text] [PDF]  

Specific c-kit Mutations in Sinonasal Natural Killer/T-Cell Lymphoma in China and Japan

Tadashi Hongyo, Ting Li, Mukh Syaifudin, Rajamanickam Baskar, Hirokazu Ikeda, Yuzuru Kanakura, Katsuyuki Aozasa, and Taisei Nomura
Cancer Res 2000 60: 2345-2347. [Abstract] [Full Text] [PDF]  

Progesterone Receptor Gene Polymorphism Is Associated with Decreased Risk for Breast Cancer by Age 50

Shan Wang-Gohrke, Jenny Chang-Claude, Heiko Becher, Dirk G. Kieback, and Ingo B. Runnebaum
Cancer Res 2000 60: 2348-2350. [Abstract] [Full Text] [PDF]  

Kinetics of Plasma Epstein-Barr Virus DNA during Radiation Therapy for Nasopharyngeal Carcinoma

Y. M. Dennis Lo, Sing-Fai Leung, Lisa Y. S. Chan, Anthony T. C. Chan, Kwok-Wai Lo, Philip J. Johnson, and Dolly P. Huang
Cancer Res 2000 60: 2351-2355. [Abstract] [Full Text] [PDF]  

Identification of Differential Methylation of the WT1 Antisense Regulatory Region and Relaxation of Imprinting in Wilms’ Tumor

Karim Malik, Ashreena Salpekar, Anne Hancock, Kim Moorwood, Sally Jackson, Adrian Charles, and Keith W. Brown
Cancer Res 2000 60: 2356-2360. [Abstract] [Full Text] [PDF]  

The Ras-Mitogen-activated Protein Kinase Pathway Is Critical for the Activation of Matrix Metalloproteinase Secretion and the Invasiveness in v-crk-transformed 3Y1

Enbo Liu, Aye Aye Thant, Fumitaka Kikkawa, Hisashi Kurata, Shinya Tanaka, Akihiro Nawa, Shigehiko Mizutani, Satoru Matsuda, Hidesaburo Hanafusa, and Michinari Hamaguchi
Cancer Res 2000 60: 2361-2364. [Abstract] [Full Text] [PDF]  

Levels of E2F-1 Expression Are Higher in Lung Metastasis of Colon Cancer As Compared with Hepatic Metastasis and Correlate with Levels of Thymidylate Synthase

Debabrata Banerjee, Richard Gorlick, Anna Liefshitz, Kathy Danenberg, Peter C. Danenberg, Peter V. Danenberg, David Klimstra, Suresh Jhanwar, Carlos Cordon-Cardo, Yuman Fong, Nancy Kemeny, and Joseph R. Bertino
Cancer Res 2000 60: 2365-2367. [Abstract] [Full Text] [PDF]  

Inactivation of the DNA Repair Gene O⁶-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation Is Associated with G to A Mutations in K-ras in Colorectal Tumorigenesis

Manel Esteller, Minoru Toyota, Montserrat Sanchez-Cespedes, Gabriel Capella, Miguel Angel Peinado, D. Neil Watkins, Jean-Pierre J. Issa, David Sidransky, Stephen B. Baylin, and James G. Herman
Cancer Res 2000 60: 2368-2371. [Abstract] [Full Text] [PDF]  

WRN or Telomerase Constructs Reverse 4-Nitroquinoline 1-Oxide Sensitivity in Transformed Werner Syndrome Fibroblasts

Fuki M. Hisama, Yao-Hui Chen, M. Stephen Meyn, Junko Oshima, and Sherman M. Weissman
Cancer Res 2000 60: 2372-2376. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Nitric Oxide Inhibits Apoptosis via AP-1-dependent CD95L Transactivation

Gerry Melino, Francesca Bernassola, Maria Valeria Catani, Antonello Rossi, Marco Corazzari, Stefania Sabatini, Francis Vilbois, and Douglas R. Green
Cancer Res 2000 60: 2377-2383. [Abstract] [Full Text] [PDF]  

Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Androgen-independent Prostate Cancer Cells

Rong Yu, Sandhya Mandlekar, Steve Ruben, Jian Ni, and A-N. Tony Kong
Cancer Res 2000 60: 2384-2389. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Identification of the Messenger RNA for Human Cutaneous Fatty Acid-binding Protein as a Metastasis Inducer

Chun Jing, Carol Beesley, Christopher S. Foster, Philip S. Rudland, Hiroshi Fujii, Terno Ono, Haijuan Chen, Paul H. Smith, and Youqiang Ke
Cancer Res 2000 60: 2390-2398. [Abstract] [Full Text] [PDF]  

Ursolic Acid Inhibits Cyclooxygenase-2 Transcription in Human Mammary Epithelial Cells

Kotha Subbaramaiah, Pedro Michaluart, Michael B. Sporn, and Andrew J. Dannenberg
Cancer Res 2000 60: 2399-2404. [Abstract] [Full Text] [PDF]  

Endocrinology:

Increased Gene Expression of Brown Fat Uncoupling Protein (UCP)1 and Skeletal Muscle UCP2 and UCP3 in MAC16-induced Cancer Cachexia

Chen Bing, Michael Brown, Peter King, Peter Collins, Michael J. Tisdale, and Gareth Williams
Cancer Res 2000 60: 2405-2410. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Functional Assay for BRCA1: Mutagenesis of the COOH-Terminal Region Reveals Critical Residues for Transcription Activation

Finbarr Hayes, Charmagne Cayanan, Daniela Barillà, and Alvaro N. A. Monteiro
Cancer Res 2000 60: 2411-2418. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Flavopiridol Binds to Duplex DNA

Keith C. Bible, Roy H. Bible, Jr., Timothy J. Kottke, Phyllis A. Svingen, Kun Xu, Yuan-Ping Pang, Elisabeth Hajdu, and Scott H. Kaufmann
Cancer Res 2000 60: 2419-2428. [Abstract] [Full Text] [PDF]  

Proteasome Inhibition Circumvents Solid Tumor Resistance to Topoisomerase II-directed Drugs

Yasunari Ogiso, Akihiro Tomida, Shuhong Lei, Satoshi Oura, and Takashi Tsuruo
Cancer Res 2000 60: 2429-2434. [Abstract] [Full Text] [PDF]  

Immunology:

Immunity to Murine Breast Cancer Cells Modified to Express MUC-1, a Human Breast Cancer Antigen, in Transgenic Mice Tolerant to Human MUC-1

Victoria Carr-Brendel, Dubravka Markovic, Karen Ferrer, Michael Smith, Joyce Taylor-Papadimitriou, and Edward P. Cohen
Cancer Res 2000 60: 2435-2443. [Abstract] [Full Text] [PDF]  

Combination Immunotherapy of Primary Prostate Cancer in a Transgenic Mouse Model Using CTLA-4 Blockade

Arthur A. Hurwitz, Barbara A. Foster, Eugene D. Kwon, Tan Truong, Eugene M. Choi, Norman M. Greenberg, Maurice B. Burg, and James P. Allison
Cancer Res 2000 60: 2444-2448. [Abstract] [Full Text] [PDF]  

Cytokine Gene Therapy of Gliomas: Induction of Reactive CD4⁺ T Cells by Interleukin-4-transfected 9L Gliosarcoma Is Essential for Protective Immunity

Katinka M. Giezeman-Smits, Hideho Okada, Cynthia S. Brissette-Storkus, Lorissa A. Villa, Jason Attanucci, Michael T. Lotze, Ian F. Pollack, Michael E. Bozik, and William H. Chambers
Cancer Res 2000 60: 2449-2457. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Photorepair Prevents Ultraviolet-induced Apoptosis in Human Cells Expressing the Marsupial Photolyase Gene

Vanessa Chiganças, Eliane Namie Miyaji, Alysson Renato Muotri, Jacqueline de Fátima Jacysyn, Gustavo Pessini Amarante-Mendes, Akira Yasui, and Carlos Frederico Martins Menck
Cancer Res 2000 60: 2458-2463. [Abstract] [Full Text] [PDF]  

A Role for the p38 Mitogen-activated Protein Kinase Pathway in the Transcriptional Activation of p53 on Genotoxic Stress by Chemotherapeutic Agents

Ricardo Sanchez-Prieto, Jose M. Rojas, Yoichi Taya, and J. Silvio Gutkind
Cancer Res 2000 60: 2464-2472. [Abstract] [Full Text] [PDF]  

Progressive Increases in de Novo Methylation of CpG Islands in Bladder Cancer

Carol Salem, Gangning Liang, Yvonne C. Tsai, Jane Coulter, Margaret A. Knowles, An-Chen Feng, Susan Groshen, Peter W. Nichols, and Peter A. Jones
Cancer Res 2000 60: 2473-2476. [Abstract] [Full Text] [PDF]  

Allelic Loss at SMAD4 in Polyps from Juvenile Polyposis Patients and Use of Fluorescence in Situ Hybridization to Demonstrate Clonal Origin of the Epithelium

Kelly Woodford-Richens, Jill Williamson, Stephen Bevan, Joanne Young, Barbara Leggett, Ian Frayling, Yi Thway, Shirley Hodgson, Jin Cheon Kim, Takeo Iwama, Marco Novelli, Denise Sheer, Richard Poulsom, Nicholas Wright, Richard Houlston, and Ian Tomlinson
Cancer Res 2000 60: 2477-2482. [Abstract] [Full Text] [PDF]  

Genome-wide Screen for Allelic Imbalance in a Mouse Model for Neuroblastoma

William A. Weiss, Tony Godfrey, Carla Francisco, and J. Michael Bishop
Cancer Res 2000 60: 2483-2487. [Abstract] [Full Text] [PDF]  

Microsatellite Instability at Selected Tetranucleotide Repeats Is Associated with p53 Mutations in Non-Small Cell Lung Cancer

Steven A. Ahrendt, P. Anthony Decker, Kara Doffek, Benny Wang, Lihua Xu, Michael J. Demeure, Jin Jen, and David Sidransky
Cancer Res 2000 60: 2488-2491. [Abstract] [Full Text] [PDF]  

Genetic Instability and Hematologic Disease Risk in Werner Syndrome Patients and Heterozygotes

Michael J. Moser, William L. Bigbee, Stephen G. Grant, Mary J. Emond, Richard G. Langlois, Ronald H. Jensen, Junko Oshima, and Raymond J. Monnat, Jr.
Cancer Res 2000 60: 2492-2496. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Role of Extracellular Matrix Assembly in Interstitial Transport in Solid Tumors

Paolo A. Netti, David A. Berk, Melody A. Swartz, Alan J. Grodzinsky, and Rakesh K. Jain
Cancer Res 2000 60: 2497-2503. [Abstract] [Full Text] [PDF]  

A Critical Step in Metastasis: In Vivo Analysis of Intravasation at the Primary Tumor

Jeffrey B. Wyckoff, Joan G. Jones, John S. Condeelis, and Jeffrey E. Segall
Cancer Res 2000 60: 2504-2511. [Abstract] [Full Text] [PDF]  

A Spontaneous Murine Melanoma Lung Metastasis Comprised of Host x Tumor Hybrids

Ashok K. Chakraborty, Stefano Sodi, Michael Rachkovsky, Natalia Kolesnikova, James T. Platt, Jean L. Bolognia, and John M. Pawelek
Cancer Res 2000 60: 2512-2519. [Abstract] [Full Text] [PDF]  

Anti-angiogenic Cues from Vascular Basement Membrane Collagen

Pablo C. Colorado, Adriana Torre, George Kamphaus, Yohei Maeshima, Helmut Hopfer, Keiko Takahashi, Ruediger Volk, Eric D. Zamborsky, Seth Herman, Pradip K. Sarkar, Mark B. Ericksen, Mohanraj Dhanabal, Michael Simons, Mark Post, Donald W. Kufe, Ralph R. Weichselbaum, Vikas P. Sukhatme, and Raghu Kalluri
Cancer Res 2000 60: 2520-2526. [Abstract] [Full Text] [PDF]  

Human Myeloid and Lymphoid Malignancies in the Non-Obese Diabetic/Severe Combined Immunodeficiency Mouse Model: Frequency of Apoptotic Cells in Solid Tumors and Efficiency and Speed of Engraftment Correlate with Vascular Endothelial Growth Factor Production

Lisa Fusetti, Giancarlo Pruneri, Alberto Gobbi, Cristina Rabascio, Nadia Carboni, Fedro Peccatori, Giovanni Martinelli, and Francesco Bertolini
Cancer Res 2000 60: 2527-2534. [Abstract] [Full Text] [PDF]  

Establishment and Characterization of a Human Lung Cancer Cell Line NCI-H460-LNM35 with Consistent Lymphogenous Metastasis via Both Subcutaneous and Orthotopic Propagation

Ken-ichi Kozaki, Osamu Miyaishi, Tetsuya Tsukamoto, Yoshio Tatematsu, Toyoaki Hida, Toshitada Takahashi, and Takashi Takahashi
Cancer Res 2000 60: 2535-2540. [Abstract] [Full Text] [PDF]  

Temporal Progression of Metastasis in Lung: Cell Survival, Dormancy, and Location Dependence of Metastatic Inefficiency

M. Dianne Cameron, Eric E. Schmidt, Nancy Kerkvliet, Kishore V. Nadkarni, Vincent L. Morris, Alan C. Groom, Ann F. Chambers, and Ian C. MacDonald
Cancer Res 2000 60: 2541-2546. [Abstract] [Full Text] [PDF]  

Acquisition of Chemoresistant Phenotype by Overexpression of the Antiapoptotic Gene Testosterone-repressed Prostate Message-2 in Prostate Cancer Xenograft Models

Hideaki Miyake, Colleen Nelson, Paul S. Rennie, and Martin E. Gleave
Cancer Res 2000 60: 2547-2554. [Abstract] [Full Text] [PDF]  

Aspirin Inhibits Tumor Cell Invasiveness Induced by Epstein-Barr Virus Latent Membrane Protein 1 through Suppression of Matrix Metalloproteinase-9 Expression

Shigeyuki Murono, Tomokazu Yoshizaki, Hiroshi Sato, Hajime Takeshita, Mitsuru Furukawa, and Joseph S. Pagano
Cancer Res 2000 60: 2555-2561. [Abstract] [Full Text] [PDF]  

Concurrent and Independent Genetic Alterations in the Stromal and Epithelial Cells of Mammary Carcinoma: Implications for Tumorigenesis

Farid Moinfar, Yan Gao Man, Laurent Arnould, Gary L. Bratthauer, Manfred Ratschek, and Fattaneh A. Tavassoli
Cancer Res 2000 60: 2562-2566. [Abstract] [Full Text] [PDF]  

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