Review:

Exploiting Cancer Cell Cycling for Selective Protection of Normal Cells

Mikhail V. Blagosklonny and Arthur B. Pardee
Cancer Res 2001 61: 4301-4305. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Progressive Decreases in Nuclear Retinoid Receptors during Skin Squamous Carcinogenesis

Xiao-Chun Xu, Winona Y. L. Wong, Leonard Goldberg, Susan C. Baer, John E. Wolf, William M. Ramsdell, David S. Alberts, Scott M. Lippman, and Reuben Lotan
Cancer Res 2001 61: 4306-4310. [Abstract] [Full Text] [PDF]  

Molecular Identification of Latent Precancers in Histologically Normal Endometrium

George L. Mutter, Tan A. Ince, Jan P. A. Baak, Gregory A. Kust, Xiao-Ping Zhou, and Charis Eng
Cancer Res 2001 61: 4311-4314. [Abstract] [Full Text] [PDF]  

A Mechanism for Androgen Receptor-mediated Prostate Cancer Recurrence after Androgen Deprivation Therapy

Christopher W. Gregory, Bin He, Raymond T. Johnson, O. Harris Ford, James L. Mohler, Frank S. French, and Elizabeth M. Wilson
Cancer Res 2001 61: 4315-4319. [Abstract] [Full Text] [PDF]  

Discovery of New Markers of Cancer through Serial Analysis of Gene Expression: Prostate Stem Cell Antigen Is Overexpressed in Pancreatic Adenocarcinoma

Pedram Argani, Christophe Rosty, Robert E. Reiter, Robb E. Wilentz, Selva R. Murugesan, Steven D. Leach, Byungwoo Ryu, Halcyon G. Skinner, Michael Goggins, Elizabeth M. Jaffee, Charles J. Yeo, John L. Cameron, Scott E. Kern, and Ralph H. Hruban
Cancer Res 2001 61: 4320-4324. [Abstract] [Full Text] [PDF]  

Uterine Adenocarcinoma in Mice Treated Neonatally with Genistein

Retha R. Newbold, Elizabeth Padilla Banks, Bill Bullock, and Wendy N. Jefferson
Cancer Res 2001 61: 4325-4328. [Abstract] [Full Text] [PDF]  

Roles of Akt and Glycogen Synthase Kinase 3ß in the Ultraviolet B Induction of Cyclooxygenase-2 Transcription in Human Keratinocytes

Qingbo Tang, Melissa Gonzales, Hiroyasu Inoue, and G. Tim Bowden
Cancer Res 2001 61: 4329-4332. [Abstract] [Full Text] [PDF]  

Vitamin D Receptor Gene Polymorphisms, Insulin-like Growth Factors, and Prostate Cancer Risk: A Population-based Case-Control Study in China

Anand P. Chokkalingam, Katherine A. McGlynn, Yu-Tang Gao, Michael Pollak, Jie Deng, Isabell A. Sesterhenn, F. K. Mostofi, Joseph F. Fraumeni, Jr., and Ann W. Hsing
Cancer Res 2001 61: 4333-4336. [Abstract] [Full Text] [PDF]  

Expression of Nerve Growth Factor Receptors and Their Prognostic Value in Human Breast Cancer

Simon Descamps, Valérie Pawlowski, Françoise Révillion, Louis Hornez, Mohamed Hebbar, Bénoni Boilly, Hubert Hondermarck, and Jean-Philippe Peyrat
Cancer Res 2001 61: 4337-4340. [Abstract] [Full Text] [PDF]  

Kinetics and Viability of Circulating Endothelial Cells As Surrogate Angiogenesis Marker in an Animal Model of Human Lymphoma

Silvia Monestiroli, Patrizia Mancuso, Alessandra Burlini, Giancarlo Pruneri, Chiara Dell’Agnola, Alberto Gobbi, Giovanni Martinelli, and Francesco Bertolini
Cancer Res 2001 61: 4341-4344. [Abstract] [Full Text] [PDF]  

Genetic Alterations of Candidate Tumor Suppressor ING1 in Human Esophageal Squamous Cell Cancer

Lisheng Chen, Nagahide Matsubara, Tadashi Yoshino, Takeshi Nagasaka, Naoko Hoshizima, Yasuhiro Shirakawa, Yoshio Naomoto, Hiroshi Isozaki, Karl Riabowol, and Noriaki Tanaka
Cancer Res 2001 61: 4345-4349. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

p53 and K-ras Mutations in Lung Cancers from Former and Never-Smoking Women

Kirsi H. Vähäkangas, William P. Bennett, Katariina Castrén, Judith A. Welsh, Mohammed A. Khan, Brunhilde Blömeke, Michael C. R. Alavanja, and Curtis C. Harris
Cancer Res 2001 61: 4350-4356. [Abstract] [Full Text] [PDF]  

Human Cutaneous Fatty Acid-binding Protein Induces Metastasis by Up-Regulating the Expression of Vascular Endothelial Growth Factor Gene in Rat Rama 37 Model Cells

Chun Jing, Carol Beesley, Christopher S. Foster, Haijuan Chen, Philip S. Rudland, David C. West, Hiroshi Fujii, Paul H. Smith, and Youqiang Ke
Cancer Res 2001 61: 4357-4364. [Abstract] [Full Text] [PDF]  

Oxidative Stress in the Absence of Inflammation in a Mouse Model for Hepatitis C Virus-associated Hepatocarcinogenesis

Kyoji Moriya, Kiyotaka Nakagawa, Tomofumi Santa, Yoshizumi Shintani, Hajime Fujie, Hideyuki Miyoshi, Takeya Tsutsumi, Teruo Miyazawa, Kotaro Ishibashi, Toshiharu Horie, Kazuhiro Imai, Toru Todoroki, Satoshi Kimura, and Kazuhiko Koike
Cancer Res 2001 61: 4365-4370. [Abstract] [Full Text] [PDF]  

Application of the National Cancer Institute International Criteria for Determination of Microsatellite Instability in Ovarian Cancer

Anil K. Sood, Rick Holmes, Mary J. C. Hendrix, and Richard E. Buller
Cancer Res 2001 61: 4371-4374. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Cyclooxygenase-2 Expression in Human Gliomas: Prognostic Significance and Molecular Correlations

Tadahisa Shono, Philip J. Tofilon, Janet M. Bruner, Olubunmi Owolabi, and Frederick F. Lang
Cancer Res 2001 61: 4375-4381. [Abstract] [Full Text] [PDF]  

Abnormal Fragile Histidine Triad (FHIT) Expression in Advanced Cervical Carcinoma: A Poor Prognostic Factor

Thomas C. Krivak, John W. McBroom, Jeffrey Seidman, David Venzon, Barbara Crothers, Paul J. MacKoul, G. Scott Rose, Jay W. Carlson, and Michael J. Birrer
Cancer Res 2001 61: 4382-4385. [Abstract] [Full Text] [PDF]  

Endocrinology:

Caveolin-1 Mediates Testosterone-stimulated Survival/Clonal Growth and Promotes Metastatic Activities in Prostate Cancer Cells

Likun Li, Guang Yang, Shin Ebara, Takefumi Satoh, Yasutomo Nasu, Terry L. Timme, Chengzhen Ren, Jianxiang Wang, Salahaldin A. Tahir, and Timothy C. Thompson
Cancer Res 2001 61: 4386-4392. [Abstract] [Full Text] [PDF]  

¹¹¹In-labeled 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic Acid-Lys⁸-Vasotocin: A New Powerful Radioligand for Oxytocin Receptor-expressing Tumors

Gianni Bussolati, Marco Chinol, Bice Chini, Angelo Nacca, Paola Cassoni, and Giovanni Paganelli
Cancer Res 2001 61: 4393-4397. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Association of CYP1B1 Codon 432 Mutant Allele in Head and Neck Squamous Cell Cancer Is Reflected by Somatic Mutations of p53 in Tumor Tissue

Yon Ko, Josef Abel, Volker Harth, Peter Bröde, Christiane Antony, Susanne Donat, Hans-Peter Fischer, Maria Elena Ortiz-Pallardo, Ricarda Thier, Agapios Sachinidis, Hans Vetter, Hermann-Maximilian Bolt, Claus Herberhold, and Thomas Brüning
Cancer Res 2001 61: 4398-4404. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

The Use of the L-Plastin Promoter for Adenoviral-mediated, Tumor-specific Gene Expression in Ovarian and Bladder Cancer Cell Lines

Xue Yan Peng, Jong Ho Won, Thomas Rutherford, Takuma Fujii, Daniel Zelterman, Giuseppi Pizzorno, Eva Sapi, John Leavitt, Barry Kacinski, Ronald Crystal, Peter Schwartz, and Albert Deisseroth
Cancer Res 2001 61: 4405-4413. [Abstract] [Full Text] [PDF]  

Antitumor Effect of ß2-Microglobulin in Leukemic Cell-bearing Mice via Apoptosis-inducing Activity: Activation of Caspase-3 and Nuclear Factor-B

Masaki Mori, Yasuhito Terui, Miyuki Tanaka, Hiroshi Tomizuka, Yuji Mishima, Masayuki Ikeda, Tadashi Kasahara, Masaya Uwai, Masuzu Ueda, Rie Inoue, Takehito Itoh, Muneo Yamada, Hirotoshi Hayasawa, Yusuke Furukawa, Yukihito Ishizaka, Keiya Ozawa, and Kiyohiko Hatake
Cancer Res 2001 61: 4414-4417. [Abstract] [Full Text] [PDF]  

The Bisphosphonate Ibandronate Promotes Apoptosis in MDA-MB-231 Human Breast Cancer Cells in Bone Metastases

Toru Hiraga, Paul J. Williams, Gregory R. Mundy, and Toshiyuki Yoneda
Cancer Res 2001 61: 4418-4424. [Abstract] [Full Text] [PDF]  

Isotype-specific Ras·GTP-Levels Predict the Efficacy of Farnesyl Transferase Inhibitors against Human Astrocytomas Regardless of Ras Mutational Status

Matthias M. Feldkamp, Nelson Lau, Luba Roncari, and Abhijit Guha
Cancer Res 2001 61: 4425-4431. [Abstract] [Full Text] [PDF]  

Osteoprotegerin Inhibits Osteolysis and Decreases Skeletal Tumor Burden in Syngeneic and Nude Mouse Models of Experimental Bone Metastasis

Sean Morony, Casey Capparelli, Ildiko Sarosi, David L. Lacey, Colin R. Dunstan, and Paul J. Kostenuik
Cancer Res 2001 61: 4432-4436. [Abstract] [Full Text] [PDF]  

Frequent, Moderate-Dose Cyclophosphamide Administration Improves the Efficacy of Cytochrome P-450/Cytochrome P-450 Reductase-based Cancer Gene Therapy

Youssef Jounaidi and David J. Waxman
Cancer Res 2001 61: 4437-4444. [Abstract] [Full Text] [PDF]  

Selective Targeting to the Hyperactive ß-Catenin/T-Cell Factor Pathway in Colon Cancer Cells

Rui-Hong Chen and Frank McCormick
Cancer Res 2001 61: 4445-4449. [Abstract] [Full Text] [PDF]  

The c-Jun NH₂-terminal Protein Kinase/AP-1 Pathway Is Required for Efficient Apoptosis Induced by Vinblastine

Meiyun Fan, Mary E. Goodwin, Michael J. Birrer, and Timothy C. Chambers
Cancer Res 2001 61: 4450-4458. [Abstract] [Full Text] [PDF]  

Cyclic Hydroxamic-acid-containing Peptide 31, a Potent Synthetic Histone Deacetylase Inhibitor with Antitumor Activity

Yasuhiko Komatsu, Kin-ya Tomizaki, Makiko Tsukamoto, Tamaki Kato, Norikazu Nishino, Shigeo Sato, Takao Yamori, Takashi Tsuruo, Ryohei Furumai, Minoru Yoshida, Sueharu Horinouchi, and Hideya Hayashi
Cancer Res 2001 61: 4459-4466. [Abstract] [Full Text] [PDF]  

A Naturally Occurring Secreted Human ErbB3 Receptor Isoform Inhibits Heregulin-stimulated Activation of ErbB2, ErbB3, and ErbB4

Hakjoo Lee, Robert W. Akita, Mark X. Sliwkowski, and Nita J. Maihle
Cancer Res 2001 61: 4467-4473. [Abstract] [Full Text] [PDF]  

Immunology:

Specific Localization, Gamma Camera Imaging, and Intracellular Trafficking of Radiolabelled Chimeric Anti-G_D3 Ganglioside Monoclonal Antibody KM871 in SK-MEL-28 Melanoma Xenografts

Fook-Thean Lee, Angela Rigopoulos, Cathrine Hall, Kerrie Clarke, Stephen H. Cody, Fiona E. Smyth, Zhanqi Liu, Martin W. Brechbiel, Nobuo Hanai, Edouard C. Nice, Bruno Catimel, Antony W. Burgess, Sydney Welt, Gerd Ritter, Lloyd J. Old, and Andrew M. Scott
Cancer Res 2001 61: 4474-4482. [Abstract] [Full Text] [PDF]  

Immunophenotyping of Leukemias Using a Cluster of Differentiation Antibody Microarray

Larissa Belov, Odetta de la Vega, Cristobal G. dos Remedios, Stephen P. Mulligan, and Richard I. Christopherson
Cancer Res 2001 61: 4483-4489. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor-targeted Immunophotodiagnosis and Photoimmunotherapy of Oral Precancer in Vivo

Nikolaos S. Soukos, Michael R. Hamblin, Suzanne Keel, Richard L. Fabian, Thomas F. Deutsch, and Tayyaba Hasan
Cancer Res 2001 61: 4490-4496. [Abstract] [Full Text] [PDF]  

Synergy of Vaccine Strategies to Amplify Antigen-specific Immune Responses and Antitumor Effects

Douglas W. Grosenbach, Jacqueline C. Barrientos, Jeffrey Schlom, and James W. Hodge
Cancer Res 2001 61: 4497-4505. [Abstract] [Full Text] [PDF]  

Molecular Biology & Genetics:

Molecular Cytogenetic Characterization of Head and Neck Squamous Cell Carcinoma and Refinement of 3q Amplification

Bhuvanesh Singh, Swarna K. Gogineni, Peter G. Sacks, Ashok R. Shaha, Jatin P. Shah, Archontoula Stoffel, and Pulivarthi H. Rao
Cancer Res 2001 61: 4506-4513. [Abstract] [Full Text] [PDF]  

High-Throughput Tissue Microarray Analysis of 3p25 (RAF1) and 8p12 (FGFR1) Copy Number Alterations in Urinary Bladder Cancer

Ronald Simon, Jan Richter, Urs Wagner, André Fijan, James Bruderer, Ulrico Schmid, Daniel Ackermann, Robert Maurer, Göran Alund, Hartmut Knönagel, Marcus Rist, Kim Wilber, Manuel Anabitarte, Franz Hering, Thomas Hardmeier, Andreas Schönenberger, Renata Flury, Peter Jäger, Jean Luc Fehr, Peter Schraml, Holger Moch, Michael J. Mihatsch, Thomas Gasser, and Guido Sauter
Cancer Res 2001 61: 4514-4519. [Abstract] [Full Text] [PDF]  

Increased Gene Amplification in Immortal Rodent Cells Deficient for the DNA-dependent Protein Kinase Catalytic Subunit

Chiara Mondello, Paola Rebuzzini, Manuela Dolzan, Scott Edmonson, Guillermo E. Taccioli, and Elena Giulotto
Cancer Res 2001 61: 4520-4525. [Abstract] [Full Text] [PDF]  

Nuclear Factor-B Is Constitutively Active in C-Cell Carcinoma and Required for RET-induced Transformation

Leopold Ludwig, Heidi Kessler, Martin Wagner, Cuong Hoang-Vu, Henning Dralle, Guido Adler, Bernhard O. Böhm, and Roland M. Schmid
Cancer Res 2001 61: 4526-4535. [Abstract] [Full Text] [PDF]  

Detection of Differentially Expressed Genes in HeLa x Fibroblast Hybrids Using Subtractive Suppression Hybridization

Satoshi Nishizuka, Hiroyuki Tsujimoto, and Eric J. Stanbridge
Cancer Res 2001 61: 4536-4540. [Abstract] [Full Text] [PDF]  

Extensive Somatic Microsatellite Mutations in Normal Human Tissue

Susa Vilkki, Jen-Lan Tsao, Anu Loukola, Minna Pöyhönen, Outi Vierimaa, Riitta Herva, Lauri A. Aaltonen, and Darryl Shibata
Cancer Res 2001 61: 4541-4544. [Abstract] [Full Text] [PDF]  

Microsatellite Marker Analysis in Screening for Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

Anu Loukola, Katja Eklin, Päivi Laiho, Reijo Salovaara, Paula Kristo, Heikki Järvinen, Jukka-Pekka Mecklin, Virpi Launonen, and Lauri A. Aaltonen
Cancer Res 2001 61: 4545-4549. [Abstract] [Full Text] [PDF]  

Apoptotic Triggers Initiate Translocations within the MLL Gene Involving the Nonhomologous End Joining Repair System

Christopher J. Betti, Michael J. Villalobos, Manuel O. Diaz, and Andrew T. M. Vaughan
Cancer Res 2001 61: 4550-4555. [Abstract] [Full Text] [PDF]  

Loss of Expression and Aberrant Methylation of the CDH13 (H-Cadherin) Gene in Breast and Lung Carcinomas

Kiyomi O. Toyooka, Shinichi Toyooka, Arvind K. Virmani, Ubaradka G. Sathyanarayana, David M. Euhus, Michael Gilcrease, John D. Minna, and Adi F. Gazdar
Cancer Res 2001 61: 4556-4560. [Abstract] [Full Text] [PDF]  

Atm Knock-in Mice Harboring an In-frame Deletion Corresponding to the Human ATM 7636del9 Common Mutation Exhibit a Variant Phenotype

Kevin Spring, Simone Cross, Chung Li, Dianne Watters, Liat Ben-Senior, Paul Waring, Farida Ahangari, Shan-li Lu, Philip Chen, Ihor Misko, Carol Paterson, Graham Kay, Nechama I. Smorodinsky, Yosef Shiloh, and Martin F. Lavin
Cancer Res 2001 61: 4561-4568. [Abstract] [Full Text] [PDF]  

PTEN Induces G₁ Cell Cycle Arrest and Decreases Cyclin D3 Levels in Endometrial Carcinoma Cells

Xiaoyan Zhu, Chang-Hyuk Kwon, Peter W. Schlosshauer, Lora Hedrick Ellenson, and Suzanne J. Baker
Cancer Res 2001 61: 4569-4575. [Abstract] [Full Text] [PDF]  

Overexpression of Proteins HMGA1 Induces Cell Cycle Deregulation and Apoptosis in Normal Rat Thyroid Cells

Monica Fedele, Giovanna Maria Pierantoni, Maria Teresa Berlingieri, Sabrina Battista, Gustavo Baldassarre, Nikhil Munshi, Monica Dentice, Dimitris Thanos, Massimo Santoro, Giuseppe Viglietto, and Alfredo Fusco
Cancer Res 2001 61: 4583-4590. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Relative Expression of Progesterone Receptors A and B in Endometrioid Cancers of the Endometrium

Rebecca L. Arnett-Mansfield, Anna deFazio, Gerard V. Wain, Richard C. Jaworski, Karen Byth, Patricia A. Mote, and Christine L. Clarke
Cancer Res 2001 61: 4576-4582. [Abstract] [Full Text] [PDF]  

Protein Kinase C-mediated Phosphorylation of 6ß4 Is Associated with Reduced Integrin Localization to the Hemidesmosome and Decreased Keratinocyte Attachment

Addy Alt, Motoi Ohba, Luowei Li, Marina Gartsbein, Adam Belanger, Mitchell. F. Denning, Toshio Kuroki, Stuart H. Yuspa, and Tamar Tennenbaum
Cancer Res 2001 61: 4591-4598. [Abstract] [Full Text] [PDF]  

Effects of Overexpression of -Glutamyl Hydrolase on Methotrexate Metabolism and Resistance

Peter D. Cole, Barton A. Kamen, Richard Gorlick, Debarbrata Banerjee, Angela K. Smith, Elizabeth Magill, and Joseph R. Bertino
Cancer Res 2001 61: 4599-4604. [Abstract] [Full Text] [PDF]  

Overexpression of Sialyltransferase CMP-Sialic Acid:Galß1,3GalNAc-R 6-Sialyltransferase Is Related to Poor Patient Survival inHuman Colorectal Carcinomas

Frank Schneider, Wolfgang Kemmner, Wolfgang Haensch, Gudrun Franke, Stephan Gretschel, Uwe Karsten, and Peter Michael Schlag
Cancer Res 2001 61: 4605-4611. [Abstract] [Full Text] [PDF]  

Protein Kinase C and Protein Kinase C Play Opposite Roles in the Proliferation and Apoptosis of Glioma Cells

Revital Mandil, Ely Ashkenazi, Michal Blass, Ilana Kronfeld, Gila Kazimirsky, Guy Rosenthal, Felix Umansky, Patricia S. Lorenzo, Peter M. Blumberg, and Chaya Brodie
Cancer Res 2001 61: 4612-4619. [Abstract] [Full Text] [PDF]  

Increased Expression of UDP-Galactose Transporter Messenger RNA in Human Colon Cancer Tissues and Its Implication in Synthesis of Thomsen-Friedenreich Antigen and Sialyl Lewis A/X Determinants

Kensuke Kumamoto, Yoshiko Goto, Koji Sekikawa, Seiichi Takenoshita, Nobuhiro Ishida, Masao Kawakita, and Reiji Kannagi
Cancer Res 2001 61: 4620-4627. [Abstract] [Full Text] [PDF]  

Transcriptional Silencing of Cyclooxygenase-2 by Hyper-methylation of the 5' CpG Island in Human Gastric Carcinoma Cells

Sang-Hyun Song, Hyun-Soon Jong, Hyun Ho Choi, Hiroyasu Inoue, Tadashi Tanabe, Noe Kyeong Kim, and Yung-Jue Bang
Cancer Res 2001 61: 4628-4635. [Abstract] [Full Text] [PDF]  

Y₁-Mediated Effect of Neuropeptide Y in Cancer: Breast Carcinomas as Targets

Jean Claude Reubi, Mathias Gugger, Beatrice Waser, and Jean-Claude Schaer
Cancer Res 2001 61: 4636-4641. [Abstract] [Full Text] [PDF]  

Meeting Report:

Melanoma Biology and Progression

Meenhard Herlyn, Soldano Ferrone, Ze'ev Ronai, John Finerty, Richard Pelroy, and Suresh Mohla
Cancer Res 2001 61: 4642-4643. [PDF]  

Errata:

J. Xu et. al, Cancer Res., 61: 1563–1568, 2001

Cancer Res 2001 61: 4646 [Full Text] [PDF]  

Corrections:

G. Wurzer et al., Cancer Res., 60: 4238&4244, 2000

Cancer Res 2001 61: 4647 [Full Text] [PDF]  

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