Review:

Who Is the Boss in the Retinoblastoma Family? The Point of View of Rb2/p130, the Little Brother

Marco G. Paggi and Antonio Giordano
Cancer Res 2001 61: 4651-4654. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Heparanase Expression in Primary and Metastatic Pancreatic Cancer

Alexander Koliopanos, Helmut Friess, Jörg Kleeff, Xin Shi, Quan Liao, Iris Pecker, Israel Vlodavsky, Arthur Zimmermann, and Markus W. Büchler
Cancer Res 2001 61: 4655-4659. [Abstract] [Full Text] [PDF]  

Prostate Stem Cell Antigen Is Overexpressed in Human Transitional Cell Carcinoma

Nordine Amara, Ganesh S. Palapattu, Matthew Schrage, Zhennan Gu, George V. Thomas, Fred Dorey, Jonathan Said, and Robert E. Reiter
Cancer Res 2001 61: 4660-4665. [Abstract] [Full Text] [PDF]  

The Paired Box Domain Gene PAX5 Is Fused to ETV6/TEL in an Acute Lymphoblastic Leukemia Case

Giovanni Cazzaniga, Maria Daniotti, Sabrina Tosi, Giovanni Giudici, Alessandra Aloisi, Enrico Pogliani, Lyndal Kearney, and Andrea Biondi
Cancer Res 2001 61: 4666-4670. [Abstract] [Full Text] [PDF]  

NY-ESO-1 Expression and Immunogenicity Associated with Transitional Cell Carcinoma: Correlation with Tumor Grade

Takushi Kurashige, Yuji Noguchi, Takashi Saika, Toshiro Ono, Yasuhiro Nagata, Achim Jungbluth, Gerd Ritter, Yao-Tseng Chen, Elisabeth Stockert, Tomoyasu Tsushima, Hiromi Kumon, Lloyd J. Old, and Eiichi Nakayama
Cancer Res 2001 61: 4671-4674. [Abstract] [Full Text] [PDF]  

Analysis of Circulating Tumor DNA in Plasma at Diagnosis and during Follow-Up of Lung Cancer Patients

Gabriella Sozzi, Davide Conte, Luigi Mariani, Salvatore Lo Vullo, Luca Roz, Claudia Lombardo, Marco A. Pierotti, and Luca Tavecchio
Cancer Res 2001 61: 4675-4678. [Abstract] [Full Text] [PDF]  

Transforming Growth Factor-ß Receptor Type I Gene Is Frequently Mutated in Ovarian Carcinomas

Taiping Chen, Jason Triplett, Ben Dehner, Bernadette Hurst, Bruce Colligan, Jackson Pemberton, Jeremy R. Graff, and Julia H. Carter
Cancer Res 2001 61: 4679-4682. [Abstract] [Full Text] [PDF]  

Human Prostate Cancer and Benign Prostatic Hyperplasia: Molecular Dissection by Gene Expression Profiling

Jun Luo, David J. Duggan, Yidong Chen, Jurga Sauvageot, Charles M. Ewing, Michael L. Bittner, Jeffrey M. Trent, and William B. Isaacs
Cancer Res 2001 61: 4683-4688. [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation of the DNA Repair Gene O⁶-Methylguanine-DNA Methyltransferase Is Associated with the Presence of G:C to A:T Transition Mutations in p53 in Human Colorectal Tumorigenesis

Manel Esteller, Rosa-Ana Risques, Minoru Toyota, Gabriel Capella, Victor Moreno, Miquel Angel Peinado, Stephen B. Baylin, and James G. Herman
Cancer Res 2001 61: 4689-4692. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Prostate Carcinomas Developing in Transgenic Rats with SV40 T Antigen Expression under Probasin Promoter Control Are Strictly Androgen Dependent

Makoto Asamoto, Naomi Hokaiwado, Young-Man Cho, Satoru Takahashi, Yoshihisa Ikeda, Katsumi Imaida, and Tomoyuki Shirai
Cancer Res 2001 61: 4693-4700. [Abstract] [Full Text] [PDF]  

Potentiation of Nitric Oxide-induced Apoptosis of MDA-MB-468 Cells by Farnesyltransferase Inhibitor: Implications in Breast Cancer

Shehla Pervin, Rajan Singh, Chia-Ling Gau, Hironori Edamatsu, Fuyuhiko Tamanoi, and Gautam Chaudhuri
Cancer Res 2001 61: 4701-4706. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Cytokine and Cyclooxygenase-2 Protein in Brain Areas of Tumor-bearing Mice with Prostanoid-related Anorexia

Wenhua Wang, Christina Lönnroth, Elisabeth Svanberg, and Kent Lundholm
Cancer Res 2001 61: 4707-4715. [Abstract] [Full Text] [PDF]  

Eradication of Colorectal Xenografts by Combined Radioimmunotherapy and Combretastatin A-4 3-O-Phosphate

R. Barbara Pedley, Sally A. Hill, Geoffrey M. Boxer, Aiden A. Flynn, Robert Boden, Rebecca Watson, Jason Dearling, David J. Chaplin, and Richard H. J. Begent
Cancer Res 2001 61: 4716-4722. [Abstract] [Full Text] [PDF]  

Apoptosis Induction in Cancer Cells by a Novel Analogue of 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid Lacking Retinoid Receptor Transcriptional Activation Activity

Marcia I. Dawson, Peter D. Hobbs, Valerie J. Peterson, Mark Leid, Christopher W. Lange, Kai-Chia Feng, Guo-quan Chen, Jian Gu, Hui Li, Siva Kumar Kolluri, Xiao-kun Zhang, Yuxiang Zhang, and Joseph A. Fontana
Cancer Res 2001 61: 4723-4730. [Abstract] [Full Text] [PDF]  

Resveratrol Induces Extensive Apoptosis by Depolarizing Mitochondrial Membranes and Activating Caspase-9 in Acute Lymphoblastic Leukemia Cells

Jan Dörrie, Harald Gerauer, Yvonne Wachter, and Susan J. Zunino
Cancer Res 2001 61: 4731-4739. [Abstract] [Full Text] [PDF]  

The Cell Transmembrane pH Gradient in Tumors Enhances Cytotoxicity of Specific Weak Acid Chemotherapeutics

Sergey V. Kozin, Pavel Shkarin, and Leo E. Gerweck
Cancer Res 2001 61: 4740-4743. [Abstract] [Full Text] [PDF]  

Trastuzumab (Herceptin), a Humanized Anti-HER2 Receptor Monoclonal Antibody, Inhibits Basal and Activated HER2 Ectodomain Cleavage in Breast Cancer Cells

Miguel A. Molina, Jordi Codony-Servat, Joan Albanell, Federico Rojo, Joaquín Arribas, and Jose Baselga
Cancer Res 2001 61: 4744-4749. [Abstract] [Full Text] [PDF]  

Immunology:

High Affinity Restricts the Localization and Tumor Penetration of Single-Chain Fv Antibody Molecules

Gregory P. Adams, Robert Schier, Adrian M. McCall, Heidi H. Simmons, Eva M. Horak, R. Katherine Alpaugh, James D. Marks, and Louis M. Weiner
Cancer Res 2001 61: 4750-4755. [Abstract] [Full Text] [PDF]  

Activated Granulocytes and Granulocyte-derived Hydrogen Peroxide Are the Underlying Mechanism of Suppression of T-Cell Function in Advanced Cancer Patients

Jan Schmielau and Olivera J. Finn
Cancer Res 2001 61: 4756-4760. [Abstract] [Full Text] [PDF]  

Generation of Cytotoxic T Lymphocytes against Native and Altered Peptides of Human Leukocyte Antigen-A*0201 Restricted Epitopes from the Human Epithelial Cell Adhesion Molecule

Andreas Trojan, Mathias Witzens, Joachim L. Schultze, Robert H. Vonderheide, Sabine Harig, Angela M. Krackhardt, Rolf A. Stahel, and John G. Gribben
Cancer Res 2001 61: 4761-4765. [Abstract] [Full Text] [PDF]  

Regulatory CD4⁺CD25⁺ T Cells in Tumors from Patients with Early-Stage Non-Small Cell Lung Cancer and Late-Stage Ovarian Cancer

Edward Y. Woo, Christina S. Chu, Theresa J. Goletz, Katia Schlienger, Heidi Yeh, George Coukos, Stephen C. Rubin, Larry R. Kaiser, and Carl H. June
Cancer Res 2001 61: 4766-4772. [Abstract] [Full Text] [PDF]  

Tumor-reactive T Helper Lymphocytes Recognize a Promiscuous MAGE-A3 Epitope Presented by Various Major Histocompatibility Complex Class II Alleles

Hiroya Kobayashi, Yongsheng Song, Dave S. B. Hoon, Ettore Appella, and Esteban Celis
Cancer Res 2001 61: 4773-4778. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Transduction of Antisense Cyclin D1 Using Two-step Gene Transfer Inhibits the Growth of Rat Hepatoma Cells

Hirofumi Uto, Akio Ido, Akihiro Moriuchi, Yukiko Onaga, Kenji Nagata, Masaaki Onaga, Yoshihiro Tahara, Takeshi Hori, Shuichi Hirono, Katsuhiro Hayashi, and Hirohito Tsubouchi
Cancer Res 2001 61: 4779-4783. [Abstract] [Full Text] [PDF]  

Limitations of the Reporter Green Fluorescent Protein under Simulated Tumor Conditions

Claudia Coralli, Maja Cemazar, Chryso Kanthou, Gillian M. Tozer, and Gabi U. Dachs
Cancer Res 2001 61: 4784-4790. [Abstract] [Full Text] [PDF]  

A Novel Mechanism for Chaperone-mediated Telomerase Regulation during Prostate Cancer Progression

Ali Akalin, Lynne W. Elmore, Heidi L. Forsythe, Barbara A. Amaker, Eric D. McCollum, Peter S. Nelson, Joy L. Ware, and Shawn E. Holt
Cancer Res 2001 61: 4791-4796. [Abstract] [Full Text] [PDF]  

Molecular Profiling of Transformed and Metastatic Murine Squamous Carcinoma Cells by Differential Display and cDNA Microarray Reveals Altered Expression of Multiple Genes Related to Growth, Apoptosis, Angiogenesis, and the NF-B Signal Pathway

Gang Dong, Elena Loukinova, Zhong Chen, Lisa Gangi, Tatyana I. Chanturita, Edison T. Liu, and Carter Van Waes
Cancer Res 2001 61: 4797-4808. [Abstract] [Full Text] [PDF]  

MAGE-E1, a New Member of the Melanoma-associated Antigen Gene Family and its Expression in Human Glioma

Manabu Sasaki, Kensuke Nakahira, Yozo Kawano, Hiromichi Katakura, Toshiki Yoshimine, Keiji Shimizu, Seung U. Kim, and Kazuhiro Ikenaka
Cancer Res 2001 61: 4809-4814. [Abstract] [Full Text] [PDF]  

VHL and FHIT Locus Loss of Heterozygosity Is Common in All Renal Cancer Morphotypes But Differs in Pattern and Prognostic Significance

Marija Velickovic, Brett Delahunt, Stephan Störkel, and Stefan K. G. Grebem
Cancer Res 2001 61: 4815-4819. [Abstract] [Full Text] [PDF]  

Cytosine Methylation Represses Glutathione S-Transferase P1 (GSTP1) Gene Expression in Human Prostate Cancer Cells

Rakesh Singal, Jane van Wert, and Monuj Bashambu
Cancer Res 2001 61: 4820-4826. [Abstract] [Full Text] [PDF]  

Fragile Histidine Triad Expression Delays Tumor Development and Induces Apoptosis in Human Pancreatic Cancer

Kristoffel R. Dumon, Hideshi Ishii, Andrea Vecchione, Francesco Trapasso, Gustavo Baldassarre, Fatima Chakrani, Teresa Druck, Ernest F. Rosato, Noel N. Williams, Raffaele Baffa, Matthew J. During, Kay Huebner, and Carlo M. Croce
Cancer Res 2001 61: 4827-4836. [Abstract] [Full Text] [PDF]  

Induction of Anoikis and Suppression of Human Ovarian Tumor Growth in Vivo by Down-Regulation of Bcl-X_L

Andrea Frankel, Kirill Rosen, Jorge Filmus, and Robert S. Kerbel
Cancer Res 2001 61: 4837-4841. [Abstract] [Full Text] [PDF]  

Homology-directed DNA Repair, Mitomycin-C Resistance, and Chromosome Stability Is Restored with Correction of a Brca1 Mutation

Mary Ellen Moynahan, Tracy Y. Cui, and Maria Jasin
Cancer Res 2001 61: 4842-4850. [Abstract] [Full Text] [PDF]  

Tumor Biology:

The Role of Thomsen-Friedenreich Antigen in Adhesion of Human Breast and Prostate Cancer Cells to the Endothelium

Vladislav V. Glinsky, Gennadi V. Glinsky, Kate Rittenhouse-Olson, Margaret E. Huflejt, Olga V. Glinskii, Susan L. Deutscher, and Thomas P. Quinn
Cancer Res 2001 61: 4851-4857. [Abstract] [Full Text] [PDF]  

Tetrasomy Is Induced by Human Papillomavirus Type 18 E7 Gene Expression in Keratinocyte Raft Cultures

Shirley A. Southern, Francisco Noya, Craig Meyers, Thomas R. Broker, Louise T. Chow, and C. Simon Herrington
Cancer Res 2001 61: 4858-4863. [Abstract] [Full Text] [PDF]  

Fas-mediated Apoptosis in Neuroblastoma Requires Mitochondrial Activation and Is Inhibited by FLICE Inhibitor Protein and bcl-2

Vassiliki Poulaki, Nicholas Mitsiades, Maria E. Romero, and Maria Tsokos
Cancer Res 2001 61: 4864-4872. [Abstract] [Full Text] [PDF]  

In Vivo Molecular Imaging of Met Tyrosine Kinase Growth Factor Receptor Activity in Normal Organs and Breast Tumors

Miriam Shaharabany, Rinat Abramovitch, Tammar Kushnir, Galia Tsarfaty, Michal Ravid-Megido, Judith Horev, Rotem Ron, Yacov Itzchak, and Ilan Tsarfaty
Cancer Res 2001 61: 4873-4878. [Abstract] [Full Text] [PDF]  

Nonsteroidal Anti-Inflammatory Drugs Induce Apoptosis in Esophageal Cancer Cells by Restoring 15-Lipoxygenase-1 Expression

Imad Shureiqi, Xiaochun Xu, Dongning Chen, Reuben Lotan, Jeffrey S. Morris, Susan M. Fischer, and Scott M. Lippman
Cancer Res 2001 61: 4879-4884. [Abstract] [Full Text] [PDF]  

Inhibition of Epidermal Growth Factor-induced RhoA Translocation and Invasion of Human Pancreatic Cancer Cells by 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors

Toshiyuki Kusama, Mutsuko Mukai, Teruo Iwasaki, Masaharu Tatsuta, Yoshirou Matsumoto, Hitoshi Akedo, and Hiroyuki Nakamura
Cancer Res 2001 61: 4885-4891. [Abstract] [Full Text] [PDF]  

Down-Regulation of the erbB-2 Receptor by Trastuzumab (Herceptin) Enhances Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Breast and Ovarian Cancer Cell Lines that Overexpress erbB-2

Mauricio Cuello, Seth A. Ettenberg, Amy S. Clark, Maccon M. Keane, Reuben H. Posner, Marion M. Nau, Phillip A. Dennis, and Stan Lipkowitz
Cancer Res 2001 61: 4892-4900. [Abstract] [Full Text] [PDF]  

Constitutive IB Kinase Activity Correlates with Nuclear Factor-B Activation in Human Melanoma Cells

Jinming Yang and Ann Richmond
Cancer Res 2001 61: 4901-4909. [Abstract] [Full Text] [PDF]  

c-myc/p53 Interaction Determines Sensitivity of Human Colon Carcinoma Cells to 5-Fluorouracil in Vitro and in Vivo

Diego Arango, Georgia A. Corner, Scott Wadler, Paul J. Catalano, and Leonard H. Augenlicht
Cancer Res 2001 61: 4910-4915. [Abstract] [Full Text] [PDF]  

A Novel N-ras Mutation in Malignant Melanoma Is Associated with Excellent Prognosis

Anouk Demunter, Mohammad Reza Ahmadian, Louis Libbrecht, Marguerite Stas, Mathijs Baens, Klaus Scheffzek, Hugo Degreef, Chris De Wolf-Peeters, and Joost J. van den Oord
Cancer Res 2001 61: 4916-4922. [Abstract] [Full Text] [PDF]  

Special Article:

A White Paper: The Product of a Pancreas Cancer Think Tank

Scott Kern, Ralph Hruban, Michael A. Hollingsworth, Randall Brand, Thomas E. Adrian, Elizabeth Jaffee, and Margaret A. Tempero
Cancer Res 2001 61: 4923-4932. [Full Text] [PDF]  

Errata:

P. Dubey et al., Cancer Res. 61: 3256–3261, 2001

Cancer Res 2001 61: 4935 [Full Text] [PDF]  

Y. Suminami et al., Cancer Res. 61: 1776–1780, 2001

Cancer Res 2001 61: 4935 [Full Text] [PDF]  

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