Advances in Brief:

Extraction of 5-Fluorouracil by Tumor and Liver: A Noninvasive Positron Emission Tomography Study of Patients with Gastrointestinal Cancer

Eric O. Aboagye, Azeem Saleem, Vincent J. Cunningham, Safiye Osman, and Patricia M. Price
Cancer Res 2001 61: 4937-4941. [Abstract] [Full Text] [PDF]  

Mutations of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Receptor 1 (TRAIL-R1) and Receptor 2 (TRAIL-R2) Genes in Metastatic Breast Cancers

Min Sun Shin, Hong Sug Kim, Sug Hyung Lee, Won Sang Park, Su Young Kim, Jik Young Park, Jong Heun Lee, Sang Kyu Lee, Shi Nae Lee, Sang Seol Jung, Ji Youn Han, Hyang Kim, Jung Young Lee, and Nam Jin Yoo
Cancer Res 2001 61: 4942-4946. [Abstract] [Full Text] [PDF]  

Loss of Imprinting of Insulin-like Growth Factor-II in Wilms’ Tumor Commonly Involves Altered Methylation but not Mutations of CTCF or Its Binding Site

Hengmi Cui, Emily L. Niemitz, Jason D. Ravenel, Patrick Onyango, Sheri A. Brandenburg, Victor V. Lobanenkov, and Andrew P. Feinberg
Cancer Res 2001 61: 4947-4950. [Abstract] [Full Text] [PDF]  

Structural Analysis of the 17q22–23 Amplicon Identifies Several Independent Targets of Amplification in Breast Cancer Cell Lines and Tumors

Guo-jun Wu, Colleen Sinclair, Shannon Hinson, James N. Ingle, Patrick C. Roche, and Fergus J. Couch
Cancer Res 2001 61: 4951-4955. [Abstract] [Full Text] [PDF]  

Formation of Intracranial Tumors by Genetically Modified Human Astrocytes Defines Four Pathways Critical in the Development of Human Anaplastic Astrocytoma

Yukihiko Sonoda, Tomoko Ozawa, Yuichi Hirose, Ken D. Aldape, Martin McMahon, Mitchel S. Berger, and Russell O. Pieper
Cancer Res 2001 61: 4956-4960. [Abstract] [Full Text] [PDF]  

Epithelial Cancer Cell Migration: A Role for Chemokine Receptors?

Chris J. Scotton, Julia L. Wilson, David Milliken, Gordon Stamp, and Frances R. Balkwill
Cancer Res 2001 61: 4961-4965. [Abstract] [Full Text] [PDF]  

Dynamic Micro-Magnetic Resonance Imaging of Liver Micrometastasis in Mice with a Novel Liver Macromolecular Magnetic Resonance Contrast Agent DAB-Am64-(1B4M-Gd)₆₄

Hisataka Kobayashi, Tsuneo Saga, Satomi Kawamoto, Noriko Sato, Akira Hiraga, Takayoshi Ishimori, Junji Konishi, Kaori Togashi, and Martin W. Brechbiel
Cancer Res 2001 61: 4966-4970. [Abstract] [Full Text] [PDF]  

Monitoring Response to Convection-enhanced Taxol Delivery in Brain Tumor Patients Using Diffusion-weighted Magnetic Resonance Imaging

Yael Mardor, Yiftach Roth, Zvi Lidar, Tali Jonas, Raphael Pfeffer, Stephan E. Maier, Meir Faibel, Dvora Nass, Moshe Hadani, Arie Orenstein, Jack S. Cohen, and Zvi Ram
Cancer Res 2001 61: 4971-4973. [Abstract] [Full Text] [PDF]  

The Tumor Suppressor Candidate p33^ING1 Mediates Repair of UV-Damaged DNA

K-John Cheung, Jr., David Mitchell, Paul Lin, and Gang Li
Cancer Res 2001 61: 4974-4977. [Abstract] [Full Text] [PDF]  

Loss of Focal Adhesion Kinase (FAK) Inhibits Epidermal Growth Factor Receptor-dependent Migration and Induces Aggregation of NH₂-Terminal FAK in the Nuclei of Apoptotic Glioblastoma Cells

Graham Jones, Joel Machado, Jr., and Adrian Merlo
Cancer Res 2001 61: 4978-4981. [Abstract] [Full Text] [PDF]  

Polymorphisms in the Prostate Cancer Susceptibility Gene HPC2/ELAC2 in Multiplex Families and Healthy Controls

Brian K. Suarez, Daniela S. Gerhard, Jennifer Lin, Beth Haberer, Loan Nguyen, Niki K. Kesterson, and William J. Catalona
Cancer Res 2001 61: 4982-4984. [Abstract] [Full Text] [PDF]  

Regulation of PTEN Binding to MAGI-2 by Two Putative Phosphorylation Sites at Threonine 382 and 383

Tatyana Tolkacheva, Manoranjan Boddapati, Anthony Sanfiz, Kunihiro Tsuchida, Alec C. Kimmelman, and Andrew M-L. Chan
Cancer Res 2001 61: 4985-4989. [Abstract] [Full Text] [PDF]  

DNA Damage-activated Kinase Chk2 Is Independent of Proliferation or Differentiation Yet Correlates with Tissue Biology

Claudia Lukas, Jirina Bartkova, Lucia Latella, Jacob Falck, Niels Mailand, Tine Schroeder, Maxwell Sehested, Jiri Lukas, and Jiri Bartek
Cancer Res 2001 61: 4990-4993. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Runt-related Gene 2 in Endothelial Cells: Inducible Expression and Specific Regulation of Cell Migration and Invasion

Lixin Sun, Michele Vitolo, and Antonino Passaniti
Cancer Res 2001 61: 4994-5001. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Inhibitory Effects of Orally Administered Green Tea, Black Tea, and Caffeine on Skin Carcinogenesis in Mice Previously Treated with Ultraviolet B Light (High-Risk Mice): Relationship to Decreased Tissue Fat

Yao-Ping Lu, You-Rong Lou, Yong Lin, Weichung Joe Shih, Mou-Tuan Huang, Chung S. Yang, and Allan H. Conney
Cancer Res 2001 61: 5002-5009. [Abstract] [Full Text] [PDF]  

Qualitative and Quantitative Relationship between Dysplastic Aberrant Crypt Foci and Tumorigenesis in the Min/+ Mouse Colon

Jan Erik Paulsen, Inger-Lise Steffensen, Else Marit Løberg, Trine Husøy, Ellen Namork, and Jan Alexander
Cancer Res 2001 61: 5010-5015. [Abstract] [Full Text] [PDF]  

Hepatic Hyperplasia in Noncirrhotic Fatty Livers: Is Obesity-related Hepatic Steatosis a Premalignant Condition?

ShiQi Yang, Hui Zhi Lin, Jiawen Hwang, Vadappuram P. Chacko, and Anna Mae Diehl
Cancer Res 2001 61: 5016-5023. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Tubulin Detyrosination Is a Frequent Occurrence in Breast Cancers of Poor Prognosis

Agnes Mialhe, Laurence Lafanechèere, Isabelle Treilleux, Nadine Peloux, Charles Dumontet, Alain Brémond, Meng-Hong Panh, Raoul Payan, Jürgen Wehland, Robert-Louis Margolis, and Didier Job
Cancer Res 2001 61: 5024-5027. [Abstract] [Full Text] [PDF]  

Increased Level of Stromal Cell-Derived Factor-1 mRNA in Peripheral Blood Mononuclear Cells from Children with AIDS-related Lymphoma

Shizuko Sei, Dennis P. O’Neill, Sean K. Stewart, Quan-en Yang, Mutsuko Kumagai, Anne Marie Boler, Melissa A. Adde, Sheryl L. Zwerski, Lauren V. Wood, David J. Venzon, and Ian T. Magrath
Cancer Res 2001 61: 5028-5037. [Abstract] [Full Text] [PDF]  

Endocrinology:

Conversion from a Paracrine to an Autocrine Mechanism of Androgen-stimulated Growth during Malignant Transformation of Prostatic Epithelial Cells

Jin Gao, Julia T. Arnold, and John T. Isaacs
Cancer Res 2001 61: 5038-5044. [Abstract] [Full Text] [PDF]  

Soy Diets Containing Varying Amounts of Genistein Stimulate Growth of Estrogen-dependent (MCF-7) Tumors in a Dose-dependent Manner

Clinton D. Allred, Kimberly F. Allred, Young H. Ju, Suzanne M. Virant, and William G. Helferich
Cancer Res 2001 61: 5045-5050. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Association of NAT1 and NAT2 Polymorphisms to Urinary Bladder Cancer: Significantly Reduced Risk in Subjects with NAT1*10

Ingolf Cascorbi, Ivar Roots, and Jürgen Brockmöller
Cancer Res 2001 61: 5051-5056. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Inhibition of Fibroblast Growth Factor-2-induced Vascular Tumor Formation by the Acyclic Nucleoside Phosphonate Cidofovir

Sandra Liekens, Johan Neyts, Erik De Clercq, Erik Verbeken, Domenico Ribatti, and Marco Presta
Cancer Res 2001 61: 5057-5064. [Abstract] [Full Text] [PDF]  

Zinc-65 Imaging of Rat Brain Tumors

Atsushi Takeda, Haruna Tamano, Shuichi Enomoto, and Naoto Oku
Cancer Res 2001 61: 5065-5069. [Abstract] [Full Text] [PDF]  

Lowering the Isoelectric Point of the Fv Portion of Recombinant Immunotoxins Leads to Decreased Nonspecific Animal Toxicity without Affecting Antitumor Activity

Masanori Onda, Satoshi Nagata, Yasuo Tsutsumi, James J. Vincent, Qing-cheng Wang, Robert J. Kreitman, Byungkook Lee, and Ira Pastan
Cancer Res 2001 61: 5070-5077. [Abstract] [Full Text] [PDF]  

Sensitization of Human Tumor Cells to CPT-11 via Adenoviral-mediated Delivery of a Rabbit Liver Carboxylesterase

Monika Wierdl, Christopher L. Morton, James K. Weeks, Mary K. Danks, Linda C. Harris, and Philip M. Potter
Cancer Res 2001 61: 5078-5082. [Abstract] [Full Text] [PDF]  

A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11

Mandy M. Meck, Monika Wierdl, Lars M. Wagner, Rebecca A. Burger, Sylvie M. Guichard, Erik. J. Krull, Linda C. Harris, Philip M. Potter, and Mary K. Danks
Cancer Res 2001 61: 5083-5089. [Abstract] [Full Text] [PDF]  

Acquired Resistance to the Antitumor Effect of Epidermal Growth Factor Receptor-blocking Antibodies in Vivo: A Role for Altered Tumor Angiogenesis

Alicia Viloria-Petit, Tania Crombet, Serge Jothy, Daniel Hicklin, Peter Bohlen, Jean Marc Schlaeppi, Janusz Rak, and Robert S. Kerbel
Cancer Res 2001 61: 5090-5101. [Abstract] [Full Text] [PDF]  

N-(4-Hydroxyphenyl)retinamide Elevates Ceramide in Neuroblastoma Cell Lines by Coordinate Activation of Serine Palmitoyltransferase and Ceramide Synthase

Hongtao Wang, Barry J. Maurer, C. Patrick Reynolds, and Myles C. Cabot
Cancer Res 2001 61: 5102-5105. [Abstract] [Full Text] [PDF]  

Pharmacological Inhibitors of the Mitogen-activated Protein Kinase (MAPK) Kinase/MAPK Cascade Interact Synergistically with UCN-01 to Induce Mitochondrial Dysfunction and Apoptosis in Human Leukemia Cells

Yun Dai, Chunrong Yu, Victor Singh, Lin Tang, Zhiliang Wang, Robert McInistry, Paul Dent, and Steven Grant
Cancer Res 2001 61: 5106-5115. [Abstract] [Full Text] [PDF]  

Retrovirus-mediated Expression of the Base Excision Repair Proteins, Formamidopyrimidine DNA Glycosylase or Human Oxoguanine DNA Glycosylase, Protects Hematopoietic Cells from N,N',N''-Triethylenethiophosphoramide (thioTEPA)-induced Toxicity in Vitro and in Vivo

Masayoshi Kobune, Yi Xu, Christopher Baum, Mark R. Kelley, and David A. Williams
Cancer Res 2001 61: 5116-5125. [Abstract] [Full Text] [PDF]  

Immunosuppressive Effects of ¹³¹I-Anti-CD45 Antibody in Unsensitized and Donor Antigen-presensitized H2-matched, Minor Antigen-mismatched Murine Transplant Models

Katherine L. Ruffner, Paul J. Martin, Scott Hussell, Cynthia Nourigat, Darrell R. Fisher, Irwin D. Bernstein, and Dana C. Matthews
Cancer Res 2001 61: 5126-5131. [Abstract] [Full Text] [PDF]  

Immunology:

Proliferative Activity of Intratumoral CD8⁺ T-Lymphocytes As a Prognostic Factor in Human Renal Cell Carcinoma: Clinicopathologic Demonstration of Antitumor Immunity

Osamu Nakano, Makoto Sato, Yoshitaka Naito, Kenichi Suzuki, Seiichi Orikasa, Masataka Aizawa, Yasuyoshi Suzuki, Ichirou Shintaku, Hiroshi Nagura, and Haruo Ohtani
Cancer Res 2001 61: 5132-5136. [Abstract] [Full Text] [PDF]  

Rituximab Inactivates Signal Transducer and Activation of Transcription 3 (STAT3) Activity in B-Non-Hodgkin’s Lymphoma through Inhibition of the Interleukin 10 Autocrine/Paracrine Loop and Results in Down-Regulation of Bcl-2 and Sensitization to Cytotoxic Drugs

Steve Alas and Benjamin Bonavida
Cancer Res 2001 61: 5137-5144. [Abstract] [Full Text] [PDF]  

Somatically Mutated Regions of Immunoglobulin on Human B-Cell Lymphomas Code for Peptides That Bind to Autologous Major Histocompatibility Complex Class I, Providing a Potential Target for Cytotoxic T Cells

Clair S. Gricks, Eira Rawlings, Letizia Foroni, J. Alejandro Madrigal, and Peter L. Amlot
Cancer Res 2001 61: 5145-5152. [Abstract] [Full Text] [PDF]  

Combinatorial Peptide Libraries as an Alternative Approach to the Identification of Ligands for Tumor-reactive Cytolytic T Lymphocytes

Clemencia Pinilla, Verena Rubio-Godoy, Valerie Dutoit, Philippe Guillaume, Richard Simon, Yindong Zhao, Richard A. Houghten, Jean-Charles Cerottini, Pedro Romero, and Danila Valmori
Cancer Res 2001 61: 5153-5160. [Abstract] [Full Text] [PDF]  

Identification of T Helper Epitopes from Prostatic Acid Phosphatase

Douglas G. McNeel, Lan D. Nguyen, and Mary L. Disis
Cancer Res 2001 61: 5161-5167. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Identification of Gene Expression Profiles That Predict the Aggressive Behavior of Breast Cancer Cells

Deborah A. Zajchowski, Marty F. Bartholdi, Yan Gong, Lynn Webster, Hsiao-Lai Liu, Alexander Munishkin, Catherine Beauheim, Susan Harvey, Stephen P. Ethier, and Paul H. Johnson
Cancer Res 2001 61: 5168-5178. [Abstract] [Full Text] [PDF] Supplementary Data  

Constitutional Genomic Instability with Inversions, Duplications, and Amplifications in 9p23–24 in BRCA2 Mutation Carriers

Larissa Savelyeva, Andreas Claas, Isabel Matzner, Peter Schlag, Wera Hofmann, Siegfried Scherneck, Barbara Weber, and Manfred Schwab
Cancer Res 2001 61: 5179-5185. [Abstract] [Full Text] [PDF]  

Genetic Evidence for Early Divergence of Small Functioning and Nonfunctioning Endocrine Pancreatic Tumors: Gain of 9Q34 Is an Early Event in Insulinomas

Ernst J. M. Speel, Alexander F. Scheidweiler, Jianming Zhao, Claudia Matter, Parvin Saremaslani, Jürgen Roth, Philipp U. Heitz, and Paul Komminoth
Cancer Res 2001 61: 5186-5192. [Abstract] [Full Text] [PDF]  

Role of the hMLH1 DNA Mismatch Repair Protein in Fluoropyrimidine-mediated Cell Death and Cell Cycle Responses

Mark Meyers, Mark W. Wagner, Hwa-Shin Hwang, Timothy J. Kinsella, and David A. Boothman
Cancer Res 2001 61: 5193-5201. [Abstract] [Full Text] [PDF]  

Molecular Mechanisms of Transcriptional Control of bcl-2 and c-myc in Follicular and Transformed Lymphoma

Magdalena Arcinas, Caroline A. Heckman, John W. Mehew, and Linda M. Boxer
Cancer Res 2001 61: 5202-5206. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Hyaluronan Synthase 3 Overexpression Promotes the Growth of TSU Prostate Cancer Cells

Ningfei Liu, Feng Gao, Zeqiu Han, Xueming Xu, Charles B. Underhill, and Lurong Zhang
Cancer Res 2001 61: 5207-5214. [Abstract] [Full Text] [PDF]  

Constitutive Activation of Hypoxia-inducible Genes Related to Overexpression of Hypoxia-inducible Factor-1 in Clear Cell Renal Carcinomas

Michael S. Wiesener, Philine M. Münchenhagen, Irina Berger, Neil V. Morgan, Jan Roigas, Andreas Schwiertz, Jan Steffen Jürgensen, Gertrud Gruber, Patrick H. Maxwell, Stefan A. Löning, Ulrich Frei, Eamonn R. Maher, Hermann-Josef Gröne, and Kai-Uwe Eckardt
Cancer Res 2001 61: 5215-5222. [Abstract] [Full Text] [PDF]  

Global Analysis of Gene Expression in Invasion by a Lung Cancer Model

Jeremy J. W. Chen, Konan Peck, Tse-Ming Hong, Shuenn-Chen Yang, Yuh-Pyng Sher, Jin-Yuan Shih, Reen Wu, Jing-Long Cheng, Steve R. Roffler, Cheng-Wen Wu, and Pan-Chyr Yang
Cancer Res 2001 61: 5223-5230. [Abstract] [Full Text] [PDF]  

An Intact Overexpressed E-cadherin/,ß-Catenin Axis Characterizes the Lymphovascular Emboli of Inflammatory Breast Carcinoma

James S. Tomlinson, Mary L. Alpaugh, and Sanford H. Barsky
Cancer Res 2001 61: 5231-5241. [Abstract] [Full Text] [PDF]  

Entry Routes of Malignant Lymphoma into the Brain and Eyes in a Mouse Model

Jacob Hochman, Nirit Assaf, Martina Deckert-Schlüter, Otmar D. Wiestler, and Jacob Pe’er
Cancer Res 2001 61: 5242-5247. [Abstract] [Full Text] [PDF]  

Influence of ß1 Integrins on Epidermal Squamous Cell Carcinoma Formation in a Transgenic Mouse Model: 3ß1, but not 2ß1, Suppresses Malignant Conversion

David M. Owens and Fiona M. Watt
Cancer Res 2001 61: 5248-5254. [Abstract] [Full Text] [PDF]  

Reduced Blood Vessel Formation and Tumor Growth in 5-Integrin-negative Teratocarcinomas and Embryoid Bodies

Daniela Taverna and Richard O. Hynes
Cancer Res 2001 61: 5255-5261. [Abstract] [Full Text] [PDF]  

Carbonic Anhydrase IX, an Endogenous Hypoxia Marker, Expression in Head and Neck Squamous Cell Carcinoma and its Relationship to Hypoxia, Necrosis, and Microvessel Density

Nigel J. P. Beasley, Charles C. Wykoff, Peter H. Watson, Russell Leek, Helen Turley, Kevin Gatter, Jaromir Pastorek, Graham J. Cox, Peter Ratcliffe, and Adrian L. Harris
Cancer Res 2001 61: 5262-5267. [Abstract] [Full Text] [PDF]  

Clonal Variation in the B-Lineage Acute Lymphoblastic Leukemia Response to Multiple Cytokines and Bone Marrow Stromal Cells

Nisha Shah, LeAnn Oseth, Hien Tran, Betsy Hirsch, and Tucker W. LeBien
Cancer Res 2001 61: 5268-5274. [Abstract] [Full Text] [PDF]  

A CD44 Survival Pathway Triggers Chemoresistance via Lyn Kinase and Phosphoinositide 3-Kinase/Akt in Colon Carcinoma Cells

Richard C. Bates, Nathaniel S. Edwards, Gordon F. Burns, and David E. Fisher
Cancer Res 2001 61: 5275-5283. [Abstract] [Full Text] [PDF]  

Overexpression of KAI1 Suppresses in Vitro Invasiveness and in Vivo Metastasis in Breast Cancer Cells

Xiaohong Yang, Lisa L. Wei, Careen Tang, Rebecca Slack, Susette Mueller, and Marc E. Lippman
Cancer Res 2001 61: 5284-5288. [Abstract] [Full Text] [PDF]  

Role of Iron in Tumor Cell Protection from the Pro-Apoptotic Effect of Nitric Oxide

Fredéric Feger, Hélène Ferry-Dumazet, Maria Mamani Matsuda, Joëlle Bordenave, Maryse Dupouy, Andreas K. Nussler, Michel Arock, Lionel Devevey, Joëlle Nafziger, Jean-Jacques Guillosson, Josy Reiffers, and M. Djavad Mossalayi
Cancer Res 2001 61: 5289-5294. [Abstract] [Full Text] [PDF]  

A Rare Premalignant Prostate Tumor Epithelial Cell Syndecan-1 Forms a Fibroblast Growth Factor-binding Complex with Progression-promoting Ectopic Fibroblast Growth Factor Receptor 1

Xiaochong Wu, Mikio Kan, Fen Wang, Chengliu Jin, Chundong Yu, and Wallace L. McKeehan
Cancer Res 2001 61: 5295-5302. [Abstract] [Full Text] [PDF]  

Promoter Hypermethylation: A Common Cause of Reduced p16^INK4a Expression in Uveal Melanoma

Pieter A. van der Velden, Jessica A. W. Metzelaar-Blok, Wilma Bergman, H. Monique, H. Hurks, Rune R. Frants, Nelleke A. Gruis, and Martine J. Jager
Cancer Res 2001 61: 5303-5306. [Abstract] [Full Text] [PDF]  

Mutational Analysis of the Peroxisome Proliferator-activated Receptor Gene in Human Malignancies

Takayuki Ikezoe, Carl W. Miller, Seiji Kawano, Anthony Heaney, Elizabeth A. Williamson, Junichi Hisatake, Eric Green, Wolf Hofmann, Hirokuni Taguchi, and H. Phillip Koeffle
Cancer Res 2001 61: 5307-5310. [Abstract] [Full Text] [PDF]  

The COOH-Terminal Domain of FLI-1 Is Necessary for Full Tumorigenesis and Transcriptional Modulation by EWS/FLI-1

Afsane Arvand, Scott M. Welford, Michael A. Teitell, and Christopher T. Denny
Cancer Res 2001 61: 5311-5317. [Abstract] [Full Text] [PDF] Supplementary Data  

Effect of Changing Tumor Oxygenation on Glycolytic Metabolism in a Murine C3H Mammary Carcinoma Assessed by in Vivo Nuclear Magnetic Resonance Spectroscopy

Flemming U. Nielsen, Preben Daugaard, Lise Bentzen, Hans Stødkilde-Jørgensen, Jens Overgaard, Michael R. Horsman, and Ross J. Maxwell
Cancer Res 2001 61: 5318-5325. [Abstract] [Full Text] [PDF]  

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