Constitutional genomic instability of 9p23-24 in BRCA2 carriers. Top panel: Partial pedigree of a family with a germline BRCA2 mutation; +/-, heterozygote; +/+, wildtype. Middle panel: two-probe fluorescence in situ analysis of chromosome 9 homologues of lymphocytes from family members; white arrow points to rearranged distal 9p, the other homologue appears normal. Lower panel: chromosome 9 homologues from different metaphases of one individual heterozygous for BRCA2; note different rearrangements in different chromosome 9 homologues, in some cells only one homologue is rearranged, in others both are altered; n, normal; r, rearranged. For details, see the article by Savelyeva et al. on p. 5179 in this issue.

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