Advances in Brief:

Frequent Loss of Estrogen Receptor-ß Expression in Prostate Cancer

Lisa G. Horvath, Susan M. Henshall, C-Soon Lee, Darren R. Head, David I. Quinn, Sari Makela, Warick Delprado, David Golovsky, Phillip C. Brenner, Gordon O’Neill, Raji Kooner, Phillip D. Stricker, John J. Grygiel, Jan-Ake Gustafsson, and Robert L. Sutherland
Cancer Res 2001 61: 5331-5335. [Abstract] [Full Text] [PDF]  

Comparative Analyses of Transgene Delivery and Expression in Tumors Inoculated with a Replication-conditional or -defective Viral Vector

Tomotsogu Ichikawa and E. Antonio Chiocca
Cancer Res 2001 61: 5336-5339. [Abstract] [Full Text] [PDF]  

Amplification of Urokinase Gene in Prostate Cancer

Merja A. Helenius, Outi R. Saramäki, Marika J. Linja, Teuvo L. J. Tammela, and Tapio Visakorpi
Cancer Res 2001 61: 5340-5344. [Abstract] [Full Text] [PDF]  

Amplification of HER-2/neu and Topoisomerase II in Primary and Metastatic Breast Cancer

Minna Tanner, Päivi Järvinen, and Jorma Isola
Cancer Res 2001 61: 5345-5348. [Abstract] [Full Text] [PDF]  

Growth Suppression of Intracranial Xenografted Glioblastomas Overexpressing Mutant Epidermal Growth Factor Receptors by Systemic Administration of Monoclonal Antibody (mAb) 806, a Novel Monoclonal Antibody Directed to the Receptor

Kazuhiko Mishima, Terrance G. Johns, Rodney B. Luwor, Andrew M. Scott, Elisabeth Stockert, Achim A. Jungbluth, Xiang-Dong Ji, Padma Suvarna, Joseph R. Voland, Lloyd J. Old, H-J. Su Huang, and Webster K. Cavenee
Cancer Res 2001 61: 5349-5354. [Abstract] [Full Text] [PDF]  

Monoclonal Antibody 806 Inhibits the Growth of Tumor Xenografts Expressing Either the de2–7 or Amplified Epidermal Growth Factor Receptor (EGFR) but not Wild-Type EGFR

Rodney B. Luwor, Terrance G. Johns, Carmel Murone, H-J. Su Huang, Webster K. Cavenee, Gerd Ritter, Lloyd J. Old, Antony W. Burgess, and Andrew M. Scott
Cancer Res 2001 61: 5355-5361. [Abstract] [Full Text] [PDF]  

Reduced Expression and Impaired Kinase Activity of a Chk2 Mutant Identified in Human Lung Cancer

Shuhei Matsuoka, Taku Nakagawa, Akira Masuda, Nobuhiro Haruki, Stephen J. Elledge, and Takashi Takahashi
Cancer Res 2001 61: 5362-5365. [Abstract] [Full Text] [PDF]  

DNA Polymerase , Implicated in Spontaneous and DNA Damage-induced Mutagenesis, Is Overexpressed in Lung Cancer

Jiyang O-Wang, Kiyoko Kawamura, Yuji Tada, Haruo Ohmori, Hideki Kimura, Shigeru Sakiyama, and Masatoshi Tagawa
Cancer Res 2001 61: 5366-5369. [Abstract] [Full Text] [PDF]  

Cloning and Characterization of a Human Polyamine Oxidase That Is Inducible by Polyamine Analogue Exposure

Yanlin Wang, Wendy Devereux, Patrick M. Woster, Tracy Murray Stewart, Amy Hacker, and Robert A. Casero, Jr.
Cancer Res 2001 61: 5370-5373. [Abstract] [Full Text] [PDF]  

Fusion of the Homeobox Gene HLXB9 and the ETV6 Gene in Infant Acute Myeloid Leukemias with the t(7;12)(q36;p13)

H. Berna Beverloo, Ioannis Panagopoulos, Magareth Isaksson, Elisabeth van Wering, Ellen van Drunen, Annelies de Klein, Bertil Johansson, and Rosalyn Slater
Cancer Res 2001 61: 5374-5377. [Abstract] [Full Text] [PDF]  

Repair of 8-Oxodeoxyguanosine Lesions in Mitochondrial DNA Depends on the Oxoguanine DNA Glycosylase (OGG1) Gene and 8-Oxoguanine Accumulates in the Mitochondrial DNA of OGG1-defective Mice

Nadja C. de Souza-Pinto, Lars Eide, Barbara A. Hogue, Tanja Thybo, Tinna Stevnsner, Erling Seeberg, Arne Klungland, and Vilhelm A. Bohr
Cancer Res 2001 61: 5378-5381. [Abstract] [Full Text] [PDF]  

Biochemistry & Biophysics:

Overexpression of Mitochondrial Manganese Superoxide Dismutase Protects against Radiation-induced Cell Death in the Human Hepatocellular Carcinoma Cell Line HLE

Shigeatsu Motoori, Hideyuki J. Majima, Masaaki Ebara, Hirotoshi Kato, Futoshi Hirai, Shizuko Kakinuma, Chizuru Yamaguchi, Toshihiko Ozawa, Tetsuo Nagano, Hirohiko Tsujii, and Hiromitsu Saisho
Cancer Res 2001 61: 5382-5388. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Hepatocellular Carcinoma Results from Chronic Cyclin D1 Overexpression in Transgenic Mice

Natasha G. Deane, Monica A. Parker, Radhika Aramandla, Lisa Diehl, Woo-Jung Lee, M. Kay Washington, Lillian B. Nanney, Yu Shyr, and R. Daniel Beauchamp
Cancer Res 2001 61: 5389-5395. [Abstract] [Full Text] [PDF]  

Extremely Low-Dose Ionizing Radiation Causes Activation of Mitogen-activated Protein Kinase Pathway and Enhances Proliferation of Normal Human Diploid Cells

Keiji Suzuki, Seiji Kodama, and Masami Watanabe
Cancer Res 2001 61: 5396-5401. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Functional Quantification of DNA-binding Proteins p53 and Estrogen Receptor in Cells and Tumor Tissues by DNA Affinity Immunoblotting

Yuangang Liu, Harold Asch, and Molly F. Kulesz-Martin
Cancer Res 2001 61: 5402-5406. [Abstract] [Full Text] [PDF]  

High Tumor Levels of Vascular Endothelial Growth Factor Predict Poor Response to Systemic Therapy in Advanced Breast Cancer

John A. Foekens, Harry A. Peters, Nicolai Grebenchtchikov, Maxime P. Look, Marion E. Meijer-van Gelder, Anneke Geurts-Moespot, Theo H. van der Kwast, C. G. J. Sweep, and Jan G. M. Klijn
Cancer Res 2001 61: 5407-5414. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Red Meat, Family History, and Increased Risk of Gastric Cancer with Microsatellite Instability

Domenico Palli, Antonio Russo, Laura Ottini, Giovanna Masala, Calogero Saieva, Andrea Amorosi, Alessandro Cama, Cristina D’Amico, Mario Falchetti, Raffaele Palmirotta, Adriano Decarli, Renato Mariani Costantini, and Joseph F. Fraumeni, Jr.
Cancer Res 2001 61: 5415-5419. [Abstract] [Full Text] [PDF]  

Modification of BRCA1- and BRCA2-associated Breast Cancer Risk by AIB1 Genotype and Reproductive History

Timothy R. Rebbeck, Yiting Wang, Philip W. Kantoff, Krishna Krithivas, Susan L. Neuhausen, Andrew K. Godwin, Mary B. Daly, Steven A. Narod, Jean-Sebastian Brunet, Daniel Vesprini, Judy E. Garber, Henry T. Lynch, Barbara L. Weber, and Myles Brown
Cancer Res 2001 61: 5420-5424. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Inhibition of DNA Replication by Tirapazamine

Katherine B. Peters, Hongyan Wang, J. Martin Brown, and George Iliakis
Cancer Res 2001 61: 5425-5431. [Abstract] [Full Text] [PDF]  

Tumor Growth Inhibition by Arsenic Trioxide (As₂O₃) in the Orthotopic Metastasis Model of Androgen-independent Prostate Cancer

Hiroshi Maeda, Seiji Hori, Hideki Nishitoh, Hidenori Ichijo, Osamu Ogawa, Yoshiyuki Kakehi, and Akira Kakizuka
Cancer Res 2001 61: 5432-5440. [Abstract] [Full Text] [PDF]  

Effects of Angiostatin Gene Transfer on Functional Properties and in Vivo Growth of Kaposi’s Sarcoma Cells

Stefano Indraccolo, Monica Morini, Eleonora Gola, Fabio Carrozzino, Walter Habeler, Simona Minghelli, Leonardo Santi, Luigi Chieco-Bianchi, Yihai Cao, Adriana Albini, and Douglas M. Noonan
Cancer Res 2001 61: 5441-5446. [Abstract] [Full Text] [PDF]  

Multimodality Therapy with a Replication-conditional Herpes Simplex Virus 1 Mutant that Expresses Yeast Cytosine Deaminase for Intratumoral Conversion of 5-Fluorocytosine to 5-Fluorouracil

Hideo Nakamura, John T. Mullen, Soundararajalu Chandrasekhar, Timothy M. Pawlik, Sam S. Yoon, and Kenneth K. Tanabe
Cancer Res 2001 61: 5447-5452. [Abstract] [Full Text] [PDF]  

CV706, a Prostate Cancer-specific Adenovirus Variant, in Combination with Radiotherapy Produces Synergistic Antitumor Efficacy without Increasing Toxicity

Yu Chen, Theodore DeWeese, Jeanette Dilley, Yiwei Zhang, Yuanhao Li, Nagarajan Ramesh, Jake Lee, Rukmini Pennathur-Das, John Radzyminski, Joseph Wypych, Dominic Brignetti, Sara Scott, Jennifer Stephens, David B. Karpf, Daniel R. Henderson, and De-Chao Yu
Cancer Res 2001 61: 5453-5460. [Abstract] [Full Text] [PDF]  

Resistance to Mitoxantrone in Multidrug-resistant MCF7 Breast Cancer Cells: Evaluation of Mitoxantrone Transport and the Role of Multidrug Resistance Protein Family Proteins

Sri K. Diah, Pamela K. Smitherman, Jerry Aldridge, Erin L. Volk, Erasmus Schneider, Alan J. Townsend, and Charles S. Morrow
Cancer Res 2001 61: 5461-5467. [Abstract] [Full Text] [PDF]  

Inhibition of Promyelocytic Leukemia (PML)/Retinoic Acid Receptor- and PML Expression in Acute Promyelocytic Leukemia Cells by Anti-PML Peptide Nucleic Acid

Luca Mologni, Edoardo Marchesi, Peter E. Nielsen, and Carlo Gambacorti-Passerini
Cancer Res 2001 61: 5468-5473. [Abstract] [Full Text] [PDF]  

8-Chloro-cAMP and 8-Chloro-adenosine Act by the Same Mechanism in Multiple Myeloma Cells

Varsha Gandhi, Mary Ayres, Robert G. Halgren, Nancy L. Krett, Robert A. Newman, and Steve T. Rosen
Cancer Res 2001 61: 5474-5479. [Abstract] [Full Text] [PDF]  

A-204197, a New Tubulin-binding Agent with Antimitotic Activity in Tumor Cell Lines Resistant to Known Microtubule Inhibitors

Stephen K. Tahir, Edward K-H. Han, Bruce Credo, Hwan-Soo Jae, Jennifer A. Pietenpol, Caroline D. Scatena, Jinshyun R. Wu-Wong, David Frost, Hing Sham, Saul H. Rosenberg, and Shi-Chung Ng
Cancer Res 2001 61: 5480-5485. [Abstract] [Full Text] [PDF]  

Triterpenoid Saponins from Acacia victoriae (Bentham) Decrease Tumor Cell Proliferation and Induce Apoptosis

Kalpana Mujoo, Valsala Haridas, Joseph J. Hoffmann, Gerald A. Wächter, Louis K. Hutter, Yiling Lu, Mary E. Blake, Gamini S. Jayatilake, David Bailey, Gordon B. Mills, and Jordan U. Gutterman
Cancer Res 2001 61: 5486-5490. [Abstract] [Full Text] [PDF]  

Pharmacodynamic-mediated Reduction of Temozolomide Tumor Concentrations by the Angiogenesis Inhibitor TNP-470

Jianguo Ma, Sharon Pulfer, Shaolan Li, Jianxiong Chu, Karin Reed, and James M. Gallo
Cancer Res 2001 61: 5491-5498. [Abstract] [Full Text] [PDF]  

Tetra-O-methyl Nordihydroguaiaretic Acid Induces G₂ Arrest in Mammalian Cells and Exhibits Tumoricidal Activity in Vivo

Jonathan D. Heller, Jennifer Kuo, T. C. Wu, W. Martin Kast, and Ru Chih C. Huang
Cancer Res 2001 61: 5499-5504. [Abstract] [Full Text] [PDF]  

Pharmacogenomic Dissection of Resistance to Thymidylate Synthase Inhibitors

Weiguang Wang, Sharon Marsh, James Cassidy, and Howard L. McLeod
Cancer Res 2001 61: 5505-5510. [Abstract] [Full Text] [PDF]  

Immunology:

Identification of Fibroblast Growth Factor-5 as an Overexpressed Antigen in Multiple Human Adenocarcinomas

Ken-ichi Hanada, Donna M. Perry-Lalley, Galen A. Ohnmacht, Maria P. Bettinotti, and James C. Yang
Cancer Res 2001 61: 5511-5516. [Abstract] [Full Text] [PDF]  

IgEs Targeted on Tumor Cells: Therapeutic Activity and Potential in the Design of Tumor Vaccines

Eva Reali, John W. Greiner, Angelo Corti, Hannah J. Gould, Federica Bottazzoli, Giovanni Paganelli, Jeffrey Schlom, and Antonio G. Siccardi
Cancer Res 2001 61: 5517-5522. [Abstract] [Full Text] [PDF]  

Antimetastatic Effect of CpG DNA Mediated by Type I IFN

Michael Hafner, Rainer Zawatzky, Christian Hirtreiter, Wim A. Buurman, Bernd Echtenacher, Thomas Hehlgans, and Daniela N. Männel
Cancer Res 2001 61: 5523-5528. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Human Telomerase Reverse Transcriptase Promoter Regulation in Normal and Malignant Human Ovarian Epithelial Cells

Ilana Braunstein, Orit Cohen-Barak, Catherine Shachaf, Yael Ravel, Michal Yalon-Hacohen, Gordon B. Mills, Maty Tzukerman, and Karl L. Skorecki
Cancer Res 2001 61: 5529-5536. [Abstract] [Full Text] [PDF]  

Redox Modulation of the Pro-Fibrogenic Mediator Plasminogen Activator Inhibitor-1 following Ionizing Radiation

Weiling Zhao, Douglas R. Spitz, Larry W. Oberley, and Mike E. C. Robbins
Cancer Res 2001 61: 5537-5543. [Abstract] [Full Text] [PDF]  

An Overview of the MAGE Gene Family with the Identification of All Human Members of the Family

Patrick Chomez, Olivier De Backer, Mathieu Bertrand, Etienne De Plaen, Thierry Boon, and Sophie Lucas
Cancer Res 2001 61: 5544-5551. [Abstract] [Full Text] [PDF]  

Heterozygosity for the Mouse Apex Gene Results in Phenotypes Associated with Oxidative Stress

Lisiane B. Meira, Sridevi Devaraj, Glen E. Kisby, Dennis K. Burns, Russel L. Daniel, Robert E. Hammer, Scott Grundy, Ishwarlal Jialal, and Errol C. Friedberg
Cancer Res 2001 61: 5552-5557. [Abstract] [Full Text] [PDF]  

Hypermethylation Leads to Silencing of the SYK Gene in Human Breast Cancer

Yunfei Yuan, Richard Mendez, Aysegul Sahin, and Jia Le Dai
Cancer Res 2001 61: 5558-5561. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Glypican-1 Is Overexpressed in Human Breast Cancer and Modulates the Mitogenic Effects of Multiple Heparin-binding Growth Factors in Breast Cancer Cells

Kei Matsuda, Haruhisa Maruyama, Fang Guo, Jörg Kleeff, Jun Itakura, Yoshiro Matsumoto, Arthur D. Lander, and Murray Korc
Cancer Res 2001 61: 5562-5569. [Abstract] [Full Text] [PDF]  

Detection of Peritoneal Micrometastases of Gastric Carcinoma with Green Fluorescent Protein and Carcinoembryonic Antigen Promoter

Katsuhiko Kaneko, Masahiko Yano, Tomoki Yamano, Toshimasa Tsujinaka, Hirofumi Miki, Yosuke Akiyama, Masaaki Taniguchi, Yoshiyuki Fujiwara, Yuichiro Doki, Masatoshi Inoue, Hitoshi Shiozaki, Yasushi Kaneda, and Morito Monden
Cancer Res 2001 61: 5570-5574. [Abstract] [Full Text] [PDF]  

A Primary Tumor Promotes Dormancy of Solitary Tumor Cells before Inhibiting Angiogenesis

Markus Guba, Grigore Cernaianu, Gudrun Koehl, Edward K. Geissler, Karl-Walter Jauch, Matthias Anthuber, Werner Falk, and Markus Steinbauer
Cancer Res 2001 61: 5575-5579. [Abstract] [Full Text] [PDF]  

Telomerase Inhibition in RenCa, a Murine Tumor Cell Line with Short Telomeres, by Overexpression of a Dominant Negative mTERT Mutant, Reveals Fundamental Differences in Telomerase Regulation between Human and Murine Cells

Jana Sachsinger, Eva González-Suárez, Enrique Samper, Rüdiger Heicappell, Markus Müller, and María. A. Blasco
Cancer Res 2001 61: 5580-5586. [Abstract] [Full Text] [PDF]  

Plasminogen Activator Inhibitor-1 Promotes Angiogenesis by Stimulating Endothelial Cell Migration toward Fibronectin

Chiho Isogai, Walter E. Laug, Hiroyuki Shimada, Paul J. Declerck, Monique F. Stins, Donald L. Durden, Anat Erdreich-Epstein, and Yves A. DeClerck
Cancer Res 2001 61: 5587-5594. [Abstract] [Full Text] [PDF]  

High Glycolytic Activity in Rat Glioma Demonstrated in Vivo by Correlation Peak ¹H Magnetic Resonance Imaging

Anne Ziegler, Markus von Kienlin, Michel Décorps, and Chantal Rémy
Cancer Res 2001 61: 5595-5600. [Abstract] [Full Text] [PDF]  

Overexpression of 4 Chain-containing Laminins in Human Glial Tumors Identified by Gene Microarray Analysis

Julia Y. Ljubimova, Alexander J. Lakhter, Anna Loksh, William H. Yong, Mary S. Riedinger, Jeffrey H. Miner, Lydia M. Sorokin, Alexander V. Ljubimov, and Keith L. Black
Cancer Res 2001 61: 5601-5610. [Abstract] [Full Text] [PDF]  

Androgen Blocks Apoptosis of Hormone-dependent Prostate Cancer Cells

Kotohiko Kimura, Mark Markowski, Cai Bowen, and Edward P. Gelmann
Cancer Res 2001 61: 5611-5618. [Abstract] [Full Text] [PDF]  

Metastasis-inducing DNA Regulates the Expression of the Osteopontin Gene by Binding the Transcription Factor Tcf-4

Mohamed El-Tanani, Roger Barraclough, Mark C. Wilkinson, and Philip S. Rudland
Cancer Res 2001 61: 5619-5629. [Abstract] [Full Text] [PDF]  

Absence of Crabtree Effect in Human Melanoma Cells Adapted to Growth at Low pH: Reversal by Respiratory Inhibitors

Randy Burd, Phyllis R. Wachsberger, John E. Biaglow, Miriam L. Wahl, Intae Lee, and Dennis B. Leeper
Cancer Res 2001 61: 5630-5635. [Abstract] [Full Text] [PDF]  

Alterations of p14^ARF, p53, and p73 Genes Involved in the E2F-1-mediated Apoptotic Pathways in Non-Small Cell Lung Carcinoma

Siobhan A. Nicholson, Nader T. Okby, Mohammed A. Khan, Judith A. Welsh, Mary G. McMenamin, William D. Travis, James R. Jett, Henry D. Tazelaar, Victor Trastek, Peter C. Pairolero, Paul G. Corn, James G. Herman, Lance A. Liotta, Neil E. Caporaso, and Curtis C. Harris
Cancer Res 2001 61: 5636-5643. [Abstract] [Full Text] [PDF]  

The Src-suppressed C Kinase Substrate, SSeCKS, Is a Potential Metastasis Inhibitor in Prostate Cancer

Wei Xia, Pam Unger, Lorraine Miller, Joel Nelson, and Irwin H. Gelman
Cancer Res 2001 61: 5644-5651. [Abstract] [Full Text] [PDF]  

Prostate Cancer Cells Induce Osteoblast Differentiation through a Cbfa1-dependent Pathway

Jun Yang, Karim Fizazi, Sara Peleg, Charles R. Sikes, A. Kevin Raymond, Nausheen Jamal, Min Hu, Matilde Olive, Luis A. Martinez, Christopher G. Wood, Christopher J. Logothetis, Gerard Karsenty, and Nora M. Navone
Cancer Res 2001 61: 5652-5659. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: B. H. Joshi et al., Interleukin-13 Receptor Chain: A Novel Tumor-associated Transmembrane Protein in Primary Explants of Human Malignant Gliomas. Cancer Res., 60: 1168–1172, 2000.

Waldemar Debinski, Bharat H. Joshi, Gregory E. Plautz, and Raj K. Puri
Cancer Res 2001 61: 5660 [Full Text] [PDF]  

Obituary:

In Memoriam: Leonard L. Weiss, Sc.D., M.D., Ph.D.

Dorothy Glaves Rapp
Cancer Res 2001 61: 5663 [Full Text] [PDF]  

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