Perspectives in Cancer Research:

Selective Estrogen Receptor Modulation: A Personal Perspective

V. Craig Jordan
Cancer Res 2001 61: 5683-5687. [Full Text] [PDF]  

Advances in Brief:

PTEN-independent Induction of Caspase-mediated Cell Death and Reduced Invasion by the Focal Adhesion Targeting Domain (FAT) in Human Astrocytic Brain Tumors Which Highly Express Focal Adhesion Kinase (FAK)

Graham Jones, Joel Machado, Jr., Markus Tolnay, and Adrian Merlo
Cancer Res 2001 61: 5688-5691. [Abstract] [Full Text] [PDF]  

Expression Profiling Reveals Hepsin Overexpression in Prostate Cancer

Jeffrey A. Magee, Toshiyuki Araki, Sushama Patil, Torsten Ehrig, Lawrence True, Peter A. Humphrey, William J. Catalona, Mark A. Watson, and Jeffrey Milbrandt
Cancer Res 2001 61: 5692-5696. [Abstract] [Full Text] [PDF]  

A SAGE (Serial Analysis of Gene Expression) View of Breast Tumor Progression

Dale A. Porter, Ian E. Krop, Selim Nasser, Dennis Sgroi, Carolyn M. Kaelin, Jeffrey R. Marks, Gregory Riggins, and Kornelia Polyak
Cancer Res 2001 61: 5697-5702. [Abstract] [Full Text] [PDF]  

Overexpression of Id-1 Protein Is a Marker for Unfavorable Prognosis in Early-Stage Cervical Cancer

Monika Schindl, Georg Oberhuber, Andreas Obermair, Sebastian F. Schoppmann, Barbara Karner, and Peter Birner
Cancer Res 2001 61: 5703-5706. [Abstract] [Full Text] [PDF]  

Dioxin Suppresses the Checkpoint Protein, MAD2, by an Aryl Hydrocarbon Receptor-independent Pathway

Kosuke Oikawa, Tetsuya Ohbayashi, Junsei Mimura, Ryoko Iwata, Akemi Kameta, Kazumi Evine, Keiichi Iwaya, Yoshiaki Fujii-Kuriyama, Masahiko Kuroda, and Kiyoshi Mukai
Cancer Res 2001 61: 5707-5709. [Abstract] [Full Text] [PDF]  

Modest Increased Sensitivity to Radiation Oncogenesis in ATM Heterozygous versus Wild-Type Mammalian Cells

Lubomir B. Smilenov, David J. Brenner, and Eric J. Hall
Cancer Res 2001 61: 5710-5713. [Abstract] [Full Text] [PDF]  

Hepatoma-derived Growth Factor Is Associated with Reduced Sensitivity to Irradiation in Esophageal Cancer

Ayumi Matsuyama, Hiroshi Inoue, Kenji Shibuta, Yoichi Tanaka, Graham F. Barnard, Keizo Sugimachi, and Masaki Mori
Cancer Res 2001 61: 5714-5717. [Abstract] [Full Text] [PDF]  

p53, CHK2, and CHK1 Genes in Finnish Families with Li-Fraumeni Syndrome: Further Evidence of CHK2 in Inherited Cancer Predisposition

Pia Vahteristo, Anitta Tamminen, Petteri Karvinen, Hannaleena Eerola, Carita Eklund, Lauri A. Aaltonen, Carl Blomqvist, Kristiina Aittomäki, and Heli Nevanlinna
Cancer Res 2001 61: 5718-5722. [Abstract] [Full Text] [PDF]  

Prognostic Significance of Circulating Microsatellite Markers in the Plasma of Melanoma Patients

Bret Taback, Yoshiyuki Fujiwara, He-Jing Wang, Leland J. Foshag, Donald L. Morton, and Dave S. B. Hoon
Cancer Res 2001 61: 5723-5726. [Abstract] [Full Text] [PDF]  

Aberrant Methylation and Simian Virus 40 Tag Sequences in Malignant Mesothelioma

Shinichi Toyooka, Harvey I. Pass, Narayan Shivapurkar, Yasuro Fukuyama, Riichiroh Maruyama, Kiyomi O. Toyooka, Michael Gilcrease, Alfredo Farinas, John D. Minna, and Adi F. Gazdar
Cancer Res 2001 61: 5727-5730. [Abstract] [Full Text] [PDF]  

HIF-1-mediated Up-Regulation of Vascular Endothelial Growth Factor, Independent of Basic Fibroblast Growth Factor, Is Important in the Switch to the Angiogenic Phenotype during Early Tumorigenesis

Jianmin Fang, Li Yan, Yuen Shing, and Marsha A. Moses
Cancer Res 2001 61: 5731-5735. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Is an Autocrine Survival Factor for Neuropilin-expressing Breast Carcinoma Cells

Robin E. Bachelder, Aimee Crago, Jun Chung, Melissa A. Wendt, Leslie M. Shaw, Gregory Robinson, and Arthur M. Mercurio
Cancer Res 2001 61: 5736-5740. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

A Monoclonal Antibody That Induces Neuronal Apoptosis Binds a Metastasis Marker

Li-tao Zhong, Adriana Manzi, Evan Skowronski, Lucia Notterpek, Arvan L. Fluharty, Kym F. Faull, Irene Masada, Shahrooz Rabizadeh, Maria Varsanyi-Nagy, Youlin Ruan, Justin D. Oh, Larry L. Butcher, and Dale E. Bredesen
Cancer Res 2001 61: 5741-5748. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Two Novel Glycosides from the Fruits of Morinda Citrifolia (Noni) Inhibit AP-1 Transactivation and Cell Transformation in the Mouse Epidermal JB6 Cell Line

Guangming Liu, Ann Bode, Wei-Ya Ma, Shengmin Sang, Chi-Tang Ho, and Zigang Dong
Cancer Res 2001 61: 5749-5756. [Abstract] [Full Text] [PDF]  

Interactions between Methylating and Pyridyloxobutylating Agents in A/J Mouse Lungs: Implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced Lung Tumorigenesis

Lisa A. Peterson, Nicole M. Thomson, Daune L. Crankshaw, Elizabeth E. Donaldson, and Patrick J. Kenney
Cancer Res 2001 61: 5757-5763. [Abstract] [Full Text] [PDF]  

Endocrinology:

Preferential Growth Stimulation of Mammary Glands over Uterine Endometrium in Female Rats by a Naturally Occurring Estradiol-17ß-fatty Acid Ester

Laura H. Mills, Anthony J. Lee, A. F. Parlow, and Bao Ting Zhu
Cancer Res 2001 61: 5764-5770. [Abstract] [Full Text] [PDF]  

Re-expression of Estrogen Receptor in Estrogen Receptor -negative MCF-7 Cells Restores both Estrogen and Insulin-like Growth Factor-mediated Signaling and Growth

Steffi Oesterreich, Ping Zhang, Rebecca L. Guler, Xiuhua Sun, Edward M. Curran, Wade V. Welshons, C. Kent Osborne, and Adrian V. Lee
Cancer Res 2001 61: 5771-5777. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Growth Inhibition of Dermatofibrosarcoma Protuberans Tumors by the Platelet-derived Growth Factor Receptor Antagonist STI571 through Induction of Apoptosis

Tobias Sjöblom, Akira Shimizu, Kevin P. O’Brien, Kristian Pietras, Paola Dal Cin, Elisabeth Buchdunger, Jan P. Dumanski, Arne Östman, and Carl-Henrik Heldin
Cancer Res 2001 61: 5778-5783. [Abstract] [Full Text] [PDF]  

Inhibition of Glioma Growth in Vivo by Selective Activation of the CB₂ Cannabinoid Receptor

Cristina Sánchez, María L. de Ceballos, Teresa Gómez del Pulgar, Daniel Rueda, César Corbacho, Guillermo Velasco, Ismael Galve-Roperh, John W. Huffman, Santiago Ramón y Cajal, and Manuel Guzmán
Cancer Res 2001 61: 5784-5789. [Abstract] [Full Text] [PDF]  

Signaling-inactive Epidermal Growth Factor Receptor/Ligand Complexes in Intact Carcinoma Cells by Quinazoline Tyrosine Kinase Inhibitors

Rosemarie B. Lichtner, Andreas Menrad, Anette Sommer, Ulrich Klar, and Martin R. Schneider
Cancer Res 2001 61: 5790-5795. [Abstract] [Full Text] [PDF]  

Treatment of Malignant Glioma Cells with the Transfer of Constitutively Active Caspase-6 Using the Human Telomerase Catalytic Subunit (Human Telomerase Reverse Transcriptase) Gene Promoter

Tadashi Komata, Yasuko Kondo, Takao Kanzawa, Satoshi Hirohata, Shoji Koga, Hideaki Sumiyoshi, Srinivasa M. Srinivasula, Barbara P. Barna, Isabelle M. Germano, Masahiro Takakura, Masaki Inoue, Emad S. Alnemri, Jerry W. Shay, Satoru Kyo, and Seiji Kondo
Cancer Res 2001 61: 5796-5802. [Abstract] [Full Text] [PDF]  

Multiple Microtubule Alterations Are Associated with Vinca Alkaloid Resistance in Human Leukemia Cells

Maria Kavallaris, A. Sasha Tait, Bradley J. Walsh, Lifeng He, Susan B. Horwitz, Murray D. Norris, and Michelle Haber
Cancer Res 2001 61: 5803-5809. [Abstract] [Full Text] [PDF]  

Differing Contribution of Thiopurine Methyltransferase to Mercaptopurine versus Thioguanine Effects in Human Leukemic Cells

Thierry Dervieux, Javier G. Blanco, Eugene Y. Krynetski, Elio F. Vanin, Martine F. Roussel, and Mary V. Relling
Cancer Res 2001 61: 5810-5816. [Abstract] [Full Text] [PDF]  

Helenalin Triggers a CD95 Death Receptor-independent Apoptosis That Is Not Affected by Overexpression of Bcl-x_L or Bcl-2

Verena M. Dirsch, Hermann Stuppner, and Angelika M. Vollmar
Cancer Res 2001 61: 5817-5823. [Abstract] [Full Text] [PDF]  

Antitumor Effect of 5-Aminolevulinic Acid-mediated Photodynamic Therapy Can Be Enhanced by the Use of a Low Dose of Photofrin in Human Tumor Xenografts

Qian Peng, Trond Warloe, Johan Moan, Aslak Godal, Fabio Apricena, Karl-Erik Giercksky, and Jahn M. Nesland
Cancer Res 2001 61: 5824-5832. [Abstract] [Full Text] [PDF]  

Chimeric Tumor Suppressor 1, a p53-derived Chimeric Tumor Suppressor Gene, Kills p53 Mutant and p53 Wild-type Glioma Cells in Synergy with Irradiation and CD95 Ligand

Ulrike Naumann, Sebastian Kügler, Hartwig Wolburg, Wolfgang Wick, Gesa Rascher, Jörg B. Schulz, Emmanuel Conseiller, Mathias Bähr, and Michael Weller
Cancer Res 2001 61: 5833-5842. [Abstract] [Full Text] [PDF]  

Abrogation of the Chk1-mediated G₂ Checkpoint Pathway Potentiates Temozolomide-induced Toxicity in a p53-independent Manner in Human Glioblastoma Cells

Yuichi Hirose, Mitchel S. Berger, and Russell O. Pieper
Cancer Res 2001 61: 5843-5849. [Abstract] [Full Text] [PDF]  

Immunology:

Heterogeneous T-Cell Response to MAGE-A10_254–262: High Avidity-specific Cytolytic T Lymphocytes Show Superior Antitumor Activity

Valérie Dutoit, Verena Rubio-Godoy, Pierre-Yves Dietrich, Anne-Lise Quiqueres, Valérie Schnuriger, Donata Rimoldi, Danielle Liénard, Daniel Speiser, Philippe Guillaume, Pascal Batard, Jean-Charles Cerottini, Pedro Romero, and Danila Valmori
Cancer Res 2001 61: 5850-5856. [Abstract] [Full Text] [PDF]  

Murine Six-Transmembrane Epithelial Antigen of the Prostate, Prostate Stem Cell Antigen, and Prostate-specific Membrane Antigen: Prostate-specific Cell-Surface Antigens Highly Expressed in Prostate Cancer of Transgenic Adenocarcinoma Mouse Prostate Mice

Damu Yang, Gregory E. Holt, Markwin P. Velders, Eugene D. Kwon, and W. Martin Kast
Cancer Res 2001 61: 5857-5860. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Osteopontin Is an Autocrine Mediator of Hepatocyte Growth Factor-induced Invasive Growth

Enzo Medico, Alessandra Gentile, Cristina Lo Celso, Tracy A. Williams, Giovanna Gambarotta, Livio Trusolino, and Paolo M. Comoglio
Cancer Res 2001 61: 5861-5868. [Abstract] [Full Text] [PDF]  

Short Polyglutamine Tracts in the Androgen Receptor Are Protective against Breast Cancer in the General Population

Yves Giguère, Eric Dewailly, Jacques Brisson, Pierre Ayotte, Nathalie Laflamme, Alain Demers, Véronique-Isabelle Forest, Sylvie Dodin, Jean Robert, and François Rousseau
Cancer Res 2001 61: 5869-5874. [Abstract] [Full Text] [PDF]  

Global and Gene-specific Epigenetic Patterns in Human Bladder Cancer Genomes Are Relatively Stable in Vivo and in Vitro over Time

Isabel D.C. Markl, Jonathan Cheng, Gangning Liang, Darryl Shibata, Peter W. Laird, and Peter A. Jones
Cancer Res 2001 61: 5875-5884. [Abstract] [Full Text] [PDF]  

Regulation of the Catalase Gene Promoter by Sp1, CCAAT-recognizing Factors, and a WT1/Egr-related Factor in Hydrogen Peroxide-resistant HP100 Cells

Mitsuru Nenoi, Sachiko Ichimura, Kazuei Mita, Osami Yukawa, and Iain L. Cartwright
Cancer Res 2001 61: 5885-5894. [Abstract] [Full Text] [PDF]  

Genetic Analysis of Early- versus Late-Stage Ovarian Tumors

Viji Shridhar, John Lee, Ajay Pandita, Steve Iturria, Rajeswari Avula, Julie Staub, Mike Morrissey, Eric Calhoun, Ami Sen, Kimberly Kalli, Gary Keeney, Patrick Roche, William Cliby, Karen Lu, Rosemarie Schmandt, Gordon B. Mills, Robert C. Bast, Jr., C. David James, Fergus J. Couch, Lynn C. Hartmann, Jim Lillie, and David I. Smith
Cancer Res 2001 61: 5895-5904. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Tumor Suppressor Genes in the 9p21 Gene Cluster Are Selective Targets of Inactivation in Neuroendocrine Gastroenteropancreatic Tumors

Nikolaus Lubomierski, Michael Kersting, Tillmann Bert, Karin Muench, Ulrich Wulbrand, Marcus Schuermann, Detlev Bartsch, and Babette Simon
Cancer Res 2001 61: 5905-5910. [Abstract] [Full Text] [PDF]  

Hepatocyte Growth Factor/Scatter Factor-induced Activation of MEK and PI3K Signal Pathways Contributes to Expression of Proangiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor in Head and Neck Squamous Cell Carcinoma

Gang Dong, Zhong Chen, Zhi-Yu Li, Ning T. Yeh, Caren C. Bancroft, and Carter Van Waes
Cancer Res 2001 61: 5911-5918. [Abstract] [Full Text] [PDF]  

Abrogation of Transforming Growth Factor-/Epidermal Growth Factor Receptor Autocrine Signaling by an RXR-selective Retinoid (LGD1069, Targretin) in Head and Neck Cancer Cell Lines

John I. Song, Miriam N. Lango, James D. Hwang, Stephanie D. Drenning, Qing Zeng, William W. Lamph, and Jennifer Rubin Grandis
Cancer Res 2001 61: 5919-5925. [Abstract] [Full Text] [PDF]  

Ubiquitin/26S Proteasome-mediated Degradation of Topoisomerase I As a Resistance Mechanism to Camptothecin in Tumor Cells

Shyamal D. Desai, Tsai-Kun Li, Alexandra Rodriguez-Bauman, Eric H. Rubin, and Leroy F. Liu
Cancer Res 2001 61: 5926-5932. [Abstract] [Full Text] [PDF]  

Signaling from Protease-activated Receptor-1 Inhibits Migration and Invasion of Breast Cancer Cells

Lakshmi Kamath, Ahou Meydani, Francine Foss, and Athan Kuliopulos
Cancer Res 2001 61: 5933-5940. [Abstract] [Full Text] [PDF]  

Virology:

Efficient Replication of Adenovirus Despite the Overexpression of Active and Nondegradable p53

Philipp Koch, Jennifer Gatfield, Christian Löber, Urs Hobom, Claudia Lenz-Stöppler, Judith Roth, and Matthias Dobbelstein
Cancer Res 2001 61: 5941-5947. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: A. Rothfuss et al., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res., 60: 390–394, 2000.

Karin Baria, Colleen Warren, Stephen A. Roberts, Catharine M. L. West, D. Gareth R. Evans, Jenny M. Varley, and David Scott
Cancer Res 2001 61: 5948-5949. [Full Text] [PDF]  

Correspondence re: P. P. Claudio et al., Mutations in the Retinoblastoma-related Gene RB2/p130 in Primary Nasopharyngeal Carcinoma. Cancer Res., 60: 8–12, 2000.

Steven G. Gray, Xiang Guo, Darek Kedra, Bin T. Teh, Xiang Guo, and Hua-Qing Min
Cancer Res 2001 61: 5950-5951. [Full Text] [PDF]  

Reply

Pier Paolo Claudio, Caterina Cinti, Marco G. Paggi, and Antonio Giordano
Cancer Res 2001 61: 5952-5953. [Full Text] [PDF]  

Special Recognition:

V. Craig Jordan, Ph.D., D.Sc., Receives Bristol-Myers Squibb Award

Cancer Res 2001 61: 5954 [Full Text] [PDF]  

Corrections:

X. Huang et al., Cancer Res., 61: 478–481, 2001.

Cancer Res 2001 61: 5956 [Full Text] [PDF]  

S.-H. Song et al., Cancer Res., 61: 4628–4635, 2001

Cancer Res 2001 61: 5956 [Full Text] [PDF]  

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