Hierarchical clustering (upper panel) and ranking (lower left panel) of genes upregulated in malignant prostate tissues. Clustering identifies genes (in columns) showing generally high expression in 25 malignant samples (upper rows) and low expression in nine normal samples (lower rows). Red and green color squares indicate high and low gene expression levels, respectively. Differential expression of one gene product, FASN, was confirmed by immunohistochemistry (lower right panel), with more intense staining in malignant (red arrow) compared to adjacent normal (green arrow) glands. For details, see the article by Welsh et al. on p. 5974 in this issue.

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