Perspectives in Cancer Research:

Lipoxygenase Modulation to Reverse Carcinogenesis

Imad Shureiqi and Scott M. Lippman
Cancer Res 2001 61: 6307-6312. [Abstract] [Full Text] [PDF]  

Review:

Adeno-associated Virus for Cancer Gene Therapy

Selvarangan Ponnazhagan, David T. Curiel, Denise R. Shaw, Ronald D. Alvarez, and Gene P. Siegal
Cancer Res 2001 61: 6313-6321. [Full Text] [PDF]  

Advances in Brief:

Cooperative Interactions of Laminin 5 2 Chain, Matrix Metalloproteinase-2, and Membrane Type-1-Matrix/Metalloproteinase Are Required for Mimicry of Embryonic Vasculogenesis by Aggressive Melanoma

Richard E. B. Seftor, Elisabeth A. Seftor, Naohiko Koshikawa, Paul S. Meltzer, Lynn M. G. Gardner, Martin Bilban, William G. Stetler-Stevenson, Vito Quaranta, and Mary J. C. Hendrix
Cancer Res 2001 61: 6322-6327. [Abstract] [Full Text] [PDF]  

Enhanced Adenovirus Transgene Expression in Malignant Cells Treated with the Histone Deacetylase Inhibitor FR901228

Masaki Kitazono, Merrill E. Goldsmith, Takashi Aikou, Susan Bates, and Tito Fojo
Cancer Res 2001 61: 6328-6330. [Abstract] [Full Text] [PDF]  

Loss of Annexin II Heavy and Light Chains in Prostate Cancer and Its Precursors

Albert Chetcuti, Sienna H. Margan, Peter Russell, Stephen Mann, Douglas S. Millar, Susan J. Clark, John Rogers, David J. Handelsman, and Qihan Dong
Cancer Res 2001 61: 6331-6334. [Abstract] [Full Text] [PDF]  

Frequent Alterations of the p14^ARF and p16^INK4a Genes in Primary Central Nervous System Lymphomas

Mitsutoshi Nakamura, Toshisuke Sakaki, Hiroyuki Hashimoto, Hiroyuki Nakase, Eiwa Ishida, Keiji Shimada, and Noboru Konishi
Cancer Res 2001 61: 6335-6339. [Abstract] [Full Text] [PDF]  

TSU-Pr1 and JCA-1 Cells Are Derivatives of T24 Bladder Carcinoma Cells and Are Not of Prostatic Origin

Adrie van Bokhoven, Marileila Varella-Garcia, Christopher Korch, and Gary J. Miller
Cancer Res 2001 61: 6340-6344. [Abstract] [Full Text] [PDF]  

Identification of AF17 As a Downstream Gene of the ß-catenin/T-Cell Factor Pathway and Its Involvement in Colorectal Carcinogenesis

Yu-Min Lin, Kenji Ono, Seiji Satoh, Hideyuki Ishiguro, Manabu Fujita, Nobutomo Miwa, Toshihiro Tanaka, Tatsuhiko Tsunoda, Kou-Ching Yang, Yusuke Nakamura, and Yoichi Furukawa
Cancer Res 2001 61: 6345-6349. [Abstract] [Full Text] [PDF]  

Mutability of p53 Hotspot Codons to Benzo(a)pyrene Diol Epoxide (BPDE) and the Frequency of p53 Mutations in Nontumorous Human Lung

S. Perwez Hussain, Paul Amstad, Kamran Raja, Mark Sawyer, Lorne Hofseth, Peter G. Shields, Alan Hewer, David H. Phillips, David Ryberg, Aage Haugen, and Curtis C. Harris
Cancer Res 2001 61: 6350-6355. [Abstract] [Full Text] [PDF]  

Helicobacter Pylori Membrane Protein 1: A New Carcinogenic Factor of Helicobacter Pylori

Masami Suganuma, Miki Kurusu, Sachiko Okabe, Naoko Sueoka, Masaru Yoshida, Yoshio Wakatsuki, and Hirota Fujiki
Cancer Res 2001 61: 6356-6359. [Abstract] [Full Text] [PDF]  

Estrogens Do Not Modify MAP Kinase-dependent Nuclear Signaling during Stimulation of Early G₁ Progression in Human Breast Cancer Cells

Silvana Caristi, Juan Leyva Galera, Filomena Matarese, Manami Imai, Simona Caporali, Massimo Cancemi, Lucia Altucci, Luigi Cicatiello, Diana Teti, Francesco Bresciani, and Alessandro Weisz
Cancer Res 2001 61: 6360-6366. [Abstract] [Full Text] [PDF]  

Smoking Increases Carcinogenic Polycyclic Aromatic Hydrocarbons in Human Lung Tissue

Radoslav Goldman, Lindsey Enewold, Edo Pellizzari, James B. Beach, Elise D. Bowman, Shiva S. Krishnan, and Peter G. Shields
Cancer Res 2001 61: 6367-6371. [Abstract] [Full Text] [PDF]  

Therapeutic Implications of Enhanced G₀/G₁ Checkpoint Control Induced by Coculture of Prostate Cancer Cells with Osteoblasts

Jacek Pinski, Asit Parikh, G. Steven Bova, and John T. Isaacs
Cancer Res 2001 61: 6372-6376. [Abstract] [Full Text] [PDF]  

Targeting Oncolytic Adenoviral Agents to the Epidermal Growth Factor Pathway with a Secretory Fusion Molecule

Akseli Hemminki, Igor Dmitriev, Bin Liu, Renee A. Desmond, Ramon Alemany, and David T. Curiel
Cancer Res 2001 61: 6377-6381. [Abstract] [Full Text] [PDF]  

scid Thymocytes with TCRß Gene Rearrangements Are Targets for the Oncogenic Effect of SCL and LMO1 Transgenes

David S. Chervinsky, Du H. Lam, Michael P. Melman, Kenneth W. Gross, and Peter D. Aplan
Cancer Res 2001 61: 6382-6387. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Human Ogg1, a Protein Involved in the Repair of 8-Oxoguanine, Is Inhibited by Nitric Oxide

Meeta Jaiswal, Nicholas F. LaRusso, Nenichi Nishioka, Yusaka Nakabeppu, and Gregory J. Gores
Cancer Res 2001 61: 6388-6393. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Carbonic Anhydrase (CA IX) Expression, a Potential New Intrinsic Marker of Hypoxia: Correlations with Tumor Oxygen Measurements and Prognosis in Locally Advanced Carcinoma of the Cervix

Juliette A. Loncaster, Adrian L. Harris, Susan E. Davidson, John P. Logue, Robert D. Hunter, Charles C. Wycoff, Jaromir Pastorek, Peter J. Ratcliffe, Ian J. Stratford, and Catharine M. L. West
Cancer Res 2001 61: 6394-6399. [Abstract] [Full Text] [PDF]  

Interstitial Fluid Pressure Predicts Survival in Patients with Cervix Cancer Independent of Clinical Prognostic Factors and Tumor Oxygen Measurements

Michael Milosevic, Anthony Fyles, David Hedley, Melania Pintilie, Wilfred Levin, Lee Manchul, and Richard Hill
Cancer Res 2001 61: 6400-6405. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Secondary Lymphoid Organ Chemokine Reduces Pulmonary Tumor Burden in Spontaneous Murine Bronchoalveolar Cell Carcinoma

Sherven Sharma, Marina Stolina, Li Zhu, Ying Lin, Raj Batra, Min Huang, Robert Strieter, and Steven M. Dubinett
Cancer Res 2001 61: 6406-6412. [Abstract] [Full Text] [PDF]  

Mechanisms Associated with Tumor Vascular Shut-Down Induced by Combretastatin A-4 Phosphate: Intravital Microscopy and Measurement of Vascular Permeability

Gillian M. Tozer, Vivien E. Prise, John Wilson, Maja Cemazar, Siqing Shan, Mark W. Dewhirst, Paul R. Barber, Borivoj Vojnovic, and David J. Chaplin
Cancer Res 2001 61: 6413-6422. [Abstract] [Full Text] [PDF]  

Amifostine Protects against Early but not Late Toxic Effects of Doxorubicin in Infant Rats

Kirsi Jahnukainen, Timo Jahnukainen, Toivo T. Salmi, Konstantin Svechnikov, Staffan Eksborg, and Olle Söder
Cancer Res 2001 61: 6423-6427. [Abstract] [Full Text] [PDF]  

A Hepatocellular Carcinoma-specific Adenovirus Variant, CV890, Eliminates Distant Human Liver Tumors in Combination with Doxorubicin

Yuanhao Li, De-Chao Yu, Yu Chen, Pinky Amin, Hong Zhang, Natalie Nguyen, and Daniel R. Henderson
Cancer Res 2001 61: 6428-6436. [Abstract] [Full Text] [PDF]  

Apoptotic Signaling in Polyamine Analogue-treated SK-MEL-28 Human Melanoma Cells

Ying Chen, Debora L. Kramer, Paula Diegelman, Slavoljub Vujcic, and Carl W. Porter
Cancer Res 2001 61: 6437-6444. [Abstract] [Full Text] [PDF]  

Immunology:

Tumor Cell Lysate-pulsed Human Dendritic Cells Induce a T-Cell Response against Pancreatic Carcinoma Cells: an in Vitro Model for the Assessment of Tumor Vaccines

Max Schnurr, Peter Galambos, Christoph Scholz, Florian Then, Marc Dauer, Stefan Endres, and Andreas Eigler
Cancer Res 2001 61: 6445-6450. [Abstract] [Full Text] [PDF]  

Immune and Clinical Responses in Patients with Metastatic Melanoma to CD34⁺ Progenitor-derived Dendritic Cell Vaccine

Jacques Banchereau, A. Karolina Palucka, Madhav Dhodapkar, Susan Burkeholder, Nicolas Taquet, Alexandre Rolland, Sybil Taquet, Sebastien Coquery, Knut M. Wittkowski, Nina Bhardwaj, Luis Pineiro, Ralph Steinman, and Joseph Fay
Cancer Res 2001 61: 6451-6458. [Abstract] [Full Text] [PDF]  

Multidrug Resistance-associated Protein 3 Is a Tumor Rejection Antigen Recognized by HLA-A2402-restricted Cytotoxic T Lymphocytes

Akira Yamada, Kouichiro Kawano, Makoto Koga, Tomoko Matsumoto, and Kyogo Itoh
Cancer Res 2001 61: 6459-6466. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

p63 Expression Is Associated with p53 Loss in Oral-Esophageal Epithelia of p53-deficient Mice

Yasir Suliman, Oliver G. Opitz, Anjali Avadhani, Timothy C. Burns, Wafik El-Deiry, David T. Wong, and Anil K. Rustgi
Cancer Res 2001 61: 6467-6473. [Abstract] [Full Text] [PDF]  

Prediction of Sensitivity of Esophageal Tumors to Adjuvant Chemotherapy by cDNA Microarray Analysis of Gene-Expression Profiles

Chikashi Kihara, Tatsuhiko Tsunoda, Toshihiro Tanaka, Hideaki Yamana, Yoichi Furukawa, Kenji Ono, Osamu Kitahara, Hitoshi Zembutsu, Rempei Yanagawa, Koichi Hirata, Toshihisa Takagi, and Yusuke Nakamura
Cancer Res 2001 61: 6474-6479. [Abstract] [Full Text] [PDF]  

MLL-ENL Causes a Reversible and myc-dependent Block of Myelomonocytic Cell Differentiation

Silke Schreiner, Marco Birke, María-Paz García-Cuéllar, Olaf Zilles, Johann Greil, and Robert Karl Slany
Cancer Res 2001 61: 6480-6486. [Abstract] [Full Text] [PDF]  

Inverse Regulation of Cyclin B1 by c-Myc and p53 and Induction of Tetraploidy by Cyclin B1 Overexpression

Xiao-Ying Yin, Linette Grove, Nabanita S. Datta, Karen Katula, Michael W. Long, and Edward V. Prochownik
Cancer Res 2001 61: 6487-6493. [Abstract] [Full Text] [PDF]  

Role of HPC2/ELAC2 in Hereditary Prostate Cancer

Liang Wang, Shannon K. McDonnell, David A. Elkins, Susan L. Slager, Eric Christensen, Angela F. Marks, Julie M. Cunningham, Brett J. Peterson, Steven J. Jacobsen, James R. Cerhan, Michael L. Blute, Daniel J. Schaid, and Stephen N. Thibodeau
Cancer Res 2001 61: 6494-6499. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Activated Extracellular Signal-regulated Kinases: Association with Epidermal Growth Factor Receptor/Transforming Growth Factor Expression in Head and Neck Squamous Carcinoma and Inhibition by Anti-Epidermal Growth Factor Receptor Treatments

Joan Albanell, Jordi Codony-Servat, Federico Rojo, José M. Del Campo, Silvia Sauleda, Judit Anido, Guillermo Raspall, Jordi Giralt, José Roselló, Robert I. Nicholson, John Mendelsohn, and José Baselga
Cancer Res 2001 61: 6500-6510. [Abstract] [Full Text] [PDF]  

Endostatin-induced Modulation of Plasminogen Activation with Concomitant Loss of Focal Adhesions and Actin Stress Fibers in Cultured Human Endothelial Cells

Sara A. Wickström, Tanja Veikkola, Marko Rehn, Taina Pihlajaniemi, Kari Alitalo, and Jorma Keski-Oja
Cancer Res 2001 61: 6511-6516. [Abstract] [Full Text] [PDF]  

Role of Signal Transducer and Activator of Transcription 5 in Nucleophosmin/ Anaplastic Lymphoma Kinase-mediated Malignant Transformation of Lymphoid Cells

Malgorzata Nieborowska-Skorska, Artur Slupianek, Liquan Xue, Qian Zhang, Puthiyaveettil N. Raghunath, Grazyna Hoser, Mariusz A. Wasik, Stephan W. Morris, and Tomasz Skorski
Cancer Res 2001 61: 6517-6523. [Abstract] [Full Text] [PDF]  

Mapping Extracellular pH in Rat Brain Gliomas in Vivo by H Magnetic Resonance Spectroscopic Imaging: Comparison with Maps of Metabolites

María-L. García-Martín, Gwénaël Hérigault, Chantal Rémy, Régine Farion, Paloma Ballesteros, Jonathan A. Coles, Sebastián Cerdán, and Anne Ziegler
Cancer Res 2001 61: 6524-6531. [Abstract] [Full Text] [PDF]  

HOXB7: A Key Factor for Tumor-associated Angiogenic Switch

Alessandra Carè, Federica Felicetti, Ettore Meccia, Lisabianca Bottero, Mariella Parenza, Antonella Stoppacciaro, Cesare Peschle, and Mario P. Colombo
Cancer Res 2001 61: 6532-6539. [Abstract] [Full Text] [PDF]  

Overexpression of IRF9 Confers Resistance to Antimicrotubule Agents in Breast Cancer Cells

Kathryn E. Luker, Christina M. Pica, Robert D. Schreiber, and David Piwnica-Worms
Cancer Res 2001 61: 6540-6547. [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

Constitutive Expression of Hypoxia-inducible Factor-1 Renders Pancreatic Cancer Cells Resistant to Apoptosis Induced by Hypoxia and Nutrient Deprivation

Nobuaki Akakura, Masanobu Kobayashi, Iori Horiuchi, Akiko Suzuki, Jingxin Wang, Jian Chen, Hiroto Niizeki, Ken-ichi Kawamura, Masuo Hosokawa, and Masahiro Asaka
Cancer Res 2001 61: 6548-6554. [Abstract] [Full Text] [PDF]  

The Role of the DNA Mismatch Repair System in the Cytotoxicity of the Topoisomerase Inhibitors Camptothecin and Etoposide to Human Colorectal Cancer Cells

Sandrine Jacob, Mélanie Aguado, David Fallik, and Françoise Praz
Cancer Res 2001 61: 6555-6562. [Abstract] [Full Text] [PDF]  

Suppression of ß-Catenin Inhibits the Neoplastic Growth of APC-Mutant Colon Cancer Cells

Haeri Roh, Douglas W. Green, Craig B. Boswell, James A. Pippin, and Jeffrey A. Drebin
Cancer Res 2001 61: 6563-6568. [Abstract] [Full Text] [PDF]  

Activation of Extracellular Signal-regulated Kinase and c-Jun-NH₂-terminal Kinase but not p38 Mitogen-activated Protein Kinases Is Required for RRR--Tocopheryl Succinate-induced Apoptosis of Human Breast Cancer Cells

Weiping Yu, Qiao Yin Liao, Feras M. Hantash, Bob G. Sanders, and Kimberly Kline
Cancer Res 2001 61: 6569-6576. [Abstract] [Full Text] [PDF]  

Impact of Ionizing Radiation and Genetic Background on Mammary Tumorigenesis in p53-deficient Mice

Michael G. Backlund, Scott L. Trasti, Dana C. Backlund, Victoria L. Cressman, Virginia Godfrey, and Beverly H. Koller
Cancer Res 2001 61: 6577-6582. [Abstract] [Full Text] [PDF]  

ErbB2/neu Kinase Modulates Cellular p27^Kip1 and Cyclin D1 through Multiple Signaling Pathways

Anne E. G. Lenferink, Dagmar Busse, W. Michael Flanagan, F. Michael Yakes, and Carlos L. Arteaga
Cancer Res 2001 61: 6583-6591. [Abstract] [Full Text] [PDF]  

The Mechanism of the Growth-inhibitory Effect of Coxsackie and Adenovirus Receptor (CAR) on Human Bladder Cancer: A Functional Analysis of CAR Protein Structure

Takatsugu Okegawa, Rey-Chen Pong, Yingming Li, Jeffrey M. Bergelson, Arthur I. Sagalowsky, and Jer-Tsong Hsieh
Cancer Res 2001 61: 6592-6600. [Abstract] [Full Text] [PDF]  

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