Advances in Brief:

Molecular Classification of Estrogens

V. Craig Jordan, Jennifer MacGregor Schafer, Anait S. Levenson, Hong Liu, Katherine M. Pease, Laura A. Simons, and James W. Zapf
Cancer Res 2001 61: 6619-6623. [Abstract] [Full Text] [PDF]  

Inhibition of Glioma Angiogenesis and Growth in Vivo by Systemic Treatment with a Monoclonal Antibody against Vascular Endothelial Growth Factor Receptor-2

Philip Kunkel, Ulrike Ulbricht, Peter Bohlen, Marc A. Brockmann, Regina Fillbrandt, Dimitrios Stavrou, Manfred Westphal, and Katrin Lamszus
Cancer Res 2001 61: 6624-6628. [Abstract] [Full Text] [PDF]  

Identification of cIAP1 As a Candidate Target Gene within an Amplicon at 11q22 in Esophageal Squamous Cell Carcinomas

Issei Imoto, Zeng-Quan Yang, Atiphan Pimkhaokham, Hitoshi Tsuda, Yutaka Shimada, Masayuki Imamura, Misao Ohki, and Johji Inazawa
Cancer Res 2001 61: 6629-6634. [Abstract] [Full Text] [PDF]  

Acquired Mutations in the MXR/BCRP/ABCP Gene Alter Substrate Specificity in MXR/BCRP/ABCP-overexpressing Cells

Yasumasa Honjo, Christine A. Hrycyna, Qing-Wu Yan, Wilma Y. Medina-Pérez, Robert W. Robey, Anne van de Laar, Thomas Litman, Michael Dean, and Susan E. Bates
Cancer Res 2001 61: 6635-6639. [Abstract] [Full Text] [PDF]  

Characterization of the 13q14 Tumor Suppressor Locus in CLL: Identification of ALT1, an Alternative Splice Variant of the LEU2 Gene

Florencia Bullrich, Hidenori Fujii, George Calin, Hideaki Mabuchi, Massimo Negrini, Yuri Pekarsky, Laura Rassenti, Hansjuerg Alder, John C. Reed, Michael J. Keating, Thomas J. Kipps, and Carlo M. Croce
Cancer Res 2001 61: 6640-6648. [Abstract] [Full Text] [PDF]  

Cell Surface Tumor Endothelial Markers Are Conserved in Mice and Humans

Eleanor B. Carson-Walter, D. Neil Watkins, Akash Nanda, Bert Vogelstein, Kenneth W. Kinzler, and Brad St. Croix
Cancer Res 2001 61: 6649-6655. [Abstract] [Full Text] [PDF]  

Accumulation of ß-Catenin Protein and Mutations in Exon 3 of ß-Catenin Gene in Gastrointestinal Carcinoid Tumor

Masahiko Fujimori, Satoshi Ikeda, Yosuke Shimizu, Masazumi Okajima, and Toshimasa Asahara
Cancer Res 2001 61: 6656-6659. [Abstract] [Full Text] [PDF]  

APAF-1 Is a Transcriptional Target of p53 in DNA Damage-induced Apoptosis

Ana I. Robles, Nicole A. Bemmels, Amy B. Foraker, and Curtis C. Harris
Cancer Res 2001 61: 6660-6664. [Abstract] [Full Text] [PDF]  

Heterozygous Mice for the Transforming Growth Factor-ß Type II Receptor Gene Have Increased Susceptibility to Hepatocellular Carcinogenesis

Young-Hyuck Im, Heung Tae Kim, Isaac Yi Kim, Valentina M. Factor, Ki-Baik Hahm, Mario Anzano, Ja-June Jang, Kathleen Flanders, Diana C. Haines, Snorri S. Thorgeirsson, Andrew Sizeland, and Seong-Jin Kim
Cancer Res 2001 61: 6665-6668. [Abstract] [Full Text] [PDF]  

HIF-1-dependent Regulation of Hypoxic Induction of the Cell Death Factors BNIP3 and NIX in Human Tumors

Heidi M. Sowter, Peter J. Ratcliffe, Peter Watson, Arnold H. Greenberg, and Adrian L. Harris
Cancer Res 2001 61: 6669-6673. [Abstract] [Full Text] [PDF]  

Akt Pathway Activation Converts Anaplastic Astrocytoma to Glioblastoma Multiforme in a Human Astrocyte Model of Glioma

Yukihiko Sonoda, Tomoko Ozawa, Ken D. Aldape, Dennis F. Deen, Mitchel S. Berger, and Russell O. Pieper
Cancer Res 2001 61: 6674-6678. [Abstract] [Full Text] [PDF]  

Lung Tumor KRAS and TP53 Mutations in Nonsmokers Reflect Exposure to PAH-Rich Coal Combustion Emissions

David M. DeMarini, Stefano Landi, Defa Tian, Nancy M. Hanley, Xueming Li, Fuding Hu, Barbara C. Roop, Marc J. Mass, Phouthone Keohavong, Weimin Gao, Magali Olivier, Pierre Hainaut, and Judy L. Mumford
Cancer Res 2001 61: 6679-6681. [Abstract] [Full Text] [PDF]  

MAGE-A Gene Expression Pattern in Primary Breast Cancer

Marcus Otte, Menelaos Zafrakas, Lutz Riethdorf, Uwe Pichlmeier, Thomas Löning, Fritz Jänicke, and Klaus Pantel
Cancer Res 2001 61: 6682-6687. [Abstract] [Full Text] [PDF]  

Frequent Epigenetic Inactivation of RASSF1A in Human Bladder Carcinoma

Min-Goo Lee, Hee-Yul Kim, Do-Sun Byun, Sun-Ju Lee, Choong-Hyun Lee, Jin Il Kim, Sung-Goo Chang, and Sung-Gil Chi
Cancer Res 2001 61: 6688-6692. [Abstract] [Full Text] [PDF]  

Transfer of E2F-1 to Human Glioma Cells Results in Transcriptional Up-Regulation of Bcl-2

Candelaria Gomez-Manzano, Paraskevi Mitlianga, Juan Fueyo, Ho-Young Lee, Min Hu, Kevin B. Spurgers, Tricia L. Glass, Dimpy Koul, Ta-Jen Liu, Timothy J. McDonnell, and W. K. Alfred Yung
Cancer Res 2001 61: 6693-6697. [Abstract] [Full Text] [PDF]  

Evidence Supporting a Role for Mitochondrial Respiration in Apoptosis Induction by the Synthetic Retinoid CD437

Numsen Hail, Jr., Emile M. Youssef, and Reuben Lotan
Cancer Res 2001 61: 6698-6702. [Abstract] [Full Text] [PDF]  

Subcellular Distribution of p53 and p73 Are Differentially Regulated by MDM2

Jijie Gu, Linghu Nie, Hidehiko Kawai, and Zhi-Min Yuan
Cancer Res 2001 61: 6703-6707. [Abstract] [Full Text] [PDF]  

Association between Carcinogen-DNA Adducts in White Blood Cells and Lung Cancer Risk in the Physicians Health Study

Deliang Tang, David H. Phillips, Meir Stampfer, LaVerne A. Mooney, Yanzhi Hsu, Stan Cho, Wei-Yann Tsai, Jing Ma, Kathleen J. Cole, Meadhbh Ni Shé, and Frederica P. Perera
Cancer Res 2001 61: 6708-6712. [Abstract] [Full Text] [PDF]  

Tumor Location and Growth Pattern Correlate with Genetic Signature in Oligodendroglial Neoplasms

Magdalena C. Zlatescu, AliReza TehraniYazdi, Hikaru Sasaki, Joseph F. Megyesi, Rebecca A. Betensky, David N. Louis, and J. Gregory Cairncross
Cancer Res 2001 61: 6713-6715. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Catechol-O-Methyltransferase (COMT)-mediated Metabolism of Catechol Estrogens: Comparison of Wild-Type and Variant COMT Isoforms

Sheila Dawling, Nady Roodi, Raymond L. Mernaugh, Xiaohong Wang, and Fritz F. Parl
Cancer Res 2001 61: 6716-6722. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Modulation of Intracellular ß-Catenin Localization and Intestinal Tumorigenesis in Vivo and in Vitro by Sphingolipids

Eva M. Schmelz, Paul C. Roberts, Elizabeth M. Kustin, Lori A. Lemonnier, M. Cameron Sullards, Dirck L. Dillehay, and Alfred H. Merrill, Jr.
Cancer Res 2001 61: 6723-6729. [Abstract] [Full Text] [PDF]  

Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Epithelial Cell Proliferation and Sensitizes Transgenic Mice to Chemical Carcinogenesis

John A. Curran, Fiona S. Laverty, Donald Campbell, Jennifer Macdiarmid, and Joanna B. Wilson
Cancer Res 2001 61: 6730-6738. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Comparison of the Short-Term Biological Effects of 7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17ß-diol (Faslodex) versus Tamoxifen in Postmenopausal Women with Primary Breast Cancer

John F. Robertson, Robert I. Nicholson, Nigel J. Bundred, Elizabeth Anderson, Zenon Rayter, Mitchell Dowsett, John N. Fox, Julia M. W. Gee, Alan Webster, Alan E. Wakeling, Charles Morris, and Michael Dixon
Cancer Res 2001 61: 6739-6746. [Abstract] [Full Text] [PDF]  

Endocrinology:

Differential Insulin-like Growth Factor I Receptor Signaling and Function in Estrogen Receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 Breast Cancer Cells

Monica Bartucci, Catia Morelli, Loredana Mauro, Sebastiano Ando’, and Eva Surmacz
Cancer Res 2001 61: 6747-6754. [Abstract] [Full Text] [PDF]  

Transcriptional Regulation of the Estrogen-inducible pS2 Breast Cancer Marker Gene by the ERR Family of Orphan Nuclear Receptors

Desheng Lu, Yoshimitsu Kiriyama, Karen Y. Lee, and Vincent Giguère
Cancer Res 2001 61: 6755-6761. [Abstract] [Full Text] [PDF]  

Molecular Markers and Long-Term Recurrences in a Large Cohort of Patients with Sporadic Adrenocortical Tumors

Christine Gicquel, Xavier Bertagna, Véronique Gaston, Joël Coste, Albert Louvel, Eric Baudin, Jérome Bertherat, Yves Chapuis, Jean-Marc Duclos, Martin Schlumberger, Pierre-François Plouin, Jean-Pierre Luton, and Yves Le Bouc
Cancer Res 2001 61: 6762-6767. [Abstract] [Full Text] [PDF]  

Expression of Gonadotropin Receptor and Growth Responses to Key Reproductive Hormones in Normal and Malignant Human Ovarian Surface Epithelial Cells

Viqar Syed, Gregory Ulinski, Samuel C. Mok, Gary K. Yiu, and Shuk-Mei Ho
Cancer Res 2001 61: 6768-6776. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Genistein in the Diet Reduces the Incidence of Poorly Differentiated Prostatic Adenocarcinoma in Transgenic Mice (TRAMP)

Roycelynn Mentor-Marcel, Coral A. Lamartiniere, Isam-Eldin Eltoum, Norman M. Greenberg, and Ada Elgavish
Cancer Res 2001 61: 6777-6782. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

In Vitro Targeted Killing of Prostate Tumor Cells by a Synthetic Amoebapore Helix 3 Peptide Modified with Two -linked Glutamate Residues at the COOH Terminus

Patrick Warren, Laiji Li, Wendy Song, Eric Holle, Yangzhang Wei, Thomas Wagner, and Xianzhong Yu
Cancer Res 2001 61: 6783-6787. [Abstract] [Full Text] [PDF]  

Inhibition of Tumor Cell Invasion and Angiogenesis by Motuporamines

Calvin D. Roskelley, David E. Williams, Lianne M. McHardy, Kevin G. Leong, Armelle Troussard, Aly Karsan, Raymond J. Andersen, Shoukat Dedhar, and Michel Roberge
Cancer Res 2001 61: 6788-6794. [Abstract] [Full Text] [PDF]  

Adenovirus-mediated Tissue-targeted Expression of a Caspase-9-based Artificial Death Switch for the Treatment of Prostate Cancer

Xiaoming Xie, Xiuqin Zhao, Yuanfang Liu, Jianfeng Zhang, Robert J. Matusik, Kevin M. Slawin, and David M. Spencer
Cancer Res 2001 61: 6795-6804. [Abstract] [Full Text] [PDF]  

Methioninase Cancer Gene Therapy with Selenomethionine as Suicide Prodrug Substrate

Kenji Miki, Mingxu Xu, Anshu Gupta, Yi Ba, Yuying Tan, Waddah Al-Refaie, Michael Bouvet, Masatoshi Makuuchi, A. R. Moossa, and Robert M. Hoffman
Cancer Res 2001 61: 6805-6810. [Abstract] [Full Text] [PDF]  

The Susceptibility of Tumors to the Antivascular Drug Combretastatin A4 Phosphate Correlates with Vascular Permeability

Daniel A. Beauregard, Sally A. Hill, Dai J. Chaplin, and Kevin M. Brindle
Cancer Res 2001 61: 6811-6815. [Abstract] [Full Text] [PDF]  

Taurolidine: Cytotoxic and Mechanistic Evaluation of a Novel Antineoplastic Agent

Paul Calabresi, Frederick A. Goulette, and James W. Darnowski
Cancer Res 2001 61: 6816-6821. [Abstract] [Full Text] [PDF]  

2,6-Sialylation of Cell-Surface N-Glycans Inhibits Glioma Formation in Vivo

Hirotaka Yamamoto, Angelica Oviedo, Charla Sweeley, Tasuku Saito, and Joseph R. Moskal
Cancer Res 2001 61: 6822-6829. [Abstract] [Full Text] [PDF]  

Intravital Microscopy Reveals Novel Antivascular and Antitumor Effects of Endostatin Delivered Locally by Alginate-encapsulated Cells

Tracy-Ann Read, Mohammed Farhadi, Rolf Bjerkvig, Bjørn Reino Olsen, Anne Mari Rokstad, Peter C. Huszthy, and Peter Vajkoczy
Cancer Res 2001 61: 6830-6837. [Abstract] [Full Text] [PDF]  

Tumor-specific Up-Regulation of the Nonclassical Class I HLA-G Antigen Expression in Renal Carcinoma

El Chérif Ibrahim, Nadia Guerra, Marie-José Terrier Lacombe, Eric Angevin, Salem Chouaib, Edgardo D. Carosella, Anne Caignard, and Pascale Paul
Cancer Res 2001 61: 6838-6845. [Abstract] [Full Text] [PDF]  

The Epithelial Tumor Antigen MUC1 Is Expressed in Hematological Malignancies and Is Recognized by MUC1-specific Cytotoxic T-Lymphocytes

Peter Brossart, Anya Schneider, Patricia Dill, Theodora Schammann, Frank Grünebach, Stefan Wirths, Lothar Kanz, Hans-Jörg Bühring, and Wolfram Brugger
Cancer Res 2001 61: 6846-6850. [Abstract] [Full Text] [PDF]  

Serological Analysis of Human Anti-Human Antibody Responses in Colon Cancer Patients Treated with Repeated Doses of Humanized Monoclonal Antibody A33

Gerd Ritter, Leonard S. Cohen, Clarence Williams, Jr., Elizabeth C. Richards, Lloyd J. Old, and Sydney Welt
Cancer Res 2001 61: 6851-6859. [Abstract] [Full Text] [PDF]  

On the Site and Mode of Antigen Presentation for the Initiation of Clonal Expansion of CD8 T Cells Specific for a Natural Tumor Antigen

Xue-Feng Bai, Jian-Xin Gao, Jinqing Liu, Jing Wen, Pan Zheng, and Yang Liu
Cancer Res 2001 61: 6860-6867. [Abstract] [Full Text] [PDF]  

Antigenicity of Fusion Proteins from Sarcoma-associated Chromosomal Translocations

B. Scott Worley, Leon T. van den Broeke, Theresa J. Goletz, C. David Pendleton, Emily M. Daschbach, Elaine K. Thomas, Francesco M. Marincola, Lee J. Helman, and Jay A. Berzofsky
Cancer Res 2001 61: 6868-6875. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Specific Inhibition of Serine- and Arginine-rich Splicing Factors Phosphorylation, Spliceosome Assembly, and Splicing by the Antitumor Drug NB-506

Bartosz Pilch, Eric Allemand, Michael Facompré, Christian Bailly, Jean-François Riou, Johann Soret, and Jamal Tazi
Cancer Res 2001 61: 6876-6884. [Abstract] [Full Text] [PDF]  

Distinctive Molecular Profiles of High-Grade and Low-Grade Gliomas Based on Oligonucleotide Microarray Analysis

David S. Rickman, Miroslav P. Bobek, David E. Misek, Rork Kuick, Mila Blaivas, David M. Kurnit, Jeremy Taylor, and Samir M. Hanash
Cancer Res 2001 61: 6885-6891. [Abstract] [Full Text] [PDF]  

Neuroblastic and Schwannian Stromal Cells of Neuroblastoma Are Derived from a Tumoral Progenitor Cell

Jaume Mora, Nai-Kong V. Cheung, Gloria Juan, Peter Illei, Irene Cheung, Muzaffar Akram, Susan Chi, Marc Ladanyi, Carlos Cordon-Cardo, and William L. Gerald
Cancer Res 2001 61: 6892-6898. [Abstract] [Full Text] [PDF]  

p53-dependent Suppression of Uridine Phosphorylase Gene Expression through Direct Promoter Interaction

Dekai Zhang, Deliang Cao, Rosalind Russell, and Giuseppe Pizzorno
Cancer Res 2001 61: 6899-6905. [Abstract] [Full Text] [PDF]  

Cortactin Potentiates Bone Metastasis of Breast Cancer Cells

Yansong Li, Mehrdad Tondravi, Jiali Liu, Elizabeth Smith, Christian C. Haudenschild, Michele Kaczmarek, and Xi Zhan
Cancer Res 2001 61: 6906-6911. [Abstract] [Full Text] [PDF]  

Molecular Genetics of Ulcerative Colitis-associated Colon Cancer in the Interleukin 2- and ß₂-Microglobulin-deficient Mouse

Kyoung-Jin Sohn, Samir A. Shah, Sarah Reid, Monica Choi, Julie Carrier, Martina Comiskey, Cox Terhorst, and Young-In Kim
Cancer Res 2001 61: 6912-6917. [Abstract] [Full Text] [PDF]  

Sulindac Sulfide-induced Apoptosis Involves Death Receptor 5 and the Caspase 8-dependent Pathway in Human Colon and Prostate Cancer Cells

Ying Huang, Qin He, Michael J. Hillman, Rong Rong, and M. Saeed Sheikh
Cancer Res 2001 61: 6918-6924. [Abstract] [Full Text] [PDF]  

Self-deleting Suicide Vectors (SDSV): Selective Killing of p53-deficient Cancer Cells

Thomas Andreú, Christoph Ebensperger, Eva-Maria Westphal, Thomas Klenner, A. Francis Stewart, Andreas Westhof, Peter Müller, Rainer Knaus, and Harald von Melchner
Cancer Res 2001 61: 6925-6930. [Abstract] [Full Text] [PDF]  

ABL1 Promoter Methylation Can Exist Independently of BCR-ABL Transcription in Chronic Myeloid Leukemia Hematopoietic Progenitors

Baodong Sun, Guanchao Jiang, Muhammad-Ali A. Zaydan, Vincent F. La Russa, Hana Safah, and Melanie Ehrlich
Cancer Res 2001 61: 6931-6937. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Autotaxin (NPP-2), a Metastasis-enhancing Motogen, Is an Angiogenic Factor

Suk Woo Nam, Timothy Clair, Young-Sik Kim, Andrew McMarlin, Elliott Schiffmann, Lance A. Liotta, and Mary L. Stracke
Cancer Res 2001 61: 6938-6944. [Abstract] [Full Text] [PDF]  

Blocking Tumor Growth, Invasion, and Metastasis by Maspin in a Syngeneic Breast Cancer Model

Heidi Y Shi, Weiguo Zhang, Rong Liang, Shaji Abraham, Francis S. Kittrell, Daniel Medina, and Ming Zhang
Cancer Res 2001 61: 6945-6951. [Abstract] [Full Text] [PDF]  

Central Role of p53 on Regulation of Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) Expression in Mammary Carcinoma

Soumitro Pal, Kaustubh Datta, and Debabrata Mukhopadhyay
Cancer Res 2001 61: 6952-6957. [Abstract] [Full Text] [PDF]  

A Truncated Precursor Form of Prostate-specific Antigen Is a More Specific Serum Marker of Prostate Cancer

Stephen D. Mikolajczyk, Kathy M. Marker, Lisa S. Millar, Abhay Kumar, Mohammad S. Saedi, Janice K. Payne, Cindy L. Evans, Carlton L. Gasior, Harry J. Linton, Philip Carpenter, and Harry G. Rittenhouse
Cancer Res 2001 61: 6958-6963. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Correspondence re: W. Paile’s Letter to the Editor. Cancer Res., 60: 1146, 2000.

Alina Romanenko, Alexander Vozianov, Keiichirou Morimura, and Shoji Fukushima
Cancer Res 2001 61: 6964-6965. [Full Text] [PDF]  

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