Review:

The Selection for Mismatch Repair Defects in Hereditary Nonpolyposis Colorectal Cancer: Revising the Mutator Hypothesis

Richard Fishel
Cancer Res 2001 61: 7369-7374. [Full Text] [PDF]  

Advances in Brief:

A Polymorphism in Endostatin, an Angiogenesis Inhibitor, Predisposes for the Development of Prostatic Adenocarcinoma

Paula Iughetti, Oscar Suzuki, Paulo H. C. Godoi, Venâncio Avancini Ferreira Alves, Andrea L. Sertié, Todd Zorick, Fernando Soares, Anamaria Camargo, Eloísa S. Moreira, Celso di Loreto, Carlos Alberto Moreira-Filho, Andrew Simpson, Glaucius Oliva, and Maria Rita Passos-Bueno
Cancer Res 2001 61: 7375-7378. [Abstract] [Full Text] [PDF]  

Absence of Msh2 Protein Expression Is Associated with Alteration in the FHIT Locus and Fhit Protein Expression in Colorectal Carcinoma

Masaki Mori, Koshi Mimori, Takaaki Masuda, Keiji Yoshinaga, Keishi Yamashita, Ayumi Matsuyama, and Hiroshi Inoue
Cancer Res 2001 61: 7379-7382. [Abstract] [Full Text] [PDF]  

A Novel Growth Suppressor Gene on Chromosome 17p13.3 with a High Frequency of Mutation in Human Hepatocellular Carcinoma

Xintai Zhao, Jinjun Li, Yinghua He, Fei Lan, Lili Fu, Jianying Guo, Ruijiao Zhao, Yun Ye, Mei He, Wenming Chong, Jianguo Chen, Lisheng Zhang, Nanwu Yang, Binghua Xu, Mengchao Wu, Dafang Wan, and Jian-ren Gu
Cancer Res 2001 61: 7383-7387. [Abstract] [Full Text] [PDF]  

Molecular Classification of Human Carcinomas by Use of Gene Expression Signatures

Andrew I. Su, John B. Welsh, Lisa M. Sapinoso, Suzanne G. Kern, Petre Dimitrov, Hilmar Lapp, Peter G. Schultz, Steven M. Powell, Christopher A. Moskaluk, Henry F. Frierson, Jr., and Garret M. Hampton
Cancer Res 2001 61: 7388-7393. [Abstract] [Full Text] [PDF]  

Hypoxia-inducible Factor-1 Is an Intrinsic Marker for Hypoxia in Cervical Cancer Xenografts

Vojislav Vukovic, Hans Kristian Haugland, Trudey Nicklee, Andrew J. Morrison, and David W. Hedley
Cancer Res 2001 61: 7394-7398. [Abstract] [Full Text] [PDF]  

DNA Polymerase ß Mediates Protection of Mammalian Cells against Ganciclovir-induced Cytotoxicity and DNA Breakage

Maja T. Tomicic, Rudolf Thust, Robert W. Sobol, and Bernd Kaina
Cancer Res 2001 61: 7399-7403. [Abstract] [Full Text] [PDF]  

Age and TP53 Mutation Frequency in Childhood Malignant Gliomas: Results in a Multi-institutional Cohort

Ian F. Pollack, Sydney D. Finkelstein, Judith Burnham, Emiko J. Holmes, Ronald L. Hamilton, Allan J. Yates, Jonathan L. Finlay, and Richard Sposto
Cancer Res 2001 61: 7404-7407. [Abstract] [Full Text] [PDF]  

Tyrphostin AG825 Triggers p38 Mitogen-activated Protein Kinase-dependent Apoptosis in Androgen-independent Prostate Cancer Cells C4 and C4-2

Horacio Murillo, Lucy J. Schmidt, and Donald J. Tindall
Cancer Res 2001 61: 7408-7412. [Abstract] [Full Text] [PDF]  

E1A Inhibition of Radiation-induced NF-B Activity through Suppression of IKK Activity and IB Degradation, Independent of Akt Activation

Ruping Shao, Eing Mei Tsai, Kevin Wei, Ryan von Lindern, Yun-Houng Chen, Keishi Makino, and Mien-Chie Hung
Cancer Res 2001 61: 7413-7416. [Abstract] [Full Text] [PDF]  

Human Rad17 Is Phosphorylated upon DNA Damage and also Overexpressed in Primary Non-Small Cell Lung Cancer Tissues

Xin Wang, Luo Wang, Matthew D. Callister, Joe B. Putnam, Li Mao, and Lei Li
Cancer Res 2001 61: 7417-7421. [Abstract] [Full Text] [PDF]  

Loss of Expression of the Metastasis Suppressor Gene KiSS1 during Melanoma Progression and Its Association with LOH of Chromosome 6q16.3-q23

Fumiaki Shirasaki, Minoru Takata, Naohito Hatta, and Kazuhiko Takehara
Cancer Res 2001 61: 7422-7425. [Abstract] [Full Text] [PDF]  

The Phosphatidylinositol 3'-kinase p85 Gene Is an Oncogene in Human Ovarian and Colon Tumors

Amanda J. Philp, Ian G. Campbell, Christine Leet, Elizabeth Vincan, Steven P. Rockman, Robert H. Whitehead, Robert J. S. Thomas, and Wayne A. Phillips
Cancer Res 2001 61: 7426-7429. [Abstract] [Full Text] [PDF]  

Functional Significance of XPD Polymorphic Variants: Attenuated Apoptosis in Human Lymphoblastoid Cells with the XPD 312 Asp/Asp Genotype

Hasan Seker, Dorota Butkiewicz, Elise D. Bowman, Marek Rusin, Mohammad Hedayati, Lawrence Grossman, and Curtis C. Harris
Cancer Res 2001 61: 7430-7434. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Inducible Expression of Transforming Growth Factor ß1 in Papillomas Causes Rapid Metastasis

Brian H. Weeks, Wei He, Krista L. Olson, and Xiao-Jing Wang
Cancer Res 2001 61: 7435-7443. [Abstract] [Full Text] [PDF]  

Oxidative Stress Increases Frameshift Mutations in Human Colorectal Cancer Cells

Christoph Gasche, Christina L. Chang, Jennifer Rhees, Ajay Goel, and C. Richard Boland
Cancer Res 2001 61: 7444-7448. [Abstract] [Full Text] [PDF]  

2-Difluoromethylornithine and Dehydroepiandrosterone Inhibit Mammary Tumor Progression but not Mammary or Prostate Tumor Initiation in C3(1)/SV40 T/t-antigen Transgenic Mice

Jeffrey E. Green, Masa-Aki Shibata, Eiko Shibata, Richard C. Moon, Miriam R. Anver, Gary Kelloff, and Ronald Lubet
Cancer Res 2001 61: 7449-7455. [Abstract] [Full Text] [PDF]  

Estrogenic and Antiestrogenic Properties of Resveratrol in Mammary Tumor Models

Krishna P. L. Bhat, Daniel Lantvit, Konstantin Christov, Rajendra G. Mehta, Richard C. Moon, and John M. Pezzuto
Cancer Res 2001 61: 7456-7463. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

A Phase I Trial of CV706, a Replication-competent, PSA Selective Oncolytic Adenovirus, for the Treatment of Locally Recurrent Prostate Cancer following Radiation Therapy

Theodore L. DeWeese, Henk van der Poel, Shidong Li, Bahar Mikhak, Renee Drew, Marti Goemann, Ulrike Hamper, Robert DeJong, Nicholas Detorie, Ronald Rodriguez, Thomas Haulk, Angelo M. DeMarzo, Steven Piantadosi, D. C. Yu, Yu Chen, Daniel R. Henderson, Michael A. Carducci, William G. Nelson, and Jonathan W. Simons
Cancer Res 2001 61: 7464-7472. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Chemopreventive Property of a Soybean Peptide (Lunasin) That Binds to Deacetylated Histones and Inhibits Acetylation

Alfredo F. Galvez, Na Chen, Janet Macasieb, and Ben O. de Lumen
Cancer Res 2001 61: 7473-7478. [Abstract] [Full Text] [PDF]  

Enhanced Sensitivity of Human Oral Carcinomas to Induction of Apoptosis by Selenium Compounds: Involvement of Mitogen-activated Protein Kinase and Fas Pathways

Aurnab Ghose, Janis Fleming, Karam El-Bayoumy, and Paul R. Harrison
Cancer Res 2001 61: 7479-7487. [Abstract] [Full Text] [PDF]  

The Effects of Catechol-O-Methyltransferase Inhibition on Estrogen Metabolite and Oxidative DNA Damage Levels in Estradiol-treated MCF-7 Cells

Jackie A. Lavigne, Julie E. Goodman, Tekum Fonong, Shelly Odwin, Ping He, Dean W. Roberts, and James D. Yager
Cancer Res 2001 61: 7488-7494. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Photosensitization with Zinc (II) Phthalocyanine as a Switch in the Decision between Apoptosis and Necrosis

Clara Fabris, Giuliana Valduga, Giovanni Miotto, Lara Borsetto, Giulio Jori, Spiridione Garbisa, and Elena Reddi
Cancer Res 2001 61: 7495-7500. [Abstract] [Full Text] [PDF]  

Low-dose Chemotherapy Combined with an Antiangiogenic Drug Reduces Human Glioma Growth in Vivo

Lorenzo Bello, Giorgio Carrabba, Carlo Giussani, Valeria Lucini, Francesca Cerutti, Francesco Scaglione, Julien Landré, Mauro Pluderi, Giustino Tomei, Roberto Villani, Rona S. Carroll, Peter McL Black, and Andreas Bikfalvi
Cancer Res 2001 61: 7501-7506. [Abstract] [Full Text] [PDF]  

Preclinical Antitumor Activity of BMS-214662, a Highly Apoptotic and Novel Farnesyltransferase Inhibitor

William C. Rose, Francis Y. F. Lee, Craig R. Fairchild, Mark Lynch, Thomas Monticello, Robert A. Kramer, and Veeraswamy Manne
Cancer Res 2001 61: 7507-7517. [Abstract] [Full Text] [PDF]  

Inhibition of Growth, Invasion, and Metastasis of Human Pancreatic Carcinoma Cells by NK4 in an Orthotopic Mouse Model

Daisaku Tomioka, Naoki Maehara, Keiji Kuba, Kazuhiro Mizumoto, Masao Tanaka, Kunio Matsumoto, and Toshikazu Nakamura
Cancer Res 2001 61: 7518-7524. [Abstract] [Full Text] [PDF]  

The Farnesyl Protein Transferase Inhibitor SCH66336 Is a Potent Inhibitor of MDR1 Product P-glycoprotein

Er-jia Wang, Christopher N. Casciano, Robert P. Clement, and William W. Johnson
Cancer Res 2001 61: 7525-7529. [Abstract] [Full Text] [PDF]  

Combined Intratumoral Injection of Bone Marrow-derived Dendritic Cells and Systemic Chemotherapy to Treat Pre-existing Murine Tumors

Youzhi Tong, Wenru Song, and Ronald G. Crystal
Cancer Res 2001 61: 7530-7535. [Abstract] [Full Text] [PDF]  

Levels of Phospholipid Metabolites in Breast Cancer Cells Treated with Antimitotic Drugs: A ³¹P-Magnetic Resonance Spectroscopy Study

Marina Sterin, Jack S. Cohen, Yael Mardor, Elisha Berman, and Israel Ringel
Cancer Res 2001 61: 7536-7543. [Abstract] [Full Text] [PDF]  

Overexpressed Androgen Receptor Linked to p21^WAF1 Silencing May Be Responsible for Androgen Independence and Resistance to Apoptosis of a Prostate Cancer Cell Line

Long. G. Wang, Liliana Ossowski, and Anna C. Ferrari
Cancer Res 2001 61: 7544-7551. [Abstract] [Full Text] [PDF]  

Cross-Resistance to the Synthetic Retinoid CD437 in a Paclitaxel-resistant Human Ovarian Carcinoma Cell Line Is Independent of the Overexpression of Retinoic Acid Receptor-

Atul Kumar, Dianne R. Soprano, and Hemant K. Parekh
Cancer Res 2001 61: 7552-7555. [Abstract] [Full Text] [PDF]  

Immunology:

Recombinant CD40 Ligand Therapy Has Significant Antitumor Effects on CD40-positive Ovarian Tumor Xenografts Grown in SCID Mice and Demonstrates an Augmented Effect with Cisplatin

Sharad Ghamande, Bonnie L Hylander, Ezogelin Oflazoglu, Shashikant Lele, William Fanslow, and Elizabeth A Repasky
Cancer Res 2001 61: 7556-7562. [Abstract] [Full Text] [PDF]  

Administration of Interleukin-12 Enhances the Therapeutic Efficacy of Dendritic Cell-based Tumor Vaccines in Mouse Hepatocellular Carcinoma

Tomohide Tatsumi, Tetsuo Takehara, Tatsuya Kanto, Takuya Miyagi, Noriyoshi Kuzushita, Yoshiko Sugimoto, Masahisa Jinushi, Akinori Kasahara, Yutaka Sasaki, Masatsugu Hori, and Norio Hayashi
Cancer Res 2001 61: 7563-7567. [Abstract] [Full Text] [PDF]  

The Infection of Human Dendritic Cells with Recombinant Avipox Vectors Expressing a Costimulatory Molecule Transgene (CD80) to Enhance the Activation of Antigen-specific Cytolytic T Cells

Kwong Y. Tsang, MingZhu Zhu, Jos Even, James Gulley, Philip Arlen, and Jeffrey Schlom
Cancer Res 2001 61: 7568-7576. [Abstract] [Full Text] [PDF]  

Identification of Helper T-Cell Epitopes That Encompass or Lie Proximal to Cytotoxic T-Cell Epitopes in the gp100 Melanoma Tumor Antigen

Hiroya Kobayashi, Jun Lu, and Esteban Celis
Cancer Res 2001 61: 7577-7584. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Profiling of Cancer Cells Using Protein Microarrays: Discovery of Novel Radiation-regulated Proteins

Arun Sreekumar, Mukesh K. Nyati, Sooryanarayana Varambally, Terrence R. Barrette, Debashis Ghosh, Theodore S. Lawrence, and Arul M. Chinnaiyan
Cancer Res 2001 61: 7585-7593. [Abstract] [Full Text] [PDF]  

Regulation of Human Telomerase Activity: Repression by Normal Chromosome 3 Abolishes Nuclear Telomerase Reverse Transcriptase Transcripts but Does Not Affect c-Myc Activity

Anne-Lyse Ducrest, Mario Amacker, Yves D. Mathieu, Andrew P. Cuthbert, Deborah A. Trott, Robert F. Newbold, Markus Nabholz, and Joachim Lingner
Cancer Res 2001 61: 7594-7602. [Abstract] [Full Text] [PDF]  

Hypoxia-induced Enrichment and Mutagenesis of Cells That Have Lost DNA Mismatch Repair

Akira Kondo, Roohangiz Safaei, Misako Mishima, Hannes Niedner, Xinjian Lin, and Stephen B. Howell
Cancer Res 2001 61: 7603-7607. [Abstract] [Full Text] [PDF]  

Spectrum of ATM Gene Mutations in a Hospital-based Series of Unselected Breast Cancer Patients

Thilo Dörk, Regina Bendix, Michael Bremer, Dirk Rades, Karin Klöpper, Marion Nicke, Britta Skawran, Ariadne Hector, Paria Yamini, Diana Steinmann, Sabine Weise, Manfred Stuhrmann, and Johann H. Karstens
Cancer Res 2001 61: 7608-7615. [Abstract] [Full Text] [PDF]  

Nontruncating APC Germ-line Mutations and Mismatch Repair Deficiency Play a Minor Role in APC Mutation-negative Polyposis

Karl Heinimann, Annick Thompson, Andreas Locher, Tamara Furlanetto, Eva Bader, Angela Wolf, Remy Meier, Klaus Walter, Peter Bauerfeind, Giancarlo Marra, Hansjakob Müller, Dorothee Foernzler, and Zuzana Dobbie
Cancer Res 2001 61: 7616-7622. [Abstract] [Full Text] [PDF]  

Detection of Mitochondrial DNA Mutations in Primary Breast Cancer and Fine-Needle Aspirates

Paola Parrella, Yan Xiao, Makiko Fliss, Montserrat Sanchez-Cespedes, Paola Mazzarelli, Monica Rinaldi, Theresa Nicol, Edward Gabrielson, Carmela Cuomo, Daniel Cohen, Sunil Pandit, Myla Spencer, Carla Rabitti, Vito Michele Fazio, and David Sidransky
Cancer Res 2001 61: 7623-7626. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Structural Fragility of Blood Vessels and Peritoneum in Calponin h1-deficient Mice, Resulting in an Increase in Hematogenous Metastasis and Peritoneal Dissemination of Malignant Tumor Cells

Shun’ichiro Taniguchi, Michiko Takeoka, Takashi Ehara, Shigenari Hashimoto, Hiroto Shibuki, Nagahisa Yoshimura, Hidekazu Shigematsu, Katsuhito Takahashi, and Motoya Katsuki
Cancer Res 2001 61: 7627-7634. [Abstract] [Full Text] [PDF]  

Requirement for Mdm2 in the Survival Effects of Bcr-Abl and Interleukin 3 in Hematopoietic Cells

Alexander W. Goetz, Heiko van der Kuip, Ruth Maya, Moshe Oren, and Walter E. Aulitzky
Cancer Res 2001 61: 7635-7641. [Abstract] [Full Text] [PDF]  

HDM2 Protein Overexpression, but not Gene Amplification, is Related to Tumorigenesis of Cutaneous Melanoma

David Polsky, Boris C. Bastian, Carole Hazan, Kate Melzer, Jason Pack, Alan Houghton, Klaus Busam, Carlos Cordon-Cardo, and Iman Osman
Cancer Res 2001 61: 7642-7646. [Abstract] [Full Text] [PDF]  

Akt1 Induces Extracellular Matrix Invasion and Matrix Metalloproteinase-2 Activity in Mouse Mammary Epithelial Cells

Bae-Keun Park, Xiao Zeng, and Robert I. Glazer
Cancer Res 2001 61: 7647-7653. [Abstract] [Full Text] [PDF]  

Mobilized Human CD34+ Hematopoietic Stem Cells Enhance Tumor Growth in a Nonobese Diabetic/Severe Combined Immunodeficient Mouse Model of Human Non-Hodgkin’s Lymphoma

Eveline S. J. M. de Bont, Jeroen E. J. Guikema, Frank Scherpen, Tiny Meeuwsen, Willem A. Kamps, Edo Vellenga, and Nico A. Bos
Cancer Res 2001 61: 7654-7659. [Abstract] [Full Text] [PDF]  

Neither p21^WAF1 Nor 14-3-3 Prevents G₂ Progression to Mitotic Catastrophe in Human Colon Carcinoma Cells after DNA Damage, But p21^WAF1 Induces Stable G₁ Arrest in Resulting Tetraploid Cells

Paul R. Andreassen, Françoise B. Lacroix, Olivier D. Lohez, and Robert L. Margolis
Cancer Res 2001 61: 7660-7668. [Abstract] [Full Text] [PDF]  

Continuous Administration of Endostatin by Intraperitoneally Implanted Osmotic Pump Improves the Efficacy and Potency of Therapy in a Mouse Xenograft Tumor Model

Oliver Kisker, Christian M. Becker, Daniela Prox, Michael Fannon, Robert D’Amato, Evelyn Flynn, William E. Fogler, B. Kim Lee Sim, Elizabeth N. Allred, Steven R. Pirie-Shepherd, and Judah Folkman
Cancer Res 2001 61: 7669-7674. [Abstract] [Full Text] [PDF]  

Phosphorylation of Retinoid X Receptor at Serine 260 Impairs Its Metabolism and Function in Human Hepatocellular Carcinoma

Rie Matsushima-Nishiwaki, Masataka Okuno, Seiji Adachi, Tetsuro Sano, Kuniharu Akita, Hisataka Moriwaki, Scott L. Friedman, and Soichi Kojima
Cancer Res 2001 61: 7675-7682. [Abstract] [Full Text] [PDF]  

Genetic Subgroups of Anaplastic Astrocytomas Correlate with Patient Age and Survival

Sandeep Kunwar, Gayatry Mohapatra, Andrew Bollen, Kathleen R. Lamborn, Michael Prados, and Burt G. Feuerstein
Cancer Res 2001 61: 7683-7688. [Abstract] [Full Text] [PDF]  

Indomethacin-induced Radiosensitization and Inhibition of Ionizing Radiation-induced NF-B Activation in HeLa Cells Occur via a Mechanism Involving p38 MAP Kinase

C. Matthew Bradbury, Stephanie Markovina, S. Jack Wei, Luis M. Rene, Imran Zoberi, Nobuo Horikoshi, and David Gius
Cancer Res 2001 61: 7689-7696. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: N. C. Denko and A. J. Giaccia, Tumor Hypoxia, the Physiological Link between Trousseau’s Syndrome (Carcinoma-induced Coagulopathy) and Metastasis. Cancer Res., 61: 795–798, 2001.

Georg-Friedrich von Tempelhoff, Lothar Heilmann, and Gerhard Hommel
Cancer Res 2001 61: 7697-7698. [Full Text] [PDF]  

Correspondence re: Y. Yamada et al., Frequent ß-Catenin Gene Mutations and Accumulations of the Protein in the Putative Preneoplastic Lesions Lacking Macroscopic Aberrant Crypt Foci Appearance, In Rat Colon Carcinogenesis. Cancer Res., 60: 3323–3327, 2000; and Sequential Analysis of Morphological and Biological Properties of ß-Catenin-accumulated Crypts, Provable Premalignant Lesions Independent of Aberrant Crypt Foci in Rat Colon Carcinogenesis. Cancer Res., 61: 1874–1878, 2001.

Theresa P. Pretlow, Ranjana P. Bird, Yasuhiro Yamada, Yoshinobu Hirose, Akira Hara, and Hideki Mori
Cancer Res 2001 61: 7699-7701. [Full Text] [PDF]  

Errata:

K. Mishima et al., 61: 5349–5354, 2001.

Cancer Res 2001 61: 7703 [Full Text] [PDF]  

G. S. Prins et al., 61: 6089–6097, 2001.

Cancer Res 2001 61: 7704-7705. [Full Text] [PDF]  

Correction:

M. Jaiswal et al., 61: 6388–6393, 2001.

Cancer Res 2001 61: 7705 [Full Text] [PDF]  

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