Electrostatic surface potential of human wild-type endostatin-XVIII. Red and blue coloring represent negative and positive partial charges, respec-tively, which are altered due to the substitution of an aspartic acid (D) to an asparagine (N) residue at position 104, a polymorphism that increases by 2.5 times the chance of a male individual to develop prostate adenocarci-noma. For details, see the article by Iughetti et al. on p. 7375 in this issue.

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